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The map label for this gene is cobH

Identifier: 121637950

GI number: 121637950

Start: 2306204

End: 2306830

Strand: Direct

Name: cobH

Synonym: BCG_2084

Alternate gene names: 121637950

Gene position: 2306204-2306830 (Clockwise)

Preceding gene: 121637949

Following gene: 121637951

Centisome position: 52.72

GC content: 72.25

Gene sequence:

>627_bases
GTGCTCGACTACCTACGCGACGCCGCGGAAATCTACCGGCGGTCATTCGCGGTTATCCGCGCCGAGGCCGATCTGGCGCG
CTTCCCCGCCGACGTCGCGCGGGTGGTGGTTCGGTTGATTCACACCTGCGGGCAGGTCGACGTCGCCGAGCATGTGGCCT
ACACCGACGACGTCGTCGCGCGGGCGGGTGCCGCGCTGGCCGCCGGTGCCCCGGTGCTGTGCGATTCGTCGATGGTGGCC
GCCGGGATCACCACCTCGCGGCTGCCCGCCGACAACCAGATCGTCTCGCTGGTCGCCGATCCACGCGCCACCGAGCTGGC
CGCCCGTCGCCAGACCACCCGATCGGCGGCCGGGGTCGAGCTGTGTGCCGAGCGGCTGCCCGGCGCGGTGCTGGCCATAG
GCAACGCGCCCACCGCGCTGTTTCGGCTGCTCGAACTGGTCGACGAAGGGGCACCCCCACCGGCGGCCGTGCTGGGCGGA
CCGGTGGGTTTCGTCGGATCGGCACAGGCCAAAGAGGAGCTCATCGAGCGGCCCCGCGGGATGTCCTACCTGGTGGTGCG
CGGTCGCCGCGGCGGCAGCGCGATGGCCGCCGCCGCCGTCAATGCGATAGCCAGCGACCGCGAATGA

Upstream 100 bases:

>100_bases
TTTCGTCGGCTGCGAGCGGGCCTGCGGCAGCCCACCGGCCGGCGAGGTGCTGGTCGCCACCGGCGGTGGATACCGGCGAT
TGCGGCCGTAGGGTGAGCGA

Downstream 100 bases:

>100_bases
GCGCTCGGGGCACGCTGTGGGGAGTCGGGCTGGGGCCCGGCGATCCGGAGTTGGTGACCGTCAAGGCCGCCCGGGTGATT
GGCGAGGCCGATGTGGTGGC

Product: precorrin-8X methylmutase

Products: NA

Alternate protein names: HBA synthase; Precorrin isomerase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MLDYLRDAAEIYRRSFAVIRAEADLARFPADVARVVVRLIHTCGQVDVAEHVAYTDDVVARAGAALAAGAPVLCDSSMVA
AGITTSRLPADNQIVSLVADPRATELAARRQTTRSAAGVELCAERLPGAVLAIGNAPTALFRLLELVDEGAPPPAAVLGG
PVGFVGSAQAKEELIERPRGMSYLVVRGRRGGSAMAAAAVNAIASDRE

Sequences:

>Translated_208_residues
MLDYLRDAAEIYRRSFAVIRAEADLARFPADVARVVVRLIHTCGQVDVAEHVAYTDDVVARAGAALAAGAPVLCDSSMVA
AGITTSRLPADNQIVSLVADPRATELAARRQTTRSAAGVELCAERLPGAVLAIGNAPTALFRLLELVDEGAPPPAAVLGG
PVGFVGSAQAKEELIERPRGMSYLVVRGRRGGSAMAAAAVNAIASDRE
>Mature_208_residues
MLDYLRDAAEIYRRSFAVIRAEADLARFPADVARVVVRLIHTCGQVDVAEHVAYTDDVVARAGAALAAGAPVLCDSSMVA
AGITTSRLPADNQIVSLVADPRATELAARRQTTRSAAGVELCAERLPGAVLAIGNAPTALFRLLELVDEGAPPPAAVLGG
PVGFVGSAQAKEELIERPRGMSYLVVRGRRGGSAMAAAAVNAIASDRE

Specific function: Catalyzes the conversion of precorrin-8X to hydrogenobyrinic acid; a methyl migration reaction during the transformation of precorrin-3 to form cobyrinic acid

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBH_MYCBO (P63840)

Other databases:

- EMBL:   BX248341
- RefSeq:   NP_855741.1
- ProteinModelPortal:   P63840
- SMR:   P63840
- EnsemblBacteria:   EBMYCT00000018077
- GeneID:   1094148
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2091
- GeneTree:   EBGT00050000016191
- HOGENOM:   HBG553498
- OMA:   KAGIRYN
- ProtClustDB:   PRK08285
- BioCyc:   MBOV233413:MB2091-MONOMER
- BRENDA:   5.4.1.2
- InterPro:   IPR003722
- Gene3D:   G3DSA:3.40.50.10230

Pfam domain/function: PF02570 CbiC; SSF63965 CbiC

EC number: =5.4.1.2

Molecular weight: Translated: 21614; Mature: 21614

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: ACT_SITE 41-41

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDYLRDAAEIYRRSFAVIRAEADLARFPADVARVVVRLIHTCGQVDVAEHVAYTDDVVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RAGAALAAGAPVLCDSSMVAAGITTSRLPADNQIVSLVADPRATELAARRQTTRSAAGVE
HHCHHHHCCCCCEECCCHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
LCAERLPGAVLAIGNAPTALFRLLELVDEGAPPPAAVLGGPVGFVGSAQAKEELIERPRG
HHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHHHCCCC
MSYLVVRGRRGGSAMAAAAVNAIASDRE
CEEEEEECCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLDYLRDAAEIYRRSFAVIRAEADLARFPADVARVVVRLIHTCGQVDVAEHVAYTDDVVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RAGAALAAGAPVLCDSSMVAAGITTSRLPADNQIVSLVADPRATELAARRQTTRSAAGVE
HHCHHHHCCCCCEECCCHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
LCAERLPGAVLAIGNAPTALFRLLELVDEGAPPPAAVLGGPVGFVGSAQAKEELIERPRG
HHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHHHCCCC
MSYLVVRGRRGGSAMAAAAVNAIASDRE
CEEEEEECCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972