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The map label for this gene is gor [H]

Identifier: 124025333

GI number: 124025333

Start: 565575

End: 566936

Strand: Direct

Name: gor [H]

Synonym: NATL1_06221

Alternate gene names: 124025333

Gene position: 565575-566936 (Clockwise)

Preceding gene: 124025331

Following gene: 124025335

Centisome position: 30.33

GC content: 35.46

Gene sequence:

>1362_bases
TTGAAAAGCTCTTTTGATTTAATTGTCATTGGTGCAGGATCCGGTGGATTAGCTGCTGCAAAGAAAGCAGCAAGTTATGG
AGCATCTGTAGCGATCGTTGAGGGTGATCTTGTCGGAGGAACTTGTGTAATAAGAGGTTGCGTTCCTAAAAAATTATTAG
TTTGTGGCTCTTCTCTCTTGGAGAGTTTTTTGTCTGCAACATCCTATGGCTTTGATTTTGATAATTTAAAGATCAAGTCA
GAAGTTTTATTAGCTAATGTTCGGAAGGAAGTACATAGGCTGAATGAATTACACGAGAATTTTTTAAATAAAGCTAATGT
TGAGCTTTTTAAAGGTTGGGGTGAGTTTAGAAATTCAAATTGTGTTGAAGTAAAAGATCGAAAAAATGGAGAGACTTTAA
ATGAACTTTATGGAGAAAGAATTTTGATTGCAGTGGGAGGCAGACCTAAAAGACCAAGTATCGAGGGGGCATCTTTAGGA
TGGACAAGTGATGATATGTTTCTTCTTAAGAGCTTTCCGAAAAAAATTACAATTGTTGGTGCAGGCTATATTGCTTGCGA
ATTTGCATGCATATTGCACGGTCTAGGTGTTGAGGTTACTCAATTGGTAAGAGGTGACAGGATTTTAAGAGGGTTTGACT
TTGAACTTTCTTCATCATTAACCGAGGCAATGAAAAACAAAGGAGTTAACATAAGTTTTGGCGAAAAGATTTCTTCACTA
AAAGGAACTCCTGGATCTTTAATTATAAAAACAAATGCAGGTAAAGAGTTTGACTCTAATGGATTGCTTTTCGCTACTGG
TAGAGAGCCATTTTTAGATGGGTTGAAGTTAGAACAAGCGGGTATAGAAATTCTTGAAAATAAAATTAAAGTTGATAGTG
AAGGTAAAACTAATATTTCTAATATCTTTGCTATTGGAGATGTAACTGACAGGATCAACTTGACACCTGTCGCAATTGAT
GAGGGTAGAAAGTTTGCTGATAGAAATTATGGCGAATCAGATCATAAGGTTAATTATAATTTTGTTCCTTATGCTGTATT
TAGTCAGCCTGAAATAGCTTCTGTGGGCATGACTGAGGAGAAGGCTATCCAGTCGATAGGGAAAGATAACATTAAAGTAT
ATAGATCAATATTTAGACCCTTATCTAAATCATTGCCAAAGACTGGCTCTAAATGTATTTTAAAGCTAATAGTTGATAAA
AATAATAATAAAGTTTTGGGGTGTCACATGATTGGTGATAATGCATCTGAAATTATTCAGATGGCATCAATCTCTCTAAT
GCTAGGTGCTAAAAAAACTGACTTTGATAATACAATGGCATTGCATCCTACAATAGCCGAGGAATTCGTGACAATGAGAT
GA

Upstream 100 bases:

>100_bases
GGATCGGCTGCATATATTGCTAATTCTTCCCAACTCATTGCATTTCTGGTTGGATTCATTTATTTCAACGAGAATAGGGA
AATAATACTAGGTTGCAAAA

Downstream 100 bases:

>100_bases
TTTAGAGAAGGCATTAGTTATTAGACCTTTTTCTTAGTCTTAACCAGTAAGCAATTGTTTTGTATATAATTATTGTTATT
GATAATGATATAGCTATAAA

Product: glutathione reductase (NADPH)

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MKSSFDLIVIGAGSGGLAAAKKAASYGASVAIVEGDLVGGTCVIRGCVPKKLLVCGSSLLESFLSATSYGFDFDNLKIKS
EVLLANVRKEVHRLNELHENFLNKANVELFKGWGEFRNSNCVEVKDRKNGETLNELYGERILIAVGGRPKRPSIEGASLG
WTSDDMFLLKSFPKKITIVGAGYIACEFACILHGLGVEVTQLVRGDRILRGFDFELSSSLTEAMKNKGVNISFGEKISSL
KGTPGSLIIKTNAGKEFDSNGLLFATGREPFLDGLKLEQAGIEILENKIKVDSEGKTNISNIFAIGDVTDRINLTPVAID
EGRKFADRNYGESDHKVNYNFVPYAVFSQPEIASVGMTEEKAIQSIGKDNIKVYRSIFRPLSKSLPKTGSKCILKLIVDK
NNNKVLGCHMIGDNASEIIQMASISLMLGAKKTDFDNTMALHPTIAEEFVTMR

Sequences:

>Translated_453_residues
MKSSFDLIVIGAGSGGLAAAKKAASYGASVAIVEGDLVGGTCVIRGCVPKKLLVCGSSLLESFLSATSYGFDFDNLKIKS
EVLLANVRKEVHRLNELHENFLNKANVELFKGWGEFRNSNCVEVKDRKNGETLNELYGERILIAVGGRPKRPSIEGASLG
WTSDDMFLLKSFPKKITIVGAGYIACEFACILHGLGVEVTQLVRGDRILRGFDFELSSSLTEAMKNKGVNISFGEKISSL
KGTPGSLIIKTNAGKEFDSNGLLFATGREPFLDGLKLEQAGIEILENKIKVDSEGKTNISNIFAIGDVTDRINLTPVAID
EGRKFADRNYGESDHKVNYNFVPYAVFSQPEIASVGMTEEKAIQSIGKDNIKVYRSIFRPLSKSLPKTGSKCILKLIVDK
NNNKVLGCHMIGDNASEIIQMASISLMLGAKKTDFDNTMALHPTIAEEFVTMR
>Mature_453_residues
MKSSFDLIVIGAGSGGLAAAKKAASYGASVAIVEGDLVGGTCVIRGCVPKKLLVCGSSLLESFLSATSYGFDFDNLKIKS
EVLLANVRKEVHRLNELHENFLNKANVELFKGWGEFRNSNCVEVKDRKNGETLNELYGERILIAVGGRPKRPSIEGASLG
WTSDDMFLLKSFPKKITIVGAGYIACEFACILHGLGVEVTQLVRGDRILRGFDFELSSSLTEAMKNKGVNISFGEKISSL
KGTPGSLIIKTNAGKEFDSNGLLFATGREPFLDGLKLEQAGIEILENKIKVDSEGKTNISNIFAIGDVTDRINLTPVAID
EGRKFADRNYGESDHKVNYNFVPYAVFSQPEIASVGMTEEKAIQSIGKDNIKVYRSIFRPLSKSLPKTGSKCILKLIVDK
NNNKVLGCHMIGDNASEIIQMASISLMLGAKKTDFDNTMALHPTIAEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=471, Percent_Identity=39.7027600849257, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI33519430, Length=461, Percent_Identity=35.1409978308026, Blast_Score=241, Evalue=9e-64,
Organism=Homo sapiens, GI33519428, Length=461, Percent_Identity=35.1409978308026, Blast_Score=241, Evalue=9e-64,
Organism=Homo sapiens, GI33519426, Length=461, Percent_Identity=35.1409978308026, Blast_Score=241, Evalue=9e-64,
Organism=Homo sapiens, GI148277065, Length=461, Percent_Identity=35.1409978308026, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI148277071, Length=461, Percent_Identity=35.1409978308026, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI22035672, Length=463, Percent_Identity=35.6371490280778, Blast_Score=229, Evalue=6e-60,
Organism=Homo sapiens, GI291045266, Length=461, Percent_Identity=32.3210412147505, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI291045268, Length=461, Percent_Identity=29.2841648590022, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI91199540, Length=457, Percent_Identity=29.1028446389497, Blast_Score=158, Evalue=9e-39,
Organism=Escherichia coli, GI1789915, Length=457, Percent_Identity=39.3873085339169, Blast_Score=308, Evalue=6e-85,
Organism=Escherichia coli, GI87082354, Length=453, Percent_Identity=29.5805739514349, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1786307, Length=454, Percent_Identity=27.3127753303965, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI87081717, Length=455, Percent_Identity=28.1318681318681, Blast_Score=155, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17557007, Length=470, Percent_Identity=36.1702127659575, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71983429, Length=454, Percent_Identity=38.5462555066079, Blast_Score=267, Evalue=9e-72,
Organism=Caenorhabditis elegans, GI71983419, Length=454, Percent_Identity=38.5462555066079, Blast_Score=267, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI71982272, Length=485, Percent_Identity=35.4639175257732, Blast_Score=224, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=28.4164859002169, Blast_Score=159, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6325166, Length=465, Percent_Identity=39.3548387096774, Blast_Score=302, Evalue=7e-83,
Organism=Saccharomyces cerevisiae, GI6321091, Length=472, Percent_Identity=30.9322033898305, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6325240, Length=471, Percent_Identity=26.5392781316348, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24640549, Length=472, Percent_Identity=38.3474576271186, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24640553, Length=472, Percent_Identity=37.9237288135593, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24640551, Length=472, Percent_Identity=38.3474576271186, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=35.9408033826639, Blast_Score=266, Evalue=3e-71,
Organism=Drosophila melanogaster, GI21358499, Length=458, Percent_Identity=30.5676855895196, Blast_Score=168, Evalue=7e-42,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49267; Mature: 49267

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSSFDLIVIGAGSGGLAAAKKAASYGASVAIVEGDLVGGTCVIRGCVPKKLLVCGSSLL
CCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHH
ESFLSATSYGFDFDNLKIKSEVLLANVRKEVHRLNELHENFLNKANVELFKGWGEFRNSN
HHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECHHHHCCCC
CVEVKDRKNGETLNELYGERILIAVGGRPKRPSIEGASLGWTSDDMFLLKSFPKKITIVG
EEEECCCCCCCHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEE
AGYIACEFACILHGLGVEVTQLVRGDRILRGFDFELSSSLTEAMKNKGVNISFGEKISSL
CCHHHHHHHHHHHCCCHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCEEHHHHHHHC
KGTPGSLIIKTNAGKEFDSNGLLFATGREPFLDGLKLEQAGIEILENKIKVDSEGKTNIS
CCCCCEEEEEECCCCCCCCCCEEEECCCCCHHCCCEEHHHHHHHHHHHEEECCCCCCCCC
NIFAIGDVTDRINLTPVAIDEGRKFADRNYGESDHKVNYNFVPYAVFSQPEIASVGMTEE
CEEEEECCCCCCEEEEEEECCCCHHHCCCCCCCCCEEECEEEEEEEECCCCCEECCCCHH
KAIQSIGKDNIKVYRSIFRPLSKSLPKTGSKCILKLIVDKNNNKVLGCHMIGDNASEIIQ
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEEEECCCHHHHHH
MASISLMLGAKKTDFDNTMALHPTIAEEFVTMR
HHHHHHEECCCCCCCCCEEEECCHHHHHHHCCC
>Mature Secondary Structure
MKSSFDLIVIGAGSGGLAAAKKAASYGASVAIVEGDLVGGTCVIRGCVPKKLLVCGSSLL
CCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHH
ESFLSATSYGFDFDNLKIKSEVLLANVRKEVHRLNELHENFLNKANVELFKGWGEFRNSN
HHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECHHHHCCCC
CVEVKDRKNGETLNELYGERILIAVGGRPKRPSIEGASLGWTSDDMFLLKSFPKKITIVG
EEEECCCCCCCHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEE
AGYIACEFACILHGLGVEVTQLVRGDRILRGFDFELSSSLTEAMKNKGVNISFGEKISSL
CCHHHHHHHHHHHCCCHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCEEHHHHHHHC
KGTPGSLIIKTNAGKEFDSNGLLFATGREPFLDGLKLEQAGIEILENKIKVDSEGKTNIS
CCCCCEEEEEECCCCCCCCCCEEEECCCCCHHCCCEEHHHHHHHHHHHEEECCCCCCCCC
NIFAIGDVTDRINLTPVAIDEGRKFADRNYGESDHKVNYNFVPYAVFSQPEIASVGMTEE
CEEEEECCCCCCEEEEEEECCCCHHHCCCCCCCCCEEECEEEEEEEECCCCCEECCCCHH
KAIQSIGKDNIKVYRSIFRPLSKSLPKTGSKCILKLIVDKNNNKVLGCHMIGDNASEIIQ
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEEEECCCHHHHHH
MASISLMLGAKKTDFDNTMALHPTIAEEFVTMR
HHHHHHEECCCCCCCCCEEEECCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7559423; 11759840 [H]