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The map label for this gene is atpA

Identifier: 124027662

GI number: 124027662

Start: 777483

End: 779288

Strand: Reverse

Name: atpA

Synonym: Hbut_0784

Alternate gene names: 124027662

Gene position: 779288-777483 (Counterclockwise)

Preceding gene: 124027663

Following gene: 124027661

Centisome position: 46.74

GC content: 55.32

Gene sequence:

>1806_bases
TTGCCGGTTAAGGGCAGAATCATCCGTGTAGCAGGCCCGTTAGTCGTAGCCGAGGGTATGGAGGGCATACAGATGTACGA
GATGGTTGAGGTAGGCGAGGAACGGCTGATAGGCGAGGTTAACAGAGTGGTCGGCGACAAGGCCTACATCCAGGTATACG
AGTCCACCACTGGCCTCAAGCCCGGCGAGCCAGTCTATGGTACTGGTTCGCCACTAAGCGTCGAGCTGGGTCCAGGCCTC
ATAGGCAGGATATACGATGGTATCCAGCGCCCATTAGACGTTATACGTGAGGTAACCAAGAGCATATTCGTTAGGCGTGG
CGTGAAGGTAGACGCCCTTGATCGTAGCAGAAAGTGGCACTTCAAGCCGAACACAACGCTCAAGCCCGGCGACAAGGTCT
CTGGCGGCGACGTCCTCGGCGAGGTCCAGGAGACAAGCCTCATAACCCACAAGGTGCTCGTACCGCCTGACGTGCATGGC
AGGCTAAAGTGGCTAGCCTCTGAGGGCGACTACACGGTCGAGGATGTAATAGCAGTAGTCGAGGCTGACGGCAAGGAGAT
AGAGCTAAAGATGTATCACCGCTGGCCGGTGCGCAGAGCGAGACCAATAATCGAGAAGCTGGAGCCGGTTGAGCCGCTGA
TTACCGGTATGAGAGTTATAGACACAATGTTCCCCATGGCTAAGGGTGGTACTGGCGCTATACCAGGCCCCTTCGGCAGC
GGTAAGACCGTCACCCTTCAGAGCCTGGCAAAGTGGAGTGCTGCAAAGGTAGTCATATACATTGGCTGTGGCGAACGCGG
TAATGAGATGACGGAGGTCCTGGAGACGTTCCCCAAGCTAACCGACCCATGGACCGGCAAGCCAATGATGGAGCGTACCA
TACTCATCGCCAACACTAGCAACATGCCAGTAGCAGCTAGAGAGGCAAGCATCTACACAGGCATAACGCTTGCAGAGTAC
TACAGAGACATGGGCTACGATGTTCTGCTAGTAGCTGACTCTACAAGTCGCTGGGCTGAGGCGCTACGTGAGATTGCTGG
TCGTCTAGAGGAGATGCCCGCAGAGGAGGGCTACCCAAGCTATCTGGCATCAAGGCTTGCAGAGTTCTACGCCCGTGCCG
GTAGGGTGAAGGTGCCCGGCCGGCCAGAGAGGCTCGGCAGCGTAACCATCGTTGGCGCGGTATCGCCGCCAGGTGGCGAC
TTCACAGAGCCGGTAACAGCCAACACCAAGAGGTTCATAAGGGTGTTCTGGGCTCTGGACGCAAGGCTAGCGTATAGCAG
GCACTACCCAGCCATAAACTGGCTAGTAAGCTACTCAGCTTACGTTGAGACGGTAGCTAAGTGGTGGCACGAGAACATAA
GCCCCAAGTGGCTAGAATACCGCAACGAGGCCTACGAGATACTCCTCCGCGAGGACGAGCTGCGAGAGATAGTCCGCCTC
GTTGGTACAGAGGGCCTAAGCGAGAAGGACAAGCTGATACTAGAGATTGCAAACATTATCAAGACAGGATTCCTGCAGCA
GAACGCGTTCGACCCAGTAGACGCCTTCGCTACGCCCCAGAAGCAGTGGAAGCAGCTAGAGACAATCATAGACTTCTACC
ACGCAGCTCTAGAGGCGATAAAGCGTGGCGTAACGGTGAAGGAGATACGTGAAAAGCTAGCCCCGAAGATACGAGAACTC
ATCCTGGCAAGATATAACGTGCCAAACGACCAACTAGAAAAGCTTGACAAGCTCAAGCAAGAGCTACTCCAGGCACTCCA
AGAGCTGATAGAGGCTAAGGCTGGTAGAGCATCAGCAGCAACATAG

Upstream 100 bases:

>100_bases
ATACTCGCCCCCGCCCTCGAAGAGGCGCGGGCACGCGTACTGGAGGTGCTCAACCAATAACCCCCACTTGGACAGTAATG
TGAGGGGTGCAGGGTAAGCC

Downstream 100 bases:

>100_bases
GCAGCCTAGTCGGGGTCTTTTATCCCTCACCCGCCTCTGGTTGATGAGGGGTCGAGCTATGGAGGCTGCTATGGGTCCTT
CACCTGTGATAAGGGAGTAT

Product: V-type ATP synthase subunit A

Products: NA

Alternate protein names: V-ATPase subunit A

Number of amino acids: Translated: 601; Mature: 600

Protein sequence:

>601_residues
MPVKGRIIRVAGPLVVAEGMEGIQMYEMVEVGEERLIGEVNRVVGDKAYIQVYESTTGLKPGEPVYGTGSPLSVELGPGL
IGRIYDGIQRPLDVIREVTKSIFVRRGVKVDALDRSRKWHFKPNTTLKPGDKVSGGDVLGEVQETSLITHKVLVPPDVHG
RLKWLASEGDYTVEDVIAVVEADGKEIELKMYHRWPVRRARPIIEKLEPVEPLITGMRVIDTMFPMAKGGTGAIPGPFGS
GKTVTLQSLAKWSAAKVVIYIGCGERGNEMTEVLETFPKLTDPWTGKPMMERTILIANTSNMPVAAREASIYTGITLAEY
YRDMGYDVLLVADSTSRWAEALREIAGRLEEMPAEEGYPSYLASRLAEFYARAGRVKVPGRPERLGSVTIVGAVSPPGGD
FTEPVTANTKRFIRVFWALDARLAYSRHYPAINWLVSYSAYVETVAKWWHENISPKWLEYRNEAYEILLREDELREIVRL
VGTEGLSEKDKLILEIANIIKTGFLQQNAFDPVDAFATPQKQWKQLETIIDFYHAALEAIKRGVTVKEIREKLAPKIREL
ILARYNVPNDQLEKLDKLKQELLQALQELIEAKAGRASAAT

Sequences:

>Translated_601_residues
MPVKGRIIRVAGPLVVAEGMEGIQMYEMVEVGEERLIGEVNRVVGDKAYIQVYESTTGLKPGEPVYGTGSPLSVELGPGL
IGRIYDGIQRPLDVIREVTKSIFVRRGVKVDALDRSRKWHFKPNTTLKPGDKVSGGDVLGEVQETSLITHKVLVPPDVHG
RLKWLASEGDYTVEDVIAVVEADGKEIELKMYHRWPVRRARPIIEKLEPVEPLITGMRVIDTMFPMAKGGTGAIPGPFGS
GKTVTLQSLAKWSAAKVVIYIGCGERGNEMTEVLETFPKLTDPWTGKPMMERTILIANTSNMPVAAREASIYTGITLAEY
YRDMGYDVLLVADSTSRWAEALREIAGRLEEMPAEEGYPSYLASRLAEFYARAGRVKVPGRPERLGSVTIVGAVSPPGGD
FTEPVTANTKRFIRVFWALDARLAYSRHYPAINWLVSYSAYVETVAKWWHENISPKWLEYRNEAYEILLREDELREIVRL
VGTEGLSEKDKLILEIANIIKTGFLQQNAFDPVDAFATPQKQWKQLETIIDFYHAALEAIKRGVTVKEIREKLAPKIREL
ILARYNVPNDQLEKLDKLKQELLQALQELIEAKAGRASAAT
>Mature_600_residues
PVKGRIIRVAGPLVVAEGMEGIQMYEMVEVGEERLIGEVNRVVGDKAYIQVYESTTGLKPGEPVYGTGSPLSVELGPGLI
GRIYDGIQRPLDVIREVTKSIFVRRGVKVDALDRSRKWHFKPNTTLKPGDKVSGGDVLGEVQETSLITHKVLVPPDVHGR
LKWLASEGDYTVEDVIAVVEADGKEIELKMYHRWPVRRARPIIEKLEPVEPLITGMRVIDTMFPMAKGGTGAIPGPFGSG
KTVTLQSLAKWSAAKVVIYIGCGERGNEMTEVLETFPKLTDPWTGKPMMERTILIANTSNMPVAAREASIYTGITLAEYY
RDMGYDVLLVADSTSRWAEALREIAGRLEEMPAEEGYPSYLASRLAEFYARAGRVKVPGRPERLGSVTIVGAVSPPGGDF
TEPVTANTKRFIRVFWALDARLAYSRHYPAINWLVSYSAYVETVAKWWHENISPKWLEYRNEAYEILLREDELREIVRLV
GTEGLSEKDKLILEIANIIKTGFLQQNAFDPVDAFATPQKQWKQLETIIDFYHAALEAIKRGVTVKEIREKLAPKIRELI
LARYNVPNDQLEKLDKLKQELLQALQELIEAKAGRASAAT

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit

COG id: COG1155

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI19913424, Length=596, Percent_Identity=51.1744966442953, Blast_Score=607, Evalue=1e-174,
Organism=Homo sapiens, GI32189394, Length=313, Percent_Identity=31.629392971246, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI19913426, Length=344, Percent_Identity=25.5813953488372, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI19913428, Length=246, Percent_Identity=28.8617886178862, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI50345984, Length=279, Percent_Identity=27.2401433691756, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI4757810, Length=279, Percent_Identity=27.2401433691756, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790170, Length=349, Percent_Identity=31.8051575931232, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1788251, Length=243, Percent_Identity=29.6296296296296, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790172, Length=276, Percent_Identity=26.0869565217391, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17565854, Length=591, Percent_Identity=51.4382402707276, Blast_Score=607, Evalue=1e-174,
Organism=Caenorhabditis elegans, GI25144756, Length=332, Percent_Identity=31.6265060240964, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17510931, Length=326, Percent_Identity=26.6871165644172, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17570191, Length=339, Percent_Identity=26.2536873156342, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71988080, Length=283, Percent_Identity=26.8551236749117, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71988063, Length=283, Percent_Identity=26.8551236749117, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71988074, Length=254, Percent_Identity=26.7716535433071, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6320016, Length=350, Percent_Identity=45.4285714285714, Blast_Score=315, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6322581, Length=365, Percent_Identity=30.958904109589, Blast_Score=116, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6319603, Length=339, Percent_Identity=28.3185840707965, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6319370, Length=242, Percent_Identity=26.0330578512397, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24583988, Length=598, Percent_Identity=50.6688963210702, Blast_Score=608, Evalue=1e-174,
Organism=Drosophila melanogaster, GI24583986, Length=598, Percent_Identity=50.6688963210702, Blast_Score=608, Evalue=1e-174,
Organism=Drosophila melanogaster, GI24583984, Length=598, Percent_Identity=50.6688963210702, Blast_Score=608, Evalue=1e-174,
Organism=Drosophila melanogaster, GI24583992, Length=598, Percent_Identity=50.3344481605351, Blast_Score=601, Evalue=1e-172,
Organism=Drosophila melanogaster, GI20129479, Length=598, Percent_Identity=50.5016722408027, Blast_Score=597, Evalue=1e-171,
Organism=Drosophila melanogaster, GI24638766, Length=342, Percent_Identity=30.9941520467836, Blast_Score=114, Evalue=3e-25,
Organism=Drosophila melanogaster, GI28574560, Length=313, Percent_Identity=31.629392971246, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI281361666, Length=345, Percent_Identity=24.9275362318841, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24646341, Length=345, Percent_Identity=24.9275362318841, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17136796, Length=345, Percent_Identity=24.9275362318841, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24658560, Length=279, Percent_Identity=26.5232974910394, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: 10836 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): VATA_HYPBU (A2BKX6)

Other databases:

- EMBL:   CP000493
- RefSeq:   YP_001012982.1
- ProteinModelPortal:   A2BKX6
- SMR:   A2BKX6
- STRING:   A2BKX6
- GeneID:   4782720
- GenomeReviews:   CP000493_GR
- KEGG:   hbu:Hbut_0784
- eggNOG:   arNOG04086
- HOGENOM:   HBG288114
- OMA:   KITWNVI
- ProtClustDB:   PRK04192
- BioCyc:   HBUT415426:HBUT_0784-MONOMER
- HAMAP:   MF_00309
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005726
- InterPro:   IPR003593
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022878
- SMART:   SM00382
- TIGRFAMs:   TIGR01043

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 67187; Mature: 67056

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKGRIIRVAGPLVVAEGMEGIQMYEMVEVGEERLIGEVNRVVGDKAYIQVYESTTGLK
CCCCCEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
PGEPVYGTGSPLSVELGPGLIGRIYDGIQRPLDVIREVTKSIFVRRGVKVDALDRSRKWH
CCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEE
FKPNTTLKPGDKVSGGDVLGEVQETSLITHKVLVPPDVHGRLKWLASEGDYTVEDVIAVV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCCCCCCEEEEECCCCCCHHHHHHHH
EADGKEIELKMYHRWPVRRARPIIEKLEPVEPLITGMRVIDTMFPMAKGGTGAIPGPFGS
CCCCCEEEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GKTVTLQSLAKWSAAKVVIYIGCGERGNEMTEVLETFPKLTDPWTGKPMMERTILIANTS
CCEEEHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHCEEEEEECC
NMPVAAREASIYTGITLAEYYRDMGYDVLLVADSTSRWAEALREIAGRLEEMPAEEGYPS
CCCCEECCCHHHHCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHH
YLASRLAEFYARAGRVKVPGRPERLGSVTIVGAVSPPGGDFTEPVTANTKRFIRVFWALD
HHHHHHHHHHHHCCCEECCCCCHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
ARLAYSRHYPAINWLVSYSAYVETVAKWWHENISPKWLEYRNEAYEILLREDELREIVRL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
VGTEGLSEKDKLILEIANIIKTGFLQQNAFDPVDAFATPQKQWKQLETIIDFYHAALEAI
HCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHH
KRGVTVKEIREKLAPKIRELILARYNVPNDQLEKLDKLKQELLQALQELIEAKAGRASAA
HCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
T
C
>Mature Secondary Structure 
PVKGRIIRVAGPLVVAEGMEGIQMYEMVEVGEERLIGEVNRVVGDKAYIQVYESTTGLK
CCCCEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
PGEPVYGTGSPLSVELGPGLIGRIYDGIQRPLDVIREVTKSIFVRRGVKVDALDRSRKWH
CCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEE
FKPNTTLKPGDKVSGGDVLGEVQETSLITHKVLVPPDVHGRLKWLASEGDYTVEDVIAVV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCCCCCCEEEEECCCCCCHHHHHHHH
EADGKEIELKMYHRWPVRRARPIIEKLEPVEPLITGMRVIDTMFPMAKGGTGAIPGPFGS
CCCCCEEEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GKTVTLQSLAKWSAAKVVIYIGCGERGNEMTEVLETFPKLTDPWTGKPMMERTILIANTS
CCEEEHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHCEEEEEECC
NMPVAAREASIYTGITLAEYYRDMGYDVLLVADSTSRWAEALREIAGRLEEMPAEEGYPS
CCCCEECCCHHHHCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHH
YLASRLAEFYARAGRVKVPGRPERLGSVTIVGAVSPPGGDFTEPVTANTKRFIRVFWALD
HHHHHHHHHHHHCCCEECCCCCHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
ARLAYSRHYPAINWLVSYSAYVETVAKWWHENISPKWLEYRNEAYEILLREDELREIVRL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
VGTEGLSEKDKLILEIANIIKTGFLQQNAFDPVDAFATPQKQWKQLETIIDFYHAALEAI
HCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHH
KRGVTVKEIREKLAPKIRELILARYNVPNDQLEKLDKLKQELLQALQELIEAKAGRASAA
HCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
T
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA