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The map label for this gene is ctpD

Identifier: 121637399

GI number: 121637399

Start: 1682035

End: 1684008

Strand: Direct

Name: ctpD

Synonym: BCG_1530

Alternate gene names: 121637399

Gene position: 1682035-1684008 (Clockwise)

Preceding gene: 121637396

Following gene: 121637400

Centisome position: 38.45

GC content: 66.77

Gene sequence:

>1974_bases
ATGACCTTGACCGCTTGTGAAGTAACTGCCGCGGAGGCTCCTTTCGACCGCGTTTCAAAGACCATTCCCCACCCATTGAG
CTGGGGAGCCGCGCTGTGGTCGGTAGTCTCCGTGCGCTGGGCCACCGTGGCGCTGCTGCTGTTTCTCGCCGGACTAGTGG
CGCAACTGAACGGTGCTCCCGAGGCCATGTGGTGGACGCTTTACCTGGCCTGTTATCTGGCCGGCGGCTGGGGCTCGGCA
TGGGCGGGCGCACAAGCGTTGCGGAACAAGGCACTTGATGTGGATCTGCTGATGATTGCCGCGGCGGTCGGAGCGGTCGC
GATTGGGCAGATCTTCGACGGCGCGCTGCTGATCGTGATCTTCGCCACGTCCGGTGCGCTGGATGACATTGCCACCAGAC
ACACCGCGGAATCGGTCAAAGGCCTGCTGGACCTCGCGCCGGATCAGGCGGTGGTGGTCCAGGGCGACGGCAGCGAACGG
GTGGTGGCGGCCAGCGAGCTGGTGGTGGGGGACCGGGTGGTGGTGCGGCCGGGGGACCGGATACCCGCAGACGGTGCGGT
GCTGTCGGGGGCTAGCGACGTCGACCAACGCTCGATCACCGGTGAATCGATGCCGGTGGCCAAGGCCCGCGGTGACGAGG
TGTTCGCCGGCACCGTGAACGGATCGGGTGTATTGCATCTGGTGGTCACCCGTGACCCGAGCCAGACCGTGGTAGCCCGC
ATCGTCGAACTGGTCGCCGACGCTTCGGCGACGAAGGCCAAAACCCAACTGTTCATTGAGAAAATCGAGCAACGCTACTC
CCTGGGCATGGTCGCGGCCACCCTTGCCCTCATCGTTATTCCGCTGATGTTCGGCGCCGACCTGCGGCCGGTGCTGCTGC
GCGCCATGACCTTCATGATCGTGGCATCGCCATGCGCGGTGGTGCTGGCCACCATGCCGCCGCTGCTTTCGGCGATCGCC
AACGCAGGCCGTCATGGGGTGCTGGTCAAATCCGCGGTGGTCGTCGAACGCCTGGCCGATACCAGCATCGTCGCTTTGGA
CAAGACCGGTACGCTGACCCGTGGCATCCCGCGACTGGCTTCCGTCGCACCGCTGGACCCCAACGTGGTCGATGCCCGGC
GATTGTTGCAATTGGCAGCTGCCGCAGAACAATCCAGCGAGCACCCGCTTGGCCGGGCGATCGTCGCGGAAGCTCGTCGG
CGTGGTATCGCCATACCGCCCGCCAAGGACTTCCGCGCGGTCCCGGGCTGCGGGGTCCACGCCCTGGTGGGCAACGATTT
CGTCGAGATCGCCAGCCCGCAAAGCTACCGCGGTGCACCGCTAGCAGAGCTGGCGCCGCTCCTTTCTGCCGGCGCCACTG
CCGCCATCGTCTTGTTGGATGGAGTTGCCATCGGTGTGCTCGGGCTCACCGATCAGCTTCGTCCGGATGCCGTGGAGTCC
GTCGCGGCGATGGCTGCATTGACCGCCGCACCACCGGTGCTGCTCACGGGTGACAACGGGCGAGCGGCTTGGCGGGTCGC
TCGGAACGCCGGGATCACCGATGTGCGAGCCGCATTGCTGCCCGAGCAGAAGGTTGAAGTCGTGCGCAACCTGCAGGCCG
GTGGTCACCAGGTGCTGCTCGTCGGCGACGGCGTCAACGACGCTCCCGCCATGGCCGCCGCCCGCGCCGCTGTCGCCATG
GGCGCCGGCGCCGATCTGACCCTACAGACCGCAGACGGGGTGACCATACGGGACGAACTGCACACCATCCCGACGATCAT
CGGGTTGGCACGGCAGGCGCGCCGGGTGGTCACCGTCAACCTGGCCATCGCGGCCACCTTCATCGCCGTCCTGGTGCTGT
GGGACCTTTTTGGGCAGCTGCCGCTGCCACTGGGTGTGGTGGGTCACGAAGGGTCCACTGTGCTGGTGGCCCTCAACGGC
ATGCGGCTATTGACCAACCGGTCGTGGCGGGCCGCGGCTTCGGCTGCGCGTTAG

Upstream 100 bases:

>100_bases
CAATCGCATACCGCAATGCAATCGAGATTTTTGGTCGTTCCTGCGTCCCTACACTCGGTTCATCCTGACGAATTCGCACC
CCTGTCGTGAGGCCGCCGGA

Downstream 100 bases:

>100_bases
GCTCGATGTCGCAGAACTGACCAGGGCTGCGTTAGGGGTGCCCGTGACCACTCGAGACCTCACGGCGGCGTATTTCCAAC
AGACCATCTCCGCCAACAGC

Product: putative cation transporter P-type atpase D ctpD

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 657; Mature: 656

Protein sequence:

>657_residues
MTLTACEVTAAEAPFDRVSKTIPHPLSWGAALWSVVSVRWATVALLLFLAGLVAQLNGAPEAMWWTLYLACYLAGGWGSA
WAGAQALRNKALDVDLLMIAAAVGAVAIGQIFDGALLIVIFATSGALDDIATRHTAESVKGLLDLAPDQAVVVQGDGSER
VVAASELVVGDRVVVRPGDRIPADGAVLSGASDVDQRSITGESMPVAKARGDEVFAGTVNGSGVLHLVVTRDPSQTVVAR
IVELVADASATKAKTQLFIEKIEQRYSLGMVAATLALIVIPLMFGADLRPVLLRAMTFMIVASPCAVVLATMPPLLSAIA
NAGRHGVLVKSAVVVERLADTSIVALDKTGTLTRGIPRLASVAPLDPNVVDARRLLQLAAAAEQSSEHPLGRAIVAEARR
RGIAIPPAKDFRAVPGCGVHALVGNDFVEIASPQSYRGAPLAELAPLLSAGATAAIVLLDGVAIGVLGLTDQLRPDAVES
VAAMAALTAAPPVLLTGDNGRAAWRVARNAGITDVRAALLPEQKVEVVRNLQAGGHQVLLVGDGVNDAPAMAAARAAVAM
GAGADLTLQTADGVTIRDELHTIPTIIGLARQARRVVTVNLAIAATFIAVLVLWDLFGQLPLPLGVVGHEGSTVLVALNG
MRLLTNRSWRAAASAAR

Sequences:

>Translated_657_residues
MTLTACEVTAAEAPFDRVSKTIPHPLSWGAALWSVVSVRWATVALLLFLAGLVAQLNGAPEAMWWTLYLACYLAGGWGSA
WAGAQALRNKALDVDLLMIAAAVGAVAIGQIFDGALLIVIFATSGALDDIATRHTAESVKGLLDLAPDQAVVVQGDGSER
VVAASELVVGDRVVVRPGDRIPADGAVLSGASDVDQRSITGESMPVAKARGDEVFAGTVNGSGVLHLVVTRDPSQTVVAR
IVELVADASATKAKTQLFIEKIEQRYSLGMVAATLALIVIPLMFGADLRPVLLRAMTFMIVASPCAVVLATMPPLLSAIA
NAGRHGVLVKSAVVVERLADTSIVALDKTGTLTRGIPRLASVAPLDPNVVDARRLLQLAAAAEQSSEHPLGRAIVAEARR
RGIAIPPAKDFRAVPGCGVHALVGNDFVEIASPQSYRGAPLAELAPLLSAGATAAIVLLDGVAIGVLGLTDQLRPDAVES
VAAMAALTAAPPVLLTGDNGRAAWRVARNAGITDVRAALLPEQKVEVVRNLQAGGHQVLLVGDGVNDAPAMAAARAAVAM
GAGADLTLQTADGVTIRDELHTIPTIIGLARQARRVVTVNLAIAATFIAVLVLWDLFGQLPLPLGVVGHEGSTVLVALNG
MRLLTNRSWRAAASAAR
>Mature_656_residues
TLTACEVTAAEAPFDRVSKTIPHPLSWGAALWSVVSVRWATVALLLFLAGLVAQLNGAPEAMWWTLYLACYLAGGWGSAW
AGAQALRNKALDVDLLMIAAAVGAVAIGQIFDGALLIVIFATSGALDDIATRHTAESVKGLLDLAPDQAVVVQGDGSERV
VAASELVVGDRVVVRPGDRIPADGAVLSGASDVDQRSITGESMPVAKARGDEVFAGTVNGSGVLHLVVTRDPSQTVVARI
VELVADASATKAKTQLFIEKIEQRYSLGMVAATLALIVIPLMFGADLRPVLLRAMTFMIVASPCAVVLATMPPLLSAIAN
AGRHGVLVKSAVVVERLADTSIVALDKTGTLTRGIPRLASVAPLDPNVVDARRLLQLAAAAEQSSEHPLGRAIVAEARRR
GIAIPPAKDFRAVPGCGVHALVGNDFVEIASPQSYRGAPLAELAPLLSAGATAAIVLLDGVAIGVLGLTDQLRPDAVESV
AAMAALTAAPPVLLTGDNGRAAWRVARNAGITDVRAALLPEQKVEVVRNLQAGGHQVLLVGDGVNDAPAMAAARAAVAMG
AGADLTLQTADGVTIRDELHTIPTIIGLARQARRVVTVNLAIAATFIAVLVLWDLFGQLPLPLGVVGHEGSTVLVALNGM
RLLTNRSWRAAASAAR

Specific function: Involved In Export Of Lead, Cadmium, Zinc And Mercury. [C]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily

Homologues:

Organism=Homo sapiens, GI55743071, Length=662, Percent_Identity=29.4561933534743, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI55743073, Length=549, Percent_Identity=30.7832422586521, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI115529486, Length=413, Percent_Identity=28.8135593220339, Blast_Score=164, Evalue=4e-40,
Organism=Homo sapiens, GI51944966, Length=263, Percent_Identity=30.0380228136882, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI4502271, Length=321, Percent_Identity=27.7258566978193, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI22748667, Length=263, Percent_Identity=29.277566539924, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI83700225, Length=324, Percent_Identity=26.8518518518519, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI237681111, Length=321, Percent_Identity=27.4143302180685, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI21361181, Length=321, Percent_Identity=27.4143302180685, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI237681109, Length=321, Percent_Identity=27.4143302180685, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI153946397, Length=247, Percent_Identity=27.5303643724696, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI297374799, Length=330, Percent_Identity=26.3636363636364, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI213972621, Length=319, Percent_Identity=26.3322884012539, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1789879, Length=570, Percent_Identity=36.3157894736842, Blast_Score=279, Evalue=5e-76,
Organism=Escherichia coli, GI1786691, Length=548, Percent_Identity=34.4890510948905, Blast_Score=227, Evalue=2e-60,
Organism=Escherichia coli, GI1786914, Length=535, Percent_Identity=28.785046728972, Blast_Score=127, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17556548, Length=576, Percent_Identity=27.6041666666667, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17557486, Length=237, Percent_Identity=28.2700421940928, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17531459, Length=268, Percent_Identity=30.2238805970149, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17559224, Length=263, Percent_Identity=28.1368821292776, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71997275, Length=280, Percent_Identity=24.2857142857143, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71997262, Length=280, Percent_Identity=24.2857142857143, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71997269, Length=281, Percent_Identity=24.9110320284698, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=550, Percent_Identity=26.3636363636364, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6319772, Length=553, Percent_Identity=27.4864376130199, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6325221, Length=579, Percent_Identity=24.6977547495682, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321430, Length=603, Percent_Identity=24.3781094527363, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221329854, Length=404, Percent_Identity=30.1980198019802, Blast_Score=155, Evalue=1e-37,
Organism=Drosophila melanogaster, GI281366676, Length=333, Percent_Identity=27.3273273273273, Blast_Score=71, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CTPD_MYCBO (P63686)

Other databases:

- EMBL:   BX248339
- RefSeq:   NP_855156.1
- ProteinModelPortal:   P63686
- SMR:   P63686
- EnsemblBacteria:   EBMYCT00000017085
- GeneID:   1092361
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1504
- GeneTree:   EBGT00050000016190
- HOGENOM:   HBG507745
- OMA:   SAIVVEH
- ProtClustDB:   CLSK791183
- BioCyc:   MBOV233413:MB1504-MONOMER
- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- Gene3D:   G3DSA:3.40.50.1000
- PANTHER:   PTHR11939
- PRINTS:   PR00119
- PRINTS:   PR00941
- TIGRFAMs:   TIGR01512
- TIGRFAMs:   TIGR01525
- TIGRFAMs:   TIGR01494

Pfam domain/function: PF00122 E1-E2_ATPase; PF00702 Hydrolase; SSF56784 SSF56784

EC number: 3.6.3.3 [C]

Molecular weight: Translated: 67886; Mature: 67755

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: ACT_SITE 347-347

Signals:

None

Transmembrane regions:

HASH(0x15df8ac4)-; HASH(0x15d48e84)-; HASH(0x15d25b74)-; HASH(0x15e24044)-; HASH(0x1239bf50)-; HASH(0x158bf0a0)-; HASH(0x15d4b1a4)-; HASH(0x15446618)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTACEVTAAEAPFDRVSKTIPHPLSWGAALWSVVSVRWATVALLLFLAGLVAQLNGAP
CCEEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EAMWWTLYLACYLAGGWGSAWAGAQALRNKALDVDLLMIAAAVGAVAIGQIFDGALLIVI
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEE
FATSGALDDIATRHTAESVKGLLDLAPDQAVVVQGDGSERVVAASELVVGDRVVVRPGDR
EECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEHHEEECCEEEECCCCC
IPADGAVLSGASDVDQRSITGESMPVAKARGDEVFAGTVNGSGVLHLVVTRDPSQTVVAR
CCCCCCEECCCCCCHHHCCCCCCCCCHHCCCCEEEEEEECCCCEEEEEEECCCHHHHHHH
IVELVADASATKAKTQLFIEKIEQRYSLGMVAATLALIVIPLMFGADLRPVLLRAMTFMI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VASPCAVVLATMPPLLSAIANAGRHGVLVKSAVVVERLADTSIVALDKTGTLTRGIPRLA
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHCCHHHH
SVAPLDPNVVDARRLLQLAAAAEQSSEHPLGRAIVAEARRRGIAIPPAKDFRAVPGCGVH
HCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHCCCCCCCCEE
ALVGNDFVEIASPQSYRGAPLAELAPLLSAGATAAIVLLDGVAIGVLGLTDQLRPDAVES
EEECCCEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCCCCCHHHHHH
VAAMAALTAAPPVLLTGDNGRAAWRVARNAGITDVRAALLPEQKVEVVRNLQAGGHQVLL
HHHHHHHHCCCCEEEECCCCCEEEEECCCCCCHHHHHHHCCHHHHHHHHHHCCCCCEEEE
VGDGVNDAPAMAAARAAVAMGAGADLTLQTADGVTIRDELHTIPTIIGLARQARRVVTVN
EECCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHCCEEEEEH
LAIAATFIAVLVLWDLFGQLPLPLGVVGHEGSTVLVALNGMRLLTNRSWRAAASAAR
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEECCEEEECCCCHHHHHCCCH
>Mature Secondary Structure 
TLTACEVTAAEAPFDRVSKTIPHPLSWGAALWSVVSVRWATVALLLFLAGLVAQLNGAP
CEEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EAMWWTLYLACYLAGGWGSAWAGAQALRNKALDVDLLMIAAAVGAVAIGQIFDGALLIVI
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEE
FATSGALDDIATRHTAESVKGLLDLAPDQAVVVQGDGSERVVAASELVVGDRVVVRPGDR
EECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEHHEEECCEEEECCCCC
IPADGAVLSGASDVDQRSITGESMPVAKARGDEVFAGTVNGSGVLHLVVTRDPSQTVVAR
CCCCCCEECCCCCCHHHCCCCCCCCCHHCCCCEEEEEEECCCCEEEEEEECCCHHHHHHH
IVELVADASATKAKTQLFIEKIEQRYSLGMVAATLALIVIPLMFGADLRPVLLRAMTFMI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VASPCAVVLATMPPLLSAIANAGRHGVLVKSAVVVERLADTSIVALDKTGTLTRGIPRLA
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHCCHHHH
SVAPLDPNVVDARRLLQLAAAAEQSSEHPLGRAIVAEARRRGIAIPPAKDFRAVPGCGVH
HCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHCCCCCCCCEE
ALVGNDFVEIASPQSYRGAPLAELAPLLSAGATAAIVLLDGVAIGVLGLTDQLRPDAVES
EEECCCEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCCCCCHHHHHH
VAAMAALTAAPPVLLTGDNGRAAWRVARNAGITDVRAALLPEQKVEVVRNLQAGGHQVLL
HHHHHHHHCCCCEEEECCCCCEEEEECCCCCCHHHHHHHCCHHHHHHHHHHCCCCCEEEE
VGDGVNDAPAMAAARAAVAMGAGADLTLQTADGVTIRDELHTIPTIIGLARQARRVVTVN
EECCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHCCEEEEEH
LAIAATFIAVLVLWDLFGQLPLPLGVVGHEGSTVLVALNGMRLLTNRSWRAAASAAR
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEECCEEEECCCCHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972