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The map label for this gene is groEL [H]

Identifier: 123968044

GI number: 123968044

Start: 441717

End: 443462

Strand: Reverse

Name: groEL [H]

Synonym: A9601_05071

Alternate gene names: 123968044

Gene position: 443462-441717 (Counterclockwise)

Preceding gene: 123968046

Following gene: 123968038

Centisome position: 26.56

GC content: 37.63

Gene sequence:

>1746_bases
ATGGCTAAACAGTTAAATTTTTCTAATGAATCAAGAGAAGCGCTAGAAAAAGGTGTGAATTTTGTAGCTAATGCAGTAAA
GGTTACTATTGGGCCAAAAGCAAAAAACGTTGTAATAGAAAAGAAATTTGGTTCGCCGGATATAGTAAGAGATGGATCTA
CAGTTGCTAAAGAGATCGAGATTGAAAACCCTATTGCTAATTTAGGTGCGAAATTAATAGAACAAGTCGCATCCAAGACA
AAAGAGAGTGCTGGTGATGGGACAACAACAGCAACCATTTTGACTCAGAAGATGGTTCAGGAGGGATTAAAAAATATTGC
TTCTGGTGCCAACCCTATGGAGTTAAAAAAAGGTATGGAAGCAGGCCTAGCTTTTGTCTTAGAAAAATTAAGTTCCAAAA
GTATTTCATTAAGTGGTTCTGACATCCAAAAAGTTGCAACAGTTAGTGCTGGAGGTGATGAAGAAATTGGATCTATAATT
TCGAAAGCAATGGATATTGTTACTTCAGATGGTGTAATAACTGTTGAAGAATCTCAATCATTAGAAACAGAATTAGATAT
AACTGAAGGAATGTCTTTTGATAGAGGTTATAGTTCTCCATATTTCGTAACAGACCAAGAAAGACAAGTTTGTGAACTTG
AAAACCCTAAAATATTAATAACTGATCAAAAAATCTCAACTTTAGTTGATCTAGTTCCAATACTTGAAGAAATTCAAAAG
GCGGGCTCACCTTTTCTAATTCTTGCTGAAGATATTGAAGGAGAGGCTTTAACTACTCTGGTTTTGAATAAGAATAGTGG
GGTTTTAAATGTAGCTTCCGTGAGAGCTCCTTTATTTGGTGAGAGAAGAAAAGCTGCCCTTGAAGATATTGCAATTCTTA
CAGGGGCTAAGTTAATTAGCGAAGATAAATCGATGACACTTGATAAAGTATCTATTAATGATTTAGGCAAAGCAAAAAAA
ATAACTATCACAAAGGATAAAACTACAATTGTTGCCTTCGAAGACACTAAAGATTTAGTTGAAGCGCGAGTAGAGAAATT
AAAGAGAGAAGTTAACATAACTGAATCTGAGTATGATCAGGACAAAATCAATGAAAGGATAGCCAAACTAGCCGGAGGAG
TAGCTCTTATCAAAGTAGGAGCTGCTACAGAAACAGAGATGAAATATAAAAAGTTGAGAATTGAAGATTCCCTTAATGCT
ACGAAAGCTGCTATTGAAGAGGGTGTTGTTTCTGGAGGAGGACAAACTTTAATTGAAATATCAGATGACCTTTTAAATTT
AAGTGAAACATCTTCAGATGATTTAAGAACAGGGATAAATATAGTTAAAGAAGCCCTTTTGGAACCTACCAAACAAATAG
CAAAAAATGCTGGTTTTAATGGTGATGTAGTTGTCGCTGAAATTCAAAGGCTTAACAAAGGCTTTAATGCTAATTCAGGA
CAATATGAGGATTTAAAAGATTCAGGAATATTAGATCCAACCAAAGTAATAAGATTAGCTCTTCAAGATTCAGTATCTAT
TGCAGCTATGCTCCTCACAACAGAAGTTGCGATGGCAGACATTCCAGAGCCTGAAGCCGCGGCCCCTGGAGGACCAGGTG
GAGATCCAATGGGAGGAATGGGTGGCATGGGAATGCCAGGAATGGGTGGCATGGGAATGCCGGGTATGGGTGGCATGGGA
ATGCCGGGTATGGGTGGCATGGGAATGCCAGGAATGGGTGGCATGGGAATGCCGGGTATGATGTAA

Upstream 100 bases:

>100_bases
GTATGTCTCATGAAAAGAAATTCGGCTTTCCCCACTTAATTAAATATCCCTTAAAAATGATTCTATGGGAGATTAGAATA
AGACTAAAGATTGAGTAAAC

Downstream 100 bases:

>100_bases
TAGCTAACTAGCTTTTTTATCGTTGTTAATCCACTTTCTTAAATTTTTAATATAAGGTAGGGGTAATTCTGGGGTTTCAG
TAAATTGTTTTATTTTATTA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 581; Mature: 580

Protein sequence:

>581_residues
MAKQLNFSNESREALEKGVNFVANAVKVTIGPKAKNVVIEKKFGSPDIVRDGSTVAKEIEIENPIANLGAKLIEQVASKT
KESAGDGTTTATILTQKMVQEGLKNIASGANPMELKKGMEAGLAFVLEKLSSKSISLSGSDIQKVATVSAGGDEEIGSII
SKAMDIVTSDGVITVEESQSLETELDITEGMSFDRGYSSPYFVTDQERQVCELENPKILITDQKISTLVDLVPILEEIQK
AGSPFLILAEDIEGEALTTLVLNKNSGVLNVASVRAPLFGERRKAALEDIAILTGAKLISEDKSMTLDKVSINDLGKAKK
ITITKDKTTIVAFEDTKDLVEARVEKLKREVNITESEYDQDKINERIAKLAGGVALIKVGAATETEMKYKKLRIEDSLNA
TKAAIEEGVVSGGGQTLIEISDDLLNLSETSSDDLRTGINIVKEALLEPTKQIAKNAGFNGDVVVAEIQRLNKGFNANSG
QYEDLKDSGILDPTKVIRLALQDSVSIAAMLLTTEVAMADIPEPEAAAPGGPGGDPMGGMGGMGMPGMGGMGMPGMGGMG
MPGMGGMGMPGMGGMGMPGMM

Sequences:

>Translated_581_residues
MAKQLNFSNESREALEKGVNFVANAVKVTIGPKAKNVVIEKKFGSPDIVRDGSTVAKEIEIENPIANLGAKLIEQVASKT
KESAGDGTTTATILTQKMVQEGLKNIASGANPMELKKGMEAGLAFVLEKLSSKSISLSGSDIQKVATVSAGGDEEIGSII
SKAMDIVTSDGVITVEESQSLETELDITEGMSFDRGYSSPYFVTDQERQVCELENPKILITDQKISTLVDLVPILEEIQK
AGSPFLILAEDIEGEALTTLVLNKNSGVLNVASVRAPLFGERRKAALEDIAILTGAKLISEDKSMTLDKVSINDLGKAKK
ITITKDKTTIVAFEDTKDLVEARVEKLKREVNITESEYDQDKINERIAKLAGGVALIKVGAATETEMKYKKLRIEDSLNA
TKAAIEEGVVSGGGQTLIEISDDLLNLSETSSDDLRTGINIVKEALLEPTKQIAKNAGFNGDVVVAEIQRLNKGFNANSG
QYEDLKDSGILDPTKVIRLALQDSVSIAAMLLTTEVAMADIPEPEAAAPGGPGGDPMGGMGGMGMPGMGGMGMPGMGGMG
MPGMGGMGMPGMGGMGMPGMM
>Mature_580_residues
AKQLNFSNESREALEKGVNFVANAVKVTIGPKAKNVVIEKKFGSPDIVRDGSTVAKEIEIENPIANLGAKLIEQVASKTK
ESAGDGTTTATILTQKMVQEGLKNIASGANPMELKKGMEAGLAFVLEKLSSKSISLSGSDIQKVATVSAGGDEEIGSIIS
KAMDIVTSDGVITVEESQSLETELDITEGMSFDRGYSSPYFVTDQERQVCELENPKILITDQKISTLVDLVPILEEIQKA
GSPFLILAEDIEGEALTTLVLNKNSGVLNVASVRAPLFGERRKAALEDIAILTGAKLISEDKSMTLDKVSINDLGKAKKI
TITKDKTTIVAFEDTKDLVEARVEKLKREVNITESEYDQDKINERIAKLAGGVALIKVGAATETEMKYKKLRIEDSLNAT
KAAIEEGVVSGGGQTLIEISDDLLNLSETSSDDLRTGINIVKEALLEPTKQIAKNAGFNGDVVVAEIQRLNKGFNANSGQ
YEDLKDSGILDPTKVIRLALQDSVSIAAMLLTTEVAMADIPEPEAAAPGGPGGDPMGGMGGMGMPGMGGMGMPGMGGMGM
PGMGGMGMPGMGGMGMPGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=529, Percent_Identity=42.5330812854442, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI31542947, Length=529, Percent_Identity=42.5330812854442, Blast_Score=428, Evalue=1e-120,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=48.7712665406427, Blast_Score=509, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17555558, Length=532, Percent_Identity=43.0451127819549, Blast_Score=429, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI193210679, Length=212, Percent_Identity=41.0377358490566, Blast_Score=165, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6323288, Length=525, Percent_Identity=43.2380952380952, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6322524, Length=354, Percent_Identity=21.7514124293785, Blast_Score=64, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24641193, Length=529, Percent_Identity=43.4782608695652, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24641191, Length=529, Percent_Identity=43.4782608695652, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=40.719696969697, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=40.719696969697, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=40.719696969697, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI17864606, Length=526, Percent_Identity=40.1140684410646, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24584129, Length=528, Percent_Identity=34.6590909090909, Blast_Score=264, Evalue=2e-70,
Organism=Drosophila melanogaster, GI19921262, Length=528, Percent_Identity=34.6590909090909, Blast_Score=264, Evalue=2e-70,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 61308; Mature: 61177

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQLNFSNESREALEKGVNFVANAVKVTIGPKAKNVVIEKKFGSPDIVRDGSTVAKEIE
CCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCEECCCHHHHHEE
IENPIANLGAKLIEQVASKTKESAGDGTTTATILTQKMVQEGLKNIASGANPMELKKGME
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AGLAFVLEKLSSKSISLSGSDIQKVATVSAGGDEEIGSIISKAMDIVTSDGVITVEESQS
HHHHHHHHHHCCCCEECCCCHHHHHEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCC
LETELDITEGMSFDRGYSSPYFVTDQERQVCELENPKILITDQKISTLVDLVPILEEIQK
CCCCCCHHCCCCCCCCCCCCEEEECCCHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHH
AGSPFLILAEDIEGEALTTLVLNKNSGVLNVASVRAPLFGERRKAALEDIAILTGAKLIS
CCCCEEEEEECCCCCEEEEEEEECCCCEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
EDKSMTLDKVSINDLGKAKKITITKDKTTIVAFEDTKDLVEARVEKLKREVNITESEYDQ
CCCCCEEEEECHHHCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHCCCCHHHCCH
DKINERIAKLAGGVALIKVGAATETEMKYKKLRIEDSLNATKAAIEEGVVSGGGQTLIEI
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHEEHHCCCHHHHHHHHHHHCCCCCEEEEE
SDDLLNLSETSSDDLRTGINIVKEALLEPTKQIAKNAGFNGDVVVAEIQRLNKGFNANSG
CHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCC
QYEDLKDSGILDPTKVIRLALQDSVSIAAMLLTTEVAMADIPEPEAAAPGGPGGDPMGGM
CCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
GGMGMPGMGGMGMPGMGGMGMPGMGGMGMPGMGGMGMPGMM
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKQLNFSNESREALEKGVNFVANAVKVTIGPKAKNVVIEKKFGSPDIVRDGSTVAKEIE
CCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCEECCCHHHHHEE
IENPIANLGAKLIEQVASKTKESAGDGTTTATILTQKMVQEGLKNIASGANPMELKKGME
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AGLAFVLEKLSSKSISLSGSDIQKVATVSAGGDEEIGSIISKAMDIVTSDGVITVEESQS
HHHHHHHHHHCCCCEECCCCHHHHHEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCC
LETELDITEGMSFDRGYSSPYFVTDQERQVCELENPKILITDQKISTLVDLVPILEEIQK
CCCCCCHHCCCCCCCCCCCCEEEECCCHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHH
AGSPFLILAEDIEGEALTTLVLNKNSGVLNVASVRAPLFGERRKAALEDIAILTGAKLIS
CCCCEEEEEECCCCCEEEEEEEECCCCEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
EDKSMTLDKVSINDLGKAKKITITKDKTTIVAFEDTKDLVEARVEKLKREVNITESEYDQ
CCCCCEEEEECHHHCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHCCCCHHHCCH
DKINERIAKLAGGVALIKVGAATETEMKYKKLRIEDSLNATKAAIEEGVVSGGGQTLIEI
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHEEHHCCCHHHHHHHHHHHCCCCCEEEEE
SDDLLNLSETSSDDLRTGINIVKEALLEPTKQIAKNAGFNGDVVVAEIQRLNKGFNANSG
CHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCC
QYEDLKDSGILDPTKVIRLALQDSVSIAAMLLTTEVAMADIPEPEAAAPGGPGGDPMGGM
CCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
GGMGMPGMGGMGMPGMGGMGMPGMGGMGMPGMGGMGMPGMM
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA