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The map label for this gene is fabD

Identifier: 121638125

GI number: 121638125

Start: 2495432

End: 2496340

Strand: Direct

Name: fabD

Synonym: BCG_2260

Alternate gene names: 121638125

Gene position: 2495432-2496340 (Clockwise)

Preceding gene: 121638124

Following gene: 121638126

Centisome position: 57.04

GC content: 69.64

Gene sequence:

>909_bases
GTGATTGCGTTGCTCGCACCCGGACAGGGTTCGCAAACCGAGGGAATGTTGTCGCCGTGGCTTCAGCTGCCCGGCGCAGC
GGACCAGATCGCGGCGTGGTCGAAAGCCGCTGATCTAGATCTTGCCCGGCTGGGCACCACCGCCTCGACCGAGGAGATCA
CCGACACCGCGGTCGCCCAGCCATTGATCGTCGCCGCGACTCTGCTGGCCCACCAGGAACTGGCGCGCCGATGCGTGCTC
GCCGGCAAGGACGTCATCGTGGCCGGCCACTCCGTCGGCGAAATCGCGGCCTACGCAATCGCCGGTGTGATAGCCGCCGA
CGACGCCGTCGCGCTGGCCGCCACCCGCGGCGCCGAGATGGCCAAGGCCTGCGCCACCGAGCCGACCGGCATGTCTGCGG
TGCTCGGCGGCGACGAGACCGAGGTGCTGAGTCGCCTCGAGCAGCTCGACTTGGTCCCGGCAAACCGCAACGCCGCCGGC
CAGATCGTCGCTGCCGGCCGGCTGACCGCGTTGGAGAAGCTCGCCGAAGACCCGCCGGCCAAGGCGCGGGTGCGTGCACT
GGGTGTCGCCGGAGCGTTCCACACCGAGTTCATGGCGCCCGCACTTGACGGCTTTGCGGCGGCCGCGGCCAACATCGCAA
CCGCCGACCCCACCGCCACGCTGCTGTCCAACCGCGACGGGAAGCCGGTGACATCCGCGGCCGCGGCGATGGACACCCTG
GTCTCCCAGCTCACCCAACCGGTGCGATGGGACCTGTGCACCGCGACGCTGCGCGAACACACAGTCACGGCGATCGTGGA
GTTCCCCCCCGCGGGCACGCTTAGCGGTATCGCCAAACGCGAACTTCGGGGGGTTCCGGCACGCGCCGTCAAGTCACCCG
CAGACCTGGACGAGCTGGCAAACCTATAA

Upstream 100 bases:

>100_bases
GCTTACAGGCCCGTTTTGTTGGTTATATACAAAAACCTAAGACGAGGTTCATAATCTGTTACACCGCGCAAAACCGTCTT
CACAGTGTTCTCTTAGACAC

Downstream 100 bases:

>100_bases
CCGCGGACTCGGCCAGAACAACCACATACCCGTCAGTTCGATTTGTACACAACATATTACGAAGGGAAGCATGCTGTGCC
TGTCACTCAGGAAGAAATCA

Product: malonyl CoA-acyl carrier protein transacylase fabD

Products: NA

Alternate protein names: MCT

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MIALLAPGQGSQTEGMLSPWLQLPGAADQIAAWSKAADLDLARLGTTASTEEITDTAVAQPLIVAATLLAHQELARRCVL
AGKDVIVAGHSVGEIAAYAIAGVIAADDAVALAATRGAEMAKACATEPTGMSAVLGGDETEVLSRLEQLDLVPANRNAAG
QIVAAGRLTALEKLAEDPPAKARVRALGVAGAFHTEFMAPALDGFAAAAANIATADPTATLLSNRDGKPVTSAAAAMDTL
VSQLTQPVRWDLCTATLREHTVTAIVEFPPAGTLSGIAKRELRGVPARAVKSPADLDELANL

Sequences:

>Translated_302_residues
MIALLAPGQGSQTEGMLSPWLQLPGAADQIAAWSKAADLDLARLGTTASTEEITDTAVAQPLIVAATLLAHQELARRCVL
AGKDVIVAGHSVGEIAAYAIAGVIAADDAVALAATRGAEMAKACATEPTGMSAVLGGDETEVLSRLEQLDLVPANRNAAG
QIVAAGRLTALEKLAEDPPAKARVRALGVAGAFHTEFMAPALDGFAAAAANIATADPTATLLSNRDGKPVTSAAAAMDTL
VSQLTQPVRWDLCTATLREHTVTAIVEFPPAGTLSGIAKRELRGVPARAVKSPADLDELANL
>Mature_302_residues
MIALLAPGQGSQTEGMLSPWLQLPGAADQIAAWSKAADLDLARLGTTASTEEITDTAVAQPLIVAATLLAHQELARRCVL
AGKDVIVAGHSVGEIAAYAIAGVIAADDAVALAATRGAEMAKACATEPTGMSAVLGGDETEVLSRLEQLDLVPANRNAAG
QIVAAGRLTALEKLAEDPPAKARVRALGVAGAFHTEFMAPALDGFAAAAANIATADPTATLLSNRDGKPVTSAAAAMDTL
VSQLTQPVRWDLCTATLREHTVTAIVEFPPAGTLSGIAKRELRGVPARAVKSPADLDELANL

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family

Homologues:

Organism=Homo sapiens, GI51243059, Length=289, Percent_Identity=29.4117647058824, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1787334, Length=301, Percent_Identity=32.5581395348837, Blast_Score=115, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71984332, Length=291, Percent_Identity=27.1477663230241, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24665753, Length=282, Percent_Identity=30.4964539007092, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): FABD_MYCBO (P63459)

Other databases:

- EMBL:   BX248341
- RefSeq:   NP_855916.1
- ProteinModelPortal:   P63459
- SMR:   P63459
- PhosSite:   P63459
- EnsemblBacteria:   EBMYCT00000016951
- GeneID:   1091405
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2267
- GeneTree:   EBGT00050000015146
- HOGENOM:   HBG687898
- OMA:   LEPTGMS
- ProtClustDB:   CLSK872033
- BioCyc:   MBOV233413:MB2267-MONOMER
- BRENDA:   2.3.1.39
- GO:   GO:0005488
- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR016036
- Gene3D:   G3DSA:3.40.366.10

Pfam domain/function: PF00698 Acyl_transf_1; SSF52151 Acyl_Trfase/lysoPlipase; SSF55048 Malonyl_transacylase_ACP-bd

EC number: =2.3.1.39

Molecular weight: Translated: 30788; Mature: 30788

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: ACT_SITE 91-91 ACT_SITE 194-194

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIALLAPGQGSQTEGMLSPWLQLPGAADQIAAWSKAADLDLARLGTTASTEEITDTAVAQ
CEEEECCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHH
PLIVAATLLAHQELARRCVLAGKDVIVAGHSVGEIAAYAIAGVIAADDAVALAATRGAEM
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHCCHHH
AKACATEPTGMSAVLGGDETEVLSRLEQLDLVPANRNAAGQIVAAGRLTALEKLAEDPPA
HHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCH
KARVRALGVAGAFHTEFMAPALDGFAAAAANIATADPTATLLSNRDGKPVTSAAAAMDTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHHHHHHHHHH
VSQLTQPVRWDLCTATLREHTVTAIVEFPPAGTLSGIAKRELRGVPARAVKSPADLDELA
HHHHHCHHHHHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHHCCCCHHHHCCCCCHHHHH
NL
CC
>Mature Secondary Structure
MIALLAPGQGSQTEGMLSPWLQLPGAADQIAAWSKAADLDLARLGTTASTEEITDTAVAQ
CEEEECCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHH
PLIVAATLLAHQELARRCVLAGKDVIVAGHSVGEIAAYAIAGVIAADDAVALAATRGAEM
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHCCHHH
AKACATEPTGMSAVLGGDETEVLSRLEQLDLVPANRNAAGQIVAAGRLTALEKLAEDPPA
HHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCH
KARVRALGVAGAFHTEFMAPALDGFAAAAANIATADPTATLLSNRDGKPVTSAAAAMDTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHHHHHHHHHH
VSQLTQPVRWDLCTATLREHTVTAIVEFPPAGTLSGIAKRELRGVPARAVKSPADLDELA
HHHHHCHHHHHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHHCCCCHHHHCCCCCHHHHH
NL
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972