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The map label for this gene is crp [H]

Identifier: 121639589

GI number: 121639589

Start: 4089591

End: 4090265

Strand: Direct

Name: crp [H]

Synonym: BCG_3734

Alternate gene names: 121639589

Gene position: 4089591-4090265 (Clockwise)

Preceding gene: 121639588

Following gene: 121639593

Centisome position: 93.49

GC content: 64.89

Gene sequence:

>675_bases
GTGGACGAGATCCTGGCCAGGGCAGGAATCTTCCAAGGCGTGGAGCCCAGCGCAATCGCCGCACTGACGAAACAGCTGCA
GCCCGTCGACTTCCCCCGTGGACACACGGTCTTCGCGGAAGGGGAGCCGGGCGATCGGCCGTACATCATCATCTCGGGGA
AGGTCAAGATCGGTCGCCGGGCACCAGACGGCCGAGAAAACCTGCTAACCATCATGGGCCCGTCGGACATGTTCGGCGAG
TTGTCGATCTTCGACCCGGGTCCGCGCACGTCCAGCGCGACCACGATCACCGAGGTGCGGGCGGTGTCGATGGACCGCGA
CGCGCTGCGGTCATGGATCGCCGATCGTCCCGAAATCTCCGAACAGCTGCTGCGGGTGCTGGCCCGCCGGCTGCGCCGCA
CCAACAACAACCTGGCCGACCTCATCTTCACCGATGTGCCCGGTCGGGTGGCCAAGCAGCTGTTGCAGCTCGCCCAGCGT
TTCGGCACCCAGGAAGGTGGCGCATTGCGGGTCACCCACGACCTGACACAGAAAGAAATCGCCCAGCTGGTCGGGGCCTC
ACGCGAGACGGTGAACAAGGCACTGGCTGATTTCGCTCACCGCGGCTGGATCCGCCTTGAGGGCAAGAGTGTGCTGATCT
CTGACTCCGAAAGACTGGCCCGCCGAGCGAGGTAA

Upstream 100 bases:

>100_bases
AGCGTTGGCACGGCGAACCGGTTGGCCTACCTCTAGACTCTTCTCGTTGGCAAACGGTTAGTGTGCCCGTATCACTTCGT
CGGAAAGTTGAAGAGGCAAC

Downstream 100 bases:

>100_bases
GCGCGCGCAGCGCGGGCGCAACCGAGCGAGCTAGCTTCCTCACGCCCAGCAGACACAGAGTCGCACGCAAACGACGGATT
TTGTGCGATTGTGCGGCTGC

Product: CRP/FNR family transcriptional regulator

Products: NA

Alternate protein names: cAMP receptor protein; cAMP regulatory protein [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRPYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGE
LSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQR
FGTQEGGALRVTHDLTQKEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR

Sequences:

>Translated_224_residues
MDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRPYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGE
LSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQR
FGTQEGGALRVTHDLTQKEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR
>Mature_224_residues
MDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRPYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGE
LSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQR
FGTQEGGALRVTHDLTQKEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR

Specific function: This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of one or more genes involved in the induction of competence [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789756, Length=189, Percent_Identity=31.7460317460317, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR018488
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 24775; Mature: 24775

Theoretical pI: Translated: 10.64; Mature: 10.64

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRPYIIISGKVKIGRR
CCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCEEEEECCEEECCC
APDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEIS
CCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCHH
EQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQKEI
HHHHHHHHHHHHHCCCCHHHHEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHH
AQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR
HHHHCCCHHHHHHHHHHHHHCCEEEECCCEEEEECHHHHHHHCC
>Mature Secondary Structure
MDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRPYIIISGKVKIGRR
CCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCEEEEECCEEECCC
APDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEIS
CCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCHH
EQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQKEI
HHHHHHHHHHHHHCCCCHHHHEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHH
AQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR
HHHHCCCHHHHHHHHHHHHHCCEEEECCCEEEEECHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1542653; 7542800 [H]