| Definition | Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome. |
|---|---|
| Accession | NC_008769 |
| Length | 4,374,522 |
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The map label for this gene is glmU [H]
Identifier: 121636947
GI number: 121636947
Start: 1167058
End: 1168545
Strand: Reverse
Name: glmU [H]
Synonym: BCG_1075c
Alternate gene names: 121636947
Gene position: 1168545-1167058 (Counterclockwise)
Preceding gene: 121636956
Following gene: 121636946
Centisome position: 26.71
GC content: 67.47
Gene sequence:
>1488_bases ATGACGTTTCCTGGTGACACCGCGGTCCTGGTCCTAGCGGCCGGGCCCGGGACCCGGATGCGTTCGGACACCCCCAAGGT GCTGCACACACTCGCCGGTCGCAGCATGCTGTCGCATGTACTGCATGCGATCGCCAAGCTGGCGCCGCAGCGTCTAATCG TGGTGCTGGGACACGATCACCAGCGCATCGCGCCGCTAGTCGGTGAACTCGCCGACACCCTAGGCCGAACGATCGACGTC GCCCTGCAGGATCGACCGCTAGGGACCGGGCATGCGGTACTCTGCGGGCTGTCCGCGCTGCCCGATGACTACGCCGGCAA CGTCGTGGTCACCTCGGGAGATACCCCGCTGCTGGACGCCGACACGCTGGCCGACTTGATCGCCACCCACCGCGCGGTGT CGGCTGCGGTGACGGTGCTGACCACGACGCTGGATGATCCCTTCGGCTACGGCCGCATCCTGCGCACCCAGGATCACGAA GTCATGGCGATCGTGGAGCAAACCGACGCGACACCATCGCAGCGGGAAATCCGCGAAGTCAACGCCGGCGTCTACGCCTT CGACATCGCCGCGCTGCGGTCCGCACTGAGCCGGCTGAGCTCCAACAACGCCCAACAGGAGCTCTACCTCACCGACGTCA TCGCCATCTTGCGCTCCGACGGCCAGACCGTACATGCCAGCCACGTCGACGACAGCGCGTTGGTGGCCGGCGTCAACAAT CGCGTCCAGCTGGCCGAGCTGGCCTCCGAACTCAACCGGCGGGTGGTGGCCGCTCACCAGCTGGCCGGCGTCACCGTCGT CGACCCGGCTACCACCTGGATCGACGTCGACGTCACCATCGGCCGCGACACCGTCATTCACCCGGGTACCCAGTTGCTGG GCCGCACCCAGATCGGCGGTCGCTGTGTCGTCGGTCCCGACACCACCCTGACCGACGTCGCCGTCGGCGACGGTGCCTCG GTGGTGCGCACCCACGGTTCGTCGTCGTCGATTGGGGATGGCGCCGCGGTCGGGCCCTTCACCTACCTGCGGCCCGGAAC CGCGTTGGGCGCCGACGGCAAGCTGGGCGCGTTCGTCGAGGTCAAGAACTCCACCATCGGCACCGGCACCAAGGTGCCGC ACCTGACCTACGTCGGCGACGCCGACATCGGCGAGTACAGCAACATCGGCGCCTCCAGCGTGTTCGTCAACTACGACGGT ACGTCCAAACGGCGCACCACCGTCGGTTCGCACGTACGGACCGGGTCCGACACCATGTTCGTGGCCCCAGTAACCATCGG CGACGGCGCGTATACCGGGGCCGGCACAGTGGTGCGGGAGGATGTCCCGCCGGGGGCGCTGGCAGTGTCGGCGGGTCCGC AACGCAACATCGAGAACTGGGTGCAGCGCAAACGCCCCGGCAGCCCAGCGGCTCAGGCCTCAAAAAGAGCCTCAGAAATG GCCTGCCAACAGCCCACACAACCACCCGACGCTGATCAGACACCGTGA
Upstream 100 bases:
>100_bases CATCGATGTGCAATCCGTCGTGGTGTAATCGGCAGCACCTCTGATTTTGGTTCAGATAGTTCAGGTTCGAGTCCTGGCGA CGGAGCTTCAAGGAGGGTTG
Downstream 100 bases:
>100_bases AGTCGCATCCCGGCTACCCGGCGACAAATCCGGGCGGTGCGCTACGTACCATGGGTAATCCAATTCGATCCCAAACGGCG AGGGCAGCGCGTTGAGCCAC
Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase
Products: NA
Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]
Number of amino acids: Translated: 495; Mature: 494
Protein sequence:
>495_residues MTFPGDTAVLVLAAGPGTRMRSDTPKVLHTLAGRSMLSHVLHAIAKLAPQRLIVVLGHDHQRIAPLVGELADTLGRTIDV ALQDRPLGTGHAVLCGLSALPDDYAGNVVVTSGDTPLLDADTLADLIATHRAVSAAVTVLTTTLDDPFGYGRILRTQDHE VMAIVEQTDATPSQREIREVNAGVYAFDIAALRSALSRLSSNNAQQELYLTDVIAILRSDGQTVHASHVDDSALVAGVNN RVQLAELASELNRRVVAAHQLAGVTVVDPATTWIDVDVTIGRDTVIHPGTQLLGRTQIGGRCVVGPDTTLTDVAVGDGAS VVRTHGSSSSIGDGAAVGPFTYLRPGTALGADGKLGAFVEVKNSTIGTGTKVPHLTYVGDADIGEYSNIGASSVFVNYDG TSKRRTTVGSHVRTGSDTMFVAPVTIGDGAYTGAGTVVREDVPPGALAVSAGPQRNIENWVQRKRPGSPAAQASKRASEM ACQQPTQPPDADQTP
Sequences:
>Translated_495_residues MTFPGDTAVLVLAAGPGTRMRSDTPKVLHTLAGRSMLSHVLHAIAKLAPQRLIVVLGHDHQRIAPLVGELADTLGRTIDV ALQDRPLGTGHAVLCGLSALPDDYAGNVVVTSGDTPLLDADTLADLIATHRAVSAAVTVLTTTLDDPFGYGRILRTQDHE VMAIVEQTDATPSQREIREVNAGVYAFDIAALRSALSRLSSNNAQQELYLTDVIAILRSDGQTVHASHVDDSALVAGVNN RVQLAELASELNRRVVAAHQLAGVTVVDPATTWIDVDVTIGRDTVIHPGTQLLGRTQIGGRCVVGPDTTLTDVAVGDGAS VVRTHGSSSSIGDGAAVGPFTYLRPGTALGADGKLGAFVEVKNSTIGTGTKVPHLTYVGDADIGEYSNIGASSVFVNYDG TSKRRTTVGSHVRTGSDTMFVAPVTIGDGAYTGAGTVVREDVPPGALAVSAGPQRNIENWVQRKRPGSPAAQASKRASEM ACQQPTQPPDADQTP >Mature_494_residues TFPGDTAVLVLAAGPGTRMRSDTPKVLHTLAGRSMLSHVLHAIAKLAPQRLIVVLGHDHQRIAPLVGELADTLGRTIDVA LQDRPLGTGHAVLCGLSALPDDYAGNVVVTSGDTPLLDADTLADLIATHRAVSAAVTVLTTTLDDPFGYGRILRTQDHEV MAIVEQTDATPSQREIREVNAGVYAFDIAALRSALSRLSSNNAQQELYLTDVIAILRSDGQTVHASHVDDSALVAGVNNR VQLAELASELNRRVVAAHQLAGVTVVDPATTWIDVDVTIGRDTVIHPGTQLLGRTQIGGRCVVGPDTTLTDVAVGDGASV VRTHGSSSSIGDGAAVGPFTYLRPGTALGADGKLGAFVEVKNSTIGTGTKVPHLTYVGDADIGEYSNIGASSVFVNYDGT SKRRTTVGSHVRTGSDTMFVAPVTIGDGAYTGAGTVVREDVPPGALAVSAGPQRNIENWVQRKRPGSPAAQASKRASEMA CQQPTQPPDADQTP
Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]
COG id: COG1207
COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]
Homologues:
Organism=Escherichia coli, GI1790168, Length=460, Percent_Identity=38.695652173913, Blast_Score=297, Evalue=1e-81, Organism=Saccharomyces cerevisiae, GI6320148, Length=371, Percent_Identity=23.7196765498652, Blast_Score=66, Evalue=1e-11, Organism=Drosophila melanogaster, GI21355443, Length=405, Percent_Identity=22.4691358024691, Blast_Score=74, Evalue=2e-13, Organism=Drosophila melanogaster, GI24644084, Length=405, Percent_Identity=22.4691358024691, Blast_Score=74, Evalue=2e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005882 - InterPro: IPR005835 - InterPro: IPR011004 [H]
Pfam domain/function: PF00483 NTP_transferase [H]
EC number: =2.7.7.23; =2.3.1.157 [H]
Molecular weight: Translated: 51585; Mature: 51453
Theoretical pI: Translated: 5.98; Mature: 5.98
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 1.2 %Met (Translated Protein) 1.8 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 1.0 %Met (Mature Protein) 1.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTFPGDTAVLVLAAGPGTRMRSDTPKVLHTLAGRSMLSHVLHAIAKLAPQRLIVVLGHDH CCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC QRIAPLVGELADTLGRTIDVALQDRPLGTGHAVLCGLSALPDDYAGNVVVTSGDTPLLDA HHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCH DTLADLIATHRAVSAAVTVLTTTLDDPFGYGRILRTQDHEVMAIVEQTDATPSQREIREV HHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEEECCCCEEEEEEECCCCCCCHHHHHHH NAGVYAFDIAALRSALSRLSSNNAQQELYLTDVIAILRSDGQTVHASHVDDSALVAGVNN CCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEECCCC RVQLAELASELNRRVVAAHQLAGVTVVDPATTWIDVDVTIGRDTVIHPGTQLLGRTQIGG CCHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEEEEECCCCEECCCHHHHCCCCCCC RCVVGPDTTLTDVAVGDGASVVRTHGSSSSIGDGAAVGPFTYLRPGTALGADGKLGAFVE EEEECCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEE VKNSTIGTGTKVPHLTYVGDADIGEYSNIGASSVFVNYDGTSKRRTTVGSHVRTGSDTMF ECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEECCCCEEE VAPVTIGDGAYTGAGTVVREDVPPGALAVSAGPQRNIENWVQRKRPGSPAAQASKRASEM EEEEEECCCCCCCCCCEEECCCCCCEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHH ACQQPTQPPDADQTP HHHCCCCCCCCCCCC >Mature Secondary Structure TFPGDTAVLVLAAGPGTRMRSDTPKVLHTLAGRSMLSHVLHAIAKLAPQRLIVVLGHDH CCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC QRIAPLVGELADTLGRTIDVALQDRPLGTGHAVLCGLSALPDDYAGNVVVTSGDTPLLDA HHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCH DTLADLIATHRAVSAAVTVLTTTLDDPFGYGRILRTQDHEVMAIVEQTDATPSQREIREV HHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEEECCCCEEEEEEECCCCCCCHHHHHHH NAGVYAFDIAALRSALSRLSSNNAQQELYLTDVIAILRSDGQTVHASHVDDSALVAGVNN CCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEECCCC RVQLAELASELNRRVVAAHQLAGVTVVDPATTWIDVDVTIGRDTVIHPGTQLLGRTQIGG CCHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEEEEECCCCEECCCHHHHCCCCCCC RCVVGPDTTLTDVAVGDGASVVRTHGSSSSIGDGAAVGPFTYLRPGTALGADGKLGAFVE EEEECCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEE VKNSTIGTGTKVPHLTYVGDADIGEYSNIGASSVFVNYDGTSKRRTTVGSHVRTGSDTMF ECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEECCCCEEE VAPVTIGDGAYTGAGTVVREDVPPGALAVSAGPQRNIENWVQRKRPGSPAAQASKRASEM EEEEEECCCCCCCCCCEEECCCCCCEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHH ACQQPTQPPDADQTP HHHCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12788972 [H]