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The map label for this gene is pyrC [H]

Identifier: 124265641

GI number: 124265641

Start: 486361

End: 487407

Strand: Direct

Name: pyrC [H]

Synonym: Mpe_A0448

Alternate gene names: 124265641

Gene position: 486361-487407 (Clockwise)

Preceding gene: 124265639

Following gene: 124265642

Centisome position: 12.03

GC content: 71.44

Gene sequence:

>1047_bases
ATGAGTTCTGCTGCCCCGGACACCCTGACCCTGAGTCGGCCCGACGACTGGCACCTGCACGTGCGCGATGGCGCCGCGCT
GGCGGCCGTCGTGCCGCACACCGCGCGACAGTTCGGCCGCGCGATCATCATGCCCAATCTCAAGCCGCCGGTCACCACTG
CGGCCCAGGCGCTGGCCTACCGCGAGCGCATCCTCGCGGCTGTGCCGGCCGGCCTCGCGTTCGAGCCGCTGATGACGCTC
TACCTGACCGACAACATGCCGCCCGAGGAGATCGGCCGCGCGAAGGCGGCCGGCGTCGTGGCCGTCAAGCTCTACCCGGC
GGGCGCCACCACCAACAGCGATGCCGGCGTGACCGACCTGCGCAAGACCCAGGCCACGCTCGAGGCGATGCAGCGCGAGG
GCCTGCCTCTGCTGGTGCACGGCGAGGTCACCGATGCCGAGATCGACCTGTTCGACCGCGAGGCGGTGTTCATCGACCGC
CAGCTGATCCCGCTGCGGCGCGACTTCCCGGCCCTGAAGATCGTGTTCGAGCACATCACCACCCGCGAGGCCGCGCAGTA
CGTGGCCGGGGCCGGGCCGCACACCGCGGCCACGATCACCGCCCACCACCTGCTCTACAACCGCAACGCCATCTTCACCG
GCGGCATCCGGCCGCACTACTACTGCCTGCCGGTGCTCAAGCGCGAGCTGCATCGCGAGGCGCTGGTGGCCGCCGCCACC
TCGGGCAGCGACCGCTATTTCCTCGGTACCGACAGCGCACCGCATCCGGCCCACCTGAAAGAGCACGCCAGCGGCTGTGC
CGGCTGCTACACCGCGTTCAGTGCGCTGGAGCTGTATGCCGAGGCCTTCGACGCCGCCGGCGCGCTGGATCGGCTGGAAG
GCTTCGCCAGCGTCCACGGTCCGGCCTTCTACGGCCTGCCGCGCAACGCCGGCACGGTGACGCTGCGCCGGCAGGCCTGG
ACGCCACCCGAGACGCTGCCGTTCGGCGAAGCGACGCTCAAGCCGCTGCGCGGCGGCGAGTCGCTGGCCTGGCGGCAGGT
CGAGTGA

Upstream 100 bases:

>100_bases
CGGGCCGGCCGCGGTCGTGATCGCCGGAACAGCGCAACGCTTCCCGGCCAGTTCGGGCGGTGCCGCGGGGCGGTCGCGCG
TGCAGGCGACAATCCAGCGC

Downstream 100 bases:

>100_bases
AGAACGCCGCATCCGCGGCCCAGGAGACGCCATGACGACCCCGACGATCCGCACCGCGCTGCTGGTCGATGCCGACAACG
TGAAGGTCGAGCTGGTGGCC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MSSAAPDTLTLSRPDDWHLHVRDGAALAAVVPHTARQFGRAIIMPNLKPPVTTAAQALAYRERILAAVPAGLAFEPLMTL
YLTDNMPPEEIGRAKAAGVVAVKLYPAGATTNSDAGVTDLRKTQATLEAMQREGLPLLVHGEVTDAEIDLFDREAVFIDR
QLIPLRRDFPALKIVFEHITTREAAQYVAGAGPHTAATITAHHLLYNRNAIFTGGIRPHYYCLPVLKRELHREALVAAAT
SGSDRYFLGTDSAPHPAHLKEHASGCAGCYTAFSALELYAEAFDAAGALDRLEGFASVHGPAFYGLPRNAGTVTLRRQAW
TPPETLPFGEATLKPLRGGESLAWRQVE

Sequences:

>Translated_348_residues
MSSAAPDTLTLSRPDDWHLHVRDGAALAAVVPHTARQFGRAIIMPNLKPPVTTAAQALAYRERILAAVPAGLAFEPLMTL
YLTDNMPPEEIGRAKAAGVVAVKLYPAGATTNSDAGVTDLRKTQATLEAMQREGLPLLVHGEVTDAEIDLFDREAVFIDR
QLIPLRRDFPALKIVFEHITTREAAQYVAGAGPHTAATITAHHLLYNRNAIFTGGIRPHYYCLPVLKRELHREALVAAAT
SGSDRYFLGTDSAPHPAHLKEHASGCAGCYTAFSALELYAEAFDAAGALDRLEGFASVHGPAFYGLPRNAGTVTLRRQAW
TPPETLPFGEATLKPLRGGESLAWRQVE
>Mature_347_residues
SSAAPDTLTLSRPDDWHLHVRDGAALAAVVPHTARQFGRAIIMPNLKPPVTTAAQALAYRERILAAVPAGLAFEPLMTLY
LTDNMPPEEIGRAKAAGVVAVKLYPAGATTNSDAGVTDLRKTQATLEAMQREGLPLLVHGEVTDAEIDLFDREAVFIDRQ
LIPLRRDFPALKIVFEHITTREAAQYVAGAGPHTAATITAHHLLYNRNAIFTGGIRPHYYCLPVLKRELHREALVAAATS
GSDRYFLGTDSAPHPAHLKEHASGCAGCYTAFSALELYAEAFDAAGALDRLEGFASVHGPAFYGLPRNAGTVTLRRQAWT
PPETLPFGEATLKPLRGGESLAWRQVE

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=343, Percent_Identity=53.935860058309, Blast_Score=377, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6323452, Length=354, Percent_Identity=35.0282485875706, Blast_Score=181, Evalue=2e-46,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 37611; Mature: 37480

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAAPDTLTLSRPDDWHLHVRDGAALAAVVPHTARQFGRAIIMPNLKPPVTTAAQALAY
CCCCCCCEEEECCCCCCEEEEECCCEEEECCCHHHHHHCCEEECCCCCCCHHHHHHHHHH
RERILAAVPAGLAFEPLMTLYLTDNMPPEEIGRAKAAGVVAVKLYPAGATTNSDAGVTDL
HHHHHHHCCCCCHHHHEEEEEEECCCCHHHHCCHHHCCEEEEEEEECCCCCCCCCCCHHH
RKTQATLEAMQREGLPLLVHGEVTDAEIDLFDREAVFIDRQLIPLRRDFPALKIVFEHIT
HHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCEEEECCEECCHHCCCHHHHHHHHHHH
TREAAQYVAGAGPHTAATITAHHLLYNRNAIFTGGIRPHYYCLPVLKRELHREALVAAAT
HHHHHHHHHCCCCCCHHHHHHHHHEECCCEEEECCCCCCEEHHHHHHHHHHHHHHHEEEC
SGSDRYFLGTDSAPHPAHLKEHASGCAGCYTAFSALELYAEAFDAAGALDRLEGFASVHG
CCCCEEEECCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PAFYGLPRNAGTVTLRRQAWTPPETLPFGEATLKPLRGGESLAWRQVE
CEEECCCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCEEECC
>Mature Secondary Structure 
SSAAPDTLTLSRPDDWHLHVRDGAALAAVVPHTARQFGRAIIMPNLKPPVTTAAQALAY
CCCCCCEEEECCCCCCEEEEECCCEEEECCCHHHHHHCCEEECCCCCCCHHHHHHHHHH
RERILAAVPAGLAFEPLMTLYLTDNMPPEEIGRAKAAGVVAVKLYPAGATTNSDAGVTDL
HHHHHHHCCCCCHHHHEEEEEEECCCCHHHHCCHHHCCEEEEEEEECCCCCCCCCCCHHH
RKTQATLEAMQREGLPLLVHGEVTDAEIDLFDREAVFIDRQLIPLRRDFPALKIVFEHIT
HHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCEEEECCEECCHHCCCHHHHHHHHHHH
TREAAQYVAGAGPHTAATITAHHLLYNRNAIFTGGIRPHYYCLPVLKRELHREALVAAAT
HHHHHHHHHCCCCCCHHHHHHHHHEECCCEEEECCCCCCEEHHHHHHHHHHHHHHHEEEC
SGSDRYFLGTDSAPHPAHLKEHASGCAGCYTAFSALELYAEAFDAAGALDRLEGFASVHG
CCCCEEEECCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PAFYGLPRNAGTVTLRRQAWTPPETLPFGEATLKPLRGGESLAWRQVE
CEEECCCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA