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The map label for this gene is fucA [C]

Identifier: 120612941

GI number: 120612941

Start: 4781477

End: 4782271

Strand: Reverse

Name: fucA [C]

Synonym: Aave_4305

Alternate gene names: 120612941

Gene position: 4782271-4781477 (Counterclockwise)

Preceding gene: 120612942

Following gene: 120612940

Centisome position: 89.34

GC content: 70.06

Gene sequence:

>795_bases
ATGAATGCAATCCCCGAGGCTTCCAGCGTGCGCAGCCAGGTCACGCCCGAGGAATGGCAGACCCGCGTCGAACTGGCCGC
CGCCTACCGGCTGGTGGCCCATTTCGGCTGGGACGATCTGATCTTCACGCACATCTCCGCGCGCGTGCCGGGCCAGCCGG
ACCAGTTCCTCATCAATCCCTACGGCATGCTGTTCGACGAGATCACGGCCTCCAGCCTGGTCAAGGTGGACCACCACGGC
GAGCCCGTCATGGCGACGGAGTACGACGTGAACCCGGCGGGCTTCCTGATCCACAGCGCGATCCACGAGGGCCGGCCCGA
AGTGCAGTGCGTCCTGCACACCCACACGCAGTACGGCGTGGCGGTGTCGGCGCAGTACGGCGTGGCGGTGTCGGCGCAGG
AGGGCGGGCTGCTGCCGATCTCGCAGCAGTCCATCTTCCCGCTCGCGCGGCTGGCCTACCACGGCTACGAGGGCGTGGCG
CTGCGCGACGACGAGCGGCCGCGGCTGGTGGCCGACCTGGGGGACGCCAGCTTCCTGATCCTTCGCAACCACGGCCTGCT
GACCTGCGGGCGCAGCGTGCCCGAGGCCCTGCTGTCGATGTACACGCTCGAATCGGCCTGCCGCATCCAGATCCTGGCGC
AGTCGGGCGGCGGCGCGCTCACGCGCATTCCCGACGAGATCGTCGCCACCTCGGTGGAGCAGTCGCGGCAGGTGACCAAG
GGCAAGGGCGCGGGCCTGGCCTGGCCCGGGCTGCTGCGCCGGCTGGACCGGATCGACCCCAGCTACCGGACCTGA

Upstream 100 bases:

>100_bases
ACGGGCTGGAGGCGGACCTGTTCACCGCCGTGCCGGAGCTGGTCGGCCGGCTCTGAGGCGTGTGCCGTGCGCCCGTATTG
AACGGAAGAAAGGTTTCACC

Downstream 100 bases:

>100_bases
GCGGACGGCCTTCCCCATAAAAAGACCAGGAGACAGACACATGACCTTCCCTTCCTCCCGCCGCACCTTCCTGCACGCCG
GCACCGCCCTGGCCGCCGGT

Product: aldolase II superfamily protein

Products: Dihydroxyacetone phosphate; L-Lactaldehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MNAIPEASSVRSQVTPEEWQTRVELAAAYRLVAHFGWDDLIFTHISARVPGQPDQFLINPYGMLFDEITASSLVKVDHHG
EPVMATEYDVNPAGFLIHSAIHEGRPEVQCVLHTHTQYGVAVSAQYGVAVSAQEGGLLPISQQSIFPLARLAYHGYEGVA
LRDDERPRLVADLGDASFLILRNHGLLTCGRSVPEALLSMYTLESACRIQILAQSGGGALTRIPDEIVATSVEQSRQVTK
GKGAGLAWPGLLRRLDRIDPSYRT

Sequences:

>Translated_264_residues
MNAIPEASSVRSQVTPEEWQTRVELAAAYRLVAHFGWDDLIFTHISARVPGQPDQFLINPYGMLFDEITASSLVKVDHHG
EPVMATEYDVNPAGFLIHSAIHEGRPEVQCVLHTHTQYGVAVSAQYGVAVSAQEGGLLPISQQSIFPLARLAYHGYEGVA
LRDDERPRLVADLGDASFLILRNHGLLTCGRSVPEALLSMYTLESACRIQILAQSGGGALTRIPDEIVATSVEQSRQVTK
GKGAGLAWPGLLRRLDRIDPSYRT
>Mature_264_residues
MNAIPEASSVRSQVTPEEWQTRVELAAAYRLVAHFGWDDLIFTHISARVPGQPDQFLINPYGMLFDEITASSLVKVDHHG
EPVMATEYDVNPAGFLIHSAIHEGRPEVQCVLHTHTQYGVAVSAQYGVAVSAQEGGLLPISQQSIFPLARLAYHGYEGVA
LRDDERPRLVADLGDASFLILRNHGLLTCGRSVPEALLSMYTLESACRIQILAQSGGGALTRIPDEIVATSVEQSRQVTK
GKGAGLAWPGLLRRLDRIDPSYRT

Specific function: Fucose metabolism; third step. [C]

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family [H]

Homologues:

Organism=Homo sapiens, GI29826325, Length=257, Percent_Identity=41.6342412451362, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI29826323, Length=257, Percent_Identity=41.6342412451362, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI29826319, Length=257, Percent_Identity=41.6342412451362, Blast_Score=171, Evalue=5e-43,
Organism=Homo sapiens, GI29826321, Length=257, Percent_Identity=41.6342412451362, Blast_Score=171, Evalue=5e-43,
Organism=Homo sapiens, GI9951927, Length=284, Percent_Identity=35.2112676056338, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI62912453, Length=284, Percent_Identity=35.2112676056338, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI9943848, Length=284, Percent_Identity=35.2112676056338, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI297307158, Length=205, Percent_Identity=36.5853658536585, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI9257192, Length=205, Percent_Identity=36.5853658536585, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI9257190, Length=205, Percent_Identity=36.5853658536585, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI89276787, Length=205, Percent_Identity=36.5853658536585, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI297307160, Length=205, Percent_Identity=36.5853658536585, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI115533216, Length=263, Percent_Identity=40.6844106463878, Blast_Score=182, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI115533218, Length=267, Percent_Identity=40.8239700374532, Blast_Score=181, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71989560, Length=246, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI71989550, Length=246, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI71989544, Length=246, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI71989555, Length=246, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI71989541, Length=246, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=9e-32,
Organism=Drosophila melanogaster, GI281363755, Length=220, Percent_Identity=35.4545454545455, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI281363751, Length=220, Percent_Identity=35.4545454545455, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24655690, Length=220, Percent_Identity=35.4545454545455, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24655685, Length=220, Percent_Identity=35.4545454545455, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI281363763, Length=220, Percent_Identity=35.4545454545455, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI281363757, Length=220, Percent_Identity=35.4545454545455, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17136738, Length=220, Percent_Identity=35.4545454545455, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI281363761, Length=220, Percent_Identity=35.4545454545455, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI281363759, Length=220, Percent_Identity=35.4545454545455, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI281363753, Length=220, Percent_Identity=35.4545454545455, Blast_Score=132, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: 4.1.2.17 [C]

Molecular weight: Translated: 28837; Mature: 28837

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAIPEASSVRSQVTPEEWQTRVELAAAYRLVAHFGWDDLIFTHISARVPGQPDQFLINP
CCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEECH
YGMLFDEITASSLVKVDHHGEPVMATEYDVNPAGFLIHSAIHEGRPEVQCVLHTHTQYGV
HHHHHHHHHHHHEEEECCCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCE
AVSAQYGVAVSAQEGGLLPISQQSIFPLARLAYHGYEGVALRDDERPRLVADLGDASFLI
EEEECCCEEEECCCCCEEEECCHHHHHHHHHHHCCCCCEEECCCCCCEEEEECCCCEEEE
LRNHGLLTCGRSVPEALLSMYTLESACRIQILAQSGGGALTRIPDEIVATSVEQSRQVTK
EECCCCEEECCHHHHHHHHHHHHCCCEEEEEEEECCCCCEECCCHHHHHHHHHHHHHHHC
GKGAGLAWPGLLRRLDRIDPSYRT
CCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNAIPEASSVRSQVTPEEWQTRVELAAAYRLVAHFGWDDLIFTHISARVPGQPDQFLINP
CCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEECH
YGMLFDEITASSLVKVDHHGEPVMATEYDVNPAGFLIHSAIHEGRPEVQCVLHTHTQYGV
HHHHHHHHHHHHEEEECCCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCE
AVSAQYGVAVSAQEGGLLPISQQSIFPLARLAYHGYEGVALRDDERPRLVADLGDASFLI
EEEECCCEEEECCCCCEEEECCHHHHHHHHHHHCCCCCEEECCCCCCEEEEECCCCEEEE
LRNHGLLTCGRSVPEALLSMYTLESACRIQILAQSGGGALTRIPDEIVATSVEQSRQVTK
EECCCCEEECCHHHHHHHHHHHHCCCEEEEEEEECCCCCEECCCHHHHHHHHHHHHHHHC
GKGAGLAWPGLLRRLDRIDPSYRT
CCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+; Co2+; Mg2+; Mn2+; Zn2+ [C]

Kcat value (1/min): 19.3 [C]

Specific activity: 21.0

Km value (mM): 0.7 {L-fuculose} [C]

Substrates: L-Fuculose 1-phosphate [C]

Specific reaction: L-Fuculose 1-phosphate <==> Dihydroxyacetone phosphate + L-Lactaldehyde [C]

General reaction: Elimination of an aldehyde C-C bond; Cleavage [C]

Inhibitor: EDTA; Phosphoglycolohydroxamate [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]