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The map label for this gene is htpX

Identifier: 124265478

GI number: 124265478

Start: 310453

End: 311304

Strand: Direct

Name: htpX

Synonym: Mpe_A0285

Alternate gene names: 124265478

Gene position: 310453-311304 (Clockwise)

Preceding gene: 124265477

Following gene: 124265479

Centisome position: 7.68

GC content: 66.67

Gene sequence:

>852_bases
ATGTTCAATCTGATGAAGACCGCCGTGCTGATGGCCGCCATCACGGCGCTGTTCATGGCCATCGGCTCGGTGCTGGGCGG
GCAGCAGGGCATGGCGATCGCGCTGGTGGTCGCGCTCGGCATGAACTTCTTCAGCTACTGGTTCAGCGACAAGATGGTGC
TGAAGATGTACAACGCGCAGGAGGTCGATGCGTCCTCCGCGCCGCAGTTCTACGGCATGGTGCGAGAGCTCGCCGCGAAG
GCGGAGTTGCCGATGCCCAAGGTCTACCTGATCAACGAGGACGCGCCGAACGCGTTCGCGACCGGCCGCAATCCCCAGAA
CGCTGCGGTGGCGGCCACCACCGGCATCCTGCGTGTGCTGTCCGAGCGTGAACTGCGCGGCGTCATGGCACACGAGCTCG
CGCACGTGAAGCATCGCGATATCCTGATCAGCACCATCAGCGCGACGATGGCCGGCGCCATCTCGATGCTGGCCAATTTC
GCGATGTTCTTCGGCGGCCGTGGAAGCGACGGTCGGCCAGCCAACCCGATCGCCGGCATCCTGGTGATGCTGCTGGCGCC
GCTGGCAGCCAGCCTGATCCAGATGGCGATCAGCCGGGCCCGCGAGTTCGAGGCCGACCGGGGCGGCGCCGAGATCTCCG
GCGATCCGCAGGCCCTGGCCAGCGCGCTGCAGAAGATCCAGCGCTATGCCCAGGGGATCCCGCTGGAGGCGGCCGAGCGT
CATCCGGAGACGGCGCAGATGATGATCATGAATCCGCTGTCCGGCGGTGGGCTGCGCGGCCTGTTCAGCACCCACCCGGC
CACCGAGGAGCGCGTGGCCAAGCTGATGGCCATGGTTCCCCAACGGGTCTGA

Upstream 100 bases:

>100_bases
CAGGTCGGTGCAACACTGTGATGGTGCGGTGCGGGGATTGAACTCCCCGAGTTGTCCCGCATCTATGCCTGGGCGCCAGC
GTGGCGCAGGAGCTGGAAAC

Downstream 100 bases:

>100_bases
CACCGGCGCCGACGTGAGGGGGCCGCTTCCGCAGGGCCCTTTTTGTCGGCGGGCTCAAGTGACGGGCGGCGTGACCGATA
AGCCTGCGAAGCCTGTCCGC

Product: M48 family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MFNLMKTAVLMAAITALFMAIGSVLGGQQGMAIALVVALGMNFFSYWFSDKMVLKMYNAQEVDASSAPQFYGMVRELAAK
AELPMPKVYLINEDAPNAFATGRNPQNAAVAATTGILRVLSERELRGVMAHELAHVKHRDILISTISATMAGAISMLANF
AMFFGGRGSDGRPANPIAGILVMLLAPLAASLIQMAISRAREFEADRGGAEISGDPQALASALQKIQRYAQGIPLEAAER
HPETAQMMIMNPLSGGGLRGLFSTHPATEERVAKLMAMVPQRV

Sequences:

>Translated_283_residues
MFNLMKTAVLMAAITALFMAIGSVLGGQQGMAIALVVALGMNFFSYWFSDKMVLKMYNAQEVDASSAPQFYGMVRELAAK
AELPMPKVYLINEDAPNAFATGRNPQNAAVAATTGILRVLSERELRGVMAHELAHVKHRDILISTISATMAGAISMLANF
AMFFGGRGSDGRPANPIAGILVMLLAPLAASLIQMAISRAREFEADRGGAEISGDPQALASALQKIQRYAQGIPLEAAER
HPETAQMMIMNPLSGGGLRGLFSTHPATEERVAKLMAMVPQRV
>Mature_283_residues
MFNLMKTAVLMAAITALFMAIGSVLGGQQGMAIALVVALGMNFFSYWFSDKMVLKMYNAQEVDASSAPQFYGMVRELAAK
AELPMPKVYLINEDAPNAFATGRNPQNAAVAATTGILRVLSERELRGVMAHELAHVKHRDILISTISATMAGAISMLANF
AMFFGGRGSDGRPANPIAGILVMLLAPLAASLIQMAISRAREFEADRGGAEISGDPQALASALQKIQRYAQGIPLEAAER
HPETAQMMIMNPLSGGGLRGLFSTHPATEERVAKLMAMVPQRV

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=298, Percent_Identity=29.5302013422819, Blast_Score=91, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_METPP (A2SCF8)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001019482.1
- ProteinModelPortal:   A2SCF8
- SMR:   A2SCF8
- STRING:   A2SCF8
- MEROPS:   M48.004
- GeneID:   4786894
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0285
- NMPDR:   fig|279263.3.peg.169
- eggNOG:   COG0501
- HOGENOM:   HBG739460
- OMA:   RRGAEIC
- ProtClustDB:   PRK03001
- BioCyc:   MPET420662:MPE_A0285-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.- [C]

Molecular weight: Translated: 30268; Mature: 30268

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 132-132

Signals:

None

Transmembrane regions:

HASH(0x235c36a4)-; HASH(0x23a34fac)-; HASH(0x233d0484)-; HASH(0x2441df00)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
7.4 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
7.4 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNLMKTAVLMAAITALFMAIGSVLGGQQGMAIALVVALGMNFFSYWFSDKMVLKMYNAQ
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCH
EVDASSAPQFYGMVRELAAKAELPMPKVYLINEDAPNAFATGRNPQNAAVAATTGILRVL
HCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
SERELRGVMAHELAHVKHRDILISTISATMAGAISMLANFAMFFGGRGSDGRPANPIAGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
LVMLLAPLAASLIQMAISRAREFEADRGGAEISGDPQALASALQKIQRYAQGIPLEAAER
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHC
HPETAQMMIMNPLSGGGLRGLFSTHPATEERVAKLMAMVPQRV
CCCHHHEEEECCCCCCCCCCHHCCCCCCHHHHHHHHHHHCCCH
>Mature Secondary Structure
MFNLMKTAVLMAAITALFMAIGSVLGGQQGMAIALVVALGMNFFSYWFSDKMVLKMYNAQ
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCH
EVDASSAPQFYGMVRELAAKAELPMPKVYLINEDAPNAFATGRNPQNAAVAATTGILRVL
HCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
SERELRGVMAHELAHVKHRDILISTISATMAGAISMLANFAMFFGGRGSDGRPANPIAGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
LVMLLAPLAASLIQMAISRAREFEADRGGAEISGDPQALASALQKIQRYAQGIPLEAAER
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHC
HPETAQMMIMNPLSGGGLRGLFSTHPATEERVAKLMAMVPQRV
CCCHHHEEEECCCCCCCCCCHHCCCCCCHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA