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The map label for this gene is yngE [H]

Identifier: 120612990

GI number: 120612990

Start: 4836384

End: 4837988

Strand: Reverse

Name: yngE [H]

Synonym: Aave_4354

Alternate gene names: 120612990

Gene position: 4837988-4836384 (Counterclockwise)

Preceding gene: 120612991

Following gene: 120612989

Centisome position: 90.38

GC content: 68.91

Gene sequence:

>1605_bases
ATGATTCTCGAATCCCGCCTCAATCCCCGCTCGGCCGACTTCCAGGCCAATGCTTCCGCGATGCGCGTGCTCGTGCAGGA
TCTGCGCGAGCGCGCGGCCCAGGTGGCCCTGGGCGGCAGCGAAGCCGCGCGCGCCAAGCATACGGCGCGCGGCAAGCTGC
TGCCGCGCGACCGCGTGCGCGAGCTGCTGGACCCGGGCTCCCCGTTCCTGGAGATCGCGCCGCTGGCCGCGCTGGGCATG
TACGGCGACGAGGCGCCGGGCGCGGGCCTGATCGCGGGCATCGGGCGGGTGAGCGGCGTGGACTGCATGGTGGTGTGCAA
TGACGCCACGGTGAAGGGCGGCACCTACTATCCGATGACCGTGAAGAAGCACCTGCGTGCGCAGGAGATCGCGCAGCAGA
ACCGTCTGCCGTGCATCTATCTGGTCGATTCGGGGGGCGCCAACCTGCCGAACCAGGACGAGGTGTTTCCCGACCGAGAC
CATTTCGGCCGCATCTTCTACAACCAGGCGCAGATGAGCGCGCAGGGCATCGCGCAGATCGCGGTGGTGATGGGCAGCTG
CACGGCGGGCGGGGCATATGTGCCGGCGATGAGCGACGAGTCCATCATCGTGAAGAACCAGGGCACGATCTTCCTGGGCG
GCCCGCCGCTGGTGAAGGCGGCCACGGGCGAGGTGGTGACCGCCGAGGACCTGGGCGGCGGCGACGTGCATACGCGGCTG
TCGGGCGTGGCCGACCATCTCGCTCAGAACGACCTGCATGCGCTGCAGCTCGCGCGCCATGCGGTGCGCAACCTGAACCG
CGAGCGCGCGCCGGCCGCCGGCTGCGCGGCGCCGCAGGCGCCTGCGTTCGAGGCGCAGGAGCTGTATGGCGTGATTCCGG
TGGATACGCGCAAGCCGTTCGACGTGCGCGAGATCATCGCGCGCATCGTGGACGGCAGCGAATTCGACGAATTCAAGGCG
CGCTACGGCACCACGCTGGTCACGGGCTTCGCGCGCATCGAGGGCATGCCCGTGGGCATCATCGCCAACAACGGCATCCT
GTTCTCGGAGGCGGCCCTCAAGGGCGCGCATTTCATCGAGCTGTGCTGCCAGCGCAAGATTCCGCTGGTGTTCCTGCAGA
ACATCACCGGCTTCATGGTGGGCCGCAAGTACGAAAACGAAGGCATCGCGCGCAACGGCGCCAAGATGGTGACGGCGGTG
GCCACGGCGGCCGTGCCGAAGTTCACGATCGTCATCGGCGGCTCGTTCGGCGCCGGCAACTACGGCATGTGCGGCCGCGC
CTATTCGCCGCGCTTTCTCTGGATGTGGCCGAACGCGCGCATCTCGGTGATGGGAGGCGAGCAGGCCGCGAGCGTGCTGG
CCACCGTCCGGCGCGACGGGATCGAGGGCAAGGGCGGCACCTGGAGCGTGGAGGAGGAAGAGGCGTTCAAGGCGCCGATC
CGCCGCCAGTACGAGGAACAGGGGCACCCCTACTACGCCACGGCGCGCCTGTGGGACGATGGGGTGATCGACCCCGCGGA
CACGCGCCGCGTGCTGGCGCTGGGCCTGGCCGCCGCGCGCAATGCGCCCATAGAGGACACGAAGTTCGGCGTTTTCCGCA
TGTGA

Upstream 100 bases:

>100_bases
TGACCGGAAAGATCCAGAAATTCAAGATCCGCGATGCCATGAAGGAGCAGCTCGGCCTGACCGAGCGCGCCACCGCCTGA
AATCTTCCTCCCGCCCCGCC

Downstream 100 bases:

>100_bases
GCGCCCCGGGGCTCGCCCATCCTGACAGCACAAGGAGGAATCCACCATGACGACCACCGAATACCGCCATCTGCACGTCG
GCCAGGCCGGATCGATCGCG

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MILESRLNPRSADFQANASAMRVLVQDLRERAAQVALGGSEAARAKHTARGKLLPRDRVRELLDPGSPFLEIAPLAALGM
YGDEAPGAGLIAGIGRVSGVDCMVVCNDATVKGGTYYPMTVKKHLRAQEIAQQNRLPCIYLVDSGGANLPNQDEVFPDRD
HFGRIFYNQAQMSAQGIAQIAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEVVTAEDLGGGDVHTRL
SGVADHLAQNDLHALQLARHAVRNLNRERAPAAGCAAPQAPAFEAQELYGVIPVDTRKPFDVREIIARIVDGSEFDEFKA
RYGTTLVTGFARIEGMPVGIIANNGILFSEAALKGAHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTAV
ATAAVPKFTIVIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEGKGGTWSVEEEEAFKAPI
RRQYEEQGHPYYATARLWDDGVIDPADTRRVLALGLAAARNAPIEDTKFGVFRM

Sequences:

>Translated_534_residues
MILESRLNPRSADFQANASAMRVLVQDLRERAAQVALGGSEAARAKHTARGKLLPRDRVRELLDPGSPFLEIAPLAALGM
YGDEAPGAGLIAGIGRVSGVDCMVVCNDATVKGGTYYPMTVKKHLRAQEIAQQNRLPCIYLVDSGGANLPNQDEVFPDRD
HFGRIFYNQAQMSAQGIAQIAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEVVTAEDLGGGDVHTRL
SGVADHLAQNDLHALQLARHAVRNLNRERAPAAGCAAPQAPAFEAQELYGVIPVDTRKPFDVREIIARIVDGSEFDEFKA
RYGTTLVTGFARIEGMPVGIIANNGILFSEAALKGAHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTAV
ATAAVPKFTIVIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEGKGGTWSVEEEEAFKAPI
RRQYEEQGHPYYATARLWDDGVIDPADTRRVLALGLAAARNAPIEDTKFGVFRM
>Mature_534_residues
MILESRLNPRSADFQANASAMRVLVQDLRERAAQVALGGSEAARAKHTARGKLLPRDRVRELLDPGSPFLEIAPLAALGM
YGDEAPGAGLIAGIGRVSGVDCMVVCNDATVKGGTYYPMTVKKHLRAQEIAQQNRLPCIYLVDSGGANLPNQDEVFPDRD
HFGRIFYNQAQMSAQGIAQIAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEVVTAEDLGGGDVHTRL
SGVADHLAQNDLHALQLARHAVRNLNRERAPAAGCAAPQAPAFEAQELYGVIPVDTRKPFDVREIIARIVDGSEFDEFKA
RYGTTLVTGFARIEGMPVGIIANNGILFSEAALKGAHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTAV
ATAAVPKFTIVIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEGKGGTWSVEEEEAFKAPI
RRQYEEQGHPYYATARLWDDGVIDPADTRRVLALGLAAARNAPIEDTKFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=525, Percent_Identity=67.4285714285714, Blast_Score=729, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=518, Percent_Identity=32.2393822393822, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI295821216, Length=538, Percent_Identity=30.8550185873606, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI310133460, Length=135, Percent_Identity=62.2222222222222, Blast_Score=160, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=60.2251407129456, Blast_Score=689, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=498, Percent_Identity=33.3333333333333, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI25147359, Length=498, Percent_Identity=33.3333333333333, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24586065, Length=550, Percent_Identity=64.1818181818182, Blast_Score=722, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 57373; Mature: 57373

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILESRLNPRSADFQANASAMRVLVQDLRERAAQVALGGSEAARAKHTARGKLLPRDRVR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCCCCHHHHH
ELLDPGSPFLEIAPLAALGMYGDEAPGAGLIAGIGRVSGVDCMVVCNDATVKGGTYYPMT
HHHCCCCCCEEHHHHHHHCCCCCCCCCCCHHHHHHCCCCCEEEEEECCCEECCCEECCHH
VKKHLRAQEIAQQNRLPCIYLVDSGGANLPNQDEVFPDRDHFGRIFYNQAQMSAQGIAQI
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHCCCEEEHHHHHHHHHHHHH
AVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEVVTAEDLGGGDVHTRL
HHHHHCCCCCCEEECCCCCCEEEEECCCEEEECCCCEEEECCCCEEEECCCCCCHHHHHH
SGVADHLAQNDLHALQLARHAVRNLNRERAPAAGCAAPQAPAFEAQELYGVIPVDTRKPF
HHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCHHHHEEEEECCCCCCC
DVREIIARIVDGSEFDEFKARYGTTLVTGFARIEGMPVGIIANNGILFSEAALKGAHFIE
CHHHHHHHHHCCCCHHHHHHHHCHHHEEHHHHHCCCEEEEEECCCEEEEHHHHCCHHHHH
LCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTAVATAAVPKFTIVIGGSFGAGN
HHHCCCCCEEEECCCHHHHCCCEECCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCC
YGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEGKGGTWSVEEEEAFKAPI
CCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
RRQYEEQGHPYYATARLWDDGVIDPADTRRVLALGLAAARNAPIEDTKFGVFRM
HHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEECC
>Mature Secondary Structure
MILESRLNPRSADFQANASAMRVLVQDLRERAAQVALGGSEAARAKHTARGKLLPRDRVR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCCCCHHHHH
ELLDPGSPFLEIAPLAALGMYGDEAPGAGLIAGIGRVSGVDCMVVCNDATVKGGTYYPMT
HHHCCCCCCEEHHHHHHHCCCCCCCCCCCHHHHHHCCCCCEEEEEECCCEECCCEECCHH
VKKHLRAQEIAQQNRLPCIYLVDSGGANLPNQDEVFPDRDHFGRIFYNQAQMSAQGIAQI
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHCCCEEEHHHHHHHHHHHHH
AVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEVVTAEDLGGGDVHTRL
HHHHHCCCCCCEEECCCCCCEEEEECCCEEEECCCCEEEECCCCEEEECCCCCCHHHHHH
SGVADHLAQNDLHALQLARHAVRNLNRERAPAAGCAAPQAPAFEAQELYGVIPVDTRKPF
HHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCHHHHEEEEECCCCCCC
DVREIIARIVDGSEFDEFKARYGTTLVTGFARIEGMPVGIIANNGILFSEAALKGAHFIE
CHHHHHHHHHCCCCHHHHHHHHCHHHEEHHHHHCCCEEEEEECCCEEEEHHHHCCHHHHH
LCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTAVATAAVPKFTIVIGGSFGAGN
HHHCCCCCEEEECCCHHHHCCCEECCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCC
YGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEGKGGTWSVEEEEAFKAPI
CCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
RRQYEEQGHPYYATARLWDDGVIDPADTRRVLALGLAAARNAPIEDTKFGVFRM
HHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]