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The map label for this gene is hemE

Identifier: 124025350

GI number: 124025350

Start: 579581

End: 580639

Strand: Reverse

Name: hemE

Synonym: NATL1_06391

Alternate gene names: 124025350

Gene position: 580639-579581 (Counterclockwise)

Preceding gene: 124025351

Following gene: 124025349

Centisome position: 31.14

GC content: 41.08

Gene sequence:

>1059_bases
ATGAACGAAACTACTCCTTTACTACTCCGTGCAGCTCGCGGAGAACATGTTGAAAGGCCCCCAGTTTGGATGATGAGACA
AGCGGGGAGATACATGAAGGTATATCGCGACCTTCGTGATAATCATCCAAGCTTCAGGGAAAGATCCGAAAACCCCGATC
TTTCTTATGAAATTTCAATGCAACCTTTTACAGCTTTTCAACCAGATGGAGTGATACTTTTTTCAGATATCTTGACTCCT
CTACCTGGGATGGGAATTAACTTTGACATCGTTGAAAGCAAAGGACCCTTAATAAATGACCCAATAAGAAGCCTCAAACA
GGTTAAAGACCTTAAACCCCTTCAACCAGAAGAAAGCATGTCTTTTGTTGGGGAAGTCCTTGGAAGGCTAAGGGAAAGCG
TTGGGAACAAGGCTGCAGTTCTTGGGTTTGTAGGTGCTCCTTGGACTCTTGCTGCATATGTTGTAGAGGGAAAAAGCAGC
AAAAATTATGCAGTTATAAAGGCGATGGCATTCCAAGAGCCAGAACTACTGCATCAACTTTTAAATCACTTTGCAGAATC
AATTGCAAACTATTTATCCTATCAAATTCAATCTGGGGCCCAAGTAGTTCAAATGTTTGATTCATGGGCAGGACAATTAA
GTCCACAAGATTATGACGAGTTTGCTGCGCCTTATCAACAAAAAGTAGTCAATTTAGTAAAAGAAAAACATCCAGATACA
CCTATGATTTTATACATCTCAGGTAGCGCGGGAGTTCTTGAAAGGATGGGACAAACCGGAGTAGATATAGTCTCTCTAGA
TTGGACTGTTGACATGGCAGATGGACTAAAAAGGCTGCCTCAATCAGTTGGAGTCCAAGGAAATGTTGATCCAGGACTTT
TGTTTGGTACTCCTGATGCGATCAGATCAAGAATTGTTGATGTCGTCAAAAAAGCGAAAGGTAGAAAACATATTCTTAAC
CTTGGTCATGGAATACTTCCAGGGACGCCAGAAGAAAATGCAAGAGTATTTTTCGAGGCTGGTAAAAATGTGAATGAACT
CATAAAAGTTTCATCTTGA

Upstream 100 bases:

>100_bases
TGTAAAAATTCAAAAGGTATGTCGAACTTTTGCAGAGAACGTATTTCATGATTTTCAATTTACTGCTTCATGTAAGTTTT
TCGAATAAAAGGACAAAATA

Downstream 100 bases:

>100_bases
AAAACGAAATAATTCTGATTACTGGAGCAAGTGGATGTGTTGGGCAATACATAGCAAATTGGCTAATCGAAAACTCAACT
TCAGAATTATTTTTATGGGT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MNETTPLLLRAARGEHVERPPVWMMRQAGRYMKVYRDLRDNHPSFRERSENPDLSYEISMQPFTAFQPDGVILFSDILTP
LPGMGINFDIVESKGPLINDPIRSLKQVKDLKPLQPEESMSFVGEVLGRLRESVGNKAAVLGFVGAPWTLAAYVVEGKSS
KNYAVIKAMAFQEPELLHQLLNHFAESIANYLSYQIQSGAQVVQMFDSWAGQLSPQDYDEFAAPYQQKVVNLVKEKHPDT
PMILYISGSAGVLERMGQTGVDIVSLDWTVDMADGLKRLPQSVGVQGNVDPGLLFGTPDAIRSRIVDVVKKAKGRKHILN
LGHGILPGTPEENARVFFEAGKNVNELIKVSS

Sequences:

>Translated_352_residues
MNETTPLLLRAARGEHVERPPVWMMRQAGRYMKVYRDLRDNHPSFRERSENPDLSYEISMQPFTAFQPDGVILFSDILTP
LPGMGINFDIVESKGPLINDPIRSLKQVKDLKPLQPEESMSFVGEVLGRLRESVGNKAAVLGFVGAPWTLAAYVVEGKSS
KNYAVIKAMAFQEPELLHQLLNHFAESIANYLSYQIQSGAQVVQMFDSWAGQLSPQDYDEFAAPYQQKVVNLVKEKHPDT
PMILYISGSAGVLERMGQTGVDIVSLDWTVDMADGLKRLPQSVGVQGNVDPGLLFGTPDAIRSRIVDVVKKAKGRKHILN
LGHGILPGTPEENARVFFEAGKNVNELIKVSS
>Mature_352_residues
MNETTPLLLRAARGEHVERPPVWMMRQAGRYMKVYRDLRDNHPSFRERSENPDLSYEISMQPFTAFQPDGVILFSDILTP
LPGMGINFDIVESKGPLINDPIRSLKQVKDLKPLQPEESMSFVGEVLGRLRESVGNKAAVLGFVGAPWTLAAYVVEGKSS
KNYAVIKAMAFQEPELLHQLLNHFAESIANYLSYQIQSGAQVVQMFDSWAGQLSPQDYDEFAAPYQQKVVNLVKEKHPDT
PMILYISGSAGVLERMGQTGVDIVSLDWTVDMADGLKRLPQSVGVQGNVDPGLLFGTPDAIRSRIVDVVKKAKGRKHILN
LGHGILPGTPEENARVFFEAGKNVNELIKVSS

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=348, Percent_Identity=33.3333333333333, Blast_Score=215, Evalue=6e-56,
Organism=Escherichia coli, GI2367337, Length=341, Percent_Identity=38.7096774193548, Blast_Score=258, Evalue=5e-70,
Organism=Saccharomyces cerevisiae, GI6320252, Length=351, Percent_Identity=33.9031339031339, Blast_Score=225, Evalue=8e-60,
Organism=Drosophila melanogaster, GI221330099, Length=338, Percent_Identity=36.3905325443787, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI19921920, Length=338, Percent_Identity=36.3905325443787, Blast_Score=238, Evalue=6e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_PROM1 (A2C141)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014466.1
- ProteinModelPortal:   A2C141
- SMR:   A2C141
- STRING:   A2C141
- GeneID:   4779337
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_06391
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- BioCyc:   PMAR167555:NATL1_06391-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39073; Mature: 39073

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 76-76 BINDING 153-153 BINDING 208-208 BINDING 323-323

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNETTPLLLRAARGEHVERPPVWMMRQAGRYMKVYRDLRDNHPSFRERSENPDLSYEISM
CCCCCCHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCEEEEEE
QPFTAFQPDGVILFSDILTPLPGMGINFDIVESKGPLINDPIRSLKQVKDLKPLQPEESM
CCCCCCCCCCEEEHHHHHCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCHHHH
SFVGEVLGRLRESVGNKAAVLGFVGAPWTLAAYVVEGKSSKNYAVIKAMAFQEPELLHQL
HHHHHHHHHHHHHHCCCEEEEEECCCCHHEEEHEEECCCCCCEEEEEEHHCCCHHHHHHH
LNHFAESIANYLSYQIQSGAQVVQMFDSWAGQLSPQDYDEFAAPYQQKVVNLVKEKHPDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCHHHHHHHHHHHHCCCCC
PMILYISGSAGVLERMGQTGVDIVSLDWTVDMADGLKRLPQSVGVQGNVDPGLLFGTPDA
CEEEEECCCCHHHHHCCCCCCEEEEEEEEEEHHHHHHHHHHHCCCCCCCCCCEEECCHHH
IRSRIVDVVKKAKGRKHILNLGHGILPGTPEENARVFFEAGKNVNELIKVSS
HHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHCCCC
>Mature Secondary Structure
MNETTPLLLRAARGEHVERPPVWMMRQAGRYMKVYRDLRDNHPSFRERSENPDLSYEISM
CCCCCCHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCEEEEEE
QPFTAFQPDGVILFSDILTPLPGMGINFDIVESKGPLINDPIRSLKQVKDLKPLQPEESM
CCCCCCCCCCEEEHHHHHCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCHHHH
SFVGEVLGRLRESVGNKAAVLGFVGAPWTLAAYVVEGKSSKNYAVIKAMAFQEPELLHQL
HHHHHHHHHHHHHHCCCEEEEEECCCCHHEEEHEEECCCCCCEEEEEEHHCCCHHHHHHH
LNHFAESIANYLSYQIQSGAQVVQMFDSWAGQLSPQDYDEFAAPYQQKVVNLVKEKHPDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCHHHHHHHHHHHHCCCCC
PMILYISGSAGVLERMGQTGVDIVSLDWTVDMADGLKRLPQSVGVQGNVDPGLLFGTPDA
CEEEEECCCCHHHHHCCCCCCEEEEEEEEEEHHHHHHHHHHHCCCCCCCCCCEEECCHHH
IRSRIVDVVKKAKGRKHILNLGHGILPGTPEENARVFFEAGKNVNELIKVSS
HHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA