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The map label for this gene is adhA

Identifier: 121637765

GI number: 121637765

Start: 2110503

End: 2111543

Strand: Direct

Name: adhA

Synonym: BCG_1898

Alternate gene names: 121637765

Gene position: 2110503-2111543 (Clockwise)

Preceding gene: 121637764

Following gene: 121637769

Centisome position: 48.25

GC content: 68.68

Gene sequence:

>1041_bases
ATGGTCTCACCGGCGACCACGGCGACGATGAGTGCGTGGCAGGTGCGTCGGCCCGGCCCGATGGACACCGGCCCGCTCGA
ACGAGTGACCACCCGGGTGCCGCGCCCGGCGCCATCGGAGTTGCTGGTGGCCGTGCACGCATGCGGGGTGTGCCGCACCG
ATCTCCACGTGACCGAAGGTGACCTGCCCGTGCACCGCGAACGGGTGATTCCCGGCCACGAGGTAGTGGGAGAGGTCATT
GAGGTGGGCTCAGCGGTGGGCGCGGCTGCCGGTGGCGAATTCGACCGAGGAGACCGGGTGGGTATCGCCTGGCTGCGTCA
CACTTGCGGGGTCTGCAAGTACTGCCGGCGCGGCAGCGAGAACCTCTGCCCGCAATCCCGCTACACCGGCTGGGACGCCG
ACGGGGGATACGCCGAATTCACGACGGTTCCTGCGGCTTTCGCGCACCATCTGCCGAGCGGCTATAGCGACAGCGAGCTG
GCGCCGTTGTTGTGCGCCGGCATCATCGGATATCGATCGCTGCTGCGCACCGAGCTACCACCCGGTGGCCGGCTGGGTCT
CTACGGATTCGGCGGCAGTGCCCACATCACCGCCCAGGTCGCGTTGGCGCAAGGCGCCGAAATACATGTGATGACACGCG
GGGCCCGCGCGCGCAAGCTGGCGCTGCAACTTGGCGCTGCATCGGCTCAGGACGCCGCCGACCGGCCACCCGTGCCGCTG
GACGCCGCGATCTTATTCGCCCCGGTCGGGGATCTGGTGCTGCCCGCGCTGGAAGCGCTGGACCGTGGCGGCATCTTGGC
GATCGCCGGGATCCACCTGACCGATATTCCGGACCTGAACTACCAGCAGCACTTGTTCCAGGAGCGTCAGATCCGGTCGG
TCACGTCGAACACCCGCGCCGATGCGCGCGCGTTCTTCGACTTCGCCGCCCAGCATCACATCGAGGTCACCACGCCGGAG
TACCCGCTTGGCCAAGCCGATCGTGCGCTGGGCGACCTGAGCGCCGGCCGCATCGCCGGTGCCGCCGTGCTGCTGATCTG
A

Upstream 100 bases:

>100_bases
TCGTCGGCATGGTGCGCAAGACCTAGCGCTAAACTGTTGTCGGCCATGCAAATTGAGTGTGACTGCGGCGGCCGGCGACG
GGTAGCGGCATGATGGAGTG

Downstream 100 bases:

>100_bases
CCGAGCTCAGGTCGACAGGTGCCAGACCAGGGCAGCGGCCAGGGCACCCATCCCGTTCAGCGACCAATGCAGTGCGATCG
GTGCGATCAGGCTGCCGCTG

Product: putative alcohol dehydrogenase adhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MVSPATTATMSAWQVRRPGPMDTGPLERVTTRVPRPAPSELLVAVHACGVCRTDLHVTEGDLPVHRERVIPGHEVVGEVI
EVGSAVGAAAGGEFDRGDRVGIAWLRHTCGVCKYCRRGSENLCPQSRYTGWDADGGYAEFTTVPAAFAHHLPSGYSDSEL
APLLCAGIIGYRSLLRTELPPGGRLGLYGFGGSAHITAQVALAQGAEIHVMTRGARARKLALQLGAASAQDAADRPPVPL
DAAILFAPVGDLVLPALEALDRGGILAIAGIHLTDIPDLNYQQHLFQERQIRSVTSNTRADARAFFDFAAQHHIEVTTPE
YPLGQADRALGDLSAGRIAGAAVLLI

Sequences:

>Translated_346_residues
MVSPATTATMSAWQVRRPGPMDTGPLERVTTRVPRPAPSELLVAVHACGVCRTDLHVTEGDLPVHRERVIPGHEVVGEVI
EVGSAVGAAAGGEFDRGDRVGIAWLRHTCGVCKYCRRGSENLCPQSRYTGWDADGGYAEFTTVPAAFAHHLPSGYSDSEL
APLLCAGIIGYRSLLRTELPPGGRLGLYGFGGSAHITAQVALAQGAEIHVMTRGARARKLALQLGAASAQDAADRPPVPL
DAAILFAPVGDLVLPALEALDRGGILAIAGIHLTDIPDLNYQQHLFQERQIRSVTSNTRADARAFFDFAAQHHIEVTTPE
YPLGQADRALGDLSAGRIAGAAVLLI
>Mature_346_residues
MVSPATTATMSAWQVRRPGPMDTGPLERVTTRVPRPAPSELLVAVHACGVCRTDLHVTEGDLPVHRERVIPGHEVVGEVI
EVGSAVGAAAGGEFDRGDRVGIAWLRHTCGVCKYCRRGSENLCPQSRYTGWDADGGYAEFTTVPAAFAHHLPSGYSDSEL
APLLCAGIIGYRSLLRTELPPGGRLGLYGFGGSAHITAQVALAQGAEIHVMTRGARARKLALQLGAASAQDAADRPPVPL
DAAILFAPVGDLVLPALEALDRGGILAIAGIHLTDIPDLNYQQHLFQERQIRSVTSNTRADARAFFDFAAQHHIEVTTPE
YPLGQADRALGDLSAGRIAGAAVLLI

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI156627571, Length=219, Percent_Identity=30.1369863013699, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI87081918, Length=322, Percent_Identity=29.1925465838509, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI87082401, Length=312, Percent_Identity=27.5641025641026, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1786518, Length=309, Percent_Identity=26.537216828479, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788073, Length=264, Percent_Identity=28.030303030303, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI226510992, Length=160, Percent_Identity=27.5, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1790045, Length=276, Percent_Identity=27.8985507246377, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787863, Length=132, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082125, Length=187, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=323, Percent_Identity=26.625386996904, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17562584, Length=356, Percent_Identity=27.5280898876405, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17562582, Length=334, Percent_Identity=26.3473053892216, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562876, Length=226, Percent_Identity=30.5309734513274, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562878, Length=201, Percent_Identity=30.3482587064677, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319621, Length=337, Percent_Identity=32.3442136498516, Blast_Score=143, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6323961, Length=336, Percent_Identity=29.7619047619048, Blast_Score=133, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323729, Length=335, Percent_Identity=28.6567164179104, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324486, Length=242, Percent_Identity=32.6446280991736, Blast_Score=122, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6319949, Length=208, Percent_Identity=31.7307692307692, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6323980, Length=207, Percent_Identity=29.951690821256, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADHA_MYCTU (P95153)

Other databases:

- EMBL:   BX842578
- EMBL:   AE000516
- PIR:   F70666
- RefSeq:   NP_216378.1
- RefSeq:   NP_336368.1
- ProteinModelPortal:   P95153
- SMR:   P95153
- EnsemblBacteria:   EBMYCT00000000960
- EnsemblBacteria:   EBMYCT00000070871
- GeneID:   885652
- GeneID:   923687
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1911
- KEGG:   mtu:Rv1862
- TIGR:   MT1911
- TubercuList:   Rv1862
- GeneTree:   EBGT00050000015148
- HOGENOM:   HBG753318
- OMA:   KGGIVVC
- ProtClustDB:   CLSK791440
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695
- TIGRFAMs:   TIGR02822

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.1.1.1

Molecular weight: Translated: 36632; Mature: 36632

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSPATTATMSAWQVRRPGPMDTGPLERVTTRVPRPAPSELLVAVHACGVCRTDLHVTEG
CCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCEECCCEEECC
DLPVHRERVIPGHEVVGEVIEVGSAVGAAAGGEFDRGDRVGIAWLRHTCGVCKYCRRGSE
CCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
NLCPQSRYTGWDADGGYAEFTTVPAAFAHHLPSGYSDSELAPLLCAGIIGYRSLLRTELP
CCCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
PGGRLGLYGFGGSAHITAQVALAQGAEIHVMTRGARARKLALQLGAASAQDAADRPPVPL
CCCCEEEEECCCCCEEEEEEEECCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCC
DAAILFAPVGDLVLPALEALDRGGILAIAGIHLTDIPDLNYQQHLFQERQIRSVTSNTRA
CHHHHHHHHHHHHHHHHHHHCCCCEEEEECEEEECCCCCCHHHHHHHHHHHHHHHHCCHH
DARAFFDFAAQHHIEVTTPEYPLGQADRALGDLSAGRIAGAAVLLI
HHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHCCCCHHCCEEEEEC
>Mature Secondary Structure
MVSPATTATMSAWQVRRPGPMDTGPLERVTTRVPRPAPSELLVAVHACGVCRTDLHVTEG
CCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCEECCCEEECC
DLPVHRERVIPGHEVVGEVIEVGSAVGAAAGGEFDRGDRVGIAWLRHTCGVCKYCRRGSE
CCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
NLCPQSRYTGWDADGGYAEFTTVPAAFAHHLPSGYSDSELAPLLCAGIIGYRSLLRTELP
CCCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
PGGRLGLYGFGGSAHITAQVALAQGAEIHVMTRGARARKLALQLGAASAQDAADRPPVPL
CCCCEEEEECCCCCEEEEEEEECCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCC
DAAILFAPVGDLVLPALEALDRGGILAIAGIHLTDIPDLNYQQHLFQERQIRSVTSNTRA
CHHHHHHHHHHHHHHHHHHHCCCCEEEEECEEEECCCCCCHHHHHHHHHHHHHHHHCCHH
DARAFFDFAAQHHIEVTTPEYPLGQADRALGDLSAGRIAGAAVLLI
HHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHCCCCHHCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036