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The map label for this gene is trpF [H]

Identifier: 124025303

GI number: 124025303

Start: 538226

End: 538900

Strand: Reverse

Name: trpF [H]

Synonym: NATL1_05921

Alternate gene names: 124025303

Gene position: 538900-538226 (Counterclockwise)

Preceding gene: 124025305

Following gene: 124025297

Centisome position: 28.9

GC content: 32.74

Gene sequence:

>675_bases
ATGATCAGAAAATCATCTTCTAAAAAGTCAACAGCAATAAAAATTTGTGGCCTAACAAAGACTTCGCAAGCACGATCGAT
AGCAGAATTAAAAATAAATGCTATTGGCGTTATTGGCGTTAAAAATTCACCTCGTTTTGTACCTGAAGAAGAATGCATGA
AAATTTTTAATGAAGTAGAAAAAGTTTCGTCAAGTATTGAGAAAGTATTAGTAATCGCAAATGCAAAATTAGAGGATGTC
AAATGTATAAATAACAGATCAACCCCACCATCAGTAATCCAATTGCATGGGAATGAATCAGTTGATTATTGTCGTGAATT
AAAGAATGAATTTCCAGGAATCAAAATATGGAAAGCCTTCAGGTTAAAAGCTATTAATGATTTAGAAAATATAAGTCAAT
ATGAAAAGAATATTGATGCTATTCTCATAGATGCTTGGGATGGGAAATCACTTGGAGGCACTGGGAATAGAGTCCCAATA
GAATTACTACTTAATAAAACTTTTAAAGCTCCTTGGATCTTAGCTGGTGGAATATCTGCTGAAATAATTCCTGAAATTTT
TTCTAAACTTAGACCTGATGGTATTGATGCATCTAGCCGACTAGAGATATCTCCAGGTATTAAAGATCTTAAGAAAGTTG
CATCTCTTGTTCGCGAAATAAGAGAACAAAATTAA

Upstream 100 bases:

>100_bases
GGATACCTCTGATTTTCATAACTTCCCAACTACCCAAACTTAAATTCCTCCAAGCTCACAAAAAAATCCATTTCAATCAA
TCCTAATAAAAGTTCTGGTA

Downstream 100 bases:

>100_bases
AAGGCTCCGGCAGATGGCATCAAAGTTACATCCTCTATAATTTGATTAGTTGGTTGACTAGCAAGATGTAAAAGTTCACA
TGCAACTTGATCAACTGAAA

Product: phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MIRKSSSKKSTAIKICGLTKTSQARSIAELKINAIGVIGVKNSPRFVPEEECMKIFNEVEKVSSSIEKVLVIANAKLEDV
KCINNRSTPPSVIQLHGNESVDYCRELKNEFPGIKIWKAFRLKAINDLENISQYEKNIDAILIDAWDGKSLGGTGNRVPI
ELLLNKTFKAPWILAGGISAEIIPEIFSKLRPDGIDASSRLEISPGIKDLKKVASLVREIREQN

Sequences:

>Translated_224_residues
MIRKSSSKKSTAIKICGLTKTSQARSIAELKINAIGVIGVKNSPRFVPEEECMKIFNEVEKVSSSIEKVLVIANAKLEDV
KCINNRSTPPSVIQLHGNESVDYCRELKNEFPGIKIWKAFRLKAINDLENISQYEKNIDAILIDAWDGKSLGGTGNRVPI
ELLLNKTFKAPWILAGGISAEIIPEIFSKLRPDGIDASSRLEISPGIKDLKKVASLVREIREQN
>Mature_224_residues
MIRKSSSKKSTAIKICGLTKTSQARSIAELKINAIGVIGVKNSPRFVPEEECMKIFNEVEKVSSSIEKVLVIANAKLEDV
KCINNRSTPPSVIQLHGNESVDYCRELKNEFPGIKIWKAFRLKAINDLENISQYEKNIDAILIDAWDGKSLGGTGNRVPI
ELLLNKTFKAPWILAGGISAEIIPEIFSKLRPDGIDASSRLEISPGIKDLKKVASLVREIREQN

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=210, Percent_Identity=29.0476190476191, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 24813; Mature: 24813

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRKSSSKKSTAIKICGLTKTSQARSIAELKINAIGVIGVKNSPRFVPEEECMKIFNEVE
CCCCCCCCCCCEEEEECCCCCHHHHHHHHEEEEEEEEEEECCCCCCCCHHHHHHHHHHHH
KVSSSIEKVLVIANAKLEDVKCINNRSTPPSVIQLHGNESVDYCRELKNEFPGIKIWKAF
HHHHHHHHEEEEECCCHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCEEEHHHH
RLKAINDLENISQYEKNIDAILIDAWDGKSLGGTGNRVPIELLLNKTFKAPWILAGGISA
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHEEEECCCCCCCEEEECCCCH
EIIPEIFSKLRPDGIDASSRLEISPGIKDLKKVASLVREIREQN
HHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIRKSSSKKSTAIKICGLTKTSQARSIAELKINAIGVIGVKNSPRFVPEEECMKIFNEVE
CCCCCCCCCCCEEEEECCCCCHHHHHHHHEEEEEEEEEEECCCCCCCCHHHHHHHHHHHH
KVSSSIEKVLVIANAKLEDVKCINNRSTPPSVIQLHGNESVDYCRELKNEFPGIKIWKAF
HHHHHHHHEEEEECCCHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCEEEHHHH
RLKAINDLENISQYEKNIDAILIDAWDGKSLGGTGNRVPIELLLNKTFKAPWILAGGISA
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHEEEECCCCCCCEEEECCCCH
EIIPEIFSKLRPDGIDASSRLEISPGIKDLKKVASLVREIREQN
HHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA