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The map label for this gene is fumC [H]

Identifier: 121610156

GI number: 121610156

Start: 3589244

End: 3590650

Strand: Direct

Name: fumC [H]

Synonym: Veis_3215

Alternate gene names: 121610156

Gene position: 3589244-3590650 (Clockwise)

Preceding gene: 121610153

Following gene: 121610158

Centisome position: 64.48

GC content: 68.23

Gene sequence:

>1407_bases
ATGACATCCCCAGCCGATACGAGCGCATACCGCAGCGAAAAAGACAGCTTCGGACCTATCGATGTGCCCGCCGGGCGCCT
GTGGGGGGCGCAGACGCAGCGCTCGCTACAGCATTTTGCGATCTCGGTGGAGCGCATGGCGCCCGAGCTGATCCGGGCGC
TGGCCCGGGTCAAGCGCGCCAGCGCCTGTGTCAACCATGCGCTGGGCCTGCTGGATGCGGCCAAGACCCGGGCCATCGTC
GCTGCGGCGGACGAGGTGATCGCCGGCGGCCATTGGCAGGAGTTCCCGCTCGTGGTCTGGCAGACCGGCTCGGGCACGCA
GACCAACATGAACATGAACGAGGTGCTGGCCAACCGCGCCAGCGAGTTGCTCGGCGGCCCGCGCGGCCAGGCGCGGCTGG
TGCACCCGAACGACGAGGTGAACCTGAGCCAGTCGAGCAATGATGTCTTTCCCACGGCCATGCACCTGGCCGCCGCAGAC
GCGCTGACGCAGCGCCTGCTCCCGGCGCTGCAGGGCCTGCGCAGCAGCTTGGCGGCCAAGGCGCAGGCGTTCTCGGGCAT
CGTGAAGATCGGCCGCACCCATCTGCAGGACGCGACCCCGCTCACGCTGGGGCAGGAGATATCGGGCTGGGTGGCGCAGT
TGCAGCATGGCGATCAGCATCTGCGGGCCGCGCTGCCACACCTGTGTGAACTGGCCCTGGGCGGCACTGCCGTGGGCACC
GGGCTGAACGCGCCGGCGGGCTACGCGCAGGCGGTGGCCAAGGAACTGGCCGGCCTGACCGGCCTGCCGCTGGTCACCGC
CCCGAACAAGTTCGAGGCCCTGGCCGCTTGTGATGCGCTGGTCCATGCCCATGGCGCACTCAAGACGCTGGCCGCCAGCC
TGATGAAGATCGCCAACGATGTGCGCTGGCTGGCCAGCGGGCCGCGCAGCGGCTTGGGCGAGATCACGATTCCCGAGAAC
GAGCCGGGCTCGTCGATCATGCCCGGCAAGGTCAACCCCACGCAGTGCGAGGCGCTGACCATGCTGTGCGCGCAGGTGCT
GGGCAATGACGTGGCCATCAACATCGGCGGCGCCTCGGGCAATTTCGAGCTGAATGTGTTCCGCCCCCTGATCATCCACA
ACTTTTTGCAGAGCCTGCGGCTGCTGGCCGATGGCATGGCCAGTTTCGACGCGCACTGCGCCGTCGGCATAGCGCCCGCC
CAGGCCCGCATCGACGAGTTGCTGGAGCGCTCGCTGATGCTGGTGACGGCCCTGAACCCCCATATCGGCTACGACAAGGC
CGCGCAGATCGCCAAAAAAGCCCATGCCGAGGGCAGCAGCCTGCGTGCGGTGGCCCTGGCCTTGGGCCATGTCACGGGCG
AGCAGTTCGACCAATGGGTCGTGCCGGCGCAGATGGTGGGGCAGTAA

Upstream 100 bases:

>100_bases
GCCGCCGGACATGCCGGGCGGCATGGGGCCTGCCTGGCACGACCCGGGTATGCTGCACGCTGGTGTTCCCATTCTTTTCT
GGCGACCAGGCGTGACCGTG

Downstream 100 bases:

>100_bases
GGCAAAACCCGCGCGCGCCCTGGATGGGGCCGCGACGCCGTCGGCGCGGCACAGACGGGCGCCACGGCATCCCCGGCCTG
GGGTGCGCGCCCGCATGTTT

Product: fumarate hydratase, class II

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MTSPADTSAYRSEKDSFGPIDVPAGRLWGAQTQRSLQHFAISVERMAPELIRALARVKRASACVNHALGLLDAAKTRAIV
AAADEVIAGGHWQEFPLVVWQTGSGTQTNMNMNEVLANRASELLGGPRGQARLVHPNDEVNLSQSSNDVFPTAMHLAAAD
ALTQRLLPALQGLRSSLAAKAQAFSGIVKIGRTHLQDATPLTLGQEISGWVAQLQHGDQHLRAALPHLCELALGGTAVGT
GLNAPAGYAQAVAKELAGLTGLPLVTAPNKFEALAACDALVHAHGALKTLAASLMKIANDVRWLASGPRSGLGEITIPEN
EPGSSIMPGKVNPTQCEALTMLCAQVLGNDVAINIGGASGNFELNVFRPLIIHNFLQSLRLLADGMASFDAHCAVGIAPA
QARIDELLERSLMLVTALNPHIGYDKAAQIAKKAHAEGSSLRAVALALGHVTGEQFDQWVVPAQMVGQ

Sequences:

>Translated_468_residues
MTSPADTSAYRSEKDSFGPIDVPAGRLWGAQTQRSLQHFAISVERMAPELIRALARVKRASACVNHALGLLDAAKTRAIV
AAADEVIAGGHWQEFPLVVWQTGSGTQTNMNMNEVLANRASELLGGPRGQARLVHPNDEVNLSQSSNDVFPTAMHLAAAD
ALTQRLLPALQGLRSSLAAKAQAFSGIVKIGRTHLQDATPLTLGQEISGWVAQLQHGDQHLRAALPHLCELALGGTAVGT
GLNAPAGYAQAVAKELAGLTGLPLVTAPNKFEALAACDALVHAHGALKTLAASLMKIANDVRWLASGPRSGLGEITIPEN
EPGSSIMPGKVNPTQCEALTMLCAQVLGNDVAINIGGASGNFELNVFRPLIIHNFLQSLRLLADGMASFDAHCAVGIAPA
QARIDELLERSLMLVTALNPHIGYDKAAQIAKKAHAEGSSLRAVALALGHVTGEQFDQWVVPAQMVGQ
>Mature_467_residues
TSPADTSAYRSEKDSFGPIDVPAGRLWGAQTQRSLQHFAISVERMAPELIRALARVKRASACVNHALGLLDAAKTRAIVA
AADEVIAGGHWQEFPLVVWQTGSGTQTNMNMNEVLANRASELLGGPRGQARLVHPNDEVNLSQSSNDVFPTAMHLAAADA
LTQRLLPALQGLRSSLAAKAQAFSGIVKIGRTHLQDATPLTLGQEISGWVAQLQHGDQHLRAALPHLCELALGGTAVGTG
LNAPAGYAQAVAKELAGLTGLPLVTAPNKFEALAACDALVHAHGALKTLAASLMKIANDVRWLASGPRSGLGEITIPENE
PGSSIMPGKVNPTQCEALTMLCAQVLGNDVAINIGGASGNFELNVFRPLIIHNFLQSLRLLADGMASFDAHCAVGIAPAQ
ARIDELLERSLMLVTALNPHIGYDKAAQIAKKAHAEGSSLRAVALALGHVTGEQFDQWVVPAQMVGQ

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=465, Percent_Identity=60.2150537634409, Blast_Score=556, Evalue=1e-158,
Organism=Homo sapiens, GI266458395, Length=66, Percent_Identity=50, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1787896, Length=460, Percent_Identity=73.4782608695652, Blast_Score=677, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=450, Percent_Identity=39.7777777777778, Blast_Score=328, Evalue=7e-91,
Organism=Caenorhabditis elegans, GI17553882, Length=459, Percent_Identity=59.4771241830065, Blast_Score=555, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI32565146, Length=326, Percent_Identity=62.2699386503067, Blast_Score=423, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6324993, Length=463, Percent_Identity=56.8034557235421, Blast_Score=530, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=58.351409978308, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=58.351409978308, Blast_Score=554, Evalue=1e-158,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=57.7922077922078, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24662684, Length=461, Percent_Identity=57.9175704989154, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=50.7592190889371, Blast_Score=466, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49165; Mature: 49034

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPADTSAYRSEKDSFGPIDVPAGRLWGAQTQRSLQHFAISVERMAPELIRALARVKRA
CCCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SACVNHALGLLDAAKTRAIVAAADEVIAGGHWQEFPLVVWQTGSGTQTNMNMNEVLANRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
SELLGGPRGQARLVHPNDEVNLSQSSNDVFPTAMHLAAADALTQRLLPALQGLRSSLAAK
HHHHCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQAFSGIVKIGRTHLQDATPLTLGQEISGWVAQLQHGDQHLRAALPHLCELALGGTAVGT
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCC
GLNAPAGYAQAVAKELAGLTGLPLVTAPNKFEALAACDALVHAHGALKTLAASLMKIAND
CCCCCCHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRWLASGPRSGLGEITIPENEPGSSIMPGKVNPTQCEALTMLCAQVLGNDVAINIGGASG
HHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCC
NFELNVFRPLIIHNFLQSLRLLADGMASFDAHCAVGIAPAQARIDELLERSLMLVTALNP
CEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHEECCC
HIGYDKAAQIAKKAHAEGSSLRAVALALGHVTGEQFDQWVVPAQMVGQ
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure 
TSPADTSAYRSEKDSFGPIDVPAGRLWGAQTQRSLQHFAISVERMAPELIRALARVKRA
CCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SACVNHALGLLDAAKTRAIVAAADEVIAGGHWQEFPLVVWQTGSGTQTNMNMNEVLANRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
SELLGGPRGQARLVHPNDEVNLSQSSNDVFPTAMHLAAADALTQRLLPALQGLRSSLAAK
HHHHCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQAFSGIVKIGRTHLQDATPLTLGQEISGWVAQLQHGDQHLRAALPHLCELALGGTAVGT
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCC
GLNAPAGYAQAVAKELAGLTGLPLVTAPNKFEALAACDALVHAHGALKTLAASLMKIAND
CCCCCCHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRWLASGPRSGLGEITIPENEPGSSIMPGKVNPTQCEALTMLCAQVLGNDVAINIGGASG
HHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCC
NFELNVFRPLIIHNFLQSLRLLADGMASFDAHCAVGIAPAQARIDELLERSLMLVTALNP
CEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHEECCC
HIGYDKAAQIAKKAHAEGSSLRAVALALGHVTGEQFDQWVVPAQMVGQ
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]