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The map label for this gene is bioA [H]

Identifier: 124022163

GI number: 124022163

Start: 454420

End: 455748

Strand: Reverse

Name: bioA [H]

Synonym: P9303_04531

Alternate gene names: 124022163

Gene position: 455748-454420 (Counterclockwise)

Preceding gene: 124022164

Following gene: 124022160

Centisome position: 16.99

GC content: 56.96

Gene sequence:

>1329_bases
ATGGCAACACAATCCCATCGGATCATGGATTGCTTCGATCCACTCTCCGCCCCAAACGCCAACAACTGGCATCCCCATCT
CTGGCCTCCCTTCACCCAGATCGCATCGGCATCACCGCCGCAACGTGTCATCGCAGCGGATGGAGCGCTGTTGATGCTGG
ATGGGGCACCTCCCCTGATTGATGCAATCAGCAGCTGGTGGGTCACCCTTCATGGCCATGCCAATCCCAGCATCGCTGCC
GCCATCGCAACCCAGGCACAGCAACTGGAGCAGGTGATCTTTGCTGACTTCATTCATCCCCAAGCAGAACAACTGGCAGC
GCGCCTCAGTGCCGTAACAGGCCTTCAACGCCTGTTTTTCTCCGACAACGGCTCTACCGCCGTGGAGGTTGCACTCAAGA
TCGCTTGTCAGTGCTGGCACAACCGCGGCGAGCCTCGGCAACAACTCATCGCCTTCAACGGGGCCTACCACGGCGACACG
TTCGGGGCGATGGCAGTGGGGGAGCGCAACCTATTCAGTGCCCCATTTGAGGAGATGTTGTTTCCAGTAGCACGGGTGCC
CTGGCCCGCTACCTGGTGGGGCGATGAAGAAGTTGAAACACGTGAACGGATTGCTCTAACTGAACTGGAACGCTGCCTTC
AAACCCCAACAGCAGCAGTCATCTTGGAGCCATTAGTCCAAGGAGCAGGCGGCATGGCCATGGTGCGAGCGGAATTCCTA
CGAGGAGTCGAACAACGCGTACGTGCTGCGGGAGCCTTGCTGATTGCTGATGAGGTTCTGACTGGTTTCGGACGCTGTGG
AGCCCTATTCGCCTTCAAGCGTGCAGGGCTTGCTCCCGATTTGATCGCTTTATCGAAAGGACTCACCGGGGGATTTTTGC
CCATGGGCGTCACCATGGCCCGCGAAGAGGTGTTTGAGGCCTTCTTAGGAGATGATCCATCTCTCACCCTCTGGCACGGT
CATAGCTTCACTGCTAATCCCCTAGGTTGCGCAGCCGCAAACGCAAGCCTCGATCTACTGGAGGTCAACCCAGAAAGCTA
CGAAAACTTTGAGGCTAGGCATCAACCTCATCTCGAAGCCCTAGCTGAACATCCAAAGGTGCAGCAACCAAGACTGACCG
GCACCATCGCCGCCTTCGACCTCGCGATAGACGGAACCCATGGCTACCTCAATCCAGCAGGACGAATCGTCAAACAACAA
GCCATCAACAATGGTGTCTTCCTGCGGCCTCTAGGTCAGGTCGTTTATCTGCTGCCTCCGCTCTGCCTCAATGACGCTCA
GCTTGAGCAATGCTATGCAGCCATCCATTTAGGCTTGGAAGCCCTCTGA

Upstream 100 bases:

>100_bases
GTTTTACAAGGCCTGGCATGAGGAAGGAATGAATTCCTTCCAGCAAAAGCATTGCAAAGAGCCATCGTGATCGGTTCAGG
CCGCAACATCACGATCCAAG

Downstream 100 bases:

>100_bases
ATTCAAGCGCTCAACAGAAGCAACACCATCGTTCTTAAGGGCCTTCCGAAAGAGCAGCCTCCACATCGGAGCGGGGCAGA
CCATAAGGGAAACAGCACTG

Product: diaminopelargonic acid synthase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MATQSHRIMDCFDPLSAPNANNWHPHLWPPFTQIASASPPQRVIAADGALLMLDGAPPLIDAISSWWVTLHGHANPSIAA
AIATQAQQLEQVIFADFIHPQAEQLAARLSAVTGLQRLFFSDNGSTAVEVALKIACQCWHNRGEPRQQLIAFNGAYHGDT
FGAMAVGERNLFSAPFEEMLFPVARVPWPATWWGDEEVETRERIALTELERCLQTPTAAVILEPLVQGAGGMAMVRAEFL
RGVEQRVRAAGALLIADEVLTGFGRCGALFAFKRAGLAPDLIALSKGLTGGFLPMGVTMAREEVFEAFLGDDPSLTLWHG
HSFTANPLGCAAANASLDLLEVNPESYENFEARHQPHLEALAEHPKVQQPRLTGTIAAFDLAIDGTHGYLNPAGRIVKQQ
AINNGVFLRPLGQVVYLLPPLCLNDAQLEQCYAAIHLGLEAL

Sequences:

>Translated_442_residues
MATQSHRIMDCFDPLSAPNANNWHPHLWPPFTQIASASPPQRVIAADGALLMLDGAPPLIDAISSWWVTLHGHANPSIAA
AIATQAQQLEQVIFADFIHPQAEQLAARLSAVTGLQRLFFSDNGSTAVEVALKIACQCWHNRGEPRQQLIAFNGAYHGDT
FGAMAVGERNLFSAPFEEMLFPVARVPWPATWWGDEEVETRERIALTELERCLQTPTAAVILEPLVQGAGGMAMVRAEFL
RGVEQRVRAAGALLIADEVLTGFGRCGALFAFKRAGLAPDLIALSKGLTGGFLPMGVTMAREEVFEAFLGDDPSLTLWHG
HSFTANPLGCAAANASLDLLEVNPESYENFEARHQPHLEALAEHPKVQQPRLTGTIAAFDLAIDGTHGYLNPAGRIVKQQ
AINNGVFLRPLGQVVYLLPPLCLNDAQLEQCYAAIHLGLEAL
>Mature_441_residues
ATQSHRIMDCFDPLSAPNANNWHPHLWPPFTQIASASPPQRVIAADGALLMLDGAPPLIDAISSWWVTLHGHANPSIAAA
IATQAQQLEQVIFADFIHPQAEQLAARLSAVTGLQRLFFSDNGSTAVEVALKIACQCWHNRGEPRQQLIAFNGAYHGDTF
GAMAVGERNLFSAPFEEMLFPVARVPWPATWWGDEEVETRERIALTELERCLQTPTAAVILEPLVQGAGGMAMVRAEFLR
GVEQRVRAAGALLIADEVLTGFGRCGALFAFKRAGLAPDLIALSKGLTGGFLPMGVTMAREEVFEAFLGDDPSLTLWHGH
SFTANPLGCAAANASLDLLEVNPESYENFEARHQPHLEALAEHPKVQQPRLTGTIAAFDLAIDGTHGYLNPAGRIVKQQA
INNGVFLRPLGQVVYLLPPLCLNDAQLEQCYAAIHLGLEAL

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=420, Percent_Identity=26.1904761904762, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI13994255, Length=309, Percent_Identity=29.4498381877023, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI226442709, Length=378, Percent_Identity=26.984126984127, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI226442705, Length=421, Percent_Identity=25.6532066508314, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI4557809, Length=394, Percent_Identity=23.6040609137056, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI24119277, Length=418, Percent_Identity=24.8803827751196, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI284507298, Length=246, Percent_Identity=28.0487804878049, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786991, Length=427, Percent_Identity=36.2997658079625, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI145693181, Length=391, Percent_Identity=34.7826086956522, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1789016, Length=377, Percent_Identity=31.5649867374005, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1789759, Length=303, Percent_Identity=30.6930693069307, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1788044, Length=420, Percent_Identity=27.6190476190476, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1787560, Length=386, Percent_Identity=29.5336787564767, Blast_Score=108, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI32564660, Length=394, Percent_Identity=24.3654822335025, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI25144271, Length=377, Percent_Identity=23.0769230769231, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71992977, Length=436, Percent_Identity=24.0825688073394, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI25144274, Length=216, Percent_Identity=29.1666666666667, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324386, Length=451, Percent_Identity=29.490022172949, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6324432, Length=426, Percent_Identity=26.056338028169, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323470, Length=333, Percent_Identity=27.027027027027, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI21356575, Length=324, Percent_Identity=28.0864197530864, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI161085790, Length=409, Percent_Identity=25.4278728606357, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21357415, Length=387, Percent_Identity=24.5478036175711, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI28574759, Length=296, Percent_Identity=26.3513513513513, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 47889; Mature: 47758

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATQSHRIMDCFDPLSAPNANNWHPHLWPPFTQIASASPPQRVIAADGALLMLDGAPPLI
CCCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCCCEEEECCCCEEEECCCCHHH
DAISSWWVTLHGHANPSIAAAIATQAQQLEQVIFADFIHPQAEQLAARLSAVTGLQRLFF
HHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
SDNGSTAVEVALKIACQCWHNRGEPRQQLIAFNGAYHGDTFGAMAVGERNLFSAPFEEML
CCCCCHHHHHHHHHHHHHHHCCCCCHHHEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHH
FPVARVPWPATWWGDEEVETRERIALTELERCLQTPTAAVILEPLVQGAGGMAMVRAEFL
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHH
RGVEQRVRAAGALLIADEVLTGFGRCGALFAFKRAGLAPDLIALSKGLTGGFLPMGVTMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHH
REEVFEAFLGDDPSLTLWHGHSFTANPLGCAAANASLDLLEVNPESYENFEARHQPHLEA
HHHHHHHHHCCCCCEEEEECCCCCCCCCCCEECCCCEEEEEECCCHHHCCHHHCCHHHHH
LAEHPKVQQPRLTGTIAAFDLAIDGTHGYLNPAGRIVKQQAINNGVFLRPLGQVVYLLPP
HHCCCCCCCCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCEEECHHHHHHHHCCC
LCLNDAQLEQCYAAIHLGLEAL
CCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ATQSHRIMDCFDPLSAPNANNWHPHLWPPFTQIASASPPQRVIAADGALLMLDGAPPLI
CCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCCCEEEECCCCEEEECCCCHHH
DAISSWWVTLHGHANPSIAAAIATQAQQLEQVIFADFIHPQAEQLAARLSAVTGLQRLFF
HHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
SDNGSTAVEVALKIACQCWHNRGEPRQQLIAFNGAYHGDTFGAMAVGERNLFSAPFEEML
CCCCCHHHHHHHHHHHHHHHCCCCCHHHEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHH
FPVARVPWPATWWGDEEVETRERIALTELERCLQTPTAAVILEPLVQGAGGMAMVRAEFL
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHH
RGVEQRVRAAGALLIADEVLTGFGRCGALFAFKRAGLAPDLIALSKGLTGGFLPMGVTMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHH
REEVFEAFLGDDPSLTLWHGHSFTANPLGCAAANASLDLLEVNPESYENFEARHQPHLEA
HHHHHHHHHCCCCCEEEEECCCCCCCCCCCEECCCCEEEEEECCCHHHCCHHHCCHHHHH
LAEHPKVQQPRLTGTIAAFDLAIDGTHGYLNPAGRIVKQQAINNGVFLRPLGQVVYLLPP
HHCCCCCCCCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCEEECHHHHHHHHCCC
LCLNDAQLEQCYAAIHLGLEAL
CCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]