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The map label for this gene is prsA [H]

Identifier: 121636946

GI number: 121636946

Start: 1165986

End: 1166966

Strand: Reverse

Name: prsA [H]

Synonym: BCG_1074c

Alternate gene names: 121636946

Gene position: 1166966-1165986 (Counterclockwise)

Preceding gene: 121636947

Following gene: 121636945

Centisome position: 26.68

GC content: 64.02

Gene sequence:

>981_bases
TTGAGCCACGACTGGACCGATAATCGCAAAAACCTGATGCTCTTTGCCGGCCGCGCCCATCCGGAGCTGGCCGAGCAGGT
AGCCAAAGAGCTCGACGTCCACGTCACCTCTCAGGACGCGCGGGAGTTCGCCAACGGCGAGATCTTCGTGCGCTTCCACG
AATCGGTACGCGGTTGCGACGCCTTCGTCCTGCAATCCTGCCCGGCACCGGTGAACAGGTGGCTGATGGAACAGCTGATC
ATGATCGACGCGCTCAAACGGGGCAGCGCCAAACGGATCACCGCCGTCATGCCGTTCTATCCGTATGCCCGGCAAGACAA
GAAACACCGTGGCCGCGAACCGATCTCCGCGCGACTGATCGCCGACCTGCTCAAGACCGCGGGCGCCGACCGGATCGTGA
CGGTCGACCTGCACACCGACCAGATCCAGGGTTTCTTCGACGGGCCGGTCGATCATATGCGCGGTCAGAACCTGCTGACC
GGTTACATCAGAGACAACTACCCGGACGGCAACATGGTGGTCGTCTCCCCTGACTCCGGCCGGGTACGCATCGCCGAGAA
GTGGGCCGACGCATTAGGTGGTGTTCCCCTCGCCTTCATCCACAAGACCCGTGATCCGCGGGTACCCAACCAAGTGGTGT
CCAACCGCGTCGTCGGCGACGTGGCCGGGCGCACCTGTGTCCTGATTGACGACATGATCGACACCGGCGGCACCATCGCC
GGCGCGGTGGCATTGCTGCACAACGACGGCGCCGGTGACGTGATCATCGCGGCAACCCACGGCGTGCTCTCCGACCCCGC
TGCGCAGCGGCTGGCCTCCTGCGGCGCCCGCGAAGTGATCGTCACGAACACGCTCCCGATCGGCGAAGACAAGCGCTTCC
CCCAGCTCACCGTTTTGTCCATCGCGCCGCTGCTGGCCAGCACAATCCGGGCGGTCTTCGAAAACGGCTCAGTAACAGGA
CTTTTCGACGGGGACGCATAG

Upstream 100 bases:

>100_bases
ACACCGTGAAGTCGCATCCCGGCTACCCGGCGACAAATCCGGGCGGTGCGCTACGTACCATGGGTAATCCAATTCGATCC
CAAACGGCGAGGGCAGCGCG

Downstream 100 bases:

>100_bases
ATGGCAGCCGTCATCCTTGAGGGCATCCGGCGGGCTTGGCCGGTCGACGCTGTCCGCAAGATTCTGTGAGACCCTTGGCG
GTCGCGGTCGCGGTAGCCAC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MSHDWTDNRKNLMLFAGRAHPELAEQVAKELDVHVTSQDAREFANGEIFVRFHESVRGCDAFVLQSCPAPVNRWLMEQLI
MIDALKRGSAKRITAVMPFYPYARQDKKHRGREPISARLIADLLKTAGADRIVTVDLHTDQIQGFFDGPVDHMRGQNLLT
GYIRDNYPDGNMVVVSPDSGRVRIAEKWADALGGVPLAFIHKTRDPRVPNQVVSNRVVGDVAGRTCVLIDDMIDTGGTIA
GAVALLHNDGAGDVIIAATHGVLSDPAAQRLASCGAREVIVTNTLPIGEDKRFPQLTVLSIAPLLASTIRAVFENGSVTG
LFDGDA

Sequences:

>Translated_326_residues
MSHDWTDNRKNLMLFAGRAHPELAEQVAKELDVHVTSQDAREFANGEIFVRFHESVRGCDAFVLQSCPAPVNRWLMEQLI
MIDALKRGSAKRITAVMPFYPYARQDKKHRGREPISARLIADLLKTAGADRIVTVDLHTDQIQGFFDGPVDHMRGQNLLT
GYIRDNYPDGNMVVVSPDSGRVRIAEKWADALGGVPLAFIHKTRDPRVPNQVVSNRVVGDVAGRTCVLIDDMIDTGGTIA
GAVALLHNDGAGDVIIAATHGVLSDPAAQRLASCGAREVIVTNTLPIGEDKRFPQLTVLSIAPLLASTIRAVFENGSVTG
LFDGDA
>Mature_325_residues
SHDWTDNRKNLMLFAGRAHPELAEQVAKELDVHVTSQDAREFANGEIFVRFHESVRGCDAFVLQSCPAPVNRWLMEQLIM
IDALKRGSAKRITAVMPFYPYARQDKKHRGREPISARLIADLLKTAGADRIVTVDLHTDQIQGFFDGPVDHMRGQNLLTG
YIRDNYPDGNMVVVSPDSGRVRIAEKWADALGGVPLAFIHKTRDPRVPNQVVSNRVVGDVAGRTCVLIDDMIDTGGTIAG
AVALLHNDGAGDVIIAATHGVLSDPAAQRLASCGAREVIVTNTLPIGEDKRFPQLTVLSIAPLLASTIRAVFENGSVTGL
FDGDA

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI28557709, Length=314, Percent_Identity=42.9936305732484, Blast_Score=242, Evalue=3e-64,
Organism=Homo sapiens, GI4506129, Length=315, Percent_Identity=43.4920634920635, Blast_Score=242, Evalue=3e-64,
Organism=Homo sapiens, GI4506127, Length=315, Percent_Identity=43.1746031746032, Blast_Score=238, Evalue=4e-63,
Organism=Homo sapiens, GI84875539, Length=318, Percent_Identity=43.0817610062893, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI194018537, Length=336, Percent_Identity=34.5238095238095, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI4506133, Length=345, Percent_Identity=32.463768115942, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI310128524, Length=139, Percent_Identity=31.6546762589928, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310115209, Length=139, Percent_Identity=31.6546762589928, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310118259, Length=139, Percent_Identity=31.6546762589928, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310119946, Length=139, Percent_Identity=31.6546762589928, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1787458, Length=315, Percent_Identity=43.4920634920635, Blast_Score=244, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI25149168, Length=314, Percent_Identity=41.7197452229299, Blast_Score=243, Evalue=7e-65,
Organism=Caenorhabditis elegans, GI17554702, Length=314, Percent_Identity=41.7197452229299, Blast_Score=242, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI71989924, Length=314, Percent_Identity=41.7197452229299, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI17554704, Length=311, Percent_Identity=41.8006430868167, Blast_Score=241, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI17570245, Length=346, Percent_Identity=33.8150289017341, Blast_Score=187, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6320946, Length=314, Percent_Identity=41.4012738853503, Blast_Score=235, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6319403, Length=315, Percent_Identity=40.3174603174603, Blast_Score=233, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6321776, Length=314, Percent_Identity=41.7197452229299, Blast_Score=232, Evalue=7e-62,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=41.3265306122449, Blast_Score=149, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6324511, Length=95, Percent_Identity=42.1052631578947, Blast_Score=90, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21355239, Length=314, Percent_Identity=42.0382165605096, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI45551540, Length=337, Percent_Identity=39.4658753709199, Blast_Score=231, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24651458, Length=355, Percent_Identity=31.5492957746479, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24651456, Length=355, Percent_Identity=31.5492957746479, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI281362873, Length=355, Percent_Identity=31.5492957746479, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI24651454, Length=355, Percent_Identity=31.5492957746479, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI45552010, Length=374, Percent_Identity=28.8770053475936, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24651462, Length=374, Percent_Identity=28.8770053475936, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24651464, Length=374, Percent_Identity=28.8770053475936, Blast_Score=138, Evalue=6e-33,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 35478; Mature: 35347

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHDWTDNRKNLMLFAGRAHPELAEQVAKELDVHVTSQDAREFANGEIFVRFHESVRGCD
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCEEEECHHHHHHCCCEEEEEEECHHCCHH
AFVLQSCPAPVNRWLMEQLIMIDALKRGSAKRITAVMPFYPYARQDKKHRGREPISARLI
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHCCCCCHHHHHH
ADLLKTAGADRIVTVDLHTDQIQGFFDGPVDHMRGQNLLTGYIRDNYPDGNMVVVSPDSG
HHHHHHCCCCEEEEEEEEHHHHCCCCCCCHHHHCCCCEEEEEEECCCCCCCEEEEECCCC
RVRIAEKWADALGGVPLAFIHKTRDPRVPNQVVSNRVVGDVAGRTCVLIDDMIDTGGTIA
CEEEHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCHHHHCCCCEEEEEECHHCCCCHHH
GAVALLHNDGAGDVIIAATHGVLSDPAAQRLASCGAREVIVTNTLPIGEDKRFPQLTVLS
HEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHH
IAPLLASTIRAVFENGSVTGLFDGDA
HHHHHHHHHHHHHCCCCEEEEECCCC
>Mature Secondary Structure 
SHDWTDNRKNLMLFAGRAHPELAEQVAKELDVHVTSQDAREFANGEIFVRFHESVRGCD
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHCEEEECHHHHHHCCCEEEEEEECHHCCHH
AFVLQSCPAPVNRWLMEQLIMIDALKRGSAKRITAVMPFYPYARQDKKHRGREPISARLI
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHCCCCCHHHHHH
ADLLKTAGADRIVTVDLHTDQIQGFFDGPVDHMRGQNLLTGYIRDNYPDGNMVVVSPDSG
HHHHHHCCCCEEEEEEEEHHHHCCCCCCCHHHHCCCCEEEEEEECCCCCCCEEEEECCCC
RVRIAEKWADALGGVPLAFIHKTRDPRVPNQVVSNRVVGDVAGRTCVLIDDMIDTGGTIA
CEEEHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCHHHHCCCCEEEEEECHHCCCCHHH
GAVALLHNDGAGDVIIAATHGVLSDPAAQRLASCGAREVIVTNTLPIGEDKRFPQLTVLS
HEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHH
IAPLLASTIRAVFENGSVTGLFDGDA
HHHHHHHHHHHHHCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]