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The map label for this gene is pyrD [H]

Identifier: 121638021

GI number: 121638021

Start: 2378730

End: 2379803

Strand: Direct

Name: pyrD [H]

Synonym: BCG_2156

Alternate gene names: 121638021

Gene position: 2378730-2379803 (Clockwise)

Preceding gene: 121638020

Following gene: 121638025

Centisome position: 54.38

GC content: 68.62

Gene sequence:

>1074_bases
ATGTATCCCCTGGTGCGTCGGCTGTTGTTCCTGATCCCACCCGAGCACGCGCACAAGTTGGTTTTCGCCGTGCTGCGCGG
CGTGGCCGCCGTGGCGCCAGTGTGCCGGCTCTTGCGCCGACTGCTGGGCCCGACGGATCCGGTGCTGGCCAGCACGGTGT
TCGGGGTGCGCTTCCCGGCACCGCTCGGGCTGGCCGCGGGGTTCGACAAGGACGGCACCGCACTATCCAGTTGGGGTGCG
ATGGGGTTCGGCTACGCCGAGATCGGCACCGTCACCGCTCATCCGCAGCCCGGCAACCCGGCCCCCCGCCTGTTCCGGCT
GGCCGACGACCGCGCCCTGCTGAACCGGATGGGGTTCAACAATCACGGTGCCCGGGCACTGGCGATCCGACTCGCGCGGC
ACCGACCCGAGATCCCGATCGGGGTGAATATCGGCAAGACCAAGAAAACGCCGGCCGGCGACGCGGTCAACGACTACCGG
GCCAGCGCCCGGATGGTCGGCCCGCTGGCGTCGTATCTGGTGGTCAACGTCAGCTCTCCGAACACACCGGGGTTACGCGA
TCTGCAGGCGGTCGAATCGCTGCGGCCCATCCTGTCTGCCGTCCGCGCCGAGACTTCGACGCCGGTGCTGGTGAAGATCG
CGCCGGACTTGTCCGATTCCGACCTCGACGACATCGCGGACCTGGCCGTCGAGCTAGACCTGGCCGGCATCGTGGCAACC
AACACCACGGTGTCACGCGACGGCCTGACCACACCGGGGGTCGACCGGTTGGGTCCCGGCGGCATCTCGGGGCCACCGCT
GGCTCAGCGCGCGGTCCAGGTGCTGCGTCGGCTCTATGACCGGGTCGGTGATCGATTGGCGCTGATCAGCGTGGGCGGGA
TCGAGACGGCCGACGACGCGTGGGAGCGCATCACAGCGGGCGCATCGCTGCTACAGGGCTATACCGGCTTCATCTACGGC
GGGGAACGGTGGGCCAAGGACATCCATGAAGGCATTGCCCGCAGGCTGCATGACGGCGGGTTCGGCTCGCTGCACGAAGC
GGTCGGCTCGGCAAGACGTCGGCAACCCAGCTAA

Upstream 100 bases:

>100_bases
AGAAATCTCGCTGGGCAGACGCAGAGGCGAACCGCCGGCCAGACCAGCCGCAGCTGTGGCTCTGAAGGCCGGGGCCAGCC
CGCGCGCAGACCGCTATCGG

Downstream 100 bases:

>100_bases
AGCGCTAACGCTGCTCGTAGGTGCCGAAGATGACCGCTCGTGCAATCGCGTGCTGGAACAGGTTGAATCCCAGATATGCA
GGACTCGCGTCCTCGGGGAG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MYPLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVCRLLRRLLGPTDPVLASTVFGVRFPAPLGLAAGFDKDGTALSSWGA
MGFGYAEIGTVTAHPQPGNPAPRLFRLADDRALLNRMGFNNHGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYR
ASARMVGPLASYLVVNVSSPNTPGLRDLQAVESLRPILSAVRAETSTPVLVKIAPDLSDSDLDDIADLAVELDLAGIVAT
NTTVSRDGLTTPGVDRLGPGGISGPPLAQRAVQVLRRLYDRVGDRLALISVGGIETADDAWERITAGASLLQGYTGFIYG
GERWAKDIHEGIARRLHDGGFGSLHEAVGSARRRQPS

Sequences:

>Translated_357_residues
MYPLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVCRLLRRLLGPTDPVLASTVFGVRFPAPLGLAAGFDKDGTALSSWGA
MGFGYAEIGTVTAHPQPGNPAPRLFRLADDRALLNRMGFNNHGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYR
ASARMVGPLASYLVVNVSSPNTPGLRDLQAVESLRPILSAVRAETSTPVLVKIAPDLSDSDLDDIADLAVELDLAGIVAT
NTTVSRDGLTTPGVDRLGPGGISGPPLAQRAVQVLRRLYDRVGDRLALISVGGIETADDAWERITAGASLLQGYTGFIYG
GERWAKDIHEGIARRLHDGGFGSLHEAVGSARRRQPS
>Mature_357_residues
MYPLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVCRLLRRLLGPTDPVLASTVFGVRFPAPLGLAAGFDKDGTALSSWGA
MGFGYAEIGTVTAHPQPGNPAPRLFRLADDRALLNRMGFNNHGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYR
ASARMVGPLASYLVVNVSSPNTPGLRDLQAVESLRPILSAVRAETSTPVLVKIAPDLSDSDLDDIADLAVELDLAGIVAT
NTTVSRDGLTTPGVDRLGPGGISGPPLAQRAVQVLRRLYDRVGDRLALISVGGIETADDAWERITAGASLLQGYTGFIYG
GERWAKDIHEGIARRLHDGGFGSLHEAVGSARRRQPS

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=360, Percent_Identity=43.0555555555556, Blast_Score=249, Evalue=3e-66,
Organism=Escherichia coli, GI1787177, Length=337, Percent_Identity=43.620178041543, Blast_Score=261, Evalue=4e-71,
Organism=Escherichia coli, GI87082059, Length=335, Percent_Identity=27.4626865671642, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17509475, Length=326, Percent_Identity=39.8773006134969, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI281361352, Length=359, Percent_Identity=37.3259052924791, Blast_Score=230, Evalue=9e-61,
Organism=Drosophila melanogaster, GI17137316, Length=359, Percent_Identity=37.3259052924791, Blast_Score=230, Evalue=9e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 37946; Mature: 37946

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVCRLLRRLLGPTDPVLASTVFGVRFPA
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
PLGLAAGFDKDGTALSSWGAMGFGYAEIGTVTAHPQPGNPAPRLFRLADDRALLNRMGFN
CCCHHCCCCCCCCHHHHCCCCCCCHHHHCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCC
NHGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYRASARMVGPLASYLVVNVSSP
CCCHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCC
NTPGLRDLQAVESLRPILSAVRAETSTPVLVKIAPDLSDSDLDDIADLAVELDLAGIVAT
CCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHEEEEE
NTTVSRDGLTTPGVDRLGPGGISGPPLAQRAVQVLRRLYDRVGDRLALISVGGIETADDA
CCEECCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHH
WERITAGASLLQGYTGFIYGGERWAKDIHEGIARRLHDGGFGSLHEAVGSARRRQPS
HHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYPLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVCRLLRRLLGPTDPVLASTVFGVRFPA
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
PLGLAAGFDKDGTALSSWGAMGFGYAEIGTVTAHPQPGNPAPRLFRLADDRALLNRMGFN
CCCHHCCCCCCCCHHHHCCCCCCCHHHHCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCC
NHGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYRASARMVGPLASYLVVNVSSP
CCCHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCC
NTPGLRDLQAVESLRPILSAVRAETSTPVLVKIAPDLSDSDLDDIADLAVELDLAGIVAT
CCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHEEEEE
NTTVSRDGLTTPGVDRLGPGGISGPPLAQRAVQVLRRLYDRVGDRLALISVGGIETADDA
CCEECCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHH
WERITAGASLLQGYTGFIYGGERWAKDIHEGIARRLHDGGFGSLHEAVGSARRRQPS
HHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]