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The map label for this gene is thrS [H]

Identifier: 123968188

GI number: 123968188

Start: 576198

End: 578114

Strand: Reverse

Name: thrS [H]

Synonym: A9601_06531

Alternate gene names: 123968188

Gene position: 578114-576198 (Counterclockwise)

Preceding gene: 123968189

Following gene: 123968187

Centisome position: 34.62

GC content: 31.25

Gene sequence:

>1917_bases
ATGCCAATAATTACTTTGCCTGATGGTTCAAAAAAGGTTTTCGAAAAATCTGTAACTATTCTAGAAATTGCTCAGAGTAT
AGGCGCTGGATTAGCTAAAGCAACAATTGCTGGGAAAGTAAATGATGTTCTTCTTGATGCAACAATTCCTATAAATAAAG
ATTCCAAAGTTGTAATCATCACATCAAAAGATAAAGAAGGAATTGAAATAATAAGACATTCTTTCGCTCACCTTATTGGT
CATGCAGTTAAACAAATTTACTCTGATATTAAAATGGCGATTGGGCCTGTAATTGAGGATGGTTTTTATTACGATATTTT
CTCTGAATACAGATTTACTCCTGAAGATTTAATAAAAATCGAAAATAGAATTAATCAATTAATAAAAACAAACTATGACG
TTGAAATTTTACAAGTTTCTAAAGAAGAGGCAATTAAAACTTTTAAAGAAAGAGATGAGACTTTTAAATTAAGAATAATC
GAAGAAATTCCTGAAGAAGGTCTCATCAATTTATATAAACACGAAGAATACATCGACATGTGTAGAGGGCCTCACGTTCC
TAACACTAGACATTTGAGACACTTTAAATTACTTAAATTATCAGGTTCATATTGGAGAGGTAATAGTGAGAATGAATCAT
TACAGAGAATATATGGAACTGCATGGGCGAAAGAAAAAGAACTCAAAGATTATTTAACAAGAATTGAAGAAGCGGAAAAA
AGAGATCATAGAAAACTTGGTAAAAAACATTCACTATTTCATATACAAGAAGAATCTCCAGGAATGATTTTTTGGCATCC
AAATGGATGGACAATTTACCAAGTACTGGAAAAGTACATAAGAGAAATACTCAAAAAAAATGATTATTTAGAAATTAAAA
CCCCACAAGCTGTTGATAAATCTCTTTGGGAAAAATCCGGTCATTGGGAGAAATTTAGAGACGATATGTTCACTACTGCA
TCAGAAAATCGAACATATGCGATTAAACCAATGAATTGTCCATGCCATATTCAAATATTTAATCAAGGTTTAAAAAGTTA
TAAAGATTTACCAATTCGTCTTGCTGAATTTGGTTCTTGTCACAGAAACGAGCCCTCAGGTGCACTACATGGCTTAATGA
GAGTAAGAAACTTTACTCAAGATGATGCACACATATTCTGCACAGAAGAGCAAATTCAAGAAGAGGTATCTACTTTTATA
GATCTTGTTTTCGAAGTTTATAAAACTTTTGGTTTTGATGAAATCATTATAAAATTATCAACACGTCCTGAAAAAAGGGT
AGGTAGTGAAGATATTTGGGATAAATCAGAGGAGGCTCTTACCAAAGCGCTCGATAATAAGAATCTAAAATGGGAACTAC
AACCTGGAGAAGGTGCTTTTTATGGTCCAAAAATAGAATTTTCGTTAAAGGATTGTCTTAATAGAGTTTGGCAATGCGGA
ACTATTCAGGTTGATTTCTCAATGCCTATTAGATTGGATGCAACTTATGTAGATATAGACAATGAAAAAAGAAATCCAGT
TATGCTGCATAGAGCAATTTTAGGATCCTTTGAAAGATTCATAGGAATCTTAATTGAACAATATGAGGCAAAATTCCCAA
TTTGGCTTGCGCCTTATCAAATTATTTTATTAAGCATTACTGATAGAAATATTGAAAAATGTTTAAAGTTTAATGAATTA
ATAAATAATAATGGTTATAGATCAAAAGTTGATATTAGGAATGAAAAAATAGGATATAAAATACGAGAGGCAACTCTCGG
TAGAGTTCCTTTAATTGCAGTTATTGGTGATAAAGAAGAGGAAATTGATTCAGTCGCCTTAAGAGCTTTGAATGGAAAAA
ATTTAGGAATTTTCAATTTACCAAATCTTTTCAAATTAATGGATGAATTGATAGAAAAAAAAGGGAGAACGGAATAA

Upstream 100 bases:

>100_bases
AATCCTTAATGAAGGGAAGGAAAAAGCTGAAGATTTAGCGAATCAGACTTTAAAAAGAGTTAAATCAAAATTGGGGTTTT
TTGAAATGGAGAAATAAATT

Downstream 100 bases:

>100_bases
TTTCTTATTTATGAATTTTCTCGCTTGTGATTTAGGAGGTACAAAGGTTCTATTAGGAATTTTCAAAAAAGGAACAAATA
ATAATTCGCCTAAGTTAATA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 638; Mature: 637

Protein sequence:

>638_residues
MPIITLPDGSKKVFEKSVTILEIAQSIGAGLAKATIAGKVNDVLLDATIPINKDSKVVIITSKDKEGIEIIRHSFAHLIG
HAVKQIYSDIKMAIGPVIEDGFYYDIFSEYRFTPEDLIKIENRINQLIKTNYDVEILQVSKEEAIKTFKERDETFKLRII
EEIPEEGLINLYKHEEYIDMCRGPHVPNTRHLRHFKLLKLSGSYWRGNSENESLQRIYGTAWAKEKELKDYLTRIEEAEK
RDHRKLGKKHSLFHIQEESPGMIFWHPNGWTIYQVLEKYIREILKKNDYLEIKTPQAVDKSLWEKSGHWEKFRDDMFTTA
SENRTYAIKPMNCPCHIQIFNQGLKSYKDLPIRLAEFGSCHRNEPSGALHGLMRVRNFTQDDAHIFCTEEQIQEEVSTFI
DLVFEVYKTFGFDEIIIKLSTRPEKRVGSEDIWDKSEEALTKALDNKNLKWELQPGEGAFYGPKIEFSLKDCLNRVWQCG
TIQVDFSMPIRLDATYVDIDNEKRNPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPYQIILLSITDRNIEKCLKFNEL
INNNGYRSKVDIRNEKIGYKIREATLGRVPLIAVIGDKEEEIDSVALRALNGKNLGIFNLPNLFKLMDELIEKKGRTE

Sequences:

>Translated_638_residues
MPIITLPDGSKKVFEKSVTILEIAQSIGAGLAKATIAGKVNDVLLDATIPINKDSKVVIITSKDKEGIEIIRHSFAHLIG
HAVKQIYSDIKMAIGPVIEDGFYYDIFSEYRFTPEDLIKIENRINQLIKTNYDVEILQVSKEEAIKTFKERDETFKLRII
EEIPEEGLINLYKHEEYIDMCRGPHVPNTRHLRHFKLLKLSGSYWRGNSENESLQRIYGTAWAKEKELKDYLTRIEEAEK
RDHRKLGKKHSLFHIQEESPGMIFWHPNGWTIYQVLEKYIREILKKNDYLEIKTPQAVDKSLWEKSGHWEKFRDDMFTTA
SENRTYAIKPMNCPCHIQIFNQGLKSYKDLPIRLAEFGSCHRNEPSGALHGLMRVRNFTQDDAHIFCTEEQIQEEVSTFI
DLVFEVYKTFGFDEIIIKLSTRPEKRVGSEDIWDKSEEALTKALDNKNLKWELQPGEGAFYGPKIEFSLKDCLNRVWQCG
TIQVDFSMPIRLDATYVDIDNEKRNPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPYQIILLSITDRNIEKCLKFNEL
INNNGYRSKVDIRNEKIGYKIREATLGRVPLIAVIGDKEEEIDSVALRALNGKNLGIFNLPNLFKLMDELIEKKGRTE
>Mature_637_residues
PIITLPDGSKKVFEKSVTILEIAQSIGAGLAKATIAGKVNDVLLDATIPINKDSKVVIITSKDKEGIEIIRHSFAHLIGH
AVKQIYSDIKMAIGPVIEDGFYYDIFSEYRFTPEDLIKIENRINQLIKTNYDVEILQVSKEEAIKTFKERDETFKLRIIE
EIPEEGLINLYKHEEYIDMCRGPHVPNTRHLRHFKLLKLSGSYWRGNSENESLQRIYGTAWAKEKELKDYLTRIEEAEKR
DHRKLGKKHSLFHIQEESPGMIFWHPNGWTIYQVLEKYIREILKKNDYLEIKTPQAVDKSLWEKSGHWEKFRDDMFTTAS
ENRTYAIKPMNCPCHIQIFNQGLKSYKDLPIRLAEFGSCHRNEPSGALHGLMRVRNFTQDDAHIFCTEEQIQEEVSTFID
LVFEVYKTFGFDEIIIKLSTRPEKRVGSEDIWDKSEEALTKALDNKNLKWELQPGEGAFYGPKIEFSLKDCLNRVWQCGT
IQVDFSMPIRLDATYVDIDNEKRNPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPYQIILLSITDRNIEKCLKFNELI
NNNGYRSKVDIRNEKIGYKIREATLGRVPLIAVIGDKEEEIDSVALRALNGKNLGIFNLPNLFKLMDELIEKKGRTE

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38570111, Length=602, Percent_Identity=41.1960132890365, Blast_Score=476, Evalue=1e-134,
Organism=Homo sapiens, GI38202255, Length=637, Percent_Identity=39.403453689168, Blast_Score=474, Evalue=1e-133,
Organism=Homo sapiens, GI20070344, Length=648, Percent_Identity=35.6481481481481, Blast_Score=410, Evalue=1e-114,
Organism=Escherichia coli, GI1788013, Length=635, Percent_Identity=57.9527559055118, Blast_Score=800, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=161, Percent_Identity=24.8447204968944, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71984184, Length=648, Percent_Identity=40.2777777777778, Blast_Score=484, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI71984192, Length=648, Percent_Identity=40.2777777777778, Blast_Score=484, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6322112, Length=625, Percent_Identity=37.28, Blast_Score=433, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6322654, Length=393, Percent_Identity=38.676844783715, Blast_Score=299, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24583839, Length=639, Percent_Identity=38.810641627543, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24583842, Length=639, Percent_Identity=38.810641627543, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI28574141, Length=639, Percent_Identity=38.810641627543, Blast_Score=471, Evalue=1e-133,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 74069; Mature: 73938

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIITLPDGSKKVFEKSVTILEIAQSIGAGLAKATIAGKVNDVLLDATIPINKDSKVVII
CCEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEECCCCCCEEEEE
TSKDKEGIEIIRHSFAHLIGHAVKQIYSDIKMAIGPVIEDGFYYDIFSEYRFTPEDLIKI
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCCHHHHHHH
ENRINQLIKTNYDVEILQVSKEEAIKTFKERDETFKLRIIEEIPEEGLINLYKHEEYIDM
HHHHHHHHHCCCCEEEEEECHHHHHHHHHHCCCEEEEEEHHHCCCCCHHHHHHHHHHHHH
CRGPHVPNTRHLRHFKLLKLSGSYWRGNSENESLQRIYGTAWAKEKELKDYLTRIEEAEK
HCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDHRKLGKKHSLFHIQEESPGMIFWHPNGWTIYQVLEKYIREILKKNDYLEIKTPQAVDK
HHHHHCCCCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHH
SLWEKSGHWEKFRDDMFTTASENRTYAIKPMNCPCHIQIFNQGLKSYKDLPIRLAEFGSC
HHHHCCCCHHHHHHHHHCCCCCCCEEEEEECCCCEEEHHHHHHHHHHCCCCEEHHHHCCC
HRNEPSGALHGLMRVRNFTQDDAHIFCTEEQIQEEVSTFIDLVFEVYKTFGFDEIIIKLS
CCCCCCHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
TRPEKRVGSEDIWDKSEEALTKALDNKNLKWELQPGEGAFYGPKIEFSLKDCLNRVWQCG
CCCCHHCCCCHHCCCHHHHHHHHHCCCCCEEEEECCCCCEECCEEEEEHHHHHHHHHCCC
TIQVDFSMPIRLDATYVDIDNEKRNPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPYQ
EEEEEECCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEE
IILLSITDRNIEKCLKFNELINNNGYRSKVDIRNEKIGYKIREATLGRVPLIAVIGDKEE
EEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEECCCCCCCCEEEEECCCHH
EIDSVALRALNGKNLGIFNLPNLFKLMDELIEKKGRTE
HHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PIITLPDGSKKVFEKSVTILEIAQSIGAGLAKATIAGKVNDVLLDATIPINKDSKVVII
CEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEECCCCCCEEEEE
TSKDKEGIEIIRHSFAHLIGHAVKQIYSDIKMAIGPVIEDGFYYDIFSEYRFTPEDLIKI
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCCHHHHHHH
ENRINQLIKTNYDVEILQVSKEEAIKTFKERDETFKLRIIEEIPEEGLINLYKHEEYIDM
HHHHHHHHHCCCCEEEEEECHHHHHHHHHHCCCEEEEEEHHHCCCCCHHHHHHHHHHHHH
CRGPHVPNTRHLRHFKLLKLSGSYWRGNSENESLQRIYGTAWAKEKELKDYLTRIEEAEK
HCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDHRKLGKKHSLFHIQEESPGMIFWHPNGWTIYQVLEKYIREILKKNDYLEIKTPQAVDK
HHHHHCCCCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHH
SLWEKSGHWEKFRDDMFTTASENRTYAIKPMNCPCHIQIFNQGLKSYKDLPIRLAEFGSC
HHHHCCCCHHHHHHHHHCCCCCCCEEEEEECCCCEEEHHHHHHHHHHCCCCEEHHHHCCC
HRNEPSGALHGLMRVRNFTQDDAHIFCTEEQIQEEVSTFIDLVFEVYKTFGFDEIIIKLS
CCCCCCHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
TRPEKRVGSEDIWDKSEEALTKALDNKNLKWELQPGEGAFYGPKIEFSLKDCLNRVWQCG
CCCCHHCCCCHHCCCHHHHHHHHHCCCCCEEEEECCCCCEECCEEEEEHHHHHHHHHCCC
TIQVDFSMPIRLDATYVDIDNEKRNPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPYQ
EEEEEECCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEE
IILLSITDRNIEKCLKFNELINNNGYRSKVDIRNEKIGYKIREATLGRVPLIAVIGDKEE
EEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEECCCCCCCCEEEEECCCHH
EIDSVALRALNGKNLGIFNLPNLFKLMDELIEKKGRTE
HHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA