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The map label for this gene is espR

Identifier: 121639767

GI number: 121639767

Start: 4295902

End: 4296300

Strand: Direct

Name: espR

Synonym: BCG_3912

Alternate gene names: 121639767

Gene position: 4295902-4296300 (Clockwise)

Preceding gene: 121639766

Following gene: 121639768

Centisome position: 98.2

GC content: 64.91

Gene sequence:

>399_bases
ATGAGCACGACGTTCGCTGCCCGCCTGAACCGCCTGTTCGACACGGTTTATCCGCCCGGACGCGGGCCACATACCTCCGC
GGAGGTGATCGCGGCGCTCAAGGCAGAGGGCATCACGATGTCGGCTCCCTACCTATCACAGCTACGCTCAGGAAACCGTA
CGAACCCATCGGGGGCGACCATGGCCGCCCTGGCCAACTTCTTCCGCATCAAGGCGGCCTACTTCACCGACGACGAGTAC
TACGAAAAGCTCGACAAGGAATTGCAGTGGCTGTGCACGATGCGCGACGACGGCGTGCGCCGGATCGCGCAGCGGGCCCA
CGGGTTGCCCTCCGCGGCGCAGCAGAAGGTGTTGGACCGGATCGACGAGCTGCGGCGTGCCGAAGGGATCGACGCTTAG

Upstream 100 bases:

>100_bases
CTCAGGTTTGCACTTGGTTGTGGACACAACTGTCGCTACCATGATCAGCAAATACATACAGATAACCGTTTGCTCTTGGA
GCCCGGTGGAGGTCACATCG

Downstream 100 bases:

>100_bases
TCCCTGATACCGACCGCCCGCTCCACCCGACCTGGCGGGTTGGGGTTGGTCTGCCCCGATTAGGGTTGCCCCAGCGATCA
CCGCGATAGTCCACGAGATA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 132; Mature: 131

Protein sequence:

>132_residues
MSTTFAARLNRLFDTVYPPGRGPHTSAEVIAALKAEGITMSAPYLSQLRSGNRTNPSGATMAALANFFRIKAAYFTDDEY
YEKLDKELQWLCTMRDDGVRRIAQRAHGLPSAAQQKVLDRIDELRRAEGIDA

Sequences:

>Translated_132_residues
MSTTFAARLNRLFDTVYPPGRGPHTSAEVIAALKAEGITMSAPYLSQLRSGNRTNPSGATMAALANFFRIKAAYFTDDEY
YEKLDKELQWLCTMRDDGVRRIAQRAHGLPSAAQQKVLDRIDELRRAEGIDA
>Mature_131_residues
STTFAARLNRLFDTVYPPGRGPHTSAEVIAALKAEGITMSAPYLSQLRSGNRTNPSGATMAALANFFRIKAAYFTDDEYY
EKLDKELQWLCTMRDDGVRRIAQRAHGLPSAAQQKVLDRIDELRRAEGIDA

Specific function: Required for secretion and virulence in mice. Activates transcription of an operon that includes espA, espC and espD genes, which are ESX-1 components. Acts by binding directly to the promoter region

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Note=Probably secreted via the ESX-1 / type VII secretion system (T7SS)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ESPR_MYCTU (P96228)

Other databases:

- EMBL:   BX842584
- EMBL:   AE000516
- PIR:   F70654
- RefSeq:   NP_218366.1
- RefSeq:   NP_338517.1
- ProteinModelPortal:   P96228
- EnsemblBacteria:   EBMYCT00000001941
- EnsemblBacteria:   EBMYCT00000070916
- GeneID:   886184
- GeneID:   922559
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3964
- KEGG:   mtu:Rv3849
- TIGR:   MT3964
- TubercuList:   Rv3849
- GeneTree:   EBGT00050000016118
- HOGENOM:   HBG567485
- OMA:   SEGITMS
- ProtClustDB:   CLSK792760
- GO:   GO:0005829
- GO:   GO:0009405
- GO:   GO:0006350

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 14709; Mature: 14578

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTFAARLNRLFDTVYPPGRGPHTSAEVIAALKAEGITMSAPYLSQLRSGNRTNPSGAT
CCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHH
MAALANFFRIKAAYFTDDEYYEKLDKELQWLCTMRDDGVRRIAQRAHGLPSAAQQKVLDR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHH
IDELRRAEGIDA
HHHHHHHCCCCC
>Mature Secondary Structure 
STTFAARLNRLFDTVYPPGRGPHTSAEVIAALKAEGITMSAPYLSQLRSGNRTNPSGAT
CCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHH
MAALANFFRIKAAYFTDDEYYEKLDKELQWLCTMRDDGVRRIAQRAHGLPSAAQQKVLDR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHH
IDELRRAEGIDA
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036