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The map label for this gene is clpP1 [H]

Identifier: 124025671

GI number: 124025671

Start: 884185

End: 884802

Strand: Direct

Name: clpP1 [H]

Synonym: NATL1_09641

Alternate gene names: 124025671

Gene position: 884185-884802 (Clockwise)

Preceding gene: 124025669

Following gene: 124025675

Centisome position: 47.42

GC content: 38.67

Gene sequence:

>618_bases
ATGAAAACCGACCATTATTATCGTTCAATGATTCCAATAGTTATTGAAGAATCTGGAAGAGGAGAAAGAGCCTTTGATAT
TTATTCAAGGCTTTTAAGAGAAAGAATTGTTTTTTTGGGTGAACCAGTAACAAGTGATTCTGCTAACAGAATTGTTGCTC
AACTCCTTTTCCTTGAAGCTGACGATCCTGATAAAGATATCTTTCTGTATATCAATTCTCCAGGTGGATCTGTTTATGAC
GGCCTTGGGATTTTTGACACAATGCAGCACGTTAAGCCTGATATTCATACCGTTTGTGTTGGACTAGCTGCAAGTATGGG
CGCCTTTCTGCTTTGTGCAGGTGCAAAAGGAAAGAGAAGCAGTTTGCTCCATTCAAGGATAATGATCCATCAGCCACTCG
GAGGGGCAAGAGGTCAGGCGAGTGACATAAGGATCCAAGCTGATGAAATCTTATTTATAAAAGATAAATTAAACAAAGAA
CTATCCGATAGAACGGGTCAACCCATTGAAAGAATTAGAGAGGATACAGACAGAGACTTCTACATGTCTCCATCTGAAGC
GATCGAATATGGAATTATTGATAACGTCTTTAATAAAAGGCCAATAAATTCAGTATGA

Upstream 100 bases:

>100_bases
GAAGTCAGATTTGCTGTCTGAAATTGTTGCTCTAACGCTCAATGCCAAACCTAGTTAATTCTTAAGAGACCTTAGCTTAT
CCCCCGACTTAGCTAGGATC

Downstream 100 bases:

>100_bases
AATTGAACTGCTATTTTGCATCTGGTAGAACAGGTATAAATCTATCTTTCTCAGGAATAGTCGTGTATTGAGATAATATT
TTGCAAAATTCATCTCCATC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MKTDHYYRSMIPIVIEESGRGERAFDIYSRLLRERIVFLGEPVTSDSANRIVAQLLFLEADDPDKDIFLYINSPGGSVYD
GLGIFDTMQHVKPDIHTVCVGLAASMGAFLLCAGAKGKRSSLLHSRIMIHQPLGGARGQASDIRIQADEILFIKDKLNKE
LSDRTGQPIERIREDTDRDFYMSPSEAIEYGIIDNVFNKRPINSV

Sequences:

>Translated_205_residues
MKTDHYYRSMIPIVIEESGRGERAFDIYSRLLRERIVFLGEPVTSDSANRIVAQLLFLEADDPDKDIFLYINSPGGSVYD
GLGIFDTMQHVKPDIHTVCVGLAASMGAFLLCAGAKGKRSSLLHSRIMIHQPLGGARGQASDIRIQADEILFIKDKLNKE
LSDRTGQPIERIREDTDRDFYMSPSEAIEYGIIDNVFNKRPINSV
>Mature_205_residues
MKTDHYYRSMIPIVIEESGRGERAFDIYSRLLRERIVFLGEPVTSDSANRIVAQLLFLEADDPDKDIFLYINSPGGSVYD
GLGIFDTMQHVKPDIHTVCVGLAASMGAFLLCAGAKGKRSSLLHSRIMIHQPLGGARGQASDIRIQADEILFIKDKLNKE
LSDRTGQPIERIREDTDRDFYMSPSEAIEYGIIDNVFNKRPINSV

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=55.7291666666667, Blast_Score=214, Evalue=4e-56,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=57.7319587628866, Blast_Score=247, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17538017, Length=189, Percent_Identity=50.7936507936508, Blast_Score=193, Evalue=5e-50,
Organism=Drosophila melanogaster, GI20129427, Length=193, Percent_Identity=53.3678756476684, Blast_Score=207, Evalue=4e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23007; Mature: 23007

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00381 CLP_PROTEASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTDHYYRSMIPIVIEESGRGERAFDIYSRLLRERIVFLGEPVTSDSANRIVAQLLFLEA
CCCCHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC
DDPDKDIFLYINSPGGSVYDGLGIFDTMQHVKPDIHTVCVGLAASMGAFLLCAGAKGKRS
CCCCCEEEEEEECCCCCHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHEEEECCCCCCHH
SLLHSRIMIHQPLGGARGQASDIRIQADEILFIKDKLNKELSDRTGQPIERIREDTDRDF
HHHHHHHHEECCCCCCCCCCCCEEEECCCEEEEHHHHCHHHHHCCCCHHHHHHHCCCCCE
YMSPSEAIEYGIIDNVFNKRPINSV
EECHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKTDHYYRSMIPIVIEESGRGERAFDIYSRLLRERIVFLGEPVTSDSANRIVAQLLFLEA
CCCCHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC
DDPDKDIFLYINSPGGSVYDGLGIFDTMQHVKPDIHTVCVGLAASMGAFLLCAGAKGKRS
CCCCCEEEEEEECCCCCHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHEEEECCCCCCHH
SLLHSRIMIHQPLGGARGQASDIRIQADEILFIKDKLNKELSDRTGQPIERIREDTDRDF
HHHHHHHHEECCCCCCCCCCCCEEEECCCEEEEHHHHCHHHHHCCCCHHHHHHHCCCCCE
YMSPSEAIEYGIIDNVFNKRPINSV
EECHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA