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The map label for this gene is fabG [H]

Identifier: 123967953

GI number: 123967953

Start: 360061

End: 360825

Strand: Reverse

Name: fabG [H]

Synonym: A9601_04161

Alternate gene names: 123967953

Gene position: 360825-360061 (Counterclockwise)

Preceding gene: 123967956

Following gene: 123967950

Centisome position: 21.61

GC content: 33.86

Gene sequence:

>765_bases
ATGAACTTACAAATAGAAAAACAGACCGTTTTAGTAACAGGTGCAGGGAGAGGATTAGGTTCCGAAATCGCAAGATCATT
TCATAGAGAGGGTGCAAAAGTAATTATCAACTATAGAAATTCATATGAAAGTGCAAAAAATTTATCTGATTCTTTAGGAG
AGAATGCAATTTTAGTAAAAGGGGATATCAGAGAAAAAGATCAAGTCTCTAAAATGCACGAAGAATTGGCAAGTCAAAAT
ATCAGAGTGGATACGATAATCCACAACGCAATAAATGACTTTATTTTCAATGGTGATCAAAGAAAAAAAATAGACACTAT
AGAGTGGCAAGATTTCCAAAATCAGATTGAAACTACTCAAAAAGGATTTCTAAATCTGCTGAATATTTTTACACCAAAGA
TGAAAAATAATTCTTTTGGAAGAGTTATATCTATTGGAACTAATTTATTTCAAAATCCAGTAATTCCTTACCATGATTAC
ACTGCAGCCAAAGGCGGATTATTATCACTTACAAGAACTGCAGCAATAGATCTAGGGCAATTTAATATCACAGTAAATAT
GGTTTCAGGAGGCTTATTAAAGGTAACTGATGCTAGCAAAGGCACTCCAGATAGTGTTTTTGAATATATTTCCAGCATTA
CACCCTTAAGAAAAGTTACCACTACAGAGGACTTTTCGGATGCTGTATTATTTTTTGCTTCCCCTTGGTCGAGGGCAGTC
ACTGGTCAAAATTTAGTAGTTGATGGTGGCTTAGTTCTAAACTAA

Upstream 100 bases:

>100_bases
TAAATAAAAGTGAGATGTAAAAAATTTTATATTTAATATTTTTATTTTCCTCTAGAATCAAATATTAATTAAAAGCAGTT
TAGAAACTGACCAAAGCATT

Downstream 100 bases:

>100_bases
TTAGCTTTAATAAAATTTATTTTTTTCTAAATTATTTTTTCTTTATAGAGAATAATTAATTGATAATTCTAAAGTTTTAA
TTAATTGAGATTTAGGATTA

Product: putative dehydrogenase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MNLQIEKQTVLVTGAGRGLGSEIARSFHREGAKVIINYRNSYESAKNLSDSLGENAILVKGDIREKDQVSKMHEELASQN
IRVDTIIHNAINDFIFNGDQRKKIDTIEWQDFQNQIETTQKGFLNLLNIFTPKMKNNSFGRVISIGTNLFQNPVIPYHDY
TAAKGGLLSLTRTAAIDLGQFNITVNMVSGGLLKVTDASKGTPDSVFEYISSITPLRKVTTTEDFSDAVLFFASPWSRAV
TGQNLVVDGGLVLN

Sequences:

>Translated_254_residues
MNLQIEKQTVLVTGAGRGLGSEIARSFHREGAKVIINYRNSYESAKNLSDSLGENAILVKGDIREKDQVSKMHEELASQN
IRVDTIIHNAINDFIFNGDQRKKIDTIEWQDFQNQIETTQKGFLNLLNIFTPKMKNNSFGRVISIGTNLFQNPVIPYHDY
TAAKGGLLSLTRTAAIDLGQFNITVNMVSGGLLKVTDASKGTPDSVFEYISSITPLRKVTTTEDFSDAVLFFASPWSRAV
TGQNLVVDGGLVLN
>Mature_254_residues
MNLQIEKQTVLVTGAGRGLGSEIARSFHREGAKVIINYRNSYESAKNLSDSLGENAILVKGDIREKDQVSKMHEELASQN
IRVDTIIHNAINDFIFNGDQRKKIDTIEWQDFQNQIETTQKGFLNLLNIFTPKMKNNSFGRVISIGTNLFQNPVIPYHDY
TAAKGGLLSLTRTAAIDLGQFNITVNMVSGGLLKVTDASKGTPDSVFEYISSITPLRKVTTTEDFSDAVLFFASPWSRAV
TGQNLVVDGGLVLN

Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI10190704, Length=254, Percent_Identity=23.6220472440945, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI5031737, Length=254, Percent_Identity=28.740157480315, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI40254992, Length=248, Percent_Identity=27.0161290322581, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI32483357, Length=252, Percent_Identity=24.2063492063492, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI19923817, Length=261, Percent_Identity=23.7547892720307, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787905, Length=256, Percent_Identity=31.25, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787335, Length=251, Percent_Identity=28.2868525896414, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI87082100, Length=267, Percent_Identity=25.4681647940075, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787820, Length=232, Percent_Identity=25.4310344827586, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788459, Length=262, Percent_Identity=27.0992366412214, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1786812, Length=254, Percent_Identity=24.8031496062992, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790717, Length=254, Percent_Identity=25.5905511811024, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789057, Length=265, Percent_Identity=27.1698113207547, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI2367175, Length=248, Percent_Identity=25, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787545, Length=257, Percent_Identity=24.9027237354086, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789208, Length=258, Percent_Identity=22.8682170542636, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=264, Percent_Identity=27.6515151515151, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17560332, Length=267, Percent_Identity=28.4644194756554, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=264, Percent_Identity=27.6515151515151, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=275, Percent_Identity=28.3636363636364, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=271, Percent_Identity=29.1512915129151, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=258, Percent_Identity=24.4186046511628, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=256, Percent_Identity=26.171875, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24639444, Length=250, Percent_Identity=24.8, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 28058; Mature: 28058

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQIEKQTVLVTGAGRGLGSEIARSFHREGAKVIINYRNSYESAKNLSDSLGENAILVK
CCCEEECEEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEE
GDIREKDQVSKMHEELASQNIRVDTIIHNAINDFIFNGDQRKKIDTIEWQDFQNQIETTQ
CCCCCHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
KGFLNLLNIFTPKMKNNSFGRVISIGTNLFQNPVIPYHDYTAAKGGLLSLTRTAAIDLGQ
HHHHHHHHHHCCCCCCCCCCEEEEECCHHHHCCCCCCCCCCCCCCCEEEEHHHHEEECCE
FNITVNMVSGGLLKVTDASKGTPDSVFEYISSITPLRKVTTTEDFSDAVLFFASPWSRAV
EEEEEEEECCCEEEEECCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCEEEEEECCCCCCC
TGQNLVVDGGLVLN
CCCEEEEECCEEEC
>Mature Secondary Structure
MNLQIEKQTVLVTGAGRGLGSEIARSFHREGAKVIINYRNSYESAKNLSDSLGENAILVK
CCCEEECEEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEE
GDIREKDQVSKMHEELASQNIRVDTIIHNAINDFIFNGDQRKKIDTIEWQDFQNQIETTQ
CCCCCHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
KGFLNLLNIFTPKMKNNSFGRVISIGTNLFQNPVIPYHDYTAAKGGLLSLTRTAAIDLGQ
HHHHHHHHHHCCCCCCCCCCEEEEECCHHHHCCCCCCCCCCCCCCCEEEEHHHHEEECCE
FNITVNMVSGGLLKVTDASKGTPDSVFEYISSITPLRKVTTTEDFSDAVLFFASPWSRAV
EEEEEEEECCCEEEEECCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCEEEEEECCCCCCC
TGQNLVVDGGLVLN
CCCEEEEECCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9384377; 9534248; 8654983 [H]