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The map label for this gene is hemE [H]

Identifier: 123968174

GI number: 123968174

Start: 557876

End: 558916

Strand: Reverse

Name: hemE [H]

Synonym: A9601_06391

Alternate gene names: 123968174

Gene position: 558916-557876 (Counterclockwise)

Preceding gene: 123968175

Following gene: 123968173

Centisome position: 33.47

GC content: 35.25

Gene sequence:

>1041_bases
ATGGGTCAAGATTTACCGCTACTACTTTCTGCCGCATTAGGTAAAAAAGTAAATAGGCCTCCAGTATGGATGATGAGGCA
AGCAGGAAGATATATGAAAATCTATAGAGATTTAAGGGAGCGTTACCCAAGCTTTAGAGAGAGGTCTGAAAATCCAGAAC
TATCATATGAGATTTCAATGCAGCCTTTTCATGCTTTCAAACCGGATGGTGTGATCCTTTTTTCAGATATTCTCACACCT
CTTCCAGGGATGGGCATAAATTTTGAAATAATAGAAAGTAAAGGTCCAATTATTGAGGACCCAATAAGAACTCTTAATCA
GGTAGAAAATTTAAGAGAATTAAATCCAAGCGAGAGTTTAAGCTTTGTTGGGCAAGTTCTTTCTTCACTAAAAAAAGATG
TAAATAACGAGGCAACTATTTTAGGTTTTGTTGGCGCACCTTGGACTCTTGCTGCATATGTAGTTGAAGGTAAAAGCAGT
AAGAATTATTCCTTAATAAAATCAATGGCTTTTAATGAACCAGATTTACTTCATAAACTTCTTGATCATTTTGCAAAATC
TATTGGTGAATATCTTAAATATCAAATAAAATCTGGAGCGCAAGTAGTACAAATTTTTGATTCATGGGCAGGCCAACTAA
GCCCACAAGATTATGATATGTTTGCTGGGCCGTATCAAAAAAAAGTTGTTGAAATTGTAAAAGCGGAATACCCTGAAACA
CCAATAATTCTTTACATTTCAGGAAGTGCTGGGGTACTGGAAAGAATGGCAAAAACTGGAGTAGATATAATTTCACTAGA
CTGGACAGTAGATATTGAAGAGGCTTGTAAAAGAATCCCCAGGGGAATTGGAATTCAAGGTAATGTTGACCCTGGCATTT
TATTCGGAAACAAAAAATCAATAAAAGAAAGGATAGATGATACTTTCAATAAAATTAAAGACAGGAAATATATTCTTAAT
TTGGGTCATGGGATTTTACCTGGGACTCCAGAAGAAAATGCTCAAACATTTTTTGAACATGGGAAAAAACTCACTTACTA
G

Upstream 100 bases:

>100_bases
TAGTGCTTCATATAAATGTTCACATAACGCTTTTGCTCTGCTTTACATTGTAAGATTTTTAAGTTGGATTTTAATTTTTT
TTTAAATATCGAATTGAAAA

Downstream 100 bases:

>100_bases
TCAAAGTCTTGGCATATAAAAACTTATTAATAACAGGCGCTAATGGATGTGTTGGCCAATATTTAGTTGATTGGTTTTTG
AAAAACACAAAATTCAGGCT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MGQDLPLLLSAALGKKVNRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYEISMQPFHAFKPDGVILFSDILTP
LPGMGINFEIIESKGPIIEDPIRTLNQVENLRELNPSESLSFVGQVLSSLKKDVNNEATILGFVGAPWTLAAYVVEGKSS
KNYSLIKSMAFNEPDLLHKLLDHFAKSIGEYLKYQIKSGAQVVQIFDSWAGQLSPQDYDMFAGPYQKKVVEIVKAEYPET
PIILYISGSAGVLERMAKTGVDIISLDWTVDIEEACKRIPRGIGIQGNVDPGILFGNKKSIKERIDDTFNKIKDRKYILN
LGHGILPGTPEENAQTFFEHGKKLTY

Sequences:

>Translated_346_residues
MGQDLPLLLSAALGKKVNRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYEISMQPFHAFKPDGVILFSDILTP
LPGMGINFEIIESKGPIIEDPIRTLNQVENLRELNPSESLSFVGQVLSSLKKDVNNEATILGFVGAPWTLAAYVVEGKSS
KNYSLIKSMAFNEPDLLHKLLDHFAKSIGEYLKYQIKSGAQVVQIFDSWAGQLSPQDYDMFAGPYQKKVVEIVKAEYPET
PIILYISGSAGVLERMAKTGVDIISLDWTVDIEEACKRIPRGIGIQGNVDPGILFGNKKSIKERIDDTFNKIKDRKYILN
LGHGILPGTPEENAQTFFEHGKKLTY
>Mature_345_residues
GQDLPLLLSAALGKKVNRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYEISMQPFHAFKPDGVILFSDILTPL
PGMGINFEIIESKGPIIEDPIRTLNQVENLRELNPSESLSFVGQVLSSLKKDVNNEATILGFVGAPWTLAAYVVEGKSSK
NYSLIKSMAFNEPDLLHKLLDHFAKSIGEYLKYQIKSGAQVVQIFDSWAGQLSPQDYDMFAGPYQKKVVEIVKAEYPETP
IILYISGSAGVLERMAKTGVDIISLDWTVDIEEACKRIPRGIGIQGNVDPGILFGNKKSIKERIDDTFNKIKDRKYILNL
GHGILPGTPEENAQTFFEHGKKLTY

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=339, Percent_Identity=33.9233038348083, Blast_Score=216, Evalue=4e-56,
Organism=Escherichia coli, GI2367337, Length=340, Percent_Identity=38.2352941176471, Blast_Score=256, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6320252, Length=351, Percent_Identity=33.6182336182336, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI19921920, Length=340, Percent_Identity=35, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=34.8837209302326, Blast_Score=220, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 38989; Mature: 38858

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQDLPLLLSAALGKKVNRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYEISM
CCCCHHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHCCCCCCEEEEEEC
QPFHAFKPDGVILFSDILTPLPGMGINFEIIESKGPIIEDPIRTLNQVENLRELNPSESL
CCCCCCCCCCEEEEHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHH
SFVGQVLSSLKKDVNNEATILGFVGAPWTLAAYVVEGKSSKNYSLIKSMAFNEPDLLHKL
HHHHHHHHHHHHCCCCCEEEEEECCCCHHHEEHEEECCCCCCHHHHHHHCCCCHHHHHHH
LDHFAKSIGEYLKYQIKSGAQVVQIFDSWAGQLSPQDYDMFAGPYQKKVVEIVKAEYPET
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHCCCCC
PIILYISGSAGVLERMAKTGVDIISLDWTVDIEEACKRIPRGIGIQGNVDPGILFGNKKS
CEEEEECCCHHHHHHHHHCCCCEEEEEEEECHHHHHHHCCCCCCCCCCCCCCEEECCHHH
IKERIDDTFNKIKDRKYILNLGHGILPGTPEENAQTFFEHGKKLTY
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GQDLPLLLSAALGKKVNRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYEISM
CCCHHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHCCCCCCEEEEEEC
QPFHAFKPDGVILFSDILTPLPGMGINFEIIESKGPIIEDPIRTLNQVENLRELNPSESL
CCCCCCCCCCEEEEHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHH
SFVGQVLSSLKKDVNNEATILGFVGAPWTLAAYVVEGKSSKNYSLIKSMAFNEPDLLHKL
HHHHHHHHHHHHCCCCCEEEEEECCCCHHHEEHEEECCCCCCHHHHHHHCCCCHHHHHHH
LDHFAKSIGEYLKYQIKSGAQVVQIFDSWAGQLSPQDYDMFAGPYQKKVVEIVKAEYPET
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHCCCCC
PIILYISGSAGVLERMAKTGVDIISLDWTVDIEEACKRIPRGIGIQGNVDPGILFGNKKS
CEEEEECCCHHHHHHHHHCCCCEEEEEEEECHHHHHHHCCCCCCCCCCCCCCEEECCHHH
IKERIDDTFNKIKDRKYILNLGHGILPGTPEENAQTFFEHGKKLTY
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA