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The map label for this gene is pyrF

Identifier: 121637315

GI number: 121637315

Start: 1585605

End: 1586429

Strand: Direct

Name: pyrF

Synonym: BCG_1446

Alternate gene names: 121637315

Gene position: 1585605-1586429 (Clockwise)

Preceding gene: 121637314

Following gene: 121637316

Centisome position: 36.25

GC content: 72.97

Gene sequence:

>825_bases
GTGACCGGGTTCGGTCTCCGGTTGGCCGAGGCAAAGGCACGCCGCGGCCCGTTGTGTCTGGGCATCGATCCGCATCCCGA
GCTGCTGCGGGGCTGGGATCTGGCGACCACGGCCGACGGGCTGGCCGCGTTCTGCGACATCTGCGTACGGGCCTTCGCTG
ATTTCGCGGTGGTCAAACCGCAGGTGGCGTTTTTTGAGTCATACGGGGCTGCCGGATTCGCGGTGCTGGAGCGCACCATC
GCGGAACTGCGGGCCGCAGACGTGCTGGTGTTGGCCGACGCCAAGCGCGGCGACATTGGGGCGACCATGTCGGCGTATGC
GACGGCCTGGGTGGGCGACTCGCCGCTGGCCGCCGACGCCGTGACGGCCTCGCCCTATTTGGGCTTCGGTTCGCTGCGGC
CGCTGCTAGAGGTCGCGGCCGCCCACGGCCGAGGGGTGTTCGTGCTGGCGGCCACCTCCAATCCCGAGGGTGCGGCGGTG
CAGAATGCCGCCGCCGACGGCCGCAGCGTGGCCCAGTTGGTCGTGGACCAGGTGGGGGCGGCCAACGAGGCGGCAGGACC
CGGGCCCGGATCCATCGGCGTGGTCGTCGGCGCAACGGCGCCACAGGCCCCCGATCTCAGCGCCTTCACCGGGCCGGTGC
TGGTGCCCGGCGTGGGGGTGCAGGGCGGGCGCCCGGAGGCGCTGGGCGGTCTGGGCGGGGCCGCATCGAGCCAGCTGTTG
CCCGCGGTGGCGCGCGAGGTCTTGCGGGCCGGCCCCGGCGTGCCCGAATTGCGCGCCGCGGGCGAACGGATGCGCGATGC
CGTCGCCTATCTCGCTGCCGTGTAG

Upstream 100 bases:

>100_bases
GCGCATCCGCCGCCGTGCAGGGGATAGAGGCCGGGATCCGCGGCGACATCGGGGTGCGCTCCCTGCAGGAGCTGCACCGG
GTGATCGGGGGCGTCGAGCG

Downstream 100 bases:

>100_bases
CGGGTGCCCTGCCACCGCGCCGCTAAATCCCACCAGCATGGGGTGGTGAGCCCAGCGCTCGTGTGACCAAACTCACCGCC
CTGGGCCGTCGTCACGCTGT

Product: orotidine 5'-phosphate decarboxylase

Products: NA

Alternate protein names: OMP decarboxylase; OMPDCase; OMPdecase

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MTGFGLRLAEAKARRGPLCLGIDPHPELLRGWDLATTADGLAAFCDICVRAFADFAVVKPQVAFFESYGAAGFAVLERTI
AELRAADVLVLADAKRGDIGATMSAYATAWVGDSPLAADAVTASPYLGFGSLRPLLEVAAAHGRGVFVLAATSNPEGAAV
QNAAADGRSVAQLVVDQVGAANEAAGPGPGSIGVVVGATAPQAPDLSAFTGPVLVPGVGVQGGRPEALGGLGGAASSQLL
PAVAREVLRAGPGVPELRAAGERMRDAVAYLAAV

Sequences:

>Translated_274_residues
MTGFGLRLAEAKARRGPLCLGIDPHPELLRGWDLATTADGLAAFCDICVRAFADFAVVKPQVAFFESYGAAGFAVLERTI
AELRAADVLVLADAKRGDIGATMSAYATAWVGDSPLAADAVTASPYLGFGSLRPLLEVAAAHGRGVFVLAATSNPEGAAV
QNAAADGRSVAQLVVDQVGAANEAAGPGPGSIGVVVGATAPQAPDLSAFTGPVLVPGVGVQGGRPEALGGLGGAASSQLL
PAVAREVLRAGPGVPELRAAGERMRDAVAYLAAV
>Mature_273_residues
TGFGLRLAEAKARRGPLCLGIDPHPELLRGWDLATTADGLAAFCDICVRAFADFAVVKPQVAFFESYGAAGFAVLERTIA
ELRAADVLVLADAKRGDIGATMSAYATAWVGDSPLAADAVTASPYLGFGSLRPLLEVAAAHGRGVFVLAATSNPEGAAVQ
NAAADGRSVAQLVVDQVGAANEAAGPGPGSIGVVVGATAPQAPDLSAFTGPVLVPGVGVQGGRPEALGGLGGAASSQLLP
AVAREVLRAGPGVPELRAAGERMRDAVAYLAAV

Specific function: Unknown

COG id: COG0284

COG function: function code F; Orotidine-5'-phosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the OMP decarboxylase family. Type 2 subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRF_MYCBO (P0A5M7)

Other databases:

- EMBL:   U01072
- EMBL:   BX248338
- PIR:   B49930
- RefSeq:   NP_855072.1
- ProteinModelPortal:   P0A5M7
- SMR:   P0A5M7
- EnsemblBacteria:   EBMYCT00000017691
- GeneID:   1090710
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1420
- GeneTree:   EBGT00050000017172
- HOGENOM:   HBG348634
- OMA:   KPQSAFF
- ProtClustDB:   PRK00125
- BioCyc:   MBOV233413:MB1420-MONOMER
- BRENDA:   4.1.1.23
- HAMAP:   MF_01215
- InterPro:   IPR013785
- InterPro:   IPR018089
- InterPro:   IPR011995
- InterPro:   IPR001754
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00934
- TIGRFAMs:   TIGR02127

Pfam domain/function: PF00215 OMPdecase; SSF51366 RibP_bind_barrel

EC number: =4.1.1.23

Molecular weight: Translated: 27377; Mature: 27246

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00156 OMPDECASE

Important sites: ACT_SITE 95-95

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGFGLRLAEAKARRGPLCLGIDPHPELLRGWDLATTADGLAAFCDICVRAFADFAVVKP
CCCCCCCHHHHHHCCCCEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCH
QVAFFESYGAAGFAVLERTIAELRAADVLVLADAKRGDIGATMSAYATAWVGDSPLAADA
HHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCHH
VTASPYLGFGSLRPLLEVAAAHGRGVFVLAATSNPEGAAVQNAAADGRSVAQLVVDQVGA
CCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHCC
ANEAAGPGPGSIGVVVGATAPQAPDLSAFTGPVLVPGVGVQGGRPEALGGLGGAASSQLL
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCCCCCCCHHHCCCCCCHHHHHH
PAVAREVLRAGPGVPELRAAGERMRDAVAYLAAV
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TGFGLRLAEAKARRGPLCLGIDPHPELLRGWDLATTADGLAAFCDICVRAFADFAVVKP
CCCCCCHHHHHHCCCCEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCH
QVAFFESYGAAGFAVLERTIAELRAADVLVLADAKRGDIGATMSAYATAWVGDSPLAADA
HHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCHH
VTASPYLGFGSLRPLLEVAAAHGRGVFVLAATSNPEGAAVQNAAADGRSVAQLVVDQVGA
CCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHCC
ANEAAGPGPGSIGVVVGATAPQAPDLSAFTGPVLVPGVGVQGGRPEALGGLGGAASSQLL
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCCCCCCCHHHCCCCCCHHHHHH
PAVAREVLRAGPGVPELRAAGERMRDAVAYLAAV
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8226675; 12788972