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The map label for this gene is MCM [H]

Identifier: 124027777

GI number: 124027777

Start: 909507

End: 911597

Strand: Reverse

Name: MCM [H]

Synonym: Hbut_0903

Alternate gene names: 124027777

Gene position: 911597-909507 (Counterclockwise)

Preceding gene: 124027778

Following gene: 124027768

Centisome position: 54.68

GC content: 50.84

Gene sequence:

>2091_bases
ATGACAATAGCACTTGTTGAGGAAGCAGTACTAGATGTTAAGGAGAGGTTCTACGAGTTCATAAGAACCTACCGCGACCG
CAGTGGTCAATACAAGTACATGAATAGGATAAGGCAAATGATAACTATGGGACAAAAGAGCCTAGTAGTAGACTACAATG
ACCTCTATGTCTTCGATACAAAGCTGGCTAGACTGCTAATTGATCATCCAGACGTGGTTCTAAGGCAAGCCGCAGAGGCT
GTCCAAGACATCGTGACTTCTGAGGCGCCAGAGTATGCCGAAGGTATAGAGAGGTTCCGTGTCAGGATACGCGCTCTCCC
AAAGACAACACCACTACGTGGGCTCCGAAGCGAGTACATAGGAAGGCTAGTAATGCTCGAAGGCATTCTCGTAAGAACAA
CACCGGTCAGGGAGAAGATAGTAAAGGCTGTCTTTCAGCACTGCACAAAGGAGTCATGCCACGAGTTTGAGTGGCCACCC
GAAGGCGAGATAGTTGGCGAGGAACTAGAAAAACCACCAACATGCCCCGTCTGTGGCTCCTCAAGCGGCACATTTAGGCT
GATACCGGAGAAGTCAAAGTTGATAGACTGGCAGCGTATAGTGCTGCAAGAAAGGCCTGAGGAAGTACCCCCCGGCCAGC
TGCCACGCAGTATAGAGGTCGTACTACAAGACGAACTCGTTGATAGTGCTCGTCCCGGCGATAGGGTTACTGTCGTCGGT
ATCGTGAGGATTAAGCCTGACACATCTACTAGGAAAAAGAAGGCTATCTATGATCTCTACATAGAGGCTAACCACATAGA
GGTTTCACAGAAGGTTCTAGAGGAGGTCAAGATAACTAGGGAGGACGAGGAACGTATAAAGGCACTGGCAAGGGATCCAT
GGATACATAAGAGGATAGTTGCAAGCATAGCACCAGCAATCTACGGGCACTGGGACATCAAGGAGGCTATAGCTCTCGCG
TTGTTCGGCGGGGTACCCAAGCTGTTCCGCGATGGTGTACGAATACGCGGTGACATCCATGTACTCATTGTGGGCGACCC
AGGTACAGCCAAGAGCCAGCTCCTCCTCTACGCCTCTAAGATAGCTCCACGCGGCATTTACACCAGCGGCAAGGGCGCTA
CTGCCGCAGGCTTGACAGCTGCCGTTATACGTGACAAGACTACGGGAGAGTACTATCTCGAGGCTGGGGCGCTAGTACTA
GCTGACGGCGGTGTAGCTGCAATAGACGAGATAGACAAGATGAGAGATGAGGATCGCTCGGCAATACACGAAGCGATGGA
GCAGCAGACGGTTAGTATAGCTAAGGCCGGCATAGTAGCAAAGCTAAACGCGAGAACCACAGTTATAGCAGCTGGTAACC
CGAAGTTTGGCCGATACCTACCCAATAGAACGCTGGCCGACAACATAAACCTGCCGCCAACCATACTATCAAGGTTCGAC
CTCATATTCATACTTCGCGACACACCAAACCCCGAGGAGGATAGGAAGCTTGCGAGACACGTCCTCCAGGCGCACCGTGA
GACGGAGCTTATCAAACCTGAAATAGAACCTGAGCTACTAAGAAAGTACATTAGTTATGCAAGACGTTATGTTAGGCCCA
GGCTCACACCGGAAGCAGCCAAACTCATCGAGGACTTCTTCGTTGAAATGAGGAGGATGAGCAGTGAAAACCCGGAGGGT
CCAATATCGATCACCACGAGGCAGCTTGAAGCACTAATACGCCTGGCGGAAGCCCATGCACGGATAGCACTAAGAAACGA
AGTAACTGTTGAAGATGCAGAAGCTGCTATTAGACTCATGAAAGCCTTCCTCGAGAGTGCTGGACTCGACGTGGAGAGTG
GCCGCATAGACATAGATGTGATTATGACTGGCAAGCCTAGGAGTAAGCAGGAGAAGCTGACCAGGATACTGGAGATCATA
GAGCAGCTAGAGTCAGAGAGTGACGAGGGTTGTGCAAGACTGCGAGAGATACAGCGTAGAGCAGCTGCTGAAGGCATCGA
GTCTAGCCTTGTAGAGGAGGCTATTAGTAGCTTCAGGAGGGACGGCATTATCTACGAGAAGACAATTGGCTGCTACGCCG
TGGTACGCTAA

Upstream 100 bases:

>100_bases
GCTAGCCACTTGGGGAATTTCACCTATAAGGGGTATTACAGCGTCTAATACACTAGCCGGGCTCAGCTAGGAAAATTATA
GAGGTAGGGTAAGACGAGTC

Downstream 100 bases:

>100_bases
AACACAAACAACACAATCATTTTACTCGTAGCGAAGTGCCACAGCTGGCGGTATTCTTGCTGCTCGATAAGCCGGAAATA
ATCCGCCTATAAGCCCTACA

Product: minichromosome maintenance complex

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 696; Mature: 695

Protein sequence:

>696_residues
MTIALVEEAVLDVKERFYEFIRTYRDRSGQYKYMNRIRQMITMGQKSLVVDYNDLYVFDTKLARLLIDHPDVVLRQAAEA
VQDIVTSEAPEYAEGIERFRVRIRALPKTTPLRGLRSEYIGRLVMLEGILVRTTPVREKIVKAVFQHCTKESCHEFEWPP
EGEIVGEELEKPPTCPVCGSSSGTFRLIPEKSKLIDWQRIVLQERPEEVPPGQLPRSIEVVLQDELVDSARPGDRVTVVG
IVRIKPDTSTRKKKAIYDLYIEANHIEVSQKVLEEVKITREDEERIKALARDPWIHKRIVASIAPAIYGHWDIKEAIALA
LFGGVPKLFRDGVRIRGDIHVLIVGDPGTAKSQLLLYASKIAPRGIYTSGKGATAAGLTAAVIRDKTTGEYYLEAGALVL
ADGGVAAIDEIDKMRDEDRSAIHEAMEQQTVSIAKAGIVAKLNARTTVIAAGNPKFGRYLPNRTLADNINLPPTILSRFD
LIFILRDTPNPEEDRKLARHVLQAHRETELIKPEIEPELLRKYISYARRYVRPRLTPEAAKLIEDFFVEMRRMSSENPEG
PISITTRQLEALIRLAEAHARIALRNEVTVEDAEAAIRLMKAFLESAGLDVESGRIDIDVIMTGKPRSKQEKLTRILEII
EQLESESDEGCARLREIQRRAAAEGIESSLVEEAISSFRRDGIIYEKTIGCYAVVR

Sequences:

>Translated_696_residues
MTIALVEEAVLDVKERFYEFIRTYRDRSGQYKYMNRIRQMITMGQKSLVVDYNDLYVFDTKLARLLIDHPDVVLRQAAEA
VQDIVTSEAPEYAEGIERFRVRIRALPKTTPLRGLRSEYIGRLVMLEGILVRTTPVREKIVKAVFQHCTKESCHEFEWPP
EGEIVGEELEKPPTCPVCGSSSGTFRLIPEKSKLIDWQRIVLQERPEEVPPGQLPRSIEVVLQDELVDSARPGDRVTVVG
IVRIKPDTSTRKKKAIYDLYIEANHIEVSQKVLEEVKITREDEERIKALARDPWIHKRIVASIAPAIYGHWDIKEAIALA
LFGGVPKLFRDGVRIRGDIHVLIVGDPGTAKSQLLLYASKIAPRGIYTSGKGATAAGLTAAVIRDKTTGEYYLEAGALVL
ADGGVAAIDEIDKMRDEDRSAIHEAMEQQTVSIAKAGIVAKLNARTTVIAAGNPKFGRYLPNRTLADNINLPPTILSRFD
LIFILRDTPNPEEDRKLARHVLQAHRETELIKPEIEPELLRKYISYARRYVRPRLTPEAAKLIEDFFVEMRRMSSENPEG
PISITTRQLEALIRLAEAHARIALRNEVTVEDAEAAIRLMKAFLESAGLDVESGRIDIDVIMTGKPRSKQEKLTRILEII
EQLESESDEGCARLREIQRRAAAEGIESSLVEEAISSFRRDGIIYEKTIGCYAVVR
>Mature_695_residues
TIALVEEAVLDVKERFYEFIRTYRDRSGQYKYMNRIRQMITMGQKSLVVDYNDLYVFDTKLARLLIDHPDVVLRQAAEAV
QDIVTSEAPEYAEGIERFRVRIRALPKTTPLRGLRSEYIGRLVMLEGILVRTTPVREKIVKAVFQHCTKESCHEFEWPPE
GEIVGEELEKPPTCPVCGSSSGTFRLIPEKSKLIDWQRIVLQERPEEVPPGQLPRSIEVVLQDELVDSARPGDRVTVVGI
VRIKPDTSTRKKKAIYDLYIEANHIEVSQKVLEEVKITREDEERIKALARDPWIHKRIVASIAPAIYGHWDIKEAIALAL
FGGVPKLFRDGVRIRGDIHVLIVGDPGTAKSQLLLYASKIAPRGIYTSGKGATAAGLTAAVIRDKTTGEYYLEAGALVLA
DGGVAAIDEIDKMRDEDRSAIHEAMEQQTVSIAKAGIVAKLNARTTVIAAGNPKFGRYLPNRTLADNINLPPTILSRFDL
IFILRDTPNPEEDRKLARHVLQAHRETELIKPEIEPELLRKYISYARRYVRPRLTPEAAKLIEDFFVEMRRMSSENPEGP
ISITTRQLEALIRLAEAHARIALRNEVTVEDAEAAIRLMKAFLESAGLDVESGRIDIDVIMTGKPRSKQEKLTRILEIIE
QLESESDEGCARLREIQRRAAAEGIESSLVEEAISSFRRDGIIYEKTIGCYAVVR

Specific function: Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein) [H]

COG id: COG1241

COG function: function code L; Predicted ATPase involved in replication control, Cdc46/Mcm family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MCM domain [H]

Homologues:

Organism=Homo sapiens, GI33356547, Length=626, Percent_Identity=41.0543130990415, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI33469919, Length=667, Percent_Identity=36.7316341829085, Blast_Score=408, Evalue=1e-113,
Organism=Homo sapiens, GI33469917, Length=667, Percent_Identity=36.7316341829085, Blast_Score=408, Evalue=1e-113,
Organism=Homo sapiens, GI23510448, Length=630, Percent_Identity=39.0476190476191, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI19923727, Length=675, Percent_Identity=36.2962962962963, Blast_Score=359, Evalue=5e-99,
Organism=Homo sapiens, GI33469924, Length=676, Percent_Identity=35.3550295857988, Blast_Score=348, Evalue=1e-95,
Organism=Homo sapiens, GI7427519, Length=673, Percent_Identity=34.0267459138187, Blast_Score=348, Evalue=1e-95,
Organism=Homo sapiens, GI33469968, Length=638, Percent_Identity=35.5799373040752, Blast_Score=342, Evalue=7e-94,
Organism=Homo sapiens, GI6631095, Length=656, Percent_Identity=35.3658536585366, Blast_Score=335, Evalue=1e-91,
Organism=Homo sapiens, GI33469922, Length=437, Percent_Identity=42.3340961098398, Blast_Score=316, Evalue=4e-86,
Organism=Homo sapiens, GI310115110, Length=310, Percent_Identity=37.0967741935484, Blast_Score=181, Evalue=3e-45,
Organism=Homo sapiens, GI310128402, Length=310, Percent_Identity=37.0967741935484, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI310119838, Length=310, Percent_Identity=37.0967741935484, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI23397546, Length=323, Percent_Identity=30.030959752322, Blast_Score=152, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71997752, Length=621, Percent_Identity=40.0966183574879, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17508417, Length=676, Percent_Identity=35.207100591716, Blast_Score=390, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17554306, Length=640, Percent_Identity=37.03125, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17562702, Length=583, Percent_Identity=36.3636363636364, Blast_Score=342, Evalue=5e-94,
Organism=Caenorhabditis elegans, GI71997563, Length=655, Percent_Identity=34.8091603053435, Blast_Score=337, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI17562700, Length=640, Percent_Identity=33.59375, Blast_Score=327, Evalue=9e-90,
Organism=Caenorhabditis elegans, GI71997571, Length=334, Percent_Identity=46.4071856287425, Blast_Score=259, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6325276, Length=718, Percent_Identity=36.7688022284123, Blast_Score=424, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6323304, Length=671, Percent_Identity=36.8107302533532, Blast_Score=379, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6319448, Length=653, Percent_Identity=38.2848392036753, Blast_Score=378, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6319679, Length=562, Percent_Identity=37.0106761565836, Blast_Score=332, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6321237, Length=351, Percent_Identity=44.1595441595442, Blast_Score=293, Evalue=4e-80,
Organism=Saccharomyces cerevisiae, GI6320803, Length=408, Percent_Identity=42.8921568627451, Blast_Score=291, Evalue=2e-79,
Organism=Drosophila melanogaster, GI17137132, Length=625, Percent_Identity=40.8, Blast_Score=434, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24645774, Length=624, Percent_Identity=37.9807692307692, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI17137242, Length=663, Percent_Identity=36.3499245852187, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24639835, Length=658, Percent_Identity=35.258358662614, Blast_Score=352, Evalue=4e-97,
Organism=Drosophila melanogaster, GI17530827, Length=643, Percent_Identity=33.9035769828927, Blast_Score=333, Evalue=3e-91,
Organism=Drosophila melanogaster, GI17647617, Length=717, Percent_Identity=31.6596931659693, Blast_Score=326, Evalue=4e-89,
Organism=Drosophila melanogaster, GI24647251, Length=300, Percent_Identity=35, Blast_Score=148, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001208
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF00493 MCM [H]

EC number: NA

Molecular weight: Translated: 78524; Mature: 78392

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS50051 MCM_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIALVEEAVLDVKERFYEFIRTYRDRSGQYKYMNRIRQMITMGQKSLVVDYNDLYVFDT
CEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCEEEEHH
KLARLLIDHPDVVLRQAAEAVQDIVTSEAPEYAEGIERFRVRIRALPKTTPLRGLRSEYI
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GRLVMLEGILVRTTPVREKIVKAVFQHCTKESCHEFEWPPEGEIVGEELEKPPTCPVCGS
HHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCC
SSGTFRLIPEKSKLIDWQRIVLQERPEEVPPGQLPRSIEVVLQDELVDSARPGDRVTVVG
CCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEE
IVRIKPDTSTRKKKAIYDLYIEANHIEVSQKVLEEVKITREDEERIKALARDPWIHKRIV
EEEECCCCCCHHHHCEEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHH
ASIAPAIYGHWDIKEAIALALFGGVPKLFRDGVRIRGDIHVLIVGDPGTAKSQLLLYASK
HHHHHHHHCCCCHHHHHHHHHHCCCHHHHHCCCEEECCEEEEEEECCCCCHHHHHHHHHH
IAPRGIYTSGKGATAAGLTAAVIRDKTTGEYYLEAGALVLADGGVAAIDEIDKMRDEDRS
CCCCCCEECCCCCCHHHHHHHHHCCCCCCCEEEECCEEEEECCCCHHHHHHHHHHHHHHH
AIHEAMEQQTVSIAKAGIVAKLNARTTVIAAGNPKFGRYLPNRTLADNINLPPTILSRFD
HHHHHHHHHHHHHHHCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHCCCC
LIFILRDTPNPEEDRKLARHVLQAHRETELIKPEIEPELLRKYISYARRYVRPRLTPEAA
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHH
KLIEDFFVEMRRMSSENPEGPISITTRQLEALIRLAEAHARIALRNEVTVEDAEAAIRLM
HHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHH
KAFLESAGLDVESGRIDIDVIMTGKPRSKQEKLTRILEIIEQLESESDEGCARLREIQRR
HHHHHHCCCCEECCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AAAEGIESSLVEEAISSFRRDGIIYEKTIGCYAVVR
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEC
>Mature Secondary Structure 
TIALVEEAVLDVKERFYEFIRTYRDRSGQYKYMNRIRQMITMGQKSLVVDYNDLYVFDT
EEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCEEEEHH
KLARLLIDHPDVVLRQAAEAVQDIVTSEAPEYAEGIERFRVRIRALPKTTPLRGLRSEYI
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GRLVMLEGILVRTTPVREKIVKAVFQHCTKESCHEFEWPPEGEIVGEELEKPPTCPVCGS
HHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCC
SSGTFRLIPEKSKLIDWQRIVLQERPEEVPPGQLPRSIEVVLQDELVDSARPGDRVTVVG
CCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEE
IVRIKPDTSTRKKKAIYDLYIEANHIEVSQKVLEEVKITREDEERIKALARDPWIHKRIV
EEEECCCCCCHHHHCEEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHH
ASIAPAIYGHWDIKEAIALALFGGVPKLFRDGVRIRGDIHVLIVGDPGTAKSQLLLYASK
HHHHHHHHCCCCHHHHHHHHHHCCCHHHHHCCCEEECCEEEEEEECCCCCHHHHHHHHHH
IAPRGIYTSGKGATAAGLTAAVIRDKTTGEYYLEAGALVLADGGVAAIDEIDKMRDEDRS
CCCCCCEECCCCCCHHHHHHHHHCCCCCCCEEEECCEEEEECCCCHHHHHHHHHHHHHHH
AIHEAMEQQTVSIAKAGIVAKLNARTTVIAAGNPKFGRYLPNRTLADNINLPPTILSRFD
HHHHHHHHHHHHHHHCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHCCCC
LIFILRDTPNPEEDRKLARHVLQAHRETELIKPEIEPELLRKYISYARRYVRPRLTPEAA
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHH
KLIEDFFVEMRRMSSENPEGPISITTRQLEALIRLAEAHARIALRNEVTVEDAEAAIRLM
HHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHH
KAFLESAGLDVESGRIDIDVIMTGKPRSKQEKLTRILEIIEQLESESDEGCARLREIQRR
HHHHHHCCCCEECCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AAAEGIESSLVEEAISSFRRDGIIYEKTIGCYAVVR
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]