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The map label for this gene is trpA [H]

Identifier: 124025338

GI number: 124025338

Start: 570379

End: 571179

Strand: Direct

Name: trpA [H]

Synonym: NATL1_06271

Alternate gene names: 124025338

Gene position: 570379-571179 (Clockwise)

Preceding gene: 124025337

Following gene: 124025339

Centisome position: 30.59

GC content: 38.2

Gene sequence:

>801_bases
TTGAAAAGTACAAATATCAGTAGGTCTTTTTCCAAAATAAAAAAGGAGAAAAGAATTGCACTAATGCCTTTCCTTATGGC
AGGTGACCCTGATTTGGAAACTACAGCAAAGATTTTGTTAGAGCTTCAGGCAAATGGCGCTGACATGATTGAGCTAGGCA
TTCCATACAGTGATCCTTTAGCAGATGGTCCGATTATTCAATTAGCAGCTTCTCGAGCTCTCTCTGCAGGAACCTCCCCT
GACAGGGTTTTTAAAATGTTGTTTGAATTGAGAGATCAATTGAAAATACCAATAATTTTATTTACTTACTCAAACCCACT
TATTAATAAAGGTCTGGAAGAATTTTGCTGGCAAGCATCGAAAGTAGGTGTTTCAGGACTTGTCGTACCAGATCTTCCTC
TAGAGGAAGCAGAAAAACTTTCTGATATTGCTGAATCTAAGGAAATTGATTTGGTTTTACTTGTTGCTCCTACAACCCCA
AAGGATCGTATGAAAAAAATCGCAGCGACTTCTAATGGATTCACTTATCTTGTAAGTGTTACTGGGGTAACTGGAGAAAG
GTCATCATTAGAAGATAATGTAGGATCTCTTGTGCAACAACTAAAAGATTCTTCATCTAGTCCAATTGCTGTGGGCTTTG
GAATTTCGGATGTAAAACACATTGAACAAGTTAGAGAATGGGGCGCTGATGGCGCAATTGTTGGTAGTGCTTTAGTTAAA
AGAATTGCTAATGCCTCGATCGAAATGAAAGTCGAAGAAGCTGGTTCTTTTTGTAAAGAACTAAGAGCCGCAACTAATTA
A

Upstream 100 bases:

>100_bases
GTATTGAACAAACTTAAGTTTTAATTACTAAGTCTCAATAATTTTTTACTCTTAGGGATACAAAAATGATAAAAAAGAAA
GAGACCCAAGGCTTAGAACA

Downstream 100 bases:

>100_bases
TATTTTTTTAAATAGCAACAGATCAAGCTGAATATTGAATTCTTTTCTATGTTTTATCTTGAGAAATATTGTCTTTATTT
AACTTGAAAACCATGGATCA

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MKSTNISRSFSKIKKEKRIALMPFLMAGDPDLETTAKILLELQANGADMIELGIPYSDPLADGPIIQLAASRALSAGTSP
DRVFKMLFELRDQLKIPIILFTYSNPLINKGLEEFCWQASKVGVSGLVVPDLPLEEAEKLSDIAESKEIDLVLLVAPTTP
KDRMKKIAATSNGFTYLVSVTGVTGERSSLEDNVGSLVQQLKDSSSSPIAVGFGISDVKHIEQVREWGADGAIVGSALVK
RIANASIEMKVEEAGSFCKELRAATN

Sequences:

>Translated_266_residues
MKSTNISRSFSKIKKEKRIALMPFLMAGDPDLETTAKILLELQANGADMIELGIPYSDPLADGPIIQLAASRALSAGTSP
DRVFKMLFELRDQLKIPIILFTYSNPLINKGLEEFCWQASKVGVSGLVVPDLPLEEAEKLSDIAESKEIDLVLLVAPTTP
KDRMKKIAATSNGFTYLVSVTGVTGERSSLEDNVGSLVQQLKDSSSSPIAVGFGISDVKHIEQVREWGADGAIVGSALVK
RIANASIEMKVEEAGSFCKELRAATN
>Mature_266_residues
MKSTNISRSFSKIKKEKRIALMPFLMAGDPDLETTAKILLELQANGADMIELGIPYSDPLADGPIIQLAASRALSAGTSP
DRVFKMLFELRDQLKIPIILFTYSNPLINKGLEEFCWQASKVGVSGLVVPDLPLEEAEKLSDIAESKEIDLVLLVAPTTP
KDRMKKIAATSNGFTYLVSVTGVTGERSSLEDNVGSLVQQLKDSSSSPIAVGFGISDVKHIEQVREWGADGAIVGSALVK
RIANASIEMKVEEAGSFCKELRAATN

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=234, Percent_Identity=41.4529914529915, Blast_Score=168, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6321412, Length=245, Percent_Identity=38.3673469387755, Blast_Score=179, Evalue=5e-46,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 28696; Mature: 28696

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTNISRSFSKIKKEKRIALMPFLMAGDPDLETTAKILLELQANGADMIELGIPYSDPL
CCCCCHHHHHHHHHHHHHHEEEHHEECCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCC
ADGPIIQLAASRALSAGTSPDRVFKMLFELRDQLKIPIILFTYSNPLINKGLEEFCWQAS
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHH
KVGVSGLVVPDLPLEEAEKLSDIAESKEIDLVLLVAPTTPKDRMKKIAATSNGFTYLVSV
HCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEEEE
TGVTGERSSLEDNVGSLVQQLKDSSSSPIAVGFGISDVKHIEQVREWGADGAIVGSALVK
ECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHH
RIANASIEMKVEEAGSFCKELRAATN
HHHCCCEEEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKSTNISRSFSKIKKEKRIALMPFLMAGDPDLETTAKILLELQANGADMIELGIPYSDPL
CCCCCHHHHHHHHHHHHHHEEEHHEECCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCC
ADGPIIQLAASRALSAGTSPDRVFKMLFELRDQLKIPIILFTYSNPLINKGLEEFCWQAS
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHH
KVGVSGLVVPDLPLEEAEKLSDIAESKEIDLVLLVAPTTPKDRMKKIAATSNGFTYLVSV
HCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEEEE
TGVTGERSSLEDNVGSLVQQLKDSSSSPIAVGFGISDVKHIEQVREWGADGAIVGSALVK
ECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHH
RIANASIEMKVEEAGSFCKELRAATN
HHHCCCEEEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA