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The map label for this gene is frmA [H]

Identifier: 121610236

GI number: 121610236

Start: 3677638

End: 3678762

Strand: Direct

Name: frmA [H]

Synonym: Veis_3295

Alternate gene names: 121610236

Gene position: 3677638-3678762 (Clockwise)

Preceding gene: 121610235

Following gene: 121610237

Centisome position: 66.06

GC content: 67.56

Gene sequence:

>1125_bases
ATGCTGATCCGCTCTGCCGTCTTGCACGAAATGAACGCCGCGACACCGTTCGCGCAAACCAGGCCACTGCGCATCGAGGA
GCTCGAGCTCGACGAGCCCGGCCCGGGCCAGGTGCTGGTGAAAATGGTGGCCGCGGGCCTGTGCCACTCCGACCTTTCGG
TGATCACCGGCGTGCGGCCGCGGCCCTTGCCGCTGGCGCTGGGCCACGAAGCATCGGCAAGGGTCGTCAGAACGGGCGCC
GGCGTGACCGATCTGCGCGCCGGGGATCTGGTGGTACTGATATTCGTGCCGAGTTGCGGCCATTGCATGCCCTGTATGCA
AGGACGCCCCGCATTGTGTGAACCGGCGGCCGAAGCCAACGGCAATGGCACTCTTTTCGGCGGCGACAAACGCCTGCGCC
TGCGCAATACGGCGGTGTACCACCACACCGGCGTTTCCGCGTTCTCCGATCATGCGGTGGTTTCGCGCCAATCTTGCGTG
AAGGTCGACGCCGACATCGACCCCGTGCAAGCGGCCATGTTCGGCTGCGCGGTTCTGACCGGTGTGGGGGCCGTGATCAA
CACCGCAGGCGCGCAGGCAGGCTCGACAGCAGCGCTCGTGGGATTGGGCGGCGTCGGCCTGTGCGCGCTGCTGGCGGCCG
TGGCCTCGGGCTGCAGGCAGGTCGTGGCCGTCGACATCCATGACAGCAAACTGGCGCTTGCGCGCAGCCTGGGCGCCAGC
GCCGCCGTCAATGCGCGCGATCCGGACGCCGTCGAGCAGATCCGCGCGTTGACCCACGGAGGCGTCGACTATTCCTTCGA
GATGGCCGGCTCCGTGCCCTCGATGGAGACCGCGTACAGCATCACGCGGCGCGGCGGCATGACGGTCACTGCGGGCCTGC
CCGCCCCGACCGATCGCTGGCCGCTGCGGCAACTGAGCCTGGTGGTCGAGGAGCGCACGGTCAAAGGCAGCTACATCGGC
TCCTGCGTGCCGGTACGCGATGTGCCGCGCTACATTGCCATGTACCTCGGCGGCCAGTTGCCGATCGATCGCCTGATGGG
ACAGCGCCACCCACTCGACGACATCAACGCCGGATTCGATCGCCTGAACAGCGGCGAGAGCCTGCGCGACGTGATCGTGT
TCTGA

Upstream 100 bases:

>100_bases
ATCGTCGAAGAGTTCTCGATCGACGAGGCTTCCGAAGAGAAGGTGCTGTACGCCGCCGTGCACTGATCGATCATTCCTTG
AACGCCAACGAAAGCCTGCC

Downstream 100 bases:

>100_bases
ACGCATGATCGCCGCCCGGCCACCCGGCCGCCCGAAGGCGCTCATACCGCAGCCGAAGGTACTCCAATGAGCGTGTTCCC
GGGTGACGCCATCGACATTG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MLIRSAVLHEMNAATPFAQTRPLRIEELELDEPGPGQVLVKMVAAGLCHSDLSVITGVRPRPLPLALGHEASARVVRTGA
GVTDLRAGDLVVLIFVPSCGHCMPCMQGRPALCEPAAEANGNGTLFGGDKRLRLRNTAVYHHTGVSAFSDHAVVSRQSCV
KVDADIDPVQAAMFGCAVLTGVGAVINTAGAQAGSTAALVGLGGVGLCALLAAVASGCRQVVAVDIHDSKLALARSLGAS
AAVNARDPDAVEQIRALTHGGVDYSFEMAGSVPSMETAYSITRRGGMTVTAGLPAPTDRWPLRQLSLVVEERTVKGSYIG
SCVPVRDVPRYIAMYLGGQLPIDRLMGQRHPLDDINAGFDRLNSGESLRDVIVF

Sequences:

>Translated_374_residues
MLIRSAVLHEMNAATPFAQTRPLRIEELELDEPGPGQVLVKMVAAGLCHSDLSVITGVRPRPLPLALGHEASARVVRTGA
GVTDLRAGDLVVLIFVPSCGHCMPCMQGRPALCEPAAEANGNGTLFGGDKRLRLRNTAVYHHTGVSAFSDHAVVSRQSCV
KVDADIDPVQAAMFGCAVLTGVGAVINTAGAQAGSTAALVGLGGVGLCALLAAVASGCRQVVAVDIHDSKLALARSLGAS
AAVNARDPDAVEQIRALTHGGVDYSFEMAGSVPSMETAYSITRRGGMTVTAGLPAPTDRWPLRQLSLVVEERTVKGSYIG
SCVPVRDVPRYIAMYLGGQLPIDRLMGQRHPLDDINAGFDRLNSGESLRDVIVF
>Mature_374_residues
MLIRSAVLHEMNAATPFAQTRPLRIEELELDEPGPGQVLVKMVAAGLCHSDLSVITGVRPRPLPLALGHEASARVVRTGA
GVTDLRAGDLVVLIFVPSCGHCMPCMQGRPALCEPAAEANGNGTLFGGDKRLRLRNTAVYHHTGVSAFSDHAVVSRQSCV
KVDADIDPVQAAMFGCAVLTGVGAVINTAGAQAGSTAALVGLGGVGLCALLAAVASGCRQVVAVDIHDSKLALARSLGAS
AAVNARDPDAVEQIRALTHGGVDYSFEMAGSVPSMETAYSITRRGGMTVTAGLPAPTDRWPLRQLSLVVEERTVKGSYIG
SCVPVRDVPRYIAMYLGGQLPIDRLMGQRHPLDDINAGFDRLNSGESLRDVIVF

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=368, Percent_Identity=35.054347826087, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI4501929, Length=374, Percent_Identity=34.7593582887701, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI4501933, Length=374, Percent_Identity=35.2941176470588, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI71565154, Length=366, Percent_Identity=33.3333333333333, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI71565152, Length=377, Percent_Identity=32.6259946949602, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI262073058, Length=366, Percent_Identity=31.6939890710383, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI71743840, Length=366, Percent_Identity=31.6939890710383, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=30.6233062330623, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=31.0249307479224, Blast_Score=179, Evalue=5e-45,
Organism=Escherichia coli, GI1786552, Length=366, Percent_Identity=32.7868852459016, Blast_Score=195, Evalue=3e-51,
Organism=Escherichia coli, GI1790045, Length=365, Percent_Identity=24.6575342465753, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87081918, Length=332, Percent_Identity=30.1204819277108, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87082125, Length=375, Percent_Identity=25.0666666666667, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788407, Length=214, Percent_Identity=30.3738317757009, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790718, Length=306, Percent_Identity=24.8366013071895, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788073, Length=279, Percent_Identity=25.089605734767, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI226510992, Length=363, Percent_Identity=24.7933884297521, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1786518, Length=369, Percent_Identity=24.1192411924119, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787863, Length=225, Percent_Identity=29.7777777777778, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=375, Percent_Identity=34.9333333333333, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI71997431, Length=377, Percent_Identity=34.7480106100796, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17565904, Length=373, Percent_Identity=33.2439678284182, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17562876, Length=366, Percent_Identity=28.9617486338798, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17562584, Length=356, Percent_Identity=28.6516853932584, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17562878, Length=380, Percent_Identity=28.6842105263158, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17562582, Length=349, Percent_Identity=27.7936962750716, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71988145, Length=316, Percent_Identity=25.9493670886076, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320033, Length=368, Percent_Identity=31.5217391304348, Blast_Score=196, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6323729, Length=337, Percent_Identity=27.0029673590504, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319258, Length=374, Percent_Identity=27.2727272727273, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=330, Percent_Identity=27.2727272727273, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=330, Percent_Identity=26.6666666666667, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=375, Percent_Identity=25.8666666666667, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=387, Percent_Identity=24.031007751938, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323099, Length=351, Percent_Identity=25.0712250712251, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737895, Length=369, Percent_Identity=34.9593495934959, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI17737897, Length=356, Percent_Identity=25.8426966292135, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17137530, Length=353, Percent_Identity=24.3626062322946, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 39145; Mature: 39145

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIRSAVLHEMNAATPFAQTRPLRIEELELDEPGPGQVLVKMVAAGLCHSDLSVITGVRP
CCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHCCCCC
RPLPLALGHEASARVVRTGAGVTDLRAGDLVVLIFVPSCGHCMPCMQGRPALCEPAAEAN
CCCEEEECCCCCCEEEECCCCCCEECCCCEEEEEEECCCCCCCHHHCCCCCCCCCCCCCC
GNGTLFGGDKRLRLRNTAVYHHTGVSAFSDHAVVSRQSCVKVDADIDPVQAAMFGCAVLT
CCEEEECCCCEEEEECEEEEEECCCCHHCCCHHHCCCHHEEECCCCCHHHHHHHHHHHHH
GVGAVINTAGAQAGSTAALVGLGGVGLCALLAAVASGCRQVVAVDIHDSKLALARSLGAS
HHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHCCCC
AAVNARDPDAVEQIRALTHGGVDYSFEMAGSVPSMETAYSITRRGGMTVTAGLPAPTDRW
CCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCCC
PLRQLSLVVEERTVKGSYIGSCVPVRDVPRYIAMYLGGQLPIDRLMGQRHPLDDINAGFD
CHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHH
RLNSGESLRDVIVF
HCCCCCCHHHHHCC
>Mature Secondary Structure
MLIRSAVLHEMNAATPFAQTRPLRIEELELDEPGPGQVLVKMVAAGLCHSDLSVITGVRP
CCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHCCCCC
RPLPLALGHEASARVVRTGAGVTDLRAGDLVVLIFVPSCGHCMPCMQGRPALCEPAAEAN
CCCEEEECCCCCCEEEECCCCCCEECCCCEEEEEEECCCCCCCHHHCCCCCCCCCCCCCC
GNGTLFGGDKRLRLRNTAVYHHTGVSAFSDHAVVSRQSCVKVDADIDPVQAAMFGCAVLT
CCEEEECCCCEEEEECEEEEEECCCCHHCCCHHHCCCHHEEECCCCCHHHHHHHHHHHHH
GVGAVINTAGAQAGSTAALVGLGGVGLCALLAAVASGCRQVVAVDIHDSKLALARSLGAS
HHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHCCCC
AAVNARDPDAVEQIRALTHGGVDYSFEMAGSVPSMETAYSITRRGGMTVTAGLPAPTDRW
CCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCCC
PLRQLSLVVEERTVKGSYIGSCVPVRDVPRYIAMYLGGQLPIDRLMGQRHPLDDINAGFD
CHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHH
RLNSGESLRDVIVF
HCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]