Click here to switch to the map view.

The map label for this gene is murC

Identifier: 124265656

GI number: 124265656

Start: 503516

End: 504925

Strand: Direct

Name: murC

Synonym: Mpe_A0463

Alternate gene names: 124265656

Gene position: 503516-504925 (Clockwise)

Preceding gene: 124265655

Following gene: 124265657

Centisome position: 12.45

GC content: 71.42

Gene sequence:

>1410_bases
ATGAAGCACGCAGTCAAGCACATCCACTTCGTCGGCATCGGCGGCGCCGGCATGAGCGGCATCGCCGAGATCCTGCACAA
CCTGGGCTACCGGGTGTCGGGCTCCGACCAGAGCGACGGCGCGACGACGCGGCGGCTGGCCTCGCTGGGCATCCGCGTGG
CGATCGGCCACGACGCTGCGCACATCGCCGGCGCCGAGGCGGTGGTCACGTCCACCGCGGTGAAGGGAGACAACCCCGAG
GTGATCGCGGCGCGGTCCCGGCGCGTGCCGGTGGTGCCGCGCGCGGTGATGCTGGCCGAGCTGATGCGCCTGAAGCAGGG
CATCGCGATCGCCGGCACGCACGGCAAGACCACCACCACCTCGCTGGTCGCCAGCGTGCTGGCCGAAGCCGGGCTGGACC
CGACCTTCGTGATCGGCGGTCGGCTCAACAGCGCCGGCGCGAACTCGCGGCTCGGCGCCGGCGACTACATCGTGGTCGAG
GCGGACGAGTCGGACGCCTCGTTCCTGAACCTGCTGCCGGTGCTGAGCGTCGTGACCAACATCGACGCCGACCACATGGA
CACCTACGGCCACGACCTCGGCCGACTGAAGCACGCCTTCCTCGAATTCCTCCACCGCATGCCGTTCTACGGCGCGGCCA
TCATCTGCGGCGACGACCCCGGCGTGCGTTCCATCATCCCGATGATCTCGCGGCCCGTGGTGAGCTACGGCTTCGGCGAG
GATGCGCAGATCCGCGCGGTCGACGTGCTGGCGCTGCCGGGGGGGCAGATGCGCTTCACCGCGCAGCGCCGCAACGGCGT
GGTGATGCCCGACCTGCCGATCACGCTCAACCTGCCGGGCCGGCACAACGTGCTCAACGCGCTGGCGGTCATCGCGGTGG
CGGCCGAGCTGGAGCTGCCCGATGCGCCGGTGCAGAAGGCGCTGGCCGCCTTCGACGGCGTGGGCCGGCGCTTCCAGCGC
TACGGCGAGCTGCCGACGCCGGCCGGTGGTCGCTTCACGCTGATCGACGACTACGGCCACCACCCGGTGGAGATGGCCGC
GGTGATCGCCGCGGCGCGCGGTGCCTTCCCGGGGCGCCGCCTGGTGATCGCCTTCCAGCCGCACCGCTATACCCGCACGC
GCGACTGTTTCGAGGACTTCGTCAAGGTGATGGGTGGCGCAGACGCGGTGCTGCTGGGCGAGGTCTACGCCGCCGGCGAA
GCGCCGATCGTGGCGGCCGACGGGCGCGCGCTGGCGCGCGCGCTGCGGGTCGGCGGCAAGCTCGAACCGGTGTTCGTGGA
CGAGATCGCGGCGATGCCGCAGGCCATCGCCGACAACGTGCAGGACGGCGATGTGGTGATCACCATGGGGGCGGGCTCGA
TCGGCGCCGTGCCCGGCCAGGTGGTCGAACTGTTGGGAGCCCACGCATGA

Upstream 100 bases:

>100_bases
TGCAGACACTTGCGCACGCGGGCCGAGCGCCGGGCCGCCCCAAGCCGGCCCGTATCCCCGCGGGGGATCGGCCGACGTAC
GCGTCGGACGAGGGGCTGTC

Downstream 100 bases:

>100_bases
GCGCCACCCCCGATCCCCGGTCCTTCGGCAAGGTCGCCGTGCTGATGGGCGGCACCTCGGCCGAACGCGACATCTCGCTG
ATGTCCGGCGGCGGCGTGCT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MKHAVKHIHFVGIGGAGMSGIAEILHNLGYRVSGSDQSDGATTRRLASLGIRVAIGHDAAHIAGAEAVVTSTAVKGDNPE
VIAARSRRVPVVPRAVMLAELMRLKQGIAIAGTHGKTTTTSLVASVLAEAGLDPTFVIGGRLNSAGANSRLGAGDYIVVE
ADESDASFLNLLPVLSVVTNIDADHMDTYGHDLGRLKHAFLEFLHRMPFYGAAIICGDDPGVRSIIPMISRPVVSYGFGE
DAQIRAVDVLALPGGQMRFTAQRRNGVVMPDLPITLNLPGRHNVLNALAVIAVAAELELPDAPVQKALAAFDGVGRRFQR
YGELPTPAGGRFTLIDDYGHHPVEMAAVIAAARGAFPGRRLVIAFQPHRYTRTRDCFEDFVKVMGGADAVLLGEVYAAGE
APIVAADGRALARALRVGGKLEPVFVDEIAAMPQAIADNVQDGDVVITMGAGSIGAVPGQVVELLGAHA

Sequences:

>Translated_469_residues
MKHAVKHIHFVGIGGAGMSGIAEILHNLGYRVSGSDQSDGATTRRLASLGIRVAIGHDAAHIAGAEAVVTSTAVKGDNPE
VIAARSRRVPVVPRAVMLAELMRLKQGIAIAGTHGKTTTTSLVASVLAEAGLDPTFVIGGRLNSAGANSRLGAGDYIVVE
ADESDASFLNLLPVLSVVTNIDADHMDTYGHDLGRLKHAFLEFLHRMPFYGAAIICGDDPGVRSIIPMISRPVVSYGFGE
DAQIRAVDVLALPGGQMRFTAQRRNGVVMPDLPITLNLPGRHNVLNALAVIAVAAELELPDAPVQKALAAFDGVGRRFQR
YGELPTPAGGRFTLIDDYGHHPVEMAAVIAAARGAFPGRRLVIAFQPHRYTRTRDCFEDFVKVMGGADAVLLGEVYAAGE
APIVAADGRALARALRVGGKLEPVFVDEIAAMPQAIADNVQDGDVVITMGAGSIGAVPGQVVELLGAHA
>Mature_469_residues
MKHAVKHIHFVGIGGAGMSGIAEILHNLGYRVSGSDQSDGATTRRLASLGIRVAIGHDAAHIAGAEAVVTSTAVKGDNPE
VIAARSRRVPVVPRAVMLAELMRLKQGIAIAGTHGKTTTTSLVASVLAEAGLDPTFVIGGRLNSAGANSRLGAGDYIVVE
ADESDASFLNLLPVLSVVTNIDADHMDTYGHDLGRLKHAFLEFLHRMPFYGAAIICGDDPGVRSIIPMISRPVVSYGFGE
DAQIRAVDVLALPGGQMRFTAQRRNGVVMPDLPITLNLPGRHNVLNALAVIAVAAELELPDAPVQKALAAFDGVGRRFQR
YGELPTPAGGRFTLIDDYGHHPVEMAAVIAAARGAFPGRRLVIAFQPHRYTRTRDCFEDFVKVMGGADAVLLGEVYAAGE
APIVAADGRALARALRVGGKLEPVFVDEIAAMPQAIADNVQDGDVVITMGAGSIGAVPGQVVELLGAHA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=464, Percent_Identity=50.4310344827586, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1790680, Length=478, Percent_Identity=28.0334728033473, Blast_Score=148, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_METPP (A2SCY6)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001019660.1
- ProteinModelPortal:   A2SCY6
- SMR:   A2SCY6
- STRING:   A2SCY6
- GeneID:   4784182
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0463
- NMPDR:   fig|279263.3.peg.2707
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   A2SCY6
- ProtClustDB:   PRK00421
- BioCyc:   MPET420662:MPE_A0463-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 49124; Mature: 49124

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHAVKHIHFVGIGGAGMSGIAEILHNLGYRVSGSDQSDGATTRRLASLGIRVAIGHDAA
CCCCCCEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHCCEEEEECCCHH
HIAGAEAVVTSTAVKGDNPEVIAARSRRVPVVPRAVMLAELMRLKQGIAIAGTHGKTTTT
HHCCCHHHEEEHEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHH
SLVASVLAEAGLDPTFVIGGRLNSAGANSRLGAGDYIVVEADESDASFLNLLPVLSVVTN
HHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHC
IDADHMDTYGHDLGRLKHAFLEFLHRMPFYGAAIICGDDPGVRSIIPMISRPVVSYGFGE
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCHHHCCCCC
DAQIRAVDVLALPGGQMRFTAQRRNGVVMPDLPITLNLPGRHNVLNALAVIAVAAELELP
CCEEEEEEEEECCCCCEEEEEECCCCEECCCCCEEEECCCCHHHHHHHHHHHHHHHCCCC
DAPVQKALAAFDGVGRRFQRYGELPTPAGGRFTLIDDYGHHPVEMAAVIAAARGAFPGRR
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCE
LVIAFQPHRYTRTRDCFEDFVKVMGGADAVLLGEVYAAGEAPIVAADGRALARALRVGGK
EEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHCCCCCCEEEECCHHHHHHHHHCCC
LEPVFVDEIAAMPQAIADNVQDGDVVITMGAGSIGAVPGQVVELLGAHA
CCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MKHAVKHIHFVGIGGAGMSGIAEILHNLGYRVSGSDQSDGATTRRLASLGIRVAIGHDAA
CCCCCCEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHCCEEEEECCCHH
HIAGAEAVVTSTAVKGDNPEVIAARSRRVPVVPRAVMLAELMRLKQGIAIAGTHGKTTTT
HHCCCHHHEEEHEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHH
SLVASVLAEAGLDPTFVIGGRLNSAGANSRLGAGDYIVVEADESDASFLNLLPVLSVVTN
HHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHC
IDADHMDTYGHDLGRLKHAFLEFLHRMPFYGAAIICGDDPGVRSIIPMISRPVVSYGFGE
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCHHHCCCCC
DAQIRAVDVLALPGGQMRFTAQRRNGVVMPDLPITLNLPGRHNVLNALAVIAVAAELELP
CCEEEEEEEEECCCCCEEEEEECCCCEECCCCCEEEECCCCHHHHHHHHHHHHHHHCCCC
DAPVQKALAAFDGVGRRFQRYGELPTPAGGRFTLIDDYGHHPVEMAAVIAAARGAFPGRR
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCE
LVIAFQPHRYTRTRDCFEDFVKVMGGADAVLLGEVYAAGEAPIVAADGRALARALRVGGK
EEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHCCCCCCEEEECCHHHHHHHHHCCC
LEPVFVDEIAAMPQAIADNVQDGDVVITMGAGSIGAVPGQVVELLGAHA
CCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA