| Definition | Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome. |
|---|---|
| Accession | NC_008769 |
| Length | 4,374,522 |
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The map label for this gene is mutM [H]
Identifier: 121636869
GI number: 121636869
Start: 1084242
End: 1084718
Strand: Direct
Name: mutM [H]
Synonym: BCG_0998
Alternate gene names: 121636869
Gene position: 1084242-1084718 (Clockwise)
Preceding gene: 121636867
Following gene: 121636870
Centisome position: 24.79
GC content: 66.25
Gene sequence:
>477_bases GTGGCCGGGACGCCGCAGCCGCGCGCGCTCGGGCCCGATGCGCTGGACGTCAGCACCGACGACCTGGCCGGGCTGTTGGC CGGCAACACCGGCCGGATCAAGACCGTCATCACCGACCAGAAGGTAATTGCCGGCATCGGCAACGCCTATAGTGACGAAA TCCTGCACGTCGCGAAGATCTCGCCGTTCGCCACGGCCGGCAAGTTATCCGGCGCACAGCTCACCTGCCTGCATGAGGCG ATGGCGTCGGTGCTGTCGGACGCGGTGCGCCGGTCCGTCGGCCAGGGCGCGGCCATGCTCAAAGGGGAGAAACGTTCTGG GCTTCGAGTACATGCGCGCACCGGGTTACCCTGCCCAGTGTGCGGTGACACTGTGCGGGAGGTGTCCTTCGCGGACAAGT CTTTTCAGTACTGTCCAACGTGTCAGACCGGTGGCAAGGCGCTGGCCGACCGGCGTATGTCGCGGCTGCTCAAGTAG
Upstream 100 bases:
>100_bases GATCGCCCGTCGCGCCTGGAAACGCACCAACTTTCTGTGACCGCGACGCTCGGCCTCGCTGACGCCGGCCACCGCATTGT CATCGTCGGCAGGGGTGCTG
Downstream 100 bases:
>100_bases TCGATATGCTCACCGGAGTGACTCGCCAGAAGATCCTGATCACCGGCGCCAGTTCCGGCCTGGGCGCCGGGATGGCCCGA TCCTTCGCCGCCCAGGGCCG
Product: putative formamidopyrimidine-DNA glycosylase
Products: NA
Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]
Number of amino acids: Translated: 158; Mature: 157
Protein sequence:
>158_residues MAGTPQPRALGPDALDVSTDDLAGLLAGNTGRIKTVITDQKVIAGIGNAYSDEILHVAKISPFATAGKLSGAQLTCLHEA MASVLSDAVRRSVGQGAAMLKGEKRSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGGKALADRRMSRLLK
Sequences:
>Translated_158_residues MAGTPQPRALGPDALDVSTDDLAGLLAGNTGRIKTVITDQKVIAGIGNAYSDEILHVAKISPFATAGKLSGAQLTCLHEA MASVLSDAVRRSVGQGAAMLKGEKRSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGGKALADRRMSRLLK >Mature_157_residues AGTPQPRALGPDALDVSTDDLAGLLAGNTGRIKTVITDQKVIAGIGNAYSDEILHVAKISPFATAGKLSGAQLTCLHEAM ASVLSDAVRRSVGQGAAMLKGEKRSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGGKALADRRMSRLLK
Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr
COG id: COG0266
COG function: function code L; Formamidopyrimidine-DNA glycosylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 FPG-type zinc finger [H]
Homologues:
Organism=Escherichia coli, GI1790066, Length=144, Percent_Identity=34.0277777777778, Blast_Score=68, Evalue=3e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR015886 - InterPro: IPR015887 - InterPro: IPR000191 - InterPro: IPR012319 - InterPro: IPR020629 - InterPro: IPR010979 - InterPro: IPR000214 - InterPro: IPR010663 [H]
Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]
EC number: =3.2.2.23; =4.2.99.18 [H]
Molecular weight: Translated: 16495; Mature: 16364
Theoretical pI: Translated: 9.41; Mature: 9.41
Prosite motif: PS51066 ZF_FPG_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
3.2 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 5.7 %Cys+Met (Translated Protein) 3.2 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 5.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAGTPQPRALGPDALDVSTDDLAGLLAGNTGRIKTVITDQKVIAGIGNAYSDEILHVAKI CCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECHHHHHHCCCCHHHHHHHHHHC SPFATAGKLSGAQLTCLHEAMASVLSDAVRRSVGQGAAMLKGEKRSGLRVHARTGLPCPV CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCCCCCEEEECCCCCCCC CGDTVREVSFADKSFQYCPTCQTGGKALADRRMSRLLK CCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCC >Mature Secondary Structure AGTPQPRALGPDALDVSTDDLAGLLAGNTGRIKTVITDQKVIAGIGNAYSDEILHVAKI CCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECHHHHHHCCCCHHHHHHHHHHC SPFATAGKLSGAQLTCLHEAMASVLSDAVRRSVGQGAAMLKGEKRSGLRVHARTGLPCPV CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCCCCCEEEECCCCCCCC CGDTVREVSFADKSFQYCPTCQTGGKALADRRMSRLLK CCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA