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The map label for this gene is penA [H]

Identifier: 124265649

GI number: 124265649

Start: 493221

End: 495044

Strand: Direct

Name: penA [H]

Synonym: Mpe_A0456

Alternate gene names: 124265649

Gene position: 493221-495044 (Clockwise)

Preceding gene: 124265648

Following gene: 124265650

Centisome position: 12.2

GC content: 70.34

Gene sequence:

>1824_bases
ATGAGCGCCTGGCGCGAATGGCTGGGCCGCCTCGGCCGGGGCGGTTCCCGCCGGCCCGGTGCACGCGCCGCCAGCGGTGC
CGTGAGCGCGCGCAGCGTGCGCTACGCGAGCAGCCCGCTGCTGGCGTCGAAGACGCCGCCGTGGCGCTCCAAGTTCCTGG
TCGCTCTGGTCGGTGCCGGCTTCCTGCTGCTGCTCGGCCGCGCGGTCTACGTGCAGGTGATCGGCACCGAGTTCTACCAG
CAGCAGGGCGCGAGCCGCTACGCGCACAAGCTCGAGCTGCCGGCCAACCGCGGCCGCATCACCGACCGCGGTGGCGAACT
GCTCGCCTCCAGCGTGGAGGCACCGACGCTGTGGGCCATCCCGCGCGACGTCACCGCCACCTCTGCCGAGAAGCGCCAGC
TCGCCAGGCTGCTCGGCATGTCGGTCGGCGATCTGGAGAAGCGTCTGGCGGACAACCCGAACTTCGTCTACCTGCGCCGT
CAGGTCGACGACTCGGTGGCGCTGCAGGTGCGCGCACTCAACCTCAAGGGCGTGCACCAGCTCACCGAGTACAAGCGGCG
CTACCCGGCGGGCGAGGCGGCGGCCCACGTGGTGGGCTTCACCAACGTCGAGGACCGGGGGCAGGAGGGCATCGAACTCG
CCTTCCAGTCCGACCTGGCCGGCCGCGACGGCAGTCGCCGCGTCATCAAGGACCGTCGCGGCCGCGTGGTCGAGGACATC
GGCGAGCGCGTGCCACCGGTCGACGGTCGCGACATCGAGCTCGCGATCGACACCAAGGTGCAGTTCTTCGCCTACCAGCG
CATCCGTGACGCGGTGGCCGAGCACAAGGCCAAGGCCGGCAGCGTGGTGGTGCTCGACGTGCAGAGCGGCGAGGTGCTGG
CGCTGGCCAACTACCCGAGCTACACGCCGGGTGACCGCCGCAACCTCAGCGGAGCGCAGCTGCGCAACCGGGCGCTGACC
GATACCTTCGAGCCCGGCTCGACCATGAAGCCCTTCATCATCGGCGAGGCACTGCAGGCCGGACGCGTGTCGCCCTCGAC
GGTGATCGACACCGCACCCGGCCGCATGAGCGTCACCGGCAGCACCATCAGCGACGCCCACCCGCACGGCGCGCTCACCG
TCGAGCAGGTGATCCAGAAATCGAGCAACGTCGGCACCGTGAAGATCTCCCAGCTGCTCTCCGAGCGGGAGATGTGGGAG
ACCTTCAGCGCCATCGGCCTGGGCCAGAAGCCGCAGATCGACTTCCCCGGCGCCGTCACCGGCCGGCTGCGTCCCTACAA
GACCTGGCGGCCGATCGAGAAGGCGACCATGAGCTACGGCTACGGCCTGTCGGCCAGCCTGTTCCAGCTCGCGCGCGCCT
ACACCGTGTTCGCGCGCGACGGGGAGCTCATCCCGGTCAGCATCACCCGCGCGCAGCAGCCCGGCGCCGGCGTGCGCGTG
TTCTCGCCCGAGGTCGCGCGCGATGTGCGCCACATGCTGCAGATGGCGGCGGGCCCCGGCGGCACCGGCCCGAAGGCGCA
GACCATCGGCTACTCGGTCGGCGGCAAGTCAGGCACCGCGCACAAGCAGGAAGGCAAGGGCTACGCCGACAAGAAGTACC
GCGCCTGGTTCGTCGGCCTGGCGCCGATCGACAAGCCGCGCATCGTGGTCGCGGTGATGGTCGACGAGCCGAACGCCGGC
AAGTACTTCGGCGGCGAGGTCGCCGCACCGGTGTTCAGCGAGGTGGTGCAGAAGACGCTGCATGCGATGGGTGTTTCGCC
CGATCTCGACGTCAAGCCGCAGATCGTGGCGCGCCACGAGGACGCTGTGGAGGAGAGCTTCTGA

Upstream 100 bases:

>100_bases
GCGAGCGACTCGGCATGCGCAGCGCCACACCGGCGGTCACCGAGTACGTGGTGGTGCCGGTGGCCGCTGCGCCGGCGCCT
GATGTCGCGGAGCTGCGCCG

Downstream 100 bases:

>100_bases
TGCTCACCGCGTTGCGTTCGCCCGCCGCCGCGGCCCGCTGGCTCCAGGAATGGACCACCGGCACGCTGCGCACCGACAGC
CGCCTGGTGCAGCGCGGCGA

Product: peptidoglycan synthetase FtsI

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 607; Mature: 606

Protein sequence:

>607_residues
MSAWREWLGRLGRGGSRRPGARAASGAVSARSVRYASSPLLASKTPPWRSKFLVALVGAGFLLLLGRAVYVQVIGTEFYQ
QQGASRYAHKLELPANRGRITDRGGELLASSVEAPTLWAIPRDVTATSAEKRQLARLLGMSVGDLEKRLADNPNFVYLRR
QVDDSVALQVRALNLKGVHQLTEYKRRYPAGEAAAHVVGFTNVEDRGQEGIELAFQSDLAGRDGSRRVIKDRRGRVVEDI
GERVPPVDGRDIELAIDTKVQFFAYQRIRDAVAEHKAKAGSVVVLDVQSGEVLALANYPSYTPGDRRNLSGAQLRNRALT
DTFEPGSTMKPFIIGEALQAGRVSPSTVIDTAPGRMSVTGSTISDAHPHGALTVEQVIQKSSNVGTVKISQLLSEREMWE
TFSAIGLGQKPQIDFPGAVTGRLRPYKTWRPIEKATMSYGYGLSASLFQLARAYTVFARDGELIPVSITRAQQPGAGVRV
FSPEVARDVRHMLQMAAGPGGTGPKAQTIGYSVGGKSGTAHKQEGKGYADKKYRAWFVGLAPIDKPRIVVAVMVDEPNAG
KYFGGEVAAPVFSEVVQKTLHAMGVSPDLDVKPQIVARHEDAVEESF

Sequences:

>Translated_607_residues
MSAWREWLGRLGRGGSRRPGARAASGAVSARSVRYASSPLLASKTPPWRSKFLVALVGAGFLLLLGRAVYVQVIGTEFYQ
QQGASRYAHKLELPANRGRITDRGGELLASSVEAPTLWAIPRDVTATSAEKRQLARLLGMSVGDLEKRLADNPNFVYLRR
QVDDSVALQVRALNLKGVHQLTEYKRRYPAGEAAAHVVGFTNVEDRGQEGIELAFQSDLAGRDGSRRVIKDRRGRVVEDI
GERVPPVDGRDIELAIDTKVQFFAYQRIRDAVAEHKAKAGSVVVLDVQSGEVLALANYPSYTPGDRRNLSGAQLRNRALT
DTFEPGSTMKPFIIGEALQAGRVSPSTVIDTAPGRMSVTGSTISDAHPHGALTVEQVIQKSSNVGTVKISQLLSEREMWE
TFSAIGLGQKPQIDFPGAVTGRLRPYKTWRPIEKATMSYGYGLSASLFQLARAYTVFARDGELIPVSITRAQQPGAGVRV
FSPEVARDVRHMLQMAAGPGGTGPKAQTIGYSVGGKSGTAHKQEGKGYADKKYRAWFVGLAPIDKPRIVVAVMVDEPNAG
KYFGGEVAAPVFSEVVQKTLHAMGVSPDLDVKPQIVARHEDAVEESF
>Mature_606_residues
SAWREWLGRLGRGGSRRPGARAASGAVSARSVRYASSPLLASKTPPWRSKFLVALVGAGFLLLLGRAVYVQVIGTEFYQQ
QGASRYAHKLELPANRGRITDRGGELLASSVEAPTLWAIPRDVTATSAEKRQLARLLGMSVGDLEKRLADNPNFVYLRRQ
VDDSVALQVRALNLKGVHQLTEYKRRYPAGEAAAHVVGFTNVEDRGQEGIELAFQSDLAGRDGSRRVIKDRRGRVVEDIG
ERVPPVDGRDIELAIDTKVQFFAYQRIRDAVAEHKAKAGSVVVLDVQSGEVLALANYPSYTPGDRRNLSGAQLRNRALTD
TFEPGSTMKPFIIGEALQAGRVSPSTVIDTAPGRMSVTGSTISDAHPHGALTVEQVIQKSSNVGTVKISQLLSEREMWET
FSAIGLGQKPQIDFPGAVTGRLRPYKTWRPIEKATMSYGYGLSASLFQLARAYTVFARDGELIPVSITRAQQPGAGVRVF
SPEVARDVRHMLQMAAGPGGTGPKAQTIGYSVGGKSGTAHKQEGKGYADKKYRAWFVGLAPIDKPRIVVAVMVDEPNAGK
YFGGEVAAPVFSEVVQKTLHAMGVSPDLDVKPQIVARHEDAVEESF

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=548, Percent_Identity=39.2335766423358, Blast_Score=390, Evalue=1e-109,
Organism=Escherichia coli, GI1786854, Length=595, Percent_Identity=25.3781512605042, Blast_Score=116, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 65810; Mature: 65679

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAWREWLGRLGRGGSRRPGARAASGAVSARSVRYASSPLLASKTPPWRSKFLVALVGAG
CCHHHHHHHHHCCCCCCCCCCCHHCCCCHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHH
FLLLLGRAVYVQVIGTEFYQQQGASRYAHKLELPANRGRITDRGGELLASSVEAPTLWAI
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHEECCCCCCCCCCCCCHHHHHHCCCCCEEEEC
PRDVTATSAEKRQLARLLGMSVGDLEKRLADNPNFVYLRRQVDDSVALQVRALNLKGVHQ
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEECCCHHHH
LTEYKRRYPAGEAAAHVVGFTNVEDRGQEGIELAFQSDLAGRDGSRRVIKDRRGRVVEDI
HHHHHHHCCCCCHHEEEEEECCCHHCCCCCEEEEEECCCCCCCCCHHHHHHHCCCHHHHH
GERVPPVDGRDIELAIDTKVQFFAYQRIRDAVAEHKAKAGSVVVLDVQSGEVLALANYPS
HHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCC
YTPGDRRNLSGAQLRNRALTDTFEPGSTMKPFIIGEALQAGRVSPSTVIDTAPGRMSVTG
CCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCEEECCCCCEEECC
STISDAHPHGALTVEQVIQKSSNVGTVKISQLLSEREMWETFSAIGLGQKPQIDFPGAVT
CCCCCCCCCCCEEHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GRLRPYKTWRPIEKATMSYGYGLSASLFQLARAYTVFARDGELIPVSITRAQQPGAGVRV
CCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHEEEECCCCEEEEEEEECCCCCCCEEE
FSPEVARDVRHMLQMAAGPGGTGPKAQTIGYSVGGKSGTAHKQEGKGYADKKYRAWFVGL
ECHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCHHCCCCCCCCCEEEEEEEE
APIDKPRIVVAVMVDEPNAGKYFGGEVAAPVFSEVVQKTLHAMGVSPDLDVKPQIVARHE
CCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEECCH
DAVEESF
HHHHCCC
>Mature Secondary Structure 
SAWREWLGRLGRGGSRRPGARAASGAVSARSVRYASSPLLASKTPPWRSKFLVALVGAG
CHHHHHHHHHCCCCCCCCCCCHHCCCCHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHH
FLLLLGRAVYVQVIGTEFYQQQGASRYAHKLELPANRGRITDRGGELLASSVEAPTLWAI
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHEECCCCCCCCCCCCCHHHHHHCCCCCEEEEC
PRDVTATSAEKRQLARLLGMSVGDLEKRLADNPNFVYLRRQVDDSVALQVRALNLKGVHQ
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEECCCHHHH
LTEYKRRYPAGEAAAHVVGFTNVEDRGQEGIELAFQSDLAGRDGSRRVIKDRRGRVVEDI
HHHHHHHCCCCCHHEEEEEECCCHHCCCCCEEEEEECCCCCCCCCHHHHHHHCCCHHHHH
GERVPPVDGRDIELAIDTKVQFFAYQRIRDAVAEHKAKAGSVVVLDVQSGEVLALANYPS
HHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCC
YTPGDRRNLSGAQLRNRALTDTFEPGSTMKPFIIGEALQAGRVSPSTVIDTAPGRMSVTG
CCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCEEECCCCCEEECC
STISDAHPHGALTVEQVIQKSSNVGTVKISQLLSEREMWETFSAIGLGQKPQIDFPGAVT
CCCCCCCCCCCEEHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GRLRPYKTWRPIEKATMSYGYGLSASLFQLARAYTVFARDGELIPVSITRAQQPGAGVRV
CCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHEEEECCCCEEEEEEEECCCCCCCEEE
FSPEVARDVRHMLQMAAGPGGTGPKAQTIGYSVGGKSGTAHKQEGKGYADKKYRAWFVGL
ECHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCHHCCCCCCCCCEEEEEEEE
APIDKPRIVVAVMVDEPNAGKYFGGEVAAPVFSEVVQKTLHAMGVSPDLDVKPQIVARHE
CCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEECCH
DAVEESF
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]