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The map label for this gene is entC_1

Identifier: 121639102

GI number: 121639102

Start: 3544736

End: 3545854

Strand: Direct

Name: entC_1

Synonym: BCG_3242

Alternate gene names: 121639102

Gene position: 3544736-3545854 (Clockwise)

Preceding gene: 121639101

Following gene: 121639103

Centisome position: 81.03

GC content: 66.4

Gene sequence:

>1119_bases
GTGAGCGCACACGTGGCAACCTTGCACCCAGAACCACCGTTCGCACTGTGCGGACCAAGAGGCACCCTGATTGCCCGCGG
GGTGCGGACACGATACTGCGACGTGCGGGCCGCGCAAGCGGCACTTCGCTCAGGTACAGCACCAATACTGTTGGGCGCGT
TGCCTTTCGACGTGAGCAGACCCGCCGCATTGATGGTGCCGGATGGCGTGCTGCGGGCCCGGAAGCTGCCTGACTGGCCG
ACCGGCCCGCTGCCCAAGGTACGCGTCGCCGCCGCCCTTCCGCCACCTGCCGACTACCTGACCCGGATCGGCCGCGCACG
GGATCTGCTGGCCGCCTTCGACGGCCCGTTGCACAAAGTGGTGCTCGCGCGCGCCGTGCAACTGACCGCCGATGCTCCGC
TGGACGCGCGGGTACTGTTGCGCAGGTTGGTCGTCGCCGACCCGACCGCTTACGGCTATCTCGTCGACCTCACCTCTGCG
GGCAACGACGACACCGGGGCAGCCCTGGTCGGCGCCAGCCCAGAGCTTCTGGTCGCACGATCCGGCAATCGCGTCATGTG
CAAGCCATTTGCCGGCTCAGCCCCACGCGCCGCCGACCCCAAACTCGACGCCGCCAACGCGGCCGCACTAGCCAGTTCGG
CCAAGAACCGACACGAACACCAATTGGTCGTCGACACGATGCGGGTAGCCCTAGAGCCACTATGCGAGGACCTGACAATC
CCAGCCCAGCCCCAGTTGAACCGCACCGCAGCCGTTTGGCATCTGTGCACCGCGATCACCGGCCGGCTGCGCAACATCTC
GACGACGGCAATCGATCTGGCTTTGGCGCTACATCCCACCCCGGCGGTTGGTGGGGTCCCGACAAAAGCTGCCACCGAGC
TCATCGCCGAACTCGAGGGCGACCGTGGCTTCTACGCCGGCGCGGTTGGTTGGTGCGACGGCCGGGGCGACGGCCATTGG
GTGGTGTCTATCCGGTGCGCGCAACTTTCGGCTGATCGACGCGCAGCCCTTGCGCACGCTGGCGGTGGCATCGTCGCCGA
ATCAGACCCCGATGACGAACTTGAAGAAACCACAACGAAGTTCGCCACGATATTGACCGCACTGGGAGTTGAGCAGTGA

Upstream 100 bases:

>100_bases
CGATGCCCACCGCCTCGATCGGGATCTGCGGGTTCGAGCACGGCGTGCGTCAGCTCGCCGTGCTCGGGTTGACCGGTCAT
CCGCAGCCGATCGCAGCCGG

Downstream 100 bases:

>100_bases
CCGATACCATCCGCCGCGCTACACCGGCGGATACCGCCGACATCGTGGCCATGATTCACGCGCTGGGCGGAATTCGAGTA
TGCCGCCGATCAATGCACTG

Product: putative isochorismate synthase entC

Products: NA

Alternate protein names: Isochorismate mutase

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MSAHVATLHPEPPFALCGPRGTLIARGVRTRYCDVRAAQAALRSGTAPILLGALPFDVSRPAALMVPDGVLRARKLPDWP
TGPLPKVRVAAALPPPADYLTRIGRARDLLAAFDGPLHKVVLARAVQLTADAPLDARVLLRRLVVADPTAYGYLVDLTSA
GNDDTGAALVGASPELLVARSGNRVMCKPFAGSAPRAADPKLDAANAAALASSAKNRHEHQLVVDTMRVALEPLCEDLTI
PAQPQLNRTAAVWHLCTAITGRLRNISTTAIDLALALHPTPAVGGVPTKAATELIAELEGDRGFYAGAVGWCDGRGDGHW
VVSIRCAQLSADRRAALAHAGGGIVAESDPDDELEETTTKFATILTALGVEQ

Sequences:

>Translated_372_residues
MSAHVATLHPEPPFALCGPRGTLIARGVRTRYCDVRAAQAALRSGTAPILLGALPFDVSRPAALMVPDGVLRARKLPDWP
TGPLPKVRVAAALPPPADYLTRIGRARDLLAAFDGPLHKVVLARAVQLTADAPLDARVLLRRLVVADPTAYGYLVDLTSA
GNDDTGAALVGASPELLVARSGNRVMCKPFAGSAPRAADPKLDAANAAALASSAKNRHEHQLVVDTMRVALEPLCEDLTI
PAQPQLNRTAAVWHLCTAITGRLRNISTTAIDLALALHPTPAVGGVPTKAATELIAELEGDRGFYAGAVGWCDGRGDGHW
VVSIRCAQLSADRRAALAHAGGGIVAESDPDDELEETTTKFATILTALGVEQ
>Mature_371_residues
SAHVATLHPEPPFALCGPRGTLIARGVRTRYCDVRAAQAALRSGTAPILLGALPFDVSRPAALMVPDGVLRARKLPDWPT
GPLPKVRVAAALPPPADYLTRIGRARDLLAAFDGPLHKVVLARAVQLTADAPLDARVLLRRLVVADPTAYGYLVDLTSAG
NDDTGAALVGASPELLVARSGNRVMCKPFAGSAPRAADPKLDAANAAALASSAKNRHEHQLVVDTMRVALEPLCEDLTIP
AQPQLNRTAAVWHLCTAITGRLRNISTTAIDLALALHPTPAVGGVPTKAATELIAELEGDRGFYAGAVGWCDGRGDGHWV
VSIRCAQLSADRRAALAHAGGGIVAESDPDDELEETTTKFATILTALGVEQ

Specific function: Might be involved in the biosynthesis of menaquinone. Converts chorismate to isochorismate

COG id: COG1169

COG function: function code HQ; Isochorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isochorismate synthase family

Homologues:

Organism=Escherichia coli, GI1786809, Length=330, Percent_Identity=39.3939393939394, Blast_Score=218, Evalue=7e-58,
Organism=Escherichia coli, GI1788114, Length=204, Percent_Identity=32.843137254902, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1787518, Length=270, Percent_Identity=30, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082077, Length=265, Percent_Identity=31.3207547169811, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320935, Length=229, Percent_Identity=36.6812227074236, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324361, Length=405, Percent_Identity=21.2345679012346, Blast_Score=80, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MENF_MYCTU (O05851)

Other databases:

- EMBL:   BX842582
- EMBL:   AE000516
- PIR:   H70595
- RefSeq:   NP_217731.1
- RefSeq:   NP_337839.1
- HSSP:   P05041
- ProteinModelPortal:   O05851
- SMR:   O05851
- EnsemblBacteria:   EBMYCT00000003063
- EnsemblBacteria:   EBMYCT00000069773
- GeneID:   888824
- GeneID:   923007
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3311
- KEGG:   mtu:Rv3215
- TIGR:   MT3311
- TubercuList:   Rv3215
- GeneTree:   EBGT00050000015088
- HOGENOM:   HBG405459
- OMA:   ESSFFFA
- ProtClustDB:   CLSK872155
- InterPro:   IPR005801
- InterPro:   IPR015890
- InterPro:   IPR004561
- Gene3D:   G3DSA:3.60.120.10
- PANTHER:   PTHR11236:SF3
- PANTHER:   PTHR11236
- TIGRFAMs:   TIGR00543

Pfam domain/function: PF00425 Chorismate_bind; SSF56322 TRPE_1_chor_bd

EC number: =5.4.4.2

Molecular weight: Translated: 38938; Mature: 38807

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAHVATLHPEPPFALCGPRGTLIARGVRTRYCDVRAAQAALRSGTAPILLGALPFDVSR
CCCCEEEECCCCCEEEECCCCCEEECCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCC
PAALMVPDGVLRARKLPDWPTGPLPKVRVAAALPPPADYLTRIGRARDLLAAFDGPLHKV
CEEEECCCHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHH
VLARAVQLTADAPLDARVLLRRLVVADPTAYGYLVDLTSAGNDDTGAALVGASPELLVAR
HHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEECCCCCEEEEE
SGNRVMCKPFAGSAPRAADPKLDAANAAALASSAKNRHEHQLVVDTMRVALEPLCEDLTI
CCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCC
PAQPQLNRTAAVWHLCTAITGRLRNISTTAIDLALALHPTPAVGGVPTKAATELIAELEG
CCCCCCCHHHHHHHHHHHHHHHHCCCCHHHEEEEEEECCCCCCCCCCHHHHHHHHHHHCC
DRGFYAGAVGWCDGRGDGHWVVSIRCAQLSADRRAALAHAGGGIVAESDPDDELEETTTK
CCCEEECEEEEECCCCCCEEEEEEEEEECCCCHHHHHHHCCCCEEECCCCCHHHHHHHHH
FATILTALGVEQ
HHHHHHHHCCCC
>Mature Secondary Structure 
SAHVATLHPEPPFALCGPRGTLIARGVRTRYCDVRAAQAALRSGTAPILLGALPFDVSR
CCCEEEECCCCCEEEECCCCCEEECCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCC
PAALMVPDGVLRARKLPDWPTGPLPKVRVAAALPPPADYLTRIGRARDLLAAFDGPLHKV
CEEEECCCHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHH
VLARAVQLTADAPLDARVLLRRLVVADPTAYGYLVDLTSAGNDDTGAALVGASPELLVAR
HHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEECCCCCEEEEE
SGNRVMCKPFAGSAPRAADPKLDAANAAALASSAKNRHEHQLVVDTMRVALEPLCEDLTI
CCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCC
PAQPQLNRTAAVWHLCTAITGRLRNISTTAIDLALALHPTPAVGGVPTKAATELIAELEG
CCCCCCCHHHHHHHHHHHHHHHHCCCCHHHEEEEEEECCCCCCCCCCHHHHHHHHHHHCC
DRGFYAGAVGWCDGRGDGHWVVSIRCAQLSADRRAALAHAGGGIVAESDPDDELEETTTK
CCCEEECEEEEECCCCCCEEEEEEEEEECCCCHHHHHHHCCCCEEECCCCCHHHHHHHHH
FATILTALGVEQ
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036