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The map label for this gene is thyX [H]

Identifier: 124027729

GI number: 124027729

Start: 854507

End: 855454

Strand: Reverse

Name: thyX [H]

Synonym: Hbut_0853

Alternate gene names: 124027729

Gene position: 855454-854507 (Counterclockwise)

Preceding gene: 124027730

Following gene: 124027727

Centisome position: 51.31

GC content: 53.59

Gene sequence:

>948_bases
TTGCAATCCACAGTGGTACTTGAACCTCCTGTTCGGCTTAGGTTGCTAAGGTATACCAAGGATGCTCCTCGGCTTGTGGC
GGCAGCTGCCCGGATCACGGTGTCAAAGAAGCCAGTCGAGAAAGCCTGGGAGATGGATGAGGCTGGGGTTGAACGATGGA
TTATGGAGCTTATAAGACGTGGTCATGGTTCTCCCTTGGAGCATGCCGTGTACACGTTCGAGGCTGAGTGTAGCCGTGTG
TGTAGTCATCAGCTTGTCCGTCACCGTATTGCGAGCTATACCCAGCAGAGTATGAGGTATACAGAGGGCTTCCTACGCAA
CATGGCTCTAGAGCTCTGTAAGGCTCTAGGCGTGGAGTGTGCGGAGAAGCCGCGGGGTCGCAGCGACTACGAAGCCTATG
CTTTGGTACTGGAGAAAGCTGTATCAGTGCTTGATACGGCTACGTTAGCGTCCATAGCATCTAAAGGATTTGTCATCCCG
CCAAGCCTTACGGGCGATAATGTAACTCTCCGGGGGGCTGTCGAAGCGTATCTTCTAGCTGCTGCAAAGTATTATCGGTT
ACTAAGCCTTGGCGTGCCGAGGGAGGATGCTAGATTCTTGTTGCCCCAAGCTGTCCGTACACGTATTGTGTTCACTATGA
ATGCTAGAGAGCTCCTAGAGAGCTTCCTACCGCTCCGCATGTGTAGCCATGCACAATGGGAGATAAGGATGCTGGCATGG
CGCGCCTGGAAAGAGCTAGTCCGGATACACCCAGAGATATTCGCCTATGCTGGGCCACGCTGTGTCTACATGGAAAACCG
GGTACGCGACCAGCCATGCAGACTAGTAGACTTCCTAGAGAGAAGATGTGGCTTCGCAATACAGCGATGTCCAGAGATGG
TGCCGCGCGAAGGTATACCGTCATGCCTTAGGCATGCAGCAAAAACCGGGGGTGGGCTAGAGCCTTAG

Upstream 100 bases:

>100_bases
CTCTAGTCCTGGGATATCCTTTTCCTAATGAAGTGAAGTATTATCTGGCCACAGCTCATTCCCTGTAGTCTCGTCACTAT
ATGTCTCTCTGAGGGTAGTA

Downstream 100 bases:

>100_bases
CTCTTTCTTAATAGTCTCGATGAACTCTTCAACCGTCATCTCTTCACGGTGCTTGGGCAGCTTAACGAGTACGACACGGT
TGTCGGGTGTGAGTAGGCGG

Product: alternative thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MQSTVVLEPPVRLRLLRYTKDAPRLVAAAARITVSKKPVEKAWEMDEAGVERWIMELIRRGHGSPLEHAVYTFEAECSRV
CSHQLVRHRIASYTQQSMRYTEGFLRNMALELCKALGVECAEKPRGRSDYEAYALVLEKAVSVLDTATLASIASKGFVIP
PSLTGDNVTLRGAVEAYLLAAAKYYRLLSLGVPREDARFLLPQAVRTRIVFTMNARELLESFLPLRMCSHAQWEIRMLAW
RAWKELVRIHPEIFAYAGPRCVYMENRVRDQPCRLVDFLERRCGFAIQRCPEMVPREGIPSCLRHAAKTGGGLEP

Sequences:

>Translated_315_residues
MQSTVVLEPPVRLRLLRYTKDAPRLVAAAARITVSKKPVEKAWEMDEAGVERWIMELIRRGHGSPLEHAVYTFEAECSRV
CSHQLVRHRIASYTQQSMRYTEGFLRNMALELCKALGVECAEKPRGRSDYEAYALVLEKAVSVLDTATLASIASKGFVIP
PSLTGDNVTLRGAVEAYLLAAAKYYRLLSLGVPREDARFLLPQAVRTRIVFTMNARELLESFLPLRMCSHAQWEIRMLAW
RAWKELVRIHPEIFAYAGPRCVYMENRVRDQPCRLVDFLERRCGFAIQRCPEMVPREGIPSCLRHAAKTGGGLEP
>Mature_315_residues
MQSTVVLEPPVRLRLLRYTKDAPRLVAAAARITVSKKPVEKAWEMDEAGVERWIMELIRRGHGSPLEHAVYTFEAECSRV
CSHQLVRHRIASYTQQSMRYTEGFLRNMALELCKALGVECAEKPRGRSDYEAYALVLEKAVSVLDTATLASIASKGFVIP
PSLTGDNVTLRGAVEAYLLAAAKYYRLLSLGVPREDARFLLPQAVRTRIVFTMNARELLESFLPLRMCSHAQWEIRMLAW
RAWKELVRIHPEIFAYAGPRCVYMENRVRDQPCRLVDFLERRCGFAIQRCPEMVPREGIPSCLRHAAKTGGGLEP

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 35790; Mature: 35790

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSTVVLEPPVRLRLLRYTKDAPRLVAAAARITVSKKPVEKAWEMDEAGVERWIMELIRR
CCCCEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHC
GHGSPLEHAVYTFEAECSRVCSHQLVRHRIASYTQQSMRYTEGFLRNMALELCKALGVEC
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
AEKPRGRSDYEAYALVLEKAVSVLDTATLASIASKGFVIPPSLTGDNVTLRGAVEAYLLA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCEEEHHHHHHHHHH
AAKYYRLLSLGVPREDARFLLPQAVRTRIVFTMNARELLESFLPLRMCSHAQWEIRMLAW
HHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHH
RAWKELVRIHPEIFAYAGPRCVYMENRVRDQPCRLVDFLERRCGFAIQRCPEMVPREGIP
HHHHHHHHHCHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCCHH
SCLRHAAKTGGGLEP
HHHHHHHHCCCCCCC
>Mature Secondary Structure
MQSTVVLEPPVRLRLLRYTKDAPRLVAAAARITVSKKPVEKAWEMDEAGVERWIMELIRR
CCCCEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHC
GHGSPLEHAVYTFEAECSRVCSHQLVRHRIASYTQQSMRYTEGFLRNMALELCKALGVEC
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
AEKPRGRSDYEAYALVLEKAVSVLDTATLASIASKGFVIPPSLTGDNVTLRGAVEAYLLA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCEEEHHHHHHHHHH
AAKYYRLLSLGVPREDARFLLPQAVRTRIVFTMNARELLESFLPLRMCSHAQWEIRMLAW
HHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHH
RAWKELVRIHPEIFAYAGPRCVYMENRVRDQPCRLVDFLERRCGFAIQRCPEMVPREGIP
HHHHHHHHHCHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCCHH
SCLRHAAKTGGGLEP
HHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]