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The map label for this gene is yeaE [H]

Identifier: 124027676

GI number: 124027676

Start: 792741

End: 793559

Strand: Reverse

Name: yeaE [H]

Synonym: Hbut_0798

Alternate gene names: 124027676

Gene position: 793559-792741 (Counterclockwise)

Preceding gene: 124027678

Following gene: 124027673

Centisome position: 47.6

GC content: 47.25

Gene sequence:

>819_bases
TTGCCACGCTACTCCATTGATAATAGTGACTGGAAGCTTATTGGCAAGGATAGGGTTTCAGCTATAGGACTTGGCACGTG
GGCTATACGCAGGCCCGAGGCTGCTTACCAAGTTATGCTAGCTGCTATAGAATCGGGCAAGGTTAACCTCATAGATACAG
CTGAGATGTATGGGGCTGGATTTGCCGAGAAACTTGTAGGCCGCGTAGTTAGTAGTGTCGGTCGTGACCGGGTCTTCATT
ACTACTAAGATGCTGCCAGAGAGGCTTGTGAGCGAGGAGGAGATAGAGAAGGCTGCAAGGGCAAGTGTGAGAAGGCTAGG
TGTTGGTATGGTTGATCTATTTCTTATACATTGGCCAAACTATCAATTACCCATAAGTGTTCAGGTTAGGAGGTTTGAGC
GCATAATCTATGGGAGGTATGCAAGGTACATAGGTGTAAGCAACTTCGGCCCGGAAGAACTTCTAGAAGCCATCCACGCA
ACGTCGAGAGCTGAAATAGTTGTAAACCAAGTTCACTATAGCATCTTGCACAAGAGGCATGTTGAAGAAGAGCTTCTCCC
TATAGCGCTCAAGTATGGCGTTACCATACAAGCATATACACCTCTTGAGCGTGGTGCTGTAGCAAAACATCCCAAACTCC
TGGAGCTGTCCAGGAAGCTGGGTAAAACAGCTATCCAGATAGCGTTAAACTACCTCATATCCAGGCCGCGTGTTATCGCT
ATACCCAAGACAGAGAATATGGATCATTTGAGAGAAATACTTGGGGCACTTGGGTGGAGACTCACGGAGGATATACTCGA
GGAGCTTGAAAAACTCTAG

Upstream 100 bases:

>100_bases
TAACAGATCCGAATACAGCATGGCAATATCCAAGCCAAAAGCTCCGTAAAAATTAAGGGTAAAAGAGCCATAATGCTGGT
ATGTGGGGCTGGATTCTGTC

Downstream 100 bases:

>100_bases
CATGAGCCCCGATAGCCTATGGGTTTTAGGAGAGTTTTATGAGGCCTTTCTCTGCGAGCTTGTATAGTGCACGTAGCACT
TCATCCCTTGCTACGCCGTA

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MPRYSIDNSDWKLIGKDRVSAIGLGTWAIRRPEAAYQVMLAAIESGKVNLIDTAEMYGAGFAEKLVGRVVSSVGRDRVFI
TTKMLPERLVSEEEIEKAARASVRRLGVGMVDLFLIHWPNYQLPISVQVRRFERIIYGRYARYIGVSNFGPEELLEAIHA
TSRAEIVVNQVHYSILHKRHVEEELLPIALKYGVTIQAYTPLERGAVAKHPKLLELSRKLGKTAIQIALNYLISRPRVIA
IPKTENMDHLREILGALGWRLTEDILEELEKL

Sequences:

>Translated_272_residues
MPRYSIDNSDWKLIGKDRVSAIGLGTWAIRRPEAAYQVMLAAIESGKVNLIDTAEMYGAGFAEKLVGRVVSSVGRDRVFI
TTKMLPERLVSEEEIEKAARASVRRLGVGMVDLFLIHWPNYQLPISVQVRRFERIIYGRYARYIGVSNFGPEELLEAIHA
TSRAEIVVNQVHYSILHKRHVEEELLPIALKYGVTIQAYTPLERGAVAKHPKLLELSRKLGKTAIQIALNYLISRPRVIA
IPKTENMDHLREILGALGWRLTEDILEELEKL
>Mature_271_residues
PRYSIDNSDWKLIGKDRVSAIGLGTWAIRRPEAAYQVMLAAIESGKVNLIDTAEMYGAGFAEKLVGRVVSSVGRDRVFIT
TKMLPERLVSEEEIEKAARASVRRLGVGMVDLFLIHWPNYQLPISVQVRRFERIIYGRYARYIGVSNFGPEELLEAIHAT
SRAEIVVNQVHYSILHKRHVEEELLPIALKYGVTIQAYTPLERGAVAKHPKLLELSRKLGKTAIQIALNYLISRPRVIAI
PKTENMDHLREILGALGWRLTEDILEELEKL

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI27436969, Length=308, Percent_Identity=27.2727272727273, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4504825, Length=308, Percent_Identity=27.2727272727273, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI27436966, Length=206, Percent_Identity=32.5242718446602, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI27436964, Length=206, Percent_Identity=32.5242718446602, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI27436962, Length=206, Percent_Identity=32.5242718446602, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI27436971, Length=205, Percent_Identity=33.1707317073171, Blast_Score=89, Evalue=3e-18,
Organism=Escherichia coli, GI1788081, Length=268, Percent_Identity=30.5970149253731, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI87081735, Length=304, Percent_Identity=28.6184210526316, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788070, Length=216, Percent_Identity=31.4814814814815, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787674, Length=290, Percent_Identity=25.1724137931034, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786400, Length=249, Percent_Identity=28.5140562248996, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87082198, Length=269, Percent_Identity=28.2527881040892, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71998625, Length=262, Percent_Identity=27.8625954198473, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17552492, Length=277, Percent_Identity=26.7148014440433, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17550248, Length=294, Percent_Identity=24.8299319727891, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17566692, Length=294, Percent_Identity=27.2108843537415, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324694, Length=266, Percent_Identity=26.6917293233083, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322556, Length=275, Percent_Identity=25.0909090909091, Blast_Score=72, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6325169, Length=212, Percent_Identity=23.1132075471698, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI20129731, Length=282, Percent_Identity=30.1418439716312, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24640980, Length=208, Percent_Identity=30.2884615384615, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45549126, Length=208, Percent_Identity=30.2884615384615, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356425, Length=278, Percent_Identity=26.6187050359712, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24663317, Length=275, Percent_Identity=28, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45553081, Length=285, Percent_Identity=27.719298245614, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281366140, Length=254, Percent_Identity=26.7716535433071, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 30849; Mature: 30718

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRYSIDNSDWKLIGKDRVSAIGLGTWAIRRPEAAYQVMLAAIESGKVNLIDTAEMYGAG
CCCCCCCCCCCEEEECCCHHEEECCHHHCCCCHHHHHHHHHHHCCCCEEEEECHHHHCCC
FAEKLVGRVVSSVGRDRVFITTKMLPERLVSEEEIEKAARASVRRLGVGMVDLFLIHWPN
HHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHEEECCC
YQLPISVQVRRFERIIYGRYARYIGVSNFGPEELLEAIHATSRAEIVVNQVHYSILHKRH
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VEEELLPIALKYGVTIQAYTPLERGAVAKHPKLLELSRKLGKTAIQIALNYLISRPRVIA
HHHHHHHHHHHCCEEEEEECCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
IPKTENMDHLREILGALGWRLTEDILEELEKL
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PRYSIDNSDWKLIGKDRVSAIGLGTWAIRRPEAAYQVMLAAIESGKVNLIDTAEMYGAG
CCCCCCCCCCEEEECCCHHEEECCHHHCCCCHHHHHHHHHHHCCCCEEEEECHHHHCCC
FAEKLVGRVVSSVGRDRVFITTKMLPERLVSEEEIEKAARASVRRLGVGMVDLFLIHWPN
HHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHEEECCC
YQLPISVQVRRFERIIYGRYARYIGVSNFGPEELLEAIHATSRAEIVVNQVHYSILHKRH
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VEEELLPIALKYGVTIQAYTPLERGAVAKHPKLLELSRKLGKTAIQIALNYLISRPRVIA
HHHHHHHHHHHCCEEEEEECCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
IPKTENMDHLREILGALGWRLTEDILEELEKL
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]