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The map label for this gene is mvk [H]

Identifier: 124027753

GI number: 124027753

Start: 877127

End: 878077

Strand: Reverse

Name: mvk [H]

Synonym: Hbut_0877

Alternate gene names: 124027753

Gene position: 878077-877127 (Counterclockwise)

Preceding gene: 124027754

Following gene: 124027752

Centisome position: 52.67

GC content: 53.52

Gene sequence:

>951_bases
TTGGGGTGTGCATGGTCAGCGCCTGCTAAGGTTATAGTGTTTGGCGAGCATTGGGTTGTTCATGGCGGCCTTGCTCTTGC
AGCTGCTATTGGCTTGAGAGCACGGGCCTATGGTAGTCCTTCAGAATCGGGGTTATGGGTCTTCTCGCAGCTCTATAGAA
TCGGGGAGAACCTCATGGAGAGCTGTAGTAGGTTTTGTAATCTTCTAGCGGGATTTAGGCTTGTGGCTAGTAGTTATGGA
CGTAGCTTGTGGCCTGCACGTATACGTATAGAGTCTGACATACCGGTTGGGGCGGGGCTTGGGAGTAGTGCTGCTACAGC
GTTAGCTGCGGTAGCTGCTTATGCTTGTGTTGGCGGATTGGAGCCTGGATATGATGTGTTATGGCGTGCTGCATTTGAGG
CTGAGAAGGTTGTCCATGGGAATCCGAGCGGCGTTGACAATACCGTTGCGTTATATGGCGGATTTATACTCTATCGACGT
GGCAGTGGTTTTAAACGCGTAGAGTTTAGGGGAATGCGGGATACTAGGCTACTTATAGTTGATAGTGGGGTTTCTCGGTC
TACTAGGATTGCTGTTGAACGGTTTACAGTAAGGCTTGAGAGGCTGGGTAGGCTGGGCAGGCGGCTCCTTGAAACAGCTG
ATGGTATCGTTGAAGAGGCTCTGGCGGCGCTCTCTAGGGGGGATAGCGTAAGGCTCGGAGAACTAATGGATGTAGCGCAT
GGTCTCTTAAACGCTATGGGTGTGTCGCATCCCGTGCTTGAGGAGATAGTGTGGATAGCAAGGCGCGAAGGTGCCCTCGG
GGCTAAGCTCACTGGTGCAGGGATGGGTGGTACGGCGATAGTCCTCGTAGATCTAGAGCACGCGAGTCGTGTGAAGAAGG
CTCTTGAGCTAAGGGGGTTCCGTGTCTACGAGGTTGAGCTGGGGGTGCCGGGTCTCCAGGGACCAGTCTAG

Upstream 100 bases:

>100_bases
TGCTTCATACTTCTCTAGCAGCTTCTCCCTTTTAAGTGGTGAATTTTGGGTTTTATAGCTGGCTAATAGTGGGTCCTCTT
GTGCTTCACGGGTGTAGTGT

Downstream 100 bases:

>100_bases
ATTGTCCAGACAGGCTATGTATTTCCAGCTAGTCTAGTGTATATAGTTGGGTGTTATCGGCTCCCACTAGCCCTCTCCCA
GCTCGTGCAGCCACTATCTA

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MGCAWSAPAKVIVFGEHWVVHGGLALAAAIGLRARAYGSPSESGLWVFSQLYRIGENLMESCSRFCNLLAGFRLVASSYG
RSLWPARIRIESDIPVGAGLGSSAATALAAVAAYACVGGLEPGYDVLWRAAFEAEKVVHGNPSGVDNTVALYGGFILYRR
GSGFKRVEFRGMRDTRLLIVDSGVSRSTRIAVERFTVRLERLGRLGRRLLETADGIVEEALAALSRGDSVRLGELMDVAH
GLLNAMGVSHPVLEEIVWIARREGALGAKLTGAGMGGTAIVLVDLEHASRVKKALELRGFRVYEVELGVPGLQGPV

Sequences:

>Translated_316_residues
MGCAWSAPAKVIVFGEHWVVHGGLALAAAIGLRARAYGSPSESGLWVFSQLYRIGENLMESCSRFCNLLAGFRLVASSYG
RSLWPARIRIESDIPVGAGLGSSAATALAAVAAYACVGGLEPGYDVLWRAAFEAEKVVHGNPSGVDNTVALYGGFILYRR
GSGFKRVEFRGMRDTRLLIVDSGVSRSTRIAVERFTVRLERLGRLGRRLLETADGIVEEALAALSRGDSVRLGELMDVAH
GLLNAMGVSHPVLEEIVWIARREGALGAKLTGAGMGGTAIVLVDLEHASRVKKALELRGFRVYEVELGVPGLQGPV
>Mature_315_residues
GCAWSAPAKVIVFGEHWVVHGGLALAAAIGLRARAYGSPSESGLWVFSQLYRIGENLMESCSRFCNLLAGFRLVASSYGR
SLWPARIRIESDIPVGAGLGSSAATALAAVAAYACVGGLEPGYDVLWRAAFEAEKVVHGNPSGVDNTVALYGGFILYRRG
SGFKRVEFRGMRDTRLLIVDSGVSRSTRIAVERFTVRLERLGRLGRRLLETADGIVEEALAALSRGDSVRLGELMDVAHG
LLNAMGVSHPVLEEIVWIARREGALGAKLTGAGMGGTAIVLVDLEHASRVKKALELRGFRVYEVELGVPGLQGPV

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI167001643, Length=375, Percent_Identity=29.6, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI4557769, Length=375, Percent_Identity=29.6, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6323864, Length=386, Percent_Identity=26.9430051813472, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI78707210, Length=383, Percent_Identity=31.5926892950392, Blast_Score=121, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 33746; Mature: 33615

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS00627 GHMP_KINASES_ATP ; PS00456 NA_SOLUT_SYMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGCAWSAPAKVIVFGEHWVVHGGLALAAAIGLRARAYGSPSESGLWVFSQLYRIGENLME
CCCCCCCCCEEEEECCCEEEECHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
SCSRFCNLLAGFRLVASSYGRSLWPARIRIESDIPVGAGLGSSAATALAAVAAYACVGGL
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCC
EPGYDVLWRAAFEAEKVVHGNPSGVDNTVALYGGFILYRRGSGFKRVEFRGMRDTRLLIV
CCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCEEEEECCCCCEEEEECCCCCCEEEEE
DSGVSRSTRIAVERFTVRLERLGRLGRRLLETADGIVEEALAALSRGDSVRLGELMDVAH
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
GLLNAMGVSHPVLEEIVWIARREGALGAKLTGAGMGGTAIVLVDLEHASRVKKALELRGF
HHHHHHCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCEEEEEEECHHHHHHHHHHHHCCC
RVYEVELGVPGLQGPV
EEEEEEECCCCCCCCC
>Mature Secondary Structure 
GCAWSAPAKVIVFGEHWVVHGGLALAAAIGLRARAYGSPSESGLWVFSQLYRIGENLME
CCCCCCCCEEEEECCCEEEECHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
SCSRFCNLLAGFRLVASSYGRSLWPARIRIESDIPVGAGLGSSAATALAAVAAYACVGGL
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCC
EPGYDVLWRAAFEAEKVVHGNPSGVDNTVALYGGFILYRRGSGFKRVEFRGMRDTRLLIV
CCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCEEEEECCCCCEEEEECCCCCCEEEEE
DSGVSRSTRIAVERFTVRLERLGRLGRRLLETADGIVEEALAALSRGDSVRLGELMDVAH
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
GLLNAMGVSHPVLEEIVWIARREGALGAKLTGAGMGGTAIVLVDLEHASRVKKALELRGF
HHHHHHCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCEEEEEEECHHHHHHHHHHHHCCC
RVYEVELGVPGLQGPV
EEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]