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The map label for this gene is cobK [H]

Identifier: 124025272

GI number: 124025272

Start: 508162

End: 508971

Strand: Direct

Name: cobK [H]

Synonym: NATL1_05611

Alternate gene names: 124025272

Gene position: 508162-508971 (Clockwise)

Preceding gene: 124025270

Following gene: 124025273

Centisome position: 27.25

GC content: 32.59

Gene sequence:

>810_bases
ATGGATATAAGGGAAAAATGCCAGCCACATCTTTGGTTGTTAACAGGAACAGGCGAAGGCCATGTCTTCGCTGAGTCTCT
ATTGAAAGAAGGCTGGAAAATTACTGTTAGTGTTGTTTCGGATAGAGCCTCGATTCCATATGAAAAATTAAACTTAGAGA
AAATATTAATTGGTGCCTTAATTACTGAGGAAGAGATCCGGGGAGTCATATTAAATGCCAGAATTCATCAAAATGGATTT
CATTGCGTTGTTGATCTGACTCATCCATTTGCTATGAAAATCACACGATCAATCTCAAAAGTTTGTAAGGAACTAGGTCA
AACATTCATAAGGTATGAAAGAGCTATCGATAATATTTCAAATGCATTTTTAATAGAAAAATTTAGTGATTTAAGAAATT
ATGATCTAAAGAATAAATCTATTTTGCTTGCCGTAGGAGTAAGACATCTTCAGGAAGCCTTTGTCTTCGCGAGAAATTCA
GGGGCAAATGTTTATGCAAGAGTTTTAGCTAATCCAGAAAGTATAAGAAAAACCCTGTCTTCATCAATTCAAAAAACAAA
TTTTGCGGTATTAAATCCTTCAGTTTCAAGTAATGGAAAAATTGAAAAAGCTCTTGTTAGGAAATGGAATATTGCTGGTG
TCATTTGTAGGCAATCAGGAGGAAGTAATGAAATCTTATGGCACCGAATTTGTTTAAGTATGAGAATTAATCTTTGGTTA
TTGGAAAGACCTACTGAATTTAAAAATATTAATTCAGTAGATAGCTATGAAAAATTAAATAAGAAATTAAAATCTATTAG
TATGGAATAA

Upstream 100 bases:

>100_bases
TTGTTGTCTTGGGTAAAACGAACTGTTGGGGCCTTCTTTACCAAAACCTCAAGCATGCAATGGTTCATTTTTTTTTCTTT
AGTTATTGTGTTTTATCTTG

Downstream 100 bases:

>100_bases
AAAGTTTTTAAGATCATGTCTTTATCTGGTTTCAATCAAGAAATTTACTTGGTTATAACTACTGAAGTCGATAAAAAAAA
TGCATCTAAATTAGCTAATC

Product: precorrin-6X reductase

Products: Precorrin 6A; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MDIREKCQPHLWLLTGTGEGHVFAESLLKEGWKITVSVVSDRASIPYEKLNLEKILIGALITEEEIRGVILNARIHQNGF
HCVVDLTHPFAMKITRSISKVCKELGQTFIRYERAIDNISNAFLIEKFSDLRNYDLKNKSILLAVGVRHLQEAFVFARNS
GANVYARVLANPESIRKTLSSSIQKTNFAVLNPSVSSNGKIEKALVRKWNIAGVICRQSGGSNEILWHRICLSMRINLWL
LERPTEFKNINSVDSYEKLNKKLKSISME

Sequences:

>Translated_269_residues
MDIREKCQPHLWLLTGTGEGHVFAESLLKEGWKITVSVVSDRASIPYEKLNLEKILIGALITEEEIRGVILNARIHQNGF
HCVVDLTHPFAMKITRSISKVCKELGQTFIRYERAIDNISNAFLIEKFSDLRNYDLKNKSILLAVGVRHLQEAFVFARNS
GANVYARVLANPESIRKTLSSSIQKTNFAVLNPSVSSNGKIEKALVRKWNIAGVICRQSGGSNEILWHRICLSMRINLWL
LERPTEFKNINSVDSYEKLNKKLKSISME
>Mature_269_residues
MDIREKCQPHLWLLTGTGEGHVFAESLLKEGWKITVSVVSDRASIPYEKLNLEKILIGALITEEEIRGVILNARIHQNGF
HCVVDLTHPFAMKITRSISKVCKELGQTFIRYERAIDNISNAFLIEKFSDLRNYDLKNKSILLAVGVRHLQEAFVFARNS
GANVYARVLANPESIRKTLSSSIQKTNFAVLNPSVSSNGKIEKALVRKWNIAGVICRQSGGSNEILWHRICLSMRINLWL
LERPTEFKNINSVDSYEKLNKKLKSISME

Specific function: Catalyzes the reduction of the macrocycle of cobalt- precorrin-6X into cobalt-precorrin-6Y [H]

COG id: COG2099

COG function: function code H; Precorrin-6x reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin-6x reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003723 [H]

Pfam domain/function: PF02571 CbiJ [H]

EC number: 1.3.1.54

Molecular weight: Translated: 30537; Mature: 30537

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS51014 COBK_CBIJ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIREKCQPHLWLLTGTGEGHVFAESLLKEGWKITVSVVSDRASIPYEKLNLEKILIGAL
CCCHHHCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHCHHHHHHHHH
ITEEEIRGVILNARIHQNGFHCVVDLTHPFAMKITRSISKVCKELGQTFIRYERAIDNIS
HHHHHHCEEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAFLIEKFSDLRNYDLKNKSILLAVGVRHLQEAFVFARNSGANVYARVLANPESIRKTLS
HHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHH
SSIQKTNFAVLNPSVSSNGKIEKALVRKWNIAGVICRQSGGSNEILWHRICLSMRINLWL
HHHHHCCEEEECCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHEEEEEE
LERPTEFKNINSVDSYEKLNKKLKSISME
EECCCHHCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDIREKCQPHLWLLTGTGEGHVFAESLLKEGWKITVSVVSDRASIPYEKLNLEKILIGAL
CCCHHHCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHCHHHHHHHHH
ITEEEIRGVILNARIHQNGFHCVVDLTHPFAMKITRSISKVCKELGQTFIRYERAIDNIS
HHHHHHCEEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAFLIEKFSDLRNYDLKNKSILLAVGVRHLQEAFVFARNSGANVYARVLANPESIRKTLS
HHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHH
SSIQKTNFAVLNPSVSSNGKIEKALVRKWNIAGVICRQSGGSNEILWHRICLSMRINLWL
HHHHHCCEEEECCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHEEEEEE
LERPTEFKNINSVDSYEKLNKKLKSISME
EECCCHHCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Precorrin 6B; NADP+

Specific reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]