| Definition | Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome. |
|---|---|
| Accession | NC_008769 |
| Length | 4,374,522 |
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The map label for this gene is pbpB [H]
Identifier: 121638045
GI number: 121638045
Start: 2404936
End: 2406975
Strand: Reverse
Name: pbpB [H]
Synonym: BCG_2180c
Alternate gene names: 121638045
Gene position: 2406975-2404936 (Counterclockwise)
Preceding gene: 121638046
Following gene: 121638044
Centisome position: 55.02
GC content: 65.93
Gene sequence:
>2040_bases GTGAGCCGCGCCGCCCCCAGGCGGGCCAGTCAGTCGCAGTCGACGCGACCGGCGCGCGGTTTGCGCCGGCCACCGGGAGC CCAGGAGGTTGGGCAACGCAAACGGCCCGGCAAAACGCAGAAAGCCCGGCAAGCCCAGGAAGCCACGAAATCCCGCCCTG CGACACGGTCAGACGTCGCACCCGCGGGTCGCTCGACTCGTGCGAGGCGCACCCGGCAGGTGGTGGACGTCGGGACGCGC GGTGCGTCGTTCGTCTTTCGGCATCGGACCGGAAACGCGGTCATCTTGGTGTTGATGTTGGTCGCGGCAACACAATTGTT CTTTCTGCAGGTATCACATGCCGCGGGCCTGCGTGCGCAGGCGGCCGGCCAACTCAAGGTCACCGACGTCCAGCCAGCGG CTCGCGGCAGCATCGTCGACCGCAACAATGACCGGCTCGCGTTCACCATCGAGGCGCGTGCCCTGACGTTCCAGCCGAAG CGGATTCGGCGGCAATTGGAAGAGGCCAGGAAGAAGACGTCGGCTGCACCCGACCCGCAGCAGCGCCTGCGCGATATCGC CCAGGAGGTCGCCGGCAAGCTGAACAACAAGCCAGATGCCGCGGCCGTGCTGAAGAAGCTGCAAAGCGACGAGACCTTCG TCTACTTGGCGCGTGCGGTCGACCCGGCTGTCGCCAGCGCGATCTGCGCGAAGTATCCCGAGGTCGGTGCGGAAAGACAG GATCTGCGTCAGTACCCGGGTGGGTCGCTGGCGGCAAACGTCGTCGGTGGCATCGACTGGGATGGTCATGGGCTGCTGGG TCTGGAGGACTCCCTGGATGCGGTGCTGGCCGGAACCGACGGATCGGTCACCTACGACCGTGGGTCAGACGGCGTCGTCA TCCCCGGCAGCTACCGGAATCGGCACAAGGCGGTCCACGGTTCCACCGTCGTGCTCACCCTCGACAACGACATCCAGTTC TACGTGCAGCAGCAGGTGCAGCAGGCCAAGAACCTATCGGGGGCTCACAACGTCTCGGCCGTCGTCCTGGACGCCAAGAC CGGCGAGGTGCTCGCGATGGCCAACGACAACACCTTCGACCCGTCGCAAGACATCGGGCGCCAGGGCGACAAGCAGTTGG GCAACCCGGCGGTGTCGTCGCCCTTCGAGCCGGGCTCGGTGAACAAGATCGTCGCCGCGTCCGCGGTCATCGAGCACGGG TTGAGCAGCCCCGACGAGGTGCTACAGGTGCCTGGCTCGATCCAGATGGGCGGTGTTACCGTGCATGACGCTTGGGAGCA CGGCGTGATGCCCTATACCACCACGGGGGTGTTCGGAAAGTCCTCCAACGTCGGCACGCTGATGCTTTCCCAACGTGTCG GACCGGAACGCTATTACGATATGCTCCGCAAGTTCGGGTTGGGACAGCGCACCGGCGTGGGCCTGCCCGGTGAGAGCGCC GGACTGGTGCCGCCAATCGACCAGTGGTCGGGCAGTACGTTCGCTAATCTTCCTATTGGCCAAGGTCTTTCGATGACTTT GCTGCAGATGACCGGCATGTACCAGGCCATCGCCAACGATGGAGTGCGGGTACCCCCACGCATTATCAAGGCCACCGTCG CACCCGACGGCAGCCGGACCGAAGAACCGCGCCCCGACGACATTCGCGTGGTGTCGGCGCAGACCGCCCAGACCGTGCGC CAGATGCTGCGTGCCGTGGTGCAACGCGATCCGATGGGCTACCAGCAGGGTACCGGGCCGACGGCCGGGGTGCCCGGCTA TCAGATGGCCGGCAAGACCGGTACCGCGCAGCAGATCAACCCTGGCTGCGGCTGCTACTTCGACGACGTGTATTGGATCA CCTTCGCCGGAATCGCCACTGCCGACAATCCCCGCTACGTGATCGGCATCATGTTGGACAACCCGGCGCGCAACTCCGAC GGCGCGCCTGGGCACTCGGCCGCCCCGCTGTTCCACAACATCGCGGGCTGGCTGATGCAGCGCGAAAACGTCCCGCTGTC ACCCGATCCCGGGCCTCCTTTGGTCTTGCAGGCCACCTAG
Upstream 100 bases:
>100_bases GGTCGCAACCCATGGTGGCACCACCCGCTCCAGTGCCGGCCAACGGCGAACAGTTCGGTCCCGTCACGGCGCCGGTGCCA ACGGCGCCGGGGGCTCCCAG
Downstream 100 bases:
>100_bases GGCGGCGGCGCCGGTAACGGCGCGCGCCGGTTCGTTTCGGCTCCAACAACTTTTGCGCAACATGCGCGCGCTGACGATCG GGTTGGCGGAAGCGCTTTTA
Product: putative penicillin-binding membrane protein pbpB
Products: NA
Alternate protein names: PBP-2 [H]
Number of amino acids: Translated: 679; Mature: 678
Protein sequence:
>679_residues MSRAAPRRASQSQSTRPARGLRRPPGAQEVGQRKRPGKTQKARQAQEATKSRPATRSDVAPAGRSTRARRTRQVVDVGTR GASFVFRHRTGNAVILVLMLVAATQLFFLQVSHAAGLRAQAAGQLKVTDVQPAARGSIVDRNNDRLAFTIEARALTFQPK RIRRQLEEARKKTSAAPDPQQRLRDIAQEVAGKLNNKPDAAAVLKKLQSDETFVYLARAVDPAVASAICAKYPEVGAERQ DLRQYPGGSLAANVVGGIDWDGHGLLGLEDSLDAVLAGTDGSVTYDRGSDGVVIPGSYRNRHKAVHGSTVVLTLDNDIQF YVQQQVQQAKNLSGAHNVSAVVLDAKTGEVLAMANDNTFDPSQDIGRQGDKQLGNPAVSSPFEPGSVNKIVAASAVIEHG LSSPDEVLQVPGSIQMGGVTVHDAWEHGVMPYTTTGVFGKSSNVGTLMLSQRVGPERYYDMLRKFGLGQRTGVGLPGESA GLVPPIDQWSGSTFANLPIGQGLSMTLLQMTGMYQAIANDGVRVPPRIIKATVAPDGSRTEEPRPDDIRVVSAQTAQTVR QMLRAVVQRDPMGYQQGTGPTAGVPGYQMAGKTGTAQQINPGCGCYFDDVYWITFAGIATADNPRYVIGIMLDNPARNSD GAPGHSAAPLFHNIAGWLMQRENVPLSPDPGPPLVLQAT
Sequences:
>Translated_679_residues MSRAAPRRASQSQSTRPARGLRRPPGAQEVGQRKRPGKTQKARQAQEATKSRPATRSDVAPAGRSTRARRTRQVVDVGTR GASFVFRHRTGNAVILVLMLVAATQLFFLQVSHAAGLRAQAAGQLKVTDVQPAARGSIVDRNNDRLAFTIEARALTFQPK RIRRQLEEARKKTSAAPDPQQRLRDIAQEVAGKLNNKPDAAAVLKKLQSDETFVYLARAVDPAVASAICAKYPEVGAERQ DLRQYPGGSLAANVVGGIDWDGHGLLGLEDSLDAVLAGTDGSVTYDRGSDGVVIPGSYRNRHKAVHGSTVVLTLDNDIQF YVQQQVQQAKNLSGAHNVSAVVLDAKTGEVLAMANDNTFDPSQDIGRQGDKQLGNPAVSSPFEPGSVNKIVAASAVIEHG LSSPDEVLQVPGSIQMGGVTVHDAWEHGVMPYTTTGVFGKSSNVGTLMLSQRVGPERYYDMLRKFGLGQRTGVGLPGESA GLVPPIDQWSGSTFANLPIGQGLSMTLLQMTGMYQAIANDGVRVPPRIIKATVAPDGSRTEEPRPDDIRVVSAQTAQTVR QMLRAVVQRDPMGYQQGTGPTAGVPGYQMAGKTGTAQQINPGCGCYFDDVYWITFAGIATADNPRYVIGIMLDNPARNSD GAPGHSAAPLFHNIAGWLMQRENVPLSPDPGPPLVLQAT >Mature_678_residues SRAAPRRASQSQSTRPARGLRRPPGAQEVGQRKRPGKTQKARQAQEATKSRPATRSDVAPAGRSTRARRTRQVVDVGTRG ASFVFRHRTGNAVILVLMLVAATQLFFLQVSHAAGLRAQAAGQLKVTDVQPAARGSIVDRNNDRLAFTIEARALTFQPKR IRRQLEEARKKTSAAPDPQQRLRDIAQEVAGKLNNKPDAAAVLKKLQSDETFVYLARAVDPAVASAICAKYPEVGAERQD LRQYPGGSLAANVVGGIDWDGHGLLGLEDSLDAVLAGTDGSVTYDRGSDGVVIPGSYRNRHKAVHGSTVVLTLDNDIQFY VQQQVQQAKNLSGAHNVSAVVLDAKTGEVLAMANDNTFDPSQDIGRQGDKQLGNPAVSSPFEPGSVNKIVAASAVIEHGL SSPDEVLQVPGSIQMGGVTVHDAWEHGVMPYTTTGVFGKSSNVGTLMLSQRVGPERYYDMLRKFGLGQRTGVGLPGESAG LVPPIDQWSGSTFANLPIGQGLSMTLLQMTGMYQAIANDGVRVPPRIIKATVAPDGSRTEEPRPDDIRVVSAQTAQTVRQ MLRAVVQRDPMGYQQGTGPTAGVPGYQMAGKTGTAQQINPGCGCYFDDVYWITFAGIATADNPRYVIGIMLDNPARNSDG APGHSAAPLFHNIAGWLMQRENVPLSPDPGPPLVLQAT
Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]
COG id: COG0768
COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2
Gene ontology:
Cell location: Cell inner membrane; Peripheral membrane protein [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1786272, Length=593, Percent_Identity=28.8364249578415, Blast_Score=191, Evalue=2e-49, Organism=Escherichia coli, GI1786854, Length=579, Percent_Identity=23.6614853195164, Blast_Score=86, Evalue=8e-18,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR005311 - InterPro: IPR001460 [H]
Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]
EC number: NA
Molecular weight: Translated: 72538; Mature: 72407
Theoretical pI: Translated: 10.08; Mature: 10.08
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSRAAPRRASQSQSTRPARGLRRPPGAQEVGQRKRPGKTQKARQAQEATKSRPATRSDVA CCCCCCCCCCCCCCCCCHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCC PAGRSTRARRTRQVVDVGTRGASFVFRHRTGNAVILVLMLVAATQLFFLQVSHAAGLRAQ CCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH AAGQLKVTDVQPAARGSIVDRNNDRLAFTIEARALTFQPKRIRRQLEEARKKTSAAPDPQ CCCCEEEEECCCCCCCCEEECCCCEEEEEEEEEEEEECHHHHHHHHHHHHHHCCCCCCHH QRLRDIAQEVAGKLNNKPDAAAVLKKLQSDETFVYLARAVDPAVASAICAKYPEVGAERQ HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEHHHCHHHHHHHHHHCCCCCCCHH DLRQYPGGSLAANVVGGIDWDGHGLLGLEDSLDAVLAGTDGSVTYDRGSDGVVIPGSYRN HHHHCCCCCEEHHHHCCCCCCCCCEECCCCCCCEEEECCCCCEEEECCCCCEEECCCCCC RHKAVHGSTVVLTLDNDIQFYVQQQVQQAKNLSGAHNVSAVVLDAKTGEVLAMANDNTFD CCCEECCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEECCCCCC PSQDIGRQGDKQLGNPAVSSPFEPGSVNKIVAASAVIEHGLSSPDEVLQVPGSIQMGGVT CHHHHHCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCEE VHDAWEHGVMPYTTTGVFGKSSNVGTLMLSQRVGPERYYDMLRKFGLGQRTGVGLPGESA EECCHHCCCCCEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCC GLVPPIDQWSGSTFANLPIGQGLSMTLLQMTGMYQAIANDGVRVPPRIIKATVAPDGSRT CCCCCHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHEEEEECCCCCCC EEPRPDDIRVVSAQTAQTVRQMLRAVVQRDPMGYQQGTGPTAGVPGYQMAGKTGTAQQIN CCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCC PGCGCYFDDVYWITFAGIATADNPRYVIGIMLDNPARNSDGAPGHSAAPLFHNIAGWLMQ CCCCEEECCEEEEEEECEEECCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH RENVPLSPDPGPPLVLQAT CCCCCCCCCCCCCEEEEEC >Mature Secondary Structure SRAAPRRASQSQSTRPARGLRRPPGAQEVGQRKRPGKTQKARQAQEATKSRPATRSDVA CCCCCCCCCCCCCCCCHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCC PAGRSTRARRTRQVVDVGTRGASFVFRHRTGNAVILVLMLVAATQLFFLQVSHAAGLRAQ CCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH AAGQLKVTDVQPAARGSIVDRNNDRLAFTIEARALTFQPKRIRRQLEEARKKTSAAPDPQ CCCCEEEEECCCCCCCCEEECCCCEEEEEEEEEEEEECHHHHHHHHHHHHHHCCCCCCHH QRLRDIAQEVAGKLNNKPDAAAVLKKLQSDETFVYLARAVDPAVASAICAKYPEVGAERQ HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEHHHCHHHHHHHHHHCCCCCCCHH DLRQYPGGSLAANVVGGIDWDGHGLLGLEDSLDAVLAGTDGSVTYDRGSDGVVIPGSYRN HHHHCCCCCEEHHHHCCCCCCCCCEECCCCCCCEEEECCCCCEEEECCCCCEEECCCCCC RHKAVHGSTVVLTLDNDIQFYVQQQVQQAKNLSGAHNVSAVVLDAKTGEVLAMANDNTFD CCCEECCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEECCCCCC PSQDIGRQGDKQLGNPAVSSPFEPGSVNKIVAASAVIEHGLSSPDEVLQVPGSIQMGGVT CHHHHHCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCEE VHDAWEHGVMPYTTTGVFGKSSNVGTLMLSQRVGPERYYDMLRKFGLGQRTGVGLPGESA EECCHHCCCCCEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCC GLVPPIDQWSGSTFANLPIGQGLSMTLLQMTGMYQAIANDGVRVPPRIIKATVAPDGSRT CCCCCHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHEEEEECCCCCCC EEPRPDDIRVVSAQTAQTVRQMLRAVVQRDPMGYQQGTGPTAGVPGYQMAGKTGTAQQIN CCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCC PGCGCYFDDVYWITFAGIATADNPRYVIGIMLDNPARNSDGAPGHSAAPLFHNIAGWLMQ CCCCEEECCEEEEEEECEEECCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH RENVPLSPDPGPPLVLQAT CCCCCCCCCCCCCEEEEEC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 3126399 [H]