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The map label for this gene is lspA

Identifier: 121637460

GI number: 121637460

Start: 1754585

End: 1755193

Strand: Direct

Name: lspA

Synonym: BCG_1591

Alternate gene names: 121637460

Gene position: 1754585-1755193 (Clockwise)

Preceding gene: 121637458

Following gene: 121637461

Centisome position: 40.11

GC content: 64.53

Gene sequence:

>609_bases
GTGCCTGACGAACCAACAGGATCGGCTGATCCGCTGACCTCGACCGAGGAAGCCGGGGGGGCGGGGGAACCTAACGCTCC
CGCGCCGCCGCGACGGCTGCGCATGCTGCTGTCGGTCGCTGTGGTGGTGCTCACACTCGACATTGTCACCAAGGTGGTAG
CTGTCCAACTGTTGCCGCCCGGCCAGCCGGTGTCGATTATCGGCGACACGGTGACCTGGACTCTGGTGCGTAATTCTGGG
GCGGCCTTCTCGATGGCGACCGGATACACCTGGGTTTTGACGCTGATTGCGACGGGTGTCGTGGTCGGAATTTTCTGGAT
GGGGCGGCGGCTGGTATCGCCGTGGTGGGCGCTGGGTCTTGGGATGATCCTGGGCGGTGCCATGGGCAACCTGGTTGATC
GCTTCTTTCGGGCACCGGGGCCGCTGCGCGGGCACGTCGTCGATTTCTTGTCGGTCGGCTGGTGGCCGGTGTTCAATGTC
GCCGATCCGTCGGTAGTCGGTGGCGCCATCCTGCTGGTCATCCTGTCGATCTTTGGCTTTGACTTCGACACCGTAGGTCG
GCGACACGCCGACGGGGACACCGTAGGTCGGCGCAAAGCCGATGGCTGA

Upstream 100 bases:

>100_bases
CGGTGAGGCGGGCCATGATGGGATCATTGCGCACGTGGTTTGCTCCCATCCGGCCGCGGGGTCTGGGCGGGCCATATCGG
CCCTAGGGGATGATGATGGT

Downstream 100 bases:

>100_bases
CCGCTCAATGCCCGTTCCGGATGGATTGGCGGGAATGCGTGTTGACACCGGACTGGCCCGCTTGCTGGGACTGTCTCGGA
CCGCTGCGGCTGCCCTCGCC

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MPDEPTGSADPLTSTEEAGGAGEPNAPAPPRRLRMLLSVAVVVLTLDIVTKVVAVQLLPPGQPVSIIGDTVTWTLVRNSG
AAFSMATGYTWVLTLIATGVVVGIFWMGRRLVSPWWALGLGMILGGAMGNLVDRFFRAPGPLRGHVVDFLSVGWWPVFNV
ADPSVVGGAILLVILSIFGFDFDTVGRRHADGDTVGRRKADG

Sequences:

>Translated_202_residues
MPDEPTGSADPLTSTEEAGGAGEPNAPAPPRRLRMLLSVAVVVLTLDIVTKVVAVQLLPPGQPVSIIGDTVTWTLVRNSG
AAFSMATGYTWVLTLIATGVVVGIFWMGRRLVSPWWALGLGMILGGAMGNLVDRFFRAPGPLRGHVVDFLSVGWWPVFNV
ADPSVVGGAILLVILSIFGFDFDTVGRRHADGDTVGRRKADG
>Mature_201_residues
PDEPTGSADPLTSTEEAGGAGEPNAPAPPRRLRMLLSVAVVVLTLDIVTKVVAVQLLPPGQPVSIIGDTVTWTLVRNSGA
AFSMATGYTWVLTLIATGVVVGIFWMGRRLVSPWWALGLGMILGGAMGNLVDRFFRAPGPLRGHVVDFLSVGWWPVFNVA
DPSVVGGAILLVILSIFGFDFDTVGRRHADGDTVGRRKADG

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_MYCBO (P65263)

Other databases:

- EMBL:   BX248339
- RefSeq:   NP_855218.1
- MEROPS:   A08.001
- EnsemblBacteria:   EBMYCT00000016670
- GeneID:   1092428
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1566
- GeneTree:   EBGT00050000017480
- HOGENOM:   HBG724422
- OMA:   MATRNNG
- ProtClustDB:   PRK14764
- BioCyc:   MBOV233413:MB1566-MONOMER
- BRENDA:   3.4.23.36
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 21345; Mature: 21214

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 133-133 ACT_SITE 162-162

Signals:

None

Transmembrane regions:

HASH(0x127602f0)-; HASH(0x156605d0)-; HASH(0x1571b0d4)-; HASH(0x15f97efc)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDEPTGSADPLTSTEEAGGAGEPNAPAPPRRLRMLLSVAVVVLTLDIVTKVVAVQLLPP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GQPVSIIGDTVTWTLVRNSGAAFSMATGYTWVLTLIATGVVVGIFWMGRRLVSPWWALGL
CCCCEEECCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMILGGAMGNLVDRFFRAPGPLRGHVVDFLSVGWWPVFNVADPSVVGGAILLVILSIFGF
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHCC
DFDTVGRRHADGDTVGRRKADG
CHHHHCCCCCCCCCCCCCCCCH
>Mature Secondary Structure 
PDEPTGSADPLTSTEEAGGAGEPNAPAPPRRLRMLLSVAVVVLTLDIVTKVVAVQLLPP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GQPVSIIGDTVTWTLVRNSGAAFSMATGYTWVLTLIATGVVVGIFWMGRRLVSPWWALGL
CCCCEEECCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMILGGAMGNLVDRFFRAPGPLRGHVVDFLSVGWWPVFNVADPSVVGGAILLVILSIFGF
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHCC
DFDTVGRRHADGDTVGRRKADG
CHHHHCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972