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The map label for this gene is glcD [C]

Identifier: 121638160

GI number: 121638160

Start: 2528654

End: 2530033

Strand: Direct

Name: glcD [C]

Synonym: BCG_2295

Alternate gene names: 121638160

Gene position: 2528654-2530033 (Clockwise)

Preceding gene: 121638158

Following gene: 121638161

Centisome position: 57.8

GC content: 63.91

Gene sequence:

>1380_bases
ATGAGTGAAATGACAGCTCGGTTTTCCGAAATCGTCGGGAACGCCAATTTGCTGACCGGCGACGCAATCCCCGAGGACTA
CGCACACGACGAAGAGTTGACGGGGCCGCCGCAGAAGCCAGCCTATGCCGCCAAGCCGGCCACCCCCGAAGAGGTTGCCC
AACTGCTGAAGGCCGCCTCTGAAAACGGTGTGCCGGTGACGGCCCGCGGGTCCGGGTGCGGCTTGTCGGGGGCCGCACGA
CCAGTCGAGGGTGGGCTGCTGATCTCGTTCGACCGGATGAACAAGGTCCTCGAGGTCGACACCGCCAACCAAGTCGCCGT
CGTGCAGCCCGGGGTGGCGTTGACCGACCTGGACGCCGCTACCGCCGATACCGGGCTGCGGTACACGGTTTACCCGGGCG
AGCTGTCCTCCAGCGTCGGCGGGAATGTCGGAACCAACGCCGGCGGGATGCGCGCGGTCAAGTACGGAGTGGCCCGCCAT
AACGTGCTCGGGTTGCAAGCGGTATTGCCCACCGGCGAGATCATCCGAACCGGCGGCAGGATGGCCAAGGTGTCCACCGG
CTACGACCTCACCCAGCTGATCATCGGCTCGGAGGGCACCCTGGCCTTGGTCACCGAGGTGATCGTCAAGCTGCATCCGC
GGCTCGACCACAACGCCAGCGTGCTCGCCCCGTTCGCCGACTTCGACCAAGTCATGGCGGCGGTGCCCAAGATCCTCGCC
AGCGGCCTGGCACCTGACATCCTGGAGTACATTGACAACACTTCGATGGCCGCACTCATCTCCACTCAGAACCTGGAGCT
AGGTATTCCGGACCAGATCCGCGACAGCTGCGAAGCTTATCTCCTTGTGGCGCTTGAGAACCGCATCGCCGACCGACTGT
TCGAGGACATTCAGACGGTGGGTGAAATGCTCATGGAATTGGGAGCGGTGGACGCCTACGTGCTCGAAGGAGGCTCGGCG
CGCAAGCTGATCGAGGCCCGCGAGAAGGCATTCTGGGCGGCAAAAGCACTCGGCGCCGACGACATCATCGACACCGTCGT
CCCACGCGCGTCGATGCCAAAATTCCTGAGCACCGCGCGCGGTCTGGCGGCGGCAGCGGACGGTGCCGCGGTCGGTTGCG
GGCACGCCGGCGACGGCAACGTACACATGGCCATCGCGTGCAAGGATCCGGAGAAAAAGAAGAAGCTCATGACCGACATC
TTTGCTCTCGCAATGGAATTGGGTGGCGCGATCTCTGGCGAACACGGCGTCGGCCGGGCCAAAACCGGCTATTTCCTCGA
GCTGGAAGACCCGGTCAAGATCAGCCTCATGCGCCGTATCAAGCAGAGCTTCGATCCGGCGGGCATCCTCAACCCAGGCG
TTGTCTTCGGAGACACCTGA

Upstream 100 bases:

>100_bases
CGTACCGCTGAGAGCCAACCACGATGATTTGCCCGCACCGGCAGCGATAAAGTAAGTCGCGGTCGGGCACGCAGCGCAGC
GTTGGAAAGTGAGGCCTCCG

Downstream 100 bases:

>100_bases
GCACGGACAAGAGCCGGCCGGACCAAGGCCGGTCATCGGCCGGCCAACAGGCCTGCAAGTCTCGAGCGCAACATCTTCGT
GGACAGCTCGGTCCGCCGGT

Product: putative dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSEMTARFSEIVGNANLLTGDAIPEDYAHDEELTGPPQKPAYAAKPATPEEVAQLLKAASENGVPVTARGSGCGLSGAAR
PVEGGLLISFDRMNKVLEVDTANQVAVVQPGVALTDLDAATADTGLRYTVYPGELSSSVGGNVGTNAGGMRAVKYGVARH
NVLGLQAVLPTGEIIRTGGRMAKVSTGYDLTQLIIGSEGTLALVTEVIVKLHPRLDHNASVLAPFADFDQVMAAVPKILA
SGLAPDILEYIDNTSMAALISTQNLELGIPDQIRDSCEAYLLVALENRIADRLFEDIQTVGEMLMELGAVDAYVLEGGSA
RKLIEAREKAFWAAKALGADDIIDTVVPRASMPKFLSTARGLAAAADGAAVGCGHAGDGNVHMAIACKDPEKKKKLMTDI
FALAMELGGAISGEHGVGRAKTGYFLELEDPVKISLMRRIKQSFDPAGILNPGVVFGDT

Sequences:

>Translated_459_residues
MSEMTARFSEIVGNANLLTGDAIPEDYAHDEELTGPPQKPAYAAKPATPEEVAQLLKAASENGVPVTARGSGCGLSGAAR
PVEGGLLISFDRMNKVLEVDTANQVAVVQPGVALTDLDAATADTGLRYTVYPGELSSSVGGNVGTNAGGMRAVKYGVARH
NVLGLQAVLPTGEIIRTGGRMAKVSTGYDLTQLIIGSEGTLALVTEVIVKLHPRLDHNASVLAPFADFDQVMAAVPKILA
SGLAPDILEYIDNTSMAALISTQNLELGIPDQIRDSCEAYLLVALENRIADRLFEDIQTVGEMLMELGAVDAYVLEGGSA
RKLIEAREKAFWAAKALGADDIIDTVVPRASMPKFLSTARGLAAAADGAAVGCGHAGDGNVHMAIACKDPEKKKKLMTDI
FALAMELGGAISGEHGVGRAKTGYFLELEDPVKISLMRRIKQSFDPAGILNPGVVFGDT
>Mature_458_residues
SEMTARFSEIVGNANLLTGDAIPEDYAHDEELTGPPQKPAYAAKPATPEEVAQLLKAASENGVPVTARGSGCGLSGAARP
VEGGLLISFDRMNKVLEVDTANQVAVVQPGVALTDLDAATADTGLRYTVYPGELSSSVGGNVGTNAGGMRAVKYGVARHN
VLGLQAVLPTGEIIRTGGRMAKVSTGYDLTQLIIGSEGTLALVTEVIVKLHPRLDHNASVLAPFADFDQVMAAVPKILAS
GLAPDILEYIDNTSMAALISTQNLELGIPDQIRDSCEAYLLVALENRIADRLFEDIQTVGEMLMELGAVDAYVLEGGSAR
KLIEAREKAFWAAKALGADDIIDTVVPRASMPKFLSTARGLAAAADGAAVGCGHAGDGNVHMAIACKDPEKKKKLMTDIF
ALAMELGGAISGEHGVGRAKTGYFLELEDPVKISLMRRIKQSFDPAGILNPGVVFGDT

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Homo sapiens, GI37595756, Length=463, Percent_Identity=31.1015118790497, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI37595754, Length=486, Percent_Identity=29.6296296296296, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI119964728, Length=425, Percent_Identity=30.3529411764706, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI4501993, Length=222, Percent_Identity=30.1801801801802, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1789351, Length=423, Percent_Identity=34.7517730496454, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI48994907, Length=489, Percent_Identity=23.721881390593, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787977, Length=485, Percent_Identity=25.1546391752577, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71992373, Length=468, Percent_Identity=30.5555555555556, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71992381, Length=468, Percent_Identity=29.4871794871795, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17534361, Length=459, Percent_Identity=28.5403050108932, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71992392, Length=391, Percent_Identity=30.4347826086957, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17556096, Length=222, Percent_Identity=27.4774774774775, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320027, Length=471, Percent_Identity=28.4501061571125, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6320023, Length=428, Percent_Identity=29.2056074766355, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6320764, Length=478, Percent_Identity=28.4518828451883, Blast_Score=150, Evalue=3e-37,
Organism=Drosophila melanogaster, GI18921117, Length=461, Percent_Identity=30.1518438177874, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24639277, Length=461, Percent_Identity=30.1518438177874, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24639275, Length=461, Percent_Identity=30.1518438177874, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24653753, Length=453, Percent_Identity=24.0618101545254, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2280_MYCTU (Q50685)

Other databases:

- EMBL:   AE000516
- EMBL:   BX842579
- PIR:   D70731
- RefSeq:   NP_216796.1
- RefSeq:   NP_336808.1
- ProteinModelPortal:   Q50685
- EnsemblBacteria:   EBMYCT00000000178
- EnsemblBacteria:   EBMYCT00000069822
- GeneID:   887601
- GeneID:   924085
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2338
- KEGG:   mtu:Rv2280
- TIGR:   MT2338
- TubercuList:   Rv2280
- GeneTree:   EBGT00050000015452
- HOGENOM:   HBG553036
- OMA:   LANDEMI
- ProtClustDB:   CLSK791747
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR006094
- InterPro:   IPR016171
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.30.465.20
- Gene3D:   G3DSA:1.10.45.10

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4; SSF55103 FAD-binding_2; SSF56176 FAD-binding_2

EC number: NA

Molecular weight: Translated: 48053; Mature: 47921

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS51387 FAD_PCMH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEMTARFSEIVGNANLLTGDAIPEDYAHDEELTGPPQKPAYAAKPATPEEVAQLLKAAS
CCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
ENGVPVTARGSGCGLSGAARPVEGGLLISFDRMNKVLEVDTANQVAVVQPGVALTDLDAA
CCCCEEEECCCCCCCCCCCCCCCCCEEEEHHHCCCEEEECCCCCEEEECCCCEEEECCCH
TADTGLRYTVYPGELSSSVGGNVGTNAGGMRAVKYGVARHNVLGLQAVLPTGEIIRTGGR
HCCCCCEEEEECCCHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHCCCC
MAKVSTGYDLTQLIIGSEGTLALVTEVIVKLHPRLDHNASVLAPFADFDQVMAAVPKILA
EEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHH
SGLAPDILEYIDNTSMAALISTQNLELGIPDQIRDSCEAYLLVALENRIADRLFEDIQTV
HCCCHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHEEHHHHHHHHHHHHHHHHHHH
GEMLMELGAVDAYVLEGGSARKLIEAREKAFWAAKALGADDIIDTVVPRASMPKFLSTAR
HHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHH
GLAAAADGAAVGCGHAGDGNVHMAIACKDPEKKKKLMTDIFALAMELGGAISGEHGVGRA
HHHHCCCCCEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
KTGYFLELEDPVKISLMRRIKQSFDPAGILNPGVVFGDT
CCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEECCC
>Mature Secondary Structure 
SEMTARFSEIVGNANLLTGDAIPEDYAHDEELTGPPQKPAYAAKPATPEEVAQLLKAAS
CHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
ENGVPVTARGSGCGLSGAARPVEGGLLISFDRMNKVLEVDTANQVAVVQPGVALTDLDAA
CCCCEEEECCCCCCCCCCCCCCCCCEEEEHHHCCCEEEECCCCCEEEECCCCEEEECCCH
TADTGLRYTVYPGELSSSVGGNVGTNAGGMRAVKYGVARHNVLGLQAVLPTGEIIRTGGR
HCCCCCEEEEECCCHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHCCCC
MAKVSTGYDLTQLIIGSEGTLALVTEVIVKLHPRLDHNASVLAPFADFDQVMAAVPKILA
EEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHH
SGLAPDILEYIDNTSMAALISTQNLELGIPDQIRDSCEAYLLVALENRIADRLFEDIQTV
HCCCHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHEEHHHHHHHHHHHHHHHHHHH
GEMLMELGAVDAYVLEGGSARKLIEAREKAFWAAKALGADDIIDTVVPRASMPKFLSTAR
HHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHH
GLAAAADGAAVGCGHAGDGNVHMAIACKDPEKKKKLMTDIFALAMELGGAISGEHGVGRA
HHHHCCCCCEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
KTGYFLELEDPVKISLMRRIKQSFDPAGILNPGVVFGDT
CCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036