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The map label for this gene is tauD [C]

Identifier: 121639331

GI number: 121639331

Start: 3811832

End: 3812719

Strand: Direct

Name: tauD [C]

Synonym: BCG_3476

Alternate gene names: 121639331

Gene position: 3811832-3812719 (Clockwise)

Preceding gene: 121639326

Following gene: 121639332

Centisome position: 87.14

GC content: 65.99

Gene sequence:

>888_bases
ATGACAGATCTGATTACCGTGAAGAAGCTGGGCAGCCGTATCGGCGCCCAAATCGACGGGGTGCGCCTCGGAGGCGATCT
GGACCCCGCCGCAGTCAACGAGATTCGCGCGGCACTACTGGCCCACAAGGTGGTCTTCTTCCGCGGTCAGCACCAACTCG
ATGACGCCGAGCAGCTGGCGTTTGCCGGGTTACTGGGCACCCCGATCGGCCACCCGGCCGCGATCGCCCTCGCCGACGAT
GCACCGATCATCACGCCGATCAACTCCGAGTTCGGCAAGGCGAACCGCTGGCACACCGACGTCACGTTCGCCGCCAACTA
TCCGGCCGCCTCGGTACTGCGCGCGGTCTCCCTGCCCAGCTATGGCGGGTCGACGTTGTGGGCCAACACCGCCGCGGCCT
ACGCGGAGCTGCCCGAGCCGCTCAAGTGCCTCACCGAAAACCTGTGGGCGCTGCACACCAACCGCTATGACTACGTCACG
ACCAAACCGCTGACCGCGGCGCAGCGGGCCTTCCGTCAGGTGTTCGAGAAGCCGGACTTCCGCACCGAGCATCCCGTGGT
GCGGGTACACCCGGAGACCGGTGAGCGCACGCTGCTAGCGGGCGACTTCGTGCGCAGCTTCGTCGGGTTGGACAGCCACG
AATCAAGGGTGTTATTCGAAGTGCTGCAACGGCGAATCACCATGCCCGAAAACACCATCCGCTGGAACTGGGCGCCGGGC
GACGTAGCCATCTGGGACAACCGGGCCACCCAACACCGGGCGATCGACGACTACGACGACCAGCACCGGCTGATGCACCG
GGTCACCTTGATGGGCGACGTGCCCGTCGACGTGTACGGGCAGGCTAGCCGGGTGATCAGCGGGGCGCCGATGGAGATCG
CTGGCTGA

Upstream 100 bases:

>100_bases
GGGCATCTTGCGGCGGTCGGTTGCCGGACGCGTAGTCATCCGGCTACAGTAACCGATGTAGTCATCTGACTACACTAACC
ATTCATTGAGGACGCCAGCA

Downstream 100 bases:

>100_bases
TCAACCAGTAAGCGCAACGCAATTATGTAGCACCATGCGTGCTACCGTTGGGCTTGTGGAGGCAATCGGAATCCGAGAAC
TAAGACAGCACGCATCGCGA

Product: putative dioxygenase

Products: Aminoacetaldehyde; CO2; H+; Sulfite; Succinate [C]

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MTDLITVKKLGSRIGAQIDGVRLGGDLDPAAVNEIRAALLAHKVVFFRGQHQLDDAEQLAFAGLLGTPIGHPAAIALADD
APIITPINSEFGKANRWHTDVTFAANYPAASVLRAVSLPSYGGSTLWANTAAAYAELPEPLKCLTENLWALHTNRYDYVT
TKPLTAAQRAFRQVFEKPDFRTEHPVVRVHPETGERTLLAGDFVRSFVGLDSHESRVLFEVLQRRITMPENTIRWNWAPG
DVAIWDNRATQHRAIDDYDDQHRLMHRVTLMGDVPVDVYGQASRVISGAPMEIAG

Sequences:

>Translated_295_residues
MTDLITVKKLGSRIGAQIDGVRLGGDLDPAAVNEIRAALLAHKVVFFRGQHQLDDAEQLAFAGLLGTPIGHPAAIALADD
APIITPINSEFGKANRWHTDVTFAANYPAASVLRAVSLPSYGGSTLWANTAAAYAELPEPLKCLTENLWALHTNRYDYVT
TKPLTAAQRAFRQVFEKPDFRTEHPVVRVHPETGERTLLAGDFVRSFVGLDSHESRVLFEVLQRRITMPENTIRWNWAPG
DVAIWDNRATQHRAIDDYDDQHRLMHRVTLMGDVPVDVYGQASRVISGAPMEIAG
>Mature_294_residues
TDLITVKKLGSRIGAQIDGVRLGGDLDPAAVNEIRAALLAHKVVFFRGQHQLDDAEQLAFAGLLGTPIGHPAAIALADDA
PIITPINSEFGKANRWHTDVTFAANYPAASVLRAVSLPSYGGSTLWANTAAAYAELPEPLKCLTENLWALHTNRYDYVTT
KPLTAAQRAFRQVFEKPDFRTEHPVVRVHPETGERTLLAGDFVRSFVGLDSHESRVLFEVLQRRITMPENTIRWNWAPGD
VAIWDNRATQHRAIDDYDDQHRLMHRVTLMGDVPVDVYGQASRVISGAPMEIAG

Specific function: Catalyzes The Conversion Of Taurine And Alpha Ketoglutarate To Sulfite, Aminoacetaldehyde And Succinate. Required For The Utilization Of Taurine (2-Aminoethanesulfonic Acid) As An Alternative Sulfur Source. Pentane-Sulfonic Acid, 3- (N-Morpholino)Propanes

COG id: COG2175

COG function: function code Q; Probable taurine catabolism dioxygenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tfdA dioxygenase family

Homologues:

Organism=Escherichia coli, GI1786565, Length=281, Percent_Identity=38.0782918149466, Blast_Score=168, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6322971, Length=292, Percent_Identity=29.7945205479452, Blast_Score=105, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y3406_MYCTU (P65075)

Other databases:

- EMBL:   BX842583
- EMBL:   AE000516
- PIR:   C70736
- RefSeq:   NP_217923.1
- RefSeq:   NP_338038.1
- ProteinModelPortal:   P65075
- SMR:   P65075
- EnsemblBacteria:   EBMYCT00000000505
- EnsemblBacteria:   EBMYCT00000072499
- GeneID:   887955
- GeneID:   922941
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3514
- KEGG:   mtu:Rv3406
- TIGR:   MT3514
- TubercuList:   Rv3406
- GeneTree:   EBGT00050000016278
- HOGENOM:   HBG692281
- OMA:   QHYAIND
- ProtClustDB:   CLSK792474
- InterPro:   IPR003819

Pfam domain/function: PF02668 TauD

EC number: 1.14.11.17 [C]

Molecular weight: Translated: 32579; Mature: 32448

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLITVKKLGSRIGAQIDGVRLGGDLDPAAVNEIRAALLAHKVVFFRGQHQLDDAEQLA
CCCHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHH
FAGLLGTPIGHPAAIALADDAPIITPINSEFGKANRWHTDVTFAANYPAASVLRAVSLPS
HHHHHCCCCCCCEEEEEECCCCEEECCCCCCCCCCCEECEEEEEECCCHHHHHHHHCCCC
YGGSTLWANTAAAYAELPEPLKCLTENLWALHTNRYDYVTTKPLTAAQRAFRQVFEKPDF
CCCCEEEHHHHHHHHHCCHHHHHHHHHHHEEECCCCCEEECCCHHHHHHHHHHHHHCCCC
RTEHPVVRVHPETGERTLLAGDFVRSFVGLDSHESRVLFEVLQRRITMPENTIRWNWAPG
CCCCCEEEECCCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCC
DVAIWDNRATQHRAIDDYDDQHRLMHRVTLMGDVPVDVYGQASRVISGAPMEIAG
CEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCC
>Mature Secondary Structure 
TDLITVKKLGSRIGAQIDGVRLGGDLDPAAVNEIRAALLAHKVVFFRGQHQLDDAEQLA
CCHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHH
FAGLLGTPIGHPAAIALADDAPIITPINSEFGKANRWHTDVTFAANYPAASVLRAVSLPS
HHHHHCCCCCCCEEEEEECCCCEEECCCCCCCCCCCEECEEEEEECCCHHHHHHHHCCCC
YGGSTLWANTAAAYAELPEPLKCLTENLWALHTNRYDYVTTKPLTAAQRAFRQVFEKPDF
CCCCEEEHHHHHHHHHCCHHHHHHHHHHHEEECCCCCEEECCCHHHHHHHHHHHHHCCCC
RTEHPVVRVHPETGERTLLAGDFVRSFVGLDSHESRVLFEVLQRRITMPENTIRWNWAPG
CCCCCEEEECCCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCC
DVAIWDNRATQHRAIDDYDDQHRLMHRVTLMGDVPVDVYGQASRVISGAPMEIAG
CEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Ascorbate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-Oxoglutarate; O2; Taurine [C]

Specific reaction: 2-Oxoglutarate + O2 + Taurine --> Aminoacetaldehyde + CO2 + H+ + Sulfite + Succinate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036