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The map label for this gene is ubiB [C]

Identifier: 121636568

GI number: 121636568

Start: 772027

End: 773493

Strand: Reverse

Name: ubiB [C]

Synonym: BCG_0696c

Alternate gene names: 121636568

Gene position: 773493-772027 (Counterclockwise)

Preceding gene: 121636574

Following gene: 121636567

Centisome position: 17.68

GC content: 65.78

Gene sequence:

>1467_bases
ATGAGGGCGGAAATCGGGCCGGATTTCCGCCCTCATTACACATTCGGCGACGCTTACCCAGCAAGTGAGCGGGCTCACGT
CAATTGGGAGCTGTCTGCCCCGGTTTGGCACACTGCTCAGATGGGTTCCACCACACACCGCGAGGTGGCCAAGCTTGACC
GGGTACCGCTGCCGGTCGAAGCTGCCCGGGTGGCGGCCACCGGTTGGCAGGTCACCCGCACCGCCGTCCGGTTCATCGGC
AGGCTCCCCCGAAAAGGGCCCTGGCAACAGAAGGTGATCAAGGAGCTCCCGCAGACCTTCGCCGATCTGGGACCGACATA
CGTGAAGTTCGGCCAGATCATCGCGTCCAGCCCGGGAGCATTCGGTGAGTCGCTGTCGCGGGAATTCCGCGGCCTGCTCG
ACCGGGTGCCGCCCGCAAAAACCGACGAGGTGCACAAGCTCTTCGTCGAGGAACTCGGCGACGAGCCGGCCCGGCTGTTC
GCCTCCTTCGAGGAAGAGCCGTTCGCGTCGGCGTCCATCGCCCAGGTGCACTACGCGACCCTGCGCAGCGGCGAGGAGGT
GGTGGTCAAGATCCAGCGGCCGGGCATCCGCCGCCGCGTTGCCGCCGACCTGCAGATCCTCAAGCGCTTCGCGCAGACCG
TCGAACTGGCCAAGCTGGGCCGGCGGCTCTCGGCACAAGACGTGGTCGCCGACTTCGCCGACAACCTGGCCGAGGAGCTG
GACTTTCGCCTCGAGGCGCAGTCCATGGAGGCCTGGGTCTCCCACCTACACGCCTCGCCGCTGGGCAAAAACATCCGGGT
GCCGCAGGTGCACTGGGACTTCACCACCGAGCGGGTGTTGACGATGGAACGGGTGCACGGCATCCGCATCGACAACACCG
CCGCGATCCGCAAGGCCGGGTTCGACGGTGTCGAGCTGGTCAAGGCACTGCTGTTTTCGGTGTTCGAGGGCGGCCTGCGG
CACGGGCTGTTCCACGGCGACCTGCACGCGGGCAACCTCTACGTCGACGAGGCGGGCCGCATCGTGTTCTTCGACTTCGG
GATCATGGGCCGCATCGATCCACGCACCCGCTGGCTACTCCGCGAGCTGGTGTATGCGCTGCTGGTGAAGAAGGACCACG
CAGCCGCCGGCAAGATCGTCGTGCTCATGGGCGCCGTCGGCACCATGAAGCCCGAGACCCAGGCCGCCAAAGACCTGGAG
CGCTTCGCCACCCCGCTGACCATGCAATCGCTGGGCGACATGTCATATGCCGACATCGGCCGCCAGCTCTCGGCGCTGGC
CGACGCCTACGACGTCAAGCTGCCCCGCGAGCTGGTGCTGATCGGCAAGCAGTTCCTGTACGTGGAGCGCTACATGAAGC
TGCTGGCGCCGAGGTGGCAGATGATGTCGGACCCGCAGCTGACCGGATATTTCGCCAACTTCATGGTCGAGGTCAGCCGC
GAACATCAATCCGACATCGAGGTTTAG

Upstream 100 bases:

>100_bases
CGAAACCACCCGCATGACCGCACCTTACGGCGACCAATCGTTGCGATAAAGGAACGCCTCCGGCCCAGCAGCGGGCCAAC
CGAGCGTCGCCGAATGTGTA

Downstream 100 bases:

>100_bases
GCGAGGTCTCGGTGGACATCCGTAGCGGCACCGCGGTCTCCGGTGATGTGAAGCTGTACTACGAGGACATGGGTGACCTC
GACCACCCGCCGGTGTTGCT

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MRAEIGPDFRPHYTFGDAYPASERAHVNWELSAPVWHTAQMGSTTHREVAKLDRVPLPVEAARVAATGWQVTRTAVRFIG
RLPRKGPWQQKVIKELPQTFADLGPTYVKFGQIIASSPGAFGESLSREFRGLLDRVPPAKTDEVHKLFVEELGDEPARLF
ASFEEEPFASASIAQVHYATLRSGEEVVVKIQRPGIRRRVAADLQILKRFAQTVELAKLGRRLSAQDVVADFADNLAEEL
DFRLEAQSMEAWVSHLHASPLGKNIRVPQVHWDFTTERVLTMERVHGIRIDNTAAIRKAGFDGVELVKALLFSVFEGGLR
HGLFHGDLHAGNLYVDEAGRIVFFDFGIMGRIDPRTRWLLRELVYALLVKKDHAAAGKIVVLMGAVGTMKPETQAAKDLE
RFATPLTMQSLGDMSYADIGRQLSALADAYDVKLPRELVLIGKQFLYVERYMKLLAPRWQMMSDPQLTGYFANFMVEVSR
EHQSDIEV

Sequences:

>Translated_488_residues
MRAEIGPDFRPHYTFGDAYPASERAHVNWELSAPVWHTAQMGSTTHREVAKLDRVPLPVEAARVAATGWQVTRTAVRFIG
RLPRKGPWQQKVIKELPQTFADLGPTYVKFGQIIASSPGAFGESLSREFRGLLDRVPPAKTDEVHKLFVEELGDEPARLF
ASFEEEPFASASIAQVHYATLRSGEEVVVKIQRPGIRRRVAADLQILKRFAQTVELAKLGRRLSAQDVVADFADNLAEEL
DFRLEAQSMEAWVSHLHASPLGKNIRVPQVHWDFTTERVLTMERVHGIRIDNTAAIRKAGFDGVELVKALLFSVFEGGLR
HGLFHGDLHAGNLYVDEAGRIVFFDFGIMGRIDPRTRWLLRELVYALLVKKDHAAAGKIVVLMGAVGTMKPETQAAKDLE
RFATPLTMQSLGDMSYADIGRQLSALADAYDVKLPRELVLIGKQFLYVERYMKLLAPRWQMMSDPQLTGYFANFMVEVSR
EHQSDIEV
>Mature_488_residues
MRAEIGPDFRPHYTFGDAYPASERAHVNWELSAPVWHTAQMGSTTHREVAKLDRVPLPVEAARVAATGWQVTRTAVRFIG
RLPRKGPWQQKVIKELPQTFADLGPTYVKFGQIIASSPGAFGESLSREFRGLLDRVPPAKTDEVHKLFVEELGDEPARLF
ASFEEEPFASASIAQVHYATLRSGEEVVVKIQRPGIRRRVAADLQILKRFAQTVELAKLGRRLSAQDVVADFADNLAEEL
DFRLEAQSMEAWVSHLHASPLGKNIRVPQVHWDFTTERVLTMERVHGIRIDNTAAIRKAGFDGVELVKALLFSVFEGGLR
HGLFHGDLHAGNLYVDEAGRIVFFDFGIMGRIDPRTRWLLRELVYALLVKKDHAAAGKIVVLMGAVGTMKPETQAAKDLE
RFATPLTMQSLGDMSYADIGRQLSALADAYDVKLPRELVLIGKQFLYVERYMKLLAPRWQMMSDPQLTGYFANFMVEVSR
EHQSDIEV

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=313, Percent_Identity=29.3929712460064, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI40254938, Length=248, Percent_Identity=29.8387096774194, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI217035081, Length=195, Percent_Identity=31.7948717948718, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI27363457, Length=260, Percent_Identity=30.7692307692308, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI217416386, Length=210, Percent_Identity=32.8571428571429, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI34147522, Length=252, Percent_Identity=25.3968253968254, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI2367309, Length=367, Percent_Identity=29.700272479564, Blast_Score=152, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17559152, Length=290, Percent_Identity=28.9655172413793, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI32565180, Length=149, Percent_Identity=32.8859060402685, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6323282, Length=299, Percent_Identity=27.7591973244147, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6321319, Length=202, Percent_Identity=29.7029702970297, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325148, Length=433, Percent_Identity=21.0161662817552, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24662575, Length=300, Percent_Identity=29.6666666666667, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI22024280, Length=267, Percent_Identity=27.7153558052434, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI18859849, Length=259, Percent_Identity=28.957528957529, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 54855; Mature: 54855

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAEIGPDFRPHYTFGDAYPASERAHVNWELSAPVWHTAQMGSTTHREVAKLDRVPLPVE
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEHHHCCCCHHHHHHHHCCCCCCHH
AARVAATGWQVTRTAVRFIGRLPRKGPWQQKVIKELPQTFADLGPTYVKFGQIIASSPGA
HHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCH
FGESLSREFRGLLDRVPPAKTDEVHKLFVEELGDEPARLFASFEEEPFASASIAQVHYAT
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHH
LRSGEEVVVKIQRPGIRRRVAADLQILKRFAQTVELAKLGRRLSAQDVVADFADNLAEEL
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
DFRLEAQSMEAWVSHLHASPLGKNIRVPQVHWDFTTERVLTMERVHGIRIDNTAAIRKAG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHCCEEECCHHHHHHCC
FDGVELVKALLFSVFEGGLRHGLFHGDLHAGNLYVDEAGRIVFFDFGIMGRIDPRTRWLL
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCHHHHHHH
RELVYALLVKKDHAAAGKIVVLMGAVGTMKPETQAAKDLERFATPLTMQSLGDMSYADIG
HHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHCCCHHHHHH
RQLSALADAYDVKLPRELVLIGKQFLYVERYMKLLAPRWQMMSDPQLTGYFANFMVEVSR
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHH
EHQSDIEV
HHHCCCCC
>Mature Secondary Structure
MRAEIGPDFRPHYTFGDAYPASERAHVNWELSAPVWHTAQMGSTTHREVAKLDRVPLPVE
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEHHHCCCCHHHHHHHHCCCCCCHH
AARVAATGWQVTRTAVRFIGRLPRKGPWQQKVIKELPQTFADLGPTYVKFGQIIASSPGA
HHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCH
FGESLSREFRGLLDRVPPAKTDEVHKLFVEELGDEPARLFASFEEEPFASASIAQVHYAT
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHH
LRSGEEVVVKIQRPGIRRRVAADLQILKRFAQTVELAKLGRRLSAQDVVADFADNLAEEL
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
DFRLEAQSMEAWVSHLHASPLGKNIRVPQVHWDFTTERVLTMERVHGIRIDNTAAIRKAG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHCCEEECCHHHHHHCC
FDGVELVKALLFSVFEGGLRHGLFHGDLHAGNLYVDEAGRIVFFDFGIMGRIDPRTRWLL
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCHHHHHHH
RELVYALLVKKDHAAAGKIVVLMGAVGTMKPETQAAKDLERFATPLTMQSLGDMSYADIG
HHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHCCCHHHHHH
RQLSALADAYDVKLPRELVLIGKQFLYVERYMKLLAPRWQMMSDPQLTGYFANFMVEVSR
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHH
EHQSDIEV
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]