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The map label for this gene is gabT [H]

Identifier: 120612969

GI number: 120612969

Start: 4810765

End: 4812138

Strand: Reverse

Name: gabT [H]

Synonym: Aave_4333

Alternate gene names: 120612969

Gene position: 4812138-4810765 (Counterclockwise)

Preceding gene: 120612977

Following gene: 120612968

Centisome position: 89.9

GC content: 64.34

Gene sequence:

>1374_bases
ATGACCATCGACGCTGCCCAGCTCCTCGCGGACGAAGCCAAGTACTGCTCCTTCGGCGATACCGTCCACTACGTGAACCC
GCCCAAGATCTTCACGGGCTGCGACGGCAGCTACATGCTGGACGACAACGGCACGCAGTACCTCGACCTGCAGATGTGGT
ATTCGGCCGTGAACTTCGGCTACAAGAACAAGCGCCTCGAAGCCAAGATGATCGAGCAGCTGCAGGCGCTGCCCCAGGTC
GCCAGCCAGTACCTGCACCCGACCAAGATCGAGCTGGCCAAGTTCATCGCCGAAGACGCCAGGCGCAAGTGGGGCAGCGA
CGGCCGCGTGCACTTCAACGTGGGCGGCGCGCAGGCCATCGAGGATTCGCTGAAGGTGGTGCGCAACGCCAGCAACGGCA
AGAGCCTGATGTTCGCGTTCGAGGGCGGCTACCACGGCCGCACGCTGGGCGCTTCCAGCATCACCTCCAGCTACCGCTAC
CGCCGCCGCTTCGGCCATTTCGGCGACCGCGCGCAGTTCATTCCGTTCCCCTATCCCTTCCGCCGCCCCAAGGGCATGAC
GGCCGAGGAGTATTCGGACCAGATCGTGCGCGAGTTCGCCCGCAAGTTCGAGAACGAATACCACGCCGTCTGGGACCCCA
AGACCAACCAGTGCGAGTACGCGGCCTTCTATGTCGAGCCCATCCAGGGCACGGGCGGCTACGTCGTGCCGCCGCCGAAC
TTCTTCAAGGGCCTCAAGAAGGTGCTGGACGACCACGGCATCCTGATGGTGGTCGATGAGATCCAGATGGGCTTCTGGCG
CACCGGCACGCTCTGGTCGGTGGAGAACTTCGGCATCAAGCCCGACGTGCTGGTTTTTGCGAAGGCGCTGACCAACGGCC
TCAACGCCCTGTCCGGGCTGTGGGCGCGCGAGGAGCTGATCAACCCGAAGATCTTCCCGCCCGGCTCCACGCATTCCACC
TTCGCCTCCAACCCGCTGGGCACGGCCCTGGGCCTGGAAGTGATGAAGATGACGCACGAGATCGACTTCGGCAAGCAGGT
GCGCGAATCCGGCGCCTACTTCCTCGAAGGCCTCAAGGAGCTGCAGAAGCGCCACAAGGAGATCGGCGACGTGGACGGCC
TGGGCCTGGCGCTGCGCGCCGAGATCTGCACCGAGGACGGCTTCACGCCCAACAAGGCGCTGCTGGACAAGATGGTGGAC
ATCGGCCTCGAAGGCAACCTGGAGTACCAGGGCCAGAAGCGCGGCCTGGTGCTGGACGTGGGCGGCTACTACAAGAACGT
GATCACCTTCGCGCCGTCGCTGATGATCTCGCGCGCCGAGATCGACGAGGCGATGGTGCTGCTGGACCAGCTCCTGACCC
GCGCGAAAAAGTGA

Upstream 100 bases:

>100_bases
TCCACCATCTGCACAAATCGCACACAAACGCTCGATAGTCGATCAAGGTTGGCTGCGCAGACTCGCGCCCATTCCTTTCT
CGTTGCGGATTTTTCCTTCC

Downstream 100 bases:

>100_bases
GCCAACCCCCCGAGCAGCTTCACCGCTCCCCCCTTCTCTCGCTTCGCGGGAAGGGGGGCGACGCCAGCGCGGCGGGGCGA
CCCTTGCGCGGCGTCTGCGC

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MTIDAAQLLADEAKYCSFGDTVHYVNPPKIFTGCDGSYMLDDNGTQYLDLQMWYSAVNFGYKNKRLEAKMIEQLQALPQV
ASQYLHPTKIELAKFIAEDARRKWGSDGRVHFNVGGAQAIEDSLKVVRNASNGKSLMFAFEGGYHGRTLGASSITSSYRY
RRRFGHFGDRAQFIPFPYPFRRPKGMTAEEYSDQIVREFARKFENEYHAVWDPKTNQCEYAAFYVEPIQGTGGYVVPPPN
FFKGLKKVLDDHGILMVVDEIQMGFWRTGTLWSVENFGIKPDVLVFAKALTNGLNALSGLWAREELINPKIFPPGSTHST
FASNPLGTALGLEVMKMTHEIDFGKQVRESGAYFLEGLKELQKRHKEIGDVDGLGLALRAEICTEDGFTPNKALLDKMVD
IGLEGNLEYQGQKRGLVLDVGGYYKNVITFAPSLMISRAEIDEAMVLLDQLLTRAKK

Sequences:

>Translated_457_residues
MTIDAAQLLADEAKYCSFGDTVHYVNPPKIFTGCDGSYMLDDNGTQYLDLQMWYSAVNFGYKNKRLEAKMIEQLQALPQV
ASQYLHPTKIELAKFIAEDARRKWGSDGRVHFNVGGAQAIEDSLKVVRNASNGKSLMFAFEGGYHGRTLGASSITSSYRY
RRRFGHFGDRAQFIPFPYPFRRPKGMTAEEYSDQIVREFARKFENEYHAVWDPKTNQCEYAAFYVEPIQGTGGYVVPPPN
FFKGLKKVLDDHGILMVVDEIQMGFWRTGTLWSVENFGIKPDVLVFAKALTNGLNALSGLWAREELINPKIFPPGSTHST
FASNPLGTALGLEVMKMTHEIDFGKQVRESGAYFLEGLKELQKRHKEIGDVDGLGLALRAEICTEDGFTPNKALLDKMVD
IGLEGNLEYQGQKRGLVLDVGGYYKNVITFAPSLMISRAEIDEAMVLLDQLLTRAKK
>Mature_456_residues
TIDAAQLLADEAKYCSFGDTVHYVNPPKIFTGCDGSYMLDDNGTQYLDLQMWYSAVNFGYKNKRLEAKMIEQLQALPQVA
SQYLHPTKIELAKFIAEDARRKWGSDGRVHFNVGGAQAIEDSLKVVRNASNGKSLMFAFEGGYHGRTLGASSITSSYRYR
RRFGHFGDRAQFIPFPYPFRRPKGMTAEEYSDQIVREFARKFENEYHAVWDPKTNQCEYAAFYVEPIQGTGGYVVPPPNF
FKGLKKVLDDHGILMVVDEIQMGFWRTGTLWSVENFGIKPDVLVFAKALTNGLNALSGLWAREELINPKIFPPGSTHSTF
ASNPLGTALGLEVMKMTHEIDFGKQVRESGAYFLEGLKELQKRHKEIGDVDGLGLALRAEICTEDGFTPNKALLDKMVDI
GLEGNLEYQGQKRGLVLDVGGYYKNVITFAPSLMISRAEIDEAMVLLDQLLTRAKK

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=438, Percent_Identity=23.7442922374429, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI226442705, Length=438, Percent_Identity=23.972602739726, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI13994255, Length=443, Percent_Identity=24.1534988713318, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI4557809, Length=433, Percent_Identity=25.8660508083141, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI226442709, Length=389, Percent_Identity=23.6503856041131, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI24119277, Length=436, Percent_Identity=22.7064220183486, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI188536080, Length=435, Percent_Identity=26.2068965517241, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI38679950, Length=435, Percent_Identity=26.2068965517241, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI38679946, Length=435, Percent_Identity=26.2068965517241, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI284507298, Length=326, Percent_Identity=27.6073619631902, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1789016, Length=419, Percent_Identity=28.8782816229117, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI1787560, Length=422, Percent_Identity=27.9620853080569, Blast_Score=164, Evalue=7e-42,
Organism=Escherichia coli, GI145693181, Length=347, Percent_Identity=27.9538904899135, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1789759, Length=416, Percent_Identity=27.4038461538462, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1788044, Length=438, Percent_Identity=27.8538812785388, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1786991, Length=354, Percent_Identity=27.4011299435028, Blast_Score=101, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=443, Percent_Identity=23.4762979683973, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI32564660, Length=456, Percent_Identity=25.219298245614, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25144271, Length=439, Percent_Identity=23.4624145785877, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17541228, Length=450, Percent_Identity=24.8888888888889, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25144274, Length=357, Percent_Identity=23.5294117647059, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323470, Length=451, Percent_Identity=28.3813747228381, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6324432, Length=416, Percent_Identity=26.2019230769231, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321456, Length=368, Percent_Identity=24.1847826086957, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324386, Length=380, Percent_Identity=22.3684210526316, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161085790, Length=455, Percent_Identity=24.3956043956044, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28574759, Length=458, Percent_Identity=24.6724890829694, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21357415, Length=439, Percent_Identity=24.6013667425968, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21356575, Length=448, Percent_Identity=22.7678571428571, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI281366494, Length=449, Percent_Identity=24.7216035634744, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24667139, Length=449, Percent_Identity=24.7216035634744, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24667143, Length=449, Percent_Identity=24.7216035634744, Blast_Score=85, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 51317; Mature: 51186

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS01159 WW_DOMAIN_1 ; PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDAAQLLADEAKYCSFGDTVHYVNPPKIFTGCDGSYMLDDNGTQYLDLQMWYSAVNFG
CCCCHHHHHHHHHHHCCCCCEEEECCCCCEEECCCCCEEECCCCCEEEHHHHHHHHHHCC
YKNKRLEAKMIEQLQALPQVASQYLHPTKIELAKFIAEDARRKWGSDGRVHFNVGGAQAI
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHH
EDSLKVVRNASNGKSLMFAFEGGYHGRTLGASSITSSYRYRRRFGHFGDRAQFIPFPYPF
HHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
RRPKGMTAEEYSDQIVREFARKFENEYHAVWDPKTNQCEYAAFYVEPIQGTGGYVVPPPN
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEEECCCCCCEECCCCH
FFKGLKKVLDDHGILMVVDEIQMGFWRTGTLWSVENFGIKPDVLVFAKALTNGLNALSGL
HHHHHHHHHCCCCEEEEEECHHCCEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
WAREELINPKIFPPGSTHSTFASNPLGTALGLEVMKMTHEIDFGKQVRESGAYFLEGLKE
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LQKRHKEIGDVDGLGLALRAEICTEDGFTPNKALLDKMVDIGLEGNLEYQGQKRGLVLDV
HHHHHHHHCCCCCCCCEEEEEHHCCCCCCCCHHHHHHHHHCCCCCCEEECCCCCCEEEEC
GGYYKNVITFAPSLMISRAEIDEAMVLLDQLLTRAKK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TIDAAQLLADEAKYCSFGDTVHYVNPPKIFTGCDGSYMLDDNGTQYLDLQMWYSAVNFG
CCCHHHHHHHHHHHCCCCCEEEECCCCCEEECCCCCEEECCCCCEEEHHHHHHHHHHCC
YKNKRLEAKMIEQLQALPQVASQYLHPTKIELAKFIAEDARRKWGSDGRVHFNVGGAQAI
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHH
EDSLKVVRNASNGKSLMFAFEGGYHGRTLGASSITSSYRYRRRFGHFGDRAQFIPFPYPF
HHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
RRPKGMTAEEYSDQIVREFARKFENEYHAVWDPKTNQCEYAAFYVEPIQGTGGYVVPPPN
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEEECCCCCCEECCCCH
FFKGLKKVLDDHGILMVVDEIQMGFWRTGTLWSVENFGIKPDVLVFAKALTNGLNALSGL
HHHHHHHHHCCCCEEEEEECHHCCEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
WAREELINPKIFPPGSTHSTFASNPLGTALGLEVMKMTHEIDFGKQVRESGAYFLEGLKE
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LQKRHKEIGDVDGLGLALRAEICTEDGFTPNKALLDKMVDIGLEGNLEYQGQKRGLVLDV
HHHHHHHHCCCCCCCCEEEEEHHCCCCCCCCHHHHHHHHHCCCCCCEEECCCCCCEEEEC
GGYYKNVITFAPSLMISRAEIDEAMVLLDQLLTRAKK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]