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The map label for this gene is aceA [H]

Identifier: 121637821

GI number: 121637821

Start: 2161493

End: 2163793

Strand: Direct

Name: aceA [H]

Synonym: BCG_1954

Alternate gene names: 121637821

Gene position: 2161493-2163793 (Clockwise)

Preceding gene: 121637819

Following gene: 121637825

Centisome position: 49.41

GC content: 64.62

Gene sequence:

>2301_bases
ATGGCCATCGCCGAAACGGACACCGAGGTCCACACACCGTTCGAGCAGGACTTTGAGAAAGACGTAGCCGCCACTCAGCG
ATACTTCGACAGCTCGCGCTTTGCTGGGATCATTCGGCTCTACACCGCCCGCCAAGTCGTGGAACAGCGCGGCACGATCC
CCGTCGACCACATCGTGGCGCGAGAGGCGGCGGGCGCCTTCTACGAGCGTCTGCGCGAACTCTTTGCAGCCCGCAAGAGC
ATCACGACGTTTGGCCCCTACTCGCCGGGGCAGGCGGTGAGCATGAAGCGGATGGGTATCGAGGCGATCTACCTCGGTGG
TTGGGCTACCTCAGCTAAGGGCTCCAGCACCGAAGATCCGGGGCCCGACCTCGCCAGCTACCCGCTGAGCCAGGTGCCTG
ACGATGCCGCGGTGCTGGTGCGCGCCTTGCTCACCGCGGACCGCAACCAACACTATCTACGCCTGCAGATGAGCGAGCGA
CAGCGTGCGGCGACACCGGCTTACGACTTCCGCCCGTTTATCATCGCCGACGCCGACACCGGCCACGGCGGCGATCCGCA
CGTACGCAACCTGATCCGCCGCTTCGTCGAGGTCGGTGTGCCGGGCTACCACATCGAGGACCAACGACCCGGCACCAAGA
AGTGCGGCCACCAGGGCGGCAAGGTCCTGGTGCCGTCCGACGAACAGATCAAGCGGCTCAACGCCGCCCGCTTCCAGCTC
GACATCATGCGGGTGCCCGGCATCATCGTCGCACGCACCGACGCGGAGGCGGCCAACCTGATCGACAGTCGCGCCGACGA
GCGTGACCAGCCGTTCCTTCTCGGCGCGACCAAGCTCGACGTACCGTCCTACAAGTCCTGTTTCCTGGCAATGGTGCGGC
GTTTTTACGAACTGGGCGTCAAGGAGCTCAATGGTCATCTTCTCTATGCGCTTGGCGACAGCGAGTACGCGGCGGCCGGC
GGTTGGCTTGAGCGCCAAGGCATTTTCGGCTTGGTCTCCGACGCGGTCAACGCGTGGCGGGAGGACGGCCAGCAGTCGAT
CGACGGCATTTTCGACCAGGTCGAGTCGCGGTTCGTGGCGGCCTGGGAGGACGACGCGGGCCTGATGACCTACGGAGAGG
CCGTGGCGGACGTGCTCGAATTCGGTCAGAGCGAGGGCGAACCCATTGGCATGGCTCCCGAGGAGTGGCGGGCGTTCGCC
GCGCGTGCATCGCTGCATGCCGCCCGGGCAAAGGCCAAGGAGCTGGGCGCCGATCCGCCATGGGACTGCGAGCTGGCCAA
GACCCCGGAGGGCTACTACCAGATCCGCGGCGGCATACCGTATGCGATCGCCAAATCGCTGGCCGCGGCACCGTTTGCCG
ACATTCTTTGGATGGAGACCAAGACCGCCGATCTCGCCGACGCTCGACAGTTCGCCGAGGCGATCCATGCCGAGTTCCCC
GACCAGATGCTGGCGTACAACCTCTCACCATCGTTCAACTGGGACACCACCGGCATGACCGACGAGGAGATGCGGCGCTT
CCCCGAGGAGCTCGGCAAAATGGGCTTCGTCTTCAACTTCATCACCTATGGCGGGCACCAGATCGACGGTGTCGCGGCCG
AGGAATTCGCCACCGCGCTGCGCCAGGACGGCATGCTGGCGCTGGCTCGGTTGCAGCGCAAGATGCGCTTGGTCGAATCT
CCCTATCGCACACCGCAAACGCTAGTCGGCGGGCCGCGCAGTGACGCCGCATTGGCTGCCTCCTCCGGACGCACGGCGAC
CACGAAGGCAATGGGCAAGGGCTCCACCCAGCACCAGCACTTGGTGCAAACTGAGGTGCCGCGCAAGCTGCTAGAGGAAT
GGCTGGCCATGTGGAGCGGTCACTACCAGCTCAAAGACAAACTGCGCGTACAGCTTCGGCCGCAGCGGGCCGGCTCGGAG
GTGCTCGAGCTCGGCATCCACGGCGAAAGCGATGACAAGCTCGCCAACGTGATATTCCAACCGATCCAAGATCGCCGCGG
CCGCACCATCCTGTTGGTACGCGACCAGAACACGTTCGGTGCGGAACTACGCCAAAAGCGGCTGATGACCCTGATCCACC
TCTGGCTCGTCCACCGCTTCAAGGCGCAGGCGGTGCACTACGTCACGCCCACCGACGACAACCTCTACCAGACCTCGAAG
ATGAAGTCGCATGGAATCTTCACCGAGGTCAACCAGGAGGTGGGCGAGATCATCGTCGCCGAGGTGAACCACCCGCGCAT
CGCCGAACTGCTGACGCCCGATCGGGTGGCGCTGCGGAAGTTGATCACGAAGGAGGCGTAG

Upstream 100 bases:

>100_bases
GCGGAATTTGCGAGCCGTCATCGGTCAGTGATCTAGGTCGCCCGTCCGGGGATACACTCGGTCCGTCAGGTGAATCGGGG
CTGCAGAGGAGCGCAAGGCC

Downstream 100 bases:

>100_bases
CCAGCGCTGCCAACTGTCTTGGGGGCCAACCGGGTGTGCGTCGAGGTGGCGCACATCGCGAAACGCGAAGGATGCTGTCA
GACGGCGTCTGCGGTGGCCT

Product: putative isocitrate lyase aceA

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 766; Mature: 765

Protein sequence:

>766_residues
MAIAETDTEVHTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRGTIPVDHIVAREAAGAFYERLRELFAARKS
ITTFGPYSPGQAVSMKRMGIEAIYLGGWATSAKGSSTEDPGPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSER
QRAATPAYDFRPFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNAARFQL
DIMRVPGIIVARTDAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAMVRRFYELGVKELNGHLLYALGDSEYAAAG
GWLERQGIFGLVSDAVNAWREDGQQSIDGIFDQVESRFVAAWEDDAGLMTYGEAVADVLEFGQSEGEPIGMAPEEWRAFA
ARASLHAARAKAKELGADPPWDCELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADARQFAEAIHAEFP
DQMLAYNLSPSFNWDTTGMTDEEMRRFPEELGKMGFVFNFITYGGHQIDGVAAEEFATALRQDGMLALARLQRKMRLVES
PYRTPQTLVGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPRKLLEEWLAMWSGHYQLKDKLRVQLRPQRAGSE
VLELGIHGESDDKLANVIFQPIQDRRGRTILLVRDQNTFGAELRQKRLMTLIHLWLVHRFKAQAVHYVTPTDDNLYQTSK
MKSHGIFTEVNQEVGEIIVAEVNHPRIAELLTPDRVALRKLITKEA

Sequences:

>Translated_766_residues
MAIAETDTEVHTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRGTIPVDHIVAREAAGAFYERLRELFAARKS
ITTFGPYSPGQAVSMKRMGIEAIYLGGWATSAKGSSTEDPGPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSER
QRAATPAYDFRPFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNAARFQL
DIMRVPGIIVARTDAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAMVRRFYELGVKELNGHLLYALGDSEYAAAG
GWLERQGIFGLVSDAVNAWREDGQQSIDGIFDQVESRFVAAWEDDAGLMTYGEAVADVLEFGQSEGEPIGMAPEEWRAFA
ARASLHAARAKAKELGADPPWDCELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADARQFAEAIHAEFP
DQMLAYNLSPSFNWDTTGMTDEEMRRFPEELGKMGFVFNFITYGGHQIDGVAAEEFATALRQDGMLALARLQRKMRLVES
PYRTPQTLVGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPRKLLEEWLAMWSGHYQLKDKLRVQLRPQRAGSE
VLELGIHGESDDKLANVIFQPIQDRRGRTILLVRDQNTFGAELRQKRLMTLIHLWLVHRFKAQAVHYVTPTDDNLYQTSK
MKSHGIFTEVNQEVGEIIVAEVNHPRIAELLTPDRVALRKLITKEA
>Mature_765_residues
AIAETDTEVHTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRGTIPVDHIVAREAAGAFYERLRELFAARKSI
TTFGPYSPGQAVSMKRMGIEAIYLGGWATSAKGSSTEDPGPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSERQ
RAATPAYDFRPFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNAARFQLD
IMRVPGIIVARTDAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAMVRRFYELGVKELNGHLLYALGDSEYAAAGG
WLERQGIFGLVSDAVNAWREDGQQSIDGIFDQVESRFVAAWEDDAGLMTYGEAVADVLEFGQSEGEPIGMAPEEWRAFAA
RASLHAARAKAKELGADPPWDCELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADARQFAEAIHAEFPD
QMLAYNLSPSFNWDTTGMTDEEMRRFPEELGKMGFVFNFITYGGHQIDGVAAEEFATALRQDGMLALARLQRKMRLVESP
YRTPQTLVGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPRKLLEEWLAMWSGHYQLKDKLRVQLRPQRAGSEV
LELGIHGESDDKLANVIFQPIQDRRGRTILLVRDQNTFGAELRQKRLMTLIHLWLVHRFKAQAVHYVTPTDDNLYQTSKM
KSHGIFTEVNQEVGEIIVAEVNHPRIAELLTPDRVALRKLITKEA

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=251, Percent_Identity=37.8486055776892, Blast_Score=155, Evalue=1e-38,
Organism=Escherichia coli, GI1786525, Length=227, Percent_Identity=28.1938325991189, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17561814, Length=241, Percent_Identity=38.5892116182573, Blast_Score=165, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI71982926, Length=241, Percent_Identity=38.5892116182573, Blast_Score=165, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6320908, Length=594, Percent_Identity=32.6599326599327, Blast_Score=281, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6325263, Length=590, Percent_Identity=30, Blast_Score=244, Evalue=4e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 85321; Mature: 85189

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIAETDTEVHTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRGTIPVDHIVA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
REAAGAFYERLRELFAARKSITTFGPYSPGQAVSMKRMGIEAIYLGGWATSAKGSSTEDP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCEEEEECCEECCCCCCCCCCC
GPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSERQRAATPAYDFRPFIIADADT
CCCHHCCCHHHCCCHHHHHHHHHHHCCCCCCEEEEEEHHHHHCCCCCCCCCCEEEEECCC
GHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNAARFQL
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCEEECCCHHHHHHHHHHHHEE
DIMRVPGIIVARTDAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAMVRRFYELGV
EEEECCCEEEEECCCHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCH
KELNGHLLYALGDSEYAAAGGWLERQGIFGLVSDAVNAWREDGQQSIDGIFDQVESRFVA
HHCCCCEEEEECCCCHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
AWEDDAGLMTYGEAVADVLEFGQSEGEPIGMAPEEWRAFAARASLHAARAKAKELGADPP
EECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
WDCELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADARQFAEAIHAEFP
CCCCCCCCCCCCEEEECCCCHHHHHHHHHCCHHHHHEEECCCCHHHHHHHHHHHHHHHCC
DQMLAYNLSPSFNWDTTGMTDEEMRRFPEELGKMGFVFNFITYGGHQIDGVAAEEFATAL
CHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCEECCCHHHHHHHHH
RQDGMLALARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSGRTATTKAMGKGSTQHQH
HHCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEECCCCCCHHHHHHCCCCCHHHH
LVQTEVPRKLLEEWLAMWSGHYQLKDKLRVQLRPQRAGSEVLELGIHGESDDKLANVIFQ
HHHHHHHHHHHHHHHHHHCCCCEECCCEEEEECCCCCCCHHHHCCCCCCCCHHHHHHHHH
PIQDRRGRTILLVRDQNTFGAELRQKRLMTLIHLWLVHRFKAQAVHYVTPTDDNLYQTSK
HHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHH
MKSHGIFTEVNQEVGEIIVAEVNHPRIAELLTPDRVALRKLITKEA
HHHCCCHHHHHHHHCCEEEEECCCCHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
AIAETDTEVHTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRGTIPVDHIVA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
REAAGAFYERLRELFAARKSITTFGPYSPGQAVSMKRMGIEAIYLGGWATSAKGSSTEDP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCEEEEECCEECCCCCCCCCCC
GPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSERQRAATPAYDFRPFIIADADT
CCCHHCCCHHHCCCHHHHHHHHHHHCCCCCCEEEEEEHHHHHCCCCCCCCCCEEEEECCC
GHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNAARFQL
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCEEECCCHHHHHHHHHHHHEE
DIMRVPGIIVARTDAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAMVRRFYELGV
EEEECCCEEEEECCCHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCH
KELNGHLLYALGDSEYAAAGGWLERQGIFGLVSDAVNAWREDGQQSIDGIFDQVESRFVA
HHCCCCEEEEECCCCHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
AWEDDAGLMTYGEAVADVLEFGQSEGEPIGMAPEEWRAFAARASLHAARAKAKELGADPP
EECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
WDCELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADARQFAEAIHAEFP
CCCCCCCCCCCCEEEECCCCHHHHHHHHHCCHHHHHEEECCCCHHHHHHHHHHHHHHHCC
DQMLAYNLSPSFNWDTTGMTDEEMRRFPEELGKMGFVFNFITYGGHQIDGVAAEEFATAL
CHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCEECCCHHHHHHHHH
RQDGMLALARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSGRTATTKAMGKGSTQHQH
HHCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEECCCCCCHHHHHHCCCCCHHHH
LVQTEVPRKLLEEWLAMWSGHYQLKDKLRVQLRPQRAGSEVLELGIHGESDDKLANVIFQ
HHHHHHHHHHHHHHHHHHCCCCEECCCEEEEECCCCCCCHHHHCCCCCCCCHHHHHHHHH
PIQDRRGRTILLVRDQNTFGAELRQKRLMTLIHLWLVHRFKAQAVHYVTPTDDNLYQTSK
HHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHH
MKSHGIFTEVNQEVGEIIVAEVNHPRIAELLTPDRVALRKLITKEA
HHHCCCHHHHHHHHCCEEEEECCCCHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7476188; 11234002 [H]