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The map label for this gene is dnaA

Identifier: 124025331

GI number: 124025331

Start: 562863

End: 564257

Strand: Direct

Name: dnaA

Synonym: NATL1_06201

Alternate gene names: 124025331

Gene position: 562863-564257 (Clockwise)

Preceding gene: 124025328

Following gene: 124025333

Centisome position: 30.18

GC content: 38.57

Gene sequence:

>1395_bases
GTGCCAACTCGGGATGAGCTATGGACGAAGGTGCAGAAATTACTGCAAAAGAATTTAAGTAAGCCTTCATACGAGACATG
GATACGTCCGGCTGAATTCTTTGATTTCAAGGATGGATGCTTGACTTTGCTTGCTCCAAATAGTTTCTCAAGTGATTGGT
TAAGGAAAAATTACTCTCAAACAATTGAGGAGATTGCATCAGAGACATTTGGCCATGAAGTTAAAGTACATATAAAAGTT
AAGGAAGAATTTTCATCAAACAAAAGCAATAAGAAAAAGAATTTTTCAAATGTAGAAGCTAATTCTATTGCCACTAGTGA
GAATTCCGACGTTAAATCTAAACAAACTCCAATAAAAAAATTTTTACCGAGTTTGAATCTTCGATATGTTTTTAATAGAT
TTGTTGTTGGTCCTAATAGCCGGATGGCTCATGCTGCTGCAATGGCAGTAGCCGAGGCCCCTGGTCGGGAATTTAATCCA
TTATTTATTTGTGGGGGAGTTGGCCTAGGTAAAACACATCTAATGCAATCTATAGGTCATTACAGGTTGGAAATCGATCC
AGGAGCAAAGGTTGCATATGTTTCTACTGAGACTTTTACCAATGATTTAATAGTTGCAATCAGAAAAGATGGAATGCAAG
CTTTTAGAAATAGATATAGAGAAGCTGATTTGATTTTGGTTGACGATATTCAATTTATAGAAGGTAAGGAATATACTCAG
GAAGAATTCTTCCATACATTTAATGCTTTGCACGAGGCAGGCAGGCAAATTGTTCTTACAAGTGATAGGCCTCCAAGTCA
AATACCTCGTTTACAAGAACGATTGATTTCAAGATTCTCAATGGGACTAATTGCAGATATCCAAGCTCCCGATTTGGAGA
CGAGAATGGCAATATTACAAAAAAAAGCTGAGCATGAAAGAATGCGTCTGCCAAGAGATTTGATTCAGTTTATTGCTGGA
CGATTCACCTCTAATATAAGAGAGTTAGAGGGAGCATTTACTCGTGCTGTCGCATTTGCCTCTATAACTGGGTTGCCAAT
GACAGTGGAATCAGTAGCACCAATGCTTGATCCTACTGGACAAGGAGTAGAAGTTAAGCCTAAGCAAGTACTAGAAAAAG
TAGCTGAGGTTTTTGGAGTTACTGAGGAGGAAATGCGTAGTCCAAGTAGACGTAGGCCGGTTAGTCAGGCAAGACAGGTA
GGCATGTATTTAATGCGCCATGGGACAGATTTAAGTCTTCCTCGTATTGGAGAATCTTTTGGGGGAAAGGACCATACAAC
AGTTATGTATGCCATTGAACAAGTAGAAAAAAAATTATCAAGTGAGCCACAATTAGCAAGTCAAGTTCAAAAAGTTAAGG
ATCTTCTTCAGATCGATTCACGGAAACGTCGTTAA

Upstream 100 bases:

>100_bases
TTTTAGAATAATGTATTAGAAACTTTACAACTGGATTCCCAAATTTAAGAATGACTCATTAAGGTTTTTAGCTACACTCG
TATTCCATTAGGTAATGCCT

Downstream 100 bases:

>100_bases
ACTAATATTTGATAGTGAGTGAGATTTTTATTAATTAATTAAACTGTATGGGATTTTGATCTAGCCTATTTCGTGTAGGT
ATTTCAGGACCTGGATCGCT

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MPTRDELWTKVQKLLQKNLSKPSYETWIRPAEFFDFKDGCLTLLAPNSFSSDWLRKNYSQTIEEIASETFGHEVKVHIKV
KEEFSSNKSNKKKNFSNVEANSIATSENSDVKSKQTPIKKFLPSLNLRYVFNRFVVGPNSRMAHAAAMAVAEAPGREFNP
LFICGGVGLGKTHLMQSIGHYRLEIDPGAKVAYVSTETFTNDLIVAIRKDGMQAFRNRYREADLILVDDIQFIEGKEYTQ
EEFFHTFNALHEAGRQIVLTSDRPPSQIPRLQERLISRFSMGLIADIQAPDLETRMAILQKKAEHERMRLPRDLIQFIAG
RFTSNIRELEGAFTRAVAFASITGLPMTVESVAPMLDPTGQGVEVKPKQVLEKVAEVFGVTEEEMRSPSRRRPVSQARQV
GMYLMRHGTDLSLPRIGESFGGKDHTTVMYAIEQVEKKLSSEPQLASQVQKVKDLLQIDSRKRR

Sequences:

>Translated_464_residues
MPTRDELWTKVQKLLQKNLSKPSYETWIRPAEFFDFKDGCLTLLAPNSFSSDWLRKNYSQTIEEIASETFGHEVKVHIKV
KEEFSSNKSNKKKNFSNVEANSIATSENSDVKSKQTPIKKFLPSLNLRYVFNRFVVGPNSRMAHAAAMAVAEAPGREFNP
LFICGGVGLGKTHLMQSIGHYRLEIDPGAKVAYVSTETFTNDLIVAIRKDGMQAFRNRYREADLILVDDIQFIEGKEYTQ
EEFFHTFNALHEAGRQIVLTSDRPPSQIPRLQERLISRFSMGLIADIQAPDLETRMAILQKKAEHERMRLPRDLIQFIAG
RFTSNIRELEGAFTRAVAFASITGLPMTVESVAPMLDPTGQGVEVKPKQVLEKVAEVFGVTEEEMRSPSRRRPVSQARQV
GMYLMRHGTDLSLPRIGESFGGKDHTTVMYAIEQVEKKLSSEPQLASQVQKVKDLLQIDSRKRR
>Mature_463_residues
PTRDELWTKVQKLLQKNLSKPSYETWIRPAEFFDFKDGCLTLLAPNSFSSDWLRKNYSQTIEEIASETFGHEVKVHIKVK
EEFSSNKSNKKKNFSNVEANSIATSENSDVKSKQTPIKKFLPSLNLRYVFNRFVVGPNSRMAHAAAMAVAEAPGREFNPL
FICGGVGLGKTHLMQSIGHYRLEIDPGAKVAYVSTETFTNDLIVAIRKDGMQAFRNRYREADLILVDDIQFIEGKEYTQE
EFFHTFNALHEAGRQIVLTSDRPPSQIPRLQERLISRFSMGLIADIQAPDLETRMAILQKKAEHERMRLPRDLIQFIAGR
FTSNIRELEGAFTRAVAFASITGLPMTVESVAPMLDPTGQGVEVKPKQVLEKVAEVFGVTEEEMRSPSRRRPVSQARQVG
MYLMRHGTDLSLPRIGESFGGKDHTTVMYAIEQVEKKLSSEPQLASQVQKVKDLLQIDSRKRR

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=443, Percent_Identity=37.9232505643341, Blast_Score=308, Evalue=5e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_PROM1 (A2C122)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014447.1
- ProteinModelPortal:   A2C122
- STRING:   A2C122
- GeneID:   4779567
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_06201
- eggNOG:   COG0593
- HOGENOM:   HBG695666
- OMA:   IQRVVGQ
- ProtClustDB:   PRK00149
- BioCyc:   PMAR167555:NATL1_06201-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 52656; Mature: 52525

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTRDELWTKVQKLLQKNLSKPSYETWIRPAEFFDFKDGCLTLLAPNSFSSDWLRKNYSQ
CCCHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHCCCCCCCEEEECCCCCCHHHHHHHHHH
TIEEIASETFGHEVKVHIKVKEEFSSNKSNKKKNFSNVEANSIATSENSDVKSKQTPIKK
HHHHHHHHHCCCEEEEEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHH
FLPSLNLRYVFNRFVVGPNSRMAHAAAMAVAEAPGREFNPLFICGGVGLGKTHLMQSIGH
HHCCCCHHHHHHHHEECCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHCCC
YRLEIDPGAKVAYVSTETFTNDLIVAIRKDGMQAFRNRYREADLILVDDIQFIEGKEYTQ
EEEEECCCCEEEEEECCHHCCHHEEEEHHHHHHHHHHHHCCCCEEEECCCHHHCCCCHHH
EEFFHTFNALHEAGRQIVLTSDRPPSQIPRLQERLISRFSMGLIADIQAPDLETRMAILQ
HHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHH
KKAEHERMRLPRDLIQFIAGRFTSNIRELEGAFTRAVAFASITGLPMTVESVAPMLDPTG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHCCCCC
QGVEVKPKQVLEKVAEVFGVTEEEMRSPSRRRPVSQARQVGMYLMRHGTDLSLPRIGESF
CCCEECHHHHHHHHHHHHCCCHHHHCCCHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHC
GGKDHTTVMYAIEQVEKKLSSEPQLASQVQKVKDLLQIDSRKRR
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PTRDELWTKVQKLLQKNLSKPSYETWIRPAEFFDFKDGCLTLLAPNSFSSDWLRKNYSQ
CCHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHCCCCCCCEEEECCCCCCHHHHHHHHHH
TIEEIASETFGHEVKVHIKVKEEFSSNKSNKKKNFSNVEANSIATSENSDVKSKQTPIKK
HHHHHHHHHCCCEEEEEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHH
FLPSLNLRYVFNRFVVGPNSRMAHAAAMAVAEAPGREFNPLFICGGVGLGKTHLMQSIGH
HHCCCCHHHHHHHHEECCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHCCC
YRLEIDPGAKVAYVSTETFTNDLIVAIRKDGMQAFRNRYREADLILVDDIQFIEGKEYTQ
EEEEECCCCEEEEEECCHHCCHHEEEEHHHHHHHHHHHHCCCCEEEECCCHHHCCCCHHH
EEFFHTFNALHEAGRQIVLTSDRPPSQIPRLQERLISRFSMGLIADIQAPDLETRMAILQ
HHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHH
KKAEHERMRLPRDLIQFIAGRFTSNIRELEGAFTRAVAFASITGLPMTVESVAPMLDPTG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHCCCCC
QGVEVKPKQVLEKVAEVFGVTEEEMRSPSRRRPVSQARQVGMYLMRHGTDLSLPRIGESF
CCCEECHHHHHHHHHHHHCCCHHHHCCCHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHC
GGKDHTTVMYAIEQVEKKLSSEPQLASQVQKVKDLLQIDSRKRR
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA