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The map label for this gene is fabG [C]

Identifier: 121609880

GI number: 121609880

Start: 3284611

End: 3285666

Strand: Direct

Name: fabG [C]

Synonym: Veis_2933

Alternate gene names: 121609880

Gene position: 3284611-3285666 (Clockwise)

Preceding gene: 121609879

Following gene: 121609881

Centisome position: 59.0

GC content: 69.03

Gene sequence:

>1056_bases
ATGGAACAGCTCTGCAAGGGGCGGGTGGTCGTCATCACCGGCGCTGGCTGCGGCCTCGGCCGCGCATACGCGCTGGAGTT
CGCGCGCCAGGGCGCCAAAGTGGTTGTCAACGACCTTGGCACCCAGTCCGACGGCACGGGCATCATGAGCGCCGCCCGGC
CGCCCGAAGGCGCTCATACCGCAGCCGAAGGCGGAGGTACTCCATCCTTCGCCGCCCGGCCGCCCGAAGGCGCTCATACC
GTAGCCGAGGGCGAAGGTGCTCCAGTGAACGCCCCGGCGCAGCAAGTGGTGGCCGAGATCCGCGCCCTGGGCGGCGAGGC
CGTTGCCAACACCGACGACGTGTCCGACTGGGAGGGCGCACGGCGGCTGATCCAGACCGCGATCACCACGTTCGGTGCGC
TCGATGTGCTGGTCAACAACGCCGGCATCCTGCGCGACAAGGCGCTCGTCAACATGGACATCGCAGACTTCGATGCGGTG
ATCCGCGTCCATCTGCGCGGCACCTTTGCCCCGATGCGCCACGCCGCGATGTACTGGCGCGGGCAGGCCAAGGCTGGCCG
CCAGCGCATGGCGCGCGTCATCAACACCAGTTCGTCGTCCGGCCTGTACGGCATCGTCGGGCAGACCAACTACGGCCCGG
CCAAGGCCGGCATCGCCAACATGAGCATCGTGGCCGCGCGCGAACTGGAGCGCTATGGCGTGACGGTGAATGCGATCTAC
CCCACCGCGATGAGCCGCCTCACCGAGGATTTGTTCAAGAGCGGCAGGCTCGACCCCAAGGCCAGGGGCGGCCCCGGCTT
CGATCCGCTGGACGCGGCAAACGTTGCGCCGCTGGTCGTCTGGCTCGGCAGTGTGTCGTCGCAGGGCGTCACTGGCCGCG
TGTTTGGCGCCAAGGGCGGCCGCATCACGGTGGCCGAGGGCTGGCATGCCGGCCCCCATATCGAAAAACAGGGGCGCTGG
AGCGTGTCCGAACTCGCGCAGAGGCTGCCCGATCTCGTCCGGCGCGCGGCGCCCAATGCCGAACTGAGCGGCGAAATCCC
GATGGCGGAGGCCTGA

Upstream 100 bases:

>100_bases
CGCATCATCGGTGCACGCGCCAGCGCCGATGGGCCGGCCAGGCCGCAGCGACTCCGGGCTGGTGCATCGATCCCGGTACG
ACGAAAGGAATGCAATGGAG

Downstream 100 bases:

>100_bases
CGCATGAATGCGAACAAGTACAAACCCAAGCCGGTTCCGGTCCCGACGCCGGTCACCCAGCCGTTCTGGGACGGCACGCG
CGCCGGCGAGCTGCGTTTGC

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MEQLCKGRVVVITGAGCGLGRAYALEFARQGAKVVVNDLGTQSDGTGIMSAARPPEGAHTAAEGGGTPSFAARPPEGAHT
VAEGEGAPVNAPAQQVVAEIRALGGEAVANTDDVSDWEGARRLIQTAITTFGALDVLVNNAGILRDKALVNMDIADFDAV
IRVHLRGTFAPMRHAAMYWRGQAKAGRQRMARVINTSSSSGLYGIVGQTNYGPAKAGIANMSIVAARELERYGVTVNAIY
PTAMSRLTEDLFKSGRLDPKARGGPGFDPLDAANVAPLVVWLGSVSSQGVTGRVFGAKGGRITVAEGWHAGPHIEKQGRW
SVSELAQRLPDLVRRAAPNAELSGEIPMAEA

Sequences:

>Translated_351_residues
MEQLCKGRVVVITGAGCGLGRAYALEFARQGAKVVVNDLGTQSDGTGIMSAARPPEGAHTAAEGGGTPSFAARPPEGAHT
VAEGEGAPVNAPAQQVVAEIRALGGEAVANTDDVSDWEGARRLIQTAITTFGALDVLVNNAGILRDKALVNMDIADFDAV
IRVHLRGTFAPMRHAAMYWRGQAKAGRQRMARVINTSSSSGLYGIVGQTNYGPAKAGIANMSIVAARELERYGVTVNAIY
PTAMSRLTEDLFKSGRLDPKARGGPGFDPLDAANVAPLVVWLGSVSSQGVTGRVFGAKGGRITVAEGWHAGPHIEKQGRW
SVSELAQRLPDLVRRAAPNAELSGEIPMAEA
>Mature_351_residues
MEQLCKGRVVVITGAGCGLGRAYALEFARQGAKVVVNDLGTQSDGTGIMSAARPPEGAHTAAEGGGTPSFAARPPEGAHT
VAEGEGAPVNAPAQQVVAEIRALGGEAVANTDDVSDWEGARRLIQTAITTFGALDVLVNNAGILRDKALVNMDIADFDAV
IRVHLRGTFAPMRHAAMYWRGQAKAGRQRMARVINTSSSSGLYGIVGQTNYGPAKAGIANMSIVAARELERYGVTVNAIY
PTAMSRLTEDLFKSGRLDPKARGGPGFDPLDAANVAPLVVWLGSVSSQGVTGRVFGAKGGRITVAEGWHAGPHIEKQGRW
SVSELAQRLPDLVRRAAPNAELSGEIPMAEA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=302, Percent_Identity=37.7483443708609, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI15277342, Length=291, Percent_Identity=29.553264604811, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI4758504, Length=243, Percent_Identity=28.8065843621399, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1787335, Length=309, Percent_Identity=29.4498381877023, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789208, Length=211, Percent_Identity=26.5402843601896, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789378, Length=305, Percent_Identity=26.5573770491803, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=294, Percent_Identity=34.6938775510204, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25147288, Length=188, Percent_Identity=31.3829787234043, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17555706, Length=297, Percent_Identity=26.5993265993266, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71982365, Length=237, Percent_Identity=25.3164556962025, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=295, Percent_Identity=37.9661016949153, Blast_Score=160, Evalue=3e-40,
Organism=Drosophila melanogaster, GI18859837, Length=308, Percent_Identity=39.2857142857143, Blast_Score=161, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24639444, Length=305, Percent_Identity=28.1967213114754, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI23397609, Length=189, Percent_Identity=31.2169312169312, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 36656; Mature: 36656

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQLCKGRVVVITGAGCGLGRAYALEFARQGAKVVVNDLGTQSDGTGIMSAARPPEGAHT
CCHHHCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEECCCCCCCCCC
AAEGGGTPSFAARPPEGAHTVAEGEGAPVNAPAQQVVAEIRALGGEAVANTDDVSDWEGA
CCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHH
RRLIQTAITTFGALDVLVNNAGILRDKALVNMDIADFDAVIRVHLRGTFAPMRHAAMYWR
HHHHHHHHHHHHHHHHHHCCCCCEECCCEEECCHHHHCEEEEEEECCCHHHHHHHHHHHC
GQAKAGRQRMARVINTSSSSGLYGIVGQTNYGPAKAGIANMSIVAARELERYGVTVNAIY
CCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHCCCCCHHHHHHHHHHHHCCEEEEEC
PTAMSRLTEDLFKSGRLDPKARGGPGFDPLDAANVAPLVVWLGSVSSQGVTGRVFGAKGG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHEECCCCCCCCEEEEEECCCC
RITVAEGWHAGPHIEKQGRWSVSELAQRLPDLVRRAAPNAELSGEIPMAEA
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEQLCKGRVVVITGAGCGLGRAYALEFARQGAKVVVNDLGTQSDGTGIMSAARPPEGAHT
CCHHHCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEECCCCCCCCCC
AAEGGGTPSFAARPPEGAHTVAEGEGAPVNAPAQQVVAEIRALGGEAVANTDDVSDWEGA
CCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHH
RRLIQTAITTFGALDVLVNNAGILRDKALVNMDIADFDAVIRVHLRGTFAPMRHAAMYWR
HHHHHHHHHHHHHHHHHHCCCCCEECCCEEECCHHHHCEEEEEEECCCHHHHHHHHHHHC
GQAKAGRQRMARVINTSSSSGLYGIVGQTNYGPAKAGIANMSIVAARELERYGVTVNAIY
CCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHCCCCCHHHHHHHHHHHHCCEEEEEC
PTAMSRLTEDLFKSGRLDPKARGGPGFDPLDAANVAPLVVWLGSVSSQGVTGRVFGAKGG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHEECCCCCCCCEEEEEECCCC
RITVAEGWHAGPHIEKQGRWSVSELAQRLPDLVRRAAPNAELSGEIPMAEA
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]