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The map label for this gene is trxB1 [H]

Identifier: 121637401

GI number: 121637401

Start: 1684442

End: 1684813

Strand: Direct

Name: trxB1 [H]

Synonym: BCG_1532

Alternate gene names: 121637401

Gene position: 1684442-1684813 (Clockwise)

Preceding gene: 121637400

Following gene: 121637402

Centisome position: 38.51

GC content: 63.44

Gene sequence:

>372_bases
GTGACTACCCGAGACCTCACTGCCGCACAGTTCAACGAAACCATCCAAAGCAGCGACATGGTGCTCGTCGATTATTGGGC
CTCCTGGTGCGGCCCGTGCCGCGCGTTCGCGCCGACCTTTGCCGAGTCGTCGGAAAAACACCCCGACGTGGTGCACGCCA
AGGTCGACACCGAAGCCGAACGAGAGCTTGCAGCGGCCGCTCAGATCCGATCCATCCCCACGATCATGGCCTTCAAGAAC
GGCAAGTTGTTGTTCAACCAGGCCGGCGCGCTGCCGCCGGCAGCATTGGAGAGCCTGGTGCAGCAGCTCAAGGCCTACGA
GGTGGAGGCCGGCGAAGCCACCACCCAGAACGGGCGAGCCCAACAAGCCTGA

Upstream 100 bases:

>100_bases
CAATCTGGTGCAACAACTCCGGGCATACACCTTCAAGTCCCCGGCCGGCGAAGGTATCGGCCCTGGAACAAAGACTTCAT
CCTGAGGCGTTGAGGCAGGC

Downstream 100 bases:

>100_bases
CCGGGCGCCAGGCGCCCGGCTGTGCCCCACCGCTGCGCGGCGCAAGTCGTCGCCGGGTACCGTTCAACGGTGAGTTTGGT
CCTCGTCGAACACCCGCGGC

Product: putative thioredoxin trxB1

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 123; Mature: 122

Protein sequence:

>123_residues
MTTRDLTAAQFNETIQSSDMVLVDYWASWCGPCRAFAPTFAESSEKHPDVVHAKVDTEAERELAAAAQIRSIPTIMAFKN
GKLLFNQAGALPPAALESLVQQLKAYEVEAGEATTQNGRAQQA

Sequences:

>Translated_123_residues
MTTRDLTAAQFNETIQSSDMVLVDYWASWCGPCRAFAPTFAESSEKHPDVVHAKVDTEAERELAAAAQIRSIPTIMAFKN
GKLLFNQAGALPPAALESLVQQLKAYEVEAGEATTQNGRAQQA
>Mature_122_residues
TTRDLTAAQFNETIQSSDMVLVDYWASWCGPCRAFAPTFAESSEKHPDVVHAKVDTEAERELAAAAQIRSIPTIMAFKNG
KLLFNQAGALPPAALESLVQQLKAYEVEAGEATTQNGRAQQA

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=93, Percent_Identity=32.258064516129, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI4758304, Length=81, Percent_Identity=35.8024691358025, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1788936, Length=97, Percent_Identity=44.3298969072165, Blast_Score=92, Evalue=1e-20,
Organism=Escherichia coli, GI87082331, Length=98, Percent_Identity=34.6938775510204, Blast_Score=68, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=94, Percent_Identity=36.1702127659575, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17554386, Length=81, Percent_Identity=39.5061728395062, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI193209454, Length=81, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=81, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32566189, Length=81, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=62, Percent_Identity=33.8709677419355, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=62, Percent_Identity=33.8709677419355, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=99, Percent_Identity=34.3434343434343, Blast_Score=79, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321648, Length=100, Percent_Identity=32, Blast_Score=73, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=101, Percent_Identity=29.7029702970297, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 13341; Mature: 13210

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRDLTAAQFNETIQSSDMVLVDYWASWCGPCRAFAPTFAESSEKHPDVVHAKVDTEAE
CCCCCCHHHHHHHHHHCCCEEEEEHHHHHCCHHHHHCCCHHCCCCCCCCEEEEECCCHHH
RELAAAAQIRSIPTIMAFKNGKLLFNQAGALPPAALESLVQQLKAYEVEAGEATTQNGRA
HHHHHHHHHHCCCCEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC
QQA
CCC
>Mature Secondary Structure 
TTRDLTAAQFNETIQSSDMVLVDYWASWCGPCRAFAPTFAESSEKHPDVVHAKVDTEAE
CCCCCHHHHHHHHHHCCCEEEEEHHHHHCCHHHHHCCCHHCCCCCCCCEEEEECCCHHH
RELAAAAQIRSIPTIMAFKNGKLLFNQAGALPPAALESLVQQLKAYEVEAGEATTQNGRA
HHHHHHHHHHCCCCEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC
QQA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]