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The map label for this gene is merR1 [H]

Identifier: 121639263

GI number: 121639263

Start: 3712540

End: 3712980

Strand: Direct

Name: merR1 [H]

Synonym: BCG_3405

Alternate gene names: 121639263

Gene position: 3712540-3712980 (Clockwise)

Preceding gene: 121639262

Following gene: 121639266

Centisome position: 84.87

GC content: 63.04

Gene sequence:

>441_bases
ATGAAGATCAGCGAGGTAGCCGCGCTCACCAACACCAGCACCAAGACCCTCCGCTTCTACGAGAACTCGGGGCTGCTGCC
GCCGCCTGCACGCACAGCATCGGGGTATCGCAACTATGGACCCGAGATCGTGGATCGGCTGCGGTTTATCCATCGGGGCC
AAGCGGCCGGGCTGGCATTACAGGAAGTACGCCAAATCCTGGCCATCCACGACCGCGGCGAGGCGCCGTGCGCACACGTC
CGCCAACTACTGAGCACCCGCATCGACGAAGTCCGCGCGCAGATCGCCGAACTGATTGCCCTCGAAGGCCACTTGCAGAC
CCTGCTTGACCACGCTTCATATGGCCCGCCCACCGAACACGACCACTCCACGGTGTGTTGGATCCTGGAAAGCGACCTCG
ATGAGCCCACCGCCATCGAGGTCAGCGACATTCACGCCTAG

Upstream 100 bases:

>100_bases
GCTCACCGAGATCAGGCTCGTCACGATCGCCCGCACTGCTGGCGGCTCACATGTACCCAGTGTTAACCTTCTAGTGCACT
AGAAGGTCAAGGGGAGTCGC

Downstream 100 bases:

>100_bases
AGGTCGCTGGGTACGCGGGCTGGCCCACGGGTTTTACGCCGAAGCCGTCGCCGCCCACGCGGTGGCGAACAGGATCAGCC
ACGCGGTGACGAACGCGAAC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MKISEVAALTNTSTKTLRFYENSGLLPPPARTASGYRNYGPEIVDRLRFIHRGQAAGLALQEVRQILAIHDRGEAPCAHV
RQLLSTRIDEVRAQIAELIALEGHLQTLLDHASYGPPTEHDHSTVCWILESDLDEPTAIEVSDIHA

Sequences:

>Translated_146_residues
MKISEVAALTNTSTKTLRFYENSGLLPPPARTASGYRNYGPEIVDRLRFIHRGQAAGLALQEVRQILAIHDRGEAPCAHV
RQLLSTRIDEVRAQIAELIALEGHLQTLLDHASYGPPTEHDHSTVCWILESDLDEPTAIEVSDIHA
>Mature_146_residues
MKISEVAALTNTSTKTLRFYENSGLLPPPARTASGYRNYGPEIVDRLRFIHRGQAAGLALQEVRQILAIHDRGEAPCAHV
RQLLSTRIDEVRAQIAELIALEGHLQTLLDHASYGPPTEHDHSTVCWILESDLDEPTAIEVSDIHA

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=132, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=4e-14,
Organism=Escherichia coli, GI1786695, Length=131, Percent_Identity=29.7709923664122, Blast_Score=67, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 16169; Mature: 16169

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISEVAALTNTSTKTLRFYENSGLLPPPARTASGYRNYGPEIVDRLRFIHRGQAAGLAL
CCCHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHH
QEVRQILAIHDRGEAPCAHVRQLLSTRIDEVRAQIAELIALEGHLQTLLDHASYGPPTEH
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DHSTVCWILESDLDEPTAIEVSDIHA
CCCEEEEEEECCCCCCCEEECCCCCC
>Mature Secondary Structure
MKISEVAALTNTSTKTLRFYENSGLLPPPARTASGYRNYGPEIVDRLRFIHRGQAAGLAL
CCCHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHH
QEVRQILAIHDRGEAPCAHVRQLLSTRIDEVRAQIAELIALEGHLQTLLDHASYGPPTEH
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DHSTVCWILESDLDEPTAIEVSDIHA
CCCEEEEEEECCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2492496; 2305262 [H]