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The map label for this gene is hpcH [H]

Identifier: 120612906

GI number: 120612906

Start: 4732551

End: 4733366

Strand: Direct

Name: hpcH [H]

Synonym: Aave_4270

Alternate gene names: 120612906

Gene position: 4732551-4733366 (Clockwise)

Preceding gene: 120612905

Following gene: 120612907

Centisome position: 88.41

GC content: 73.9

Gene sequence:

>816_bases
ATGCCCCAGCCCAACCGCTTCAAGCGCGCGCTCGCCGCCGGCCAGCCGCAGATCGGACTCTGGTCCACCCTGGCCTCGCC
CTATGCGAGCGAACTGCTCGCGGGCGCGGGCTTCGACTGGATGCTGCTGGACACCGAGCATTCGCCCAGCGACGTGCCGC
ACATGCTGCAGCAACTGCAGGCCGTGGATGCCGAGCGCGACGGGCGCACGGCCGCCGTGGTGCGGCCCGCATGGAACGAC
CCGGTGCTCATCAAGCGCTACCTCGACATCGGCGCGCAGAGCCTGCTGCTGCCCTTCGTGCAGAACGCCGACGAGGCGCG
CGCCGCGGTGGCCGCCATGCGCTACGCACCGCGCGGCATCCGCGGCATGGGCGGGTCGGTGCGGGCCACCCGCTTCGGGC
GCGACACCGGCTACCTCGCGCAGGCCGAGAACGAGCTGTGCCTGCTCGTGCAGGTGGAGACGGCCGAGGCACTGGAACGC
ATCGAGGACATCGCCGCGTTGGACGGCGTGGACGGCATCTTCATCGGCCCCGCCGACCTCTCGGCCAGCATGGGGCACGC
GGGCCGGCCTCAACACCCCGAGGTGCGCTCGGCCATCGACGGCGCCATCCGCCGCATCCGCGCCTGCGGCAAGGCCCCCG
GCATCCTCATGGCCGACGAGGCCCGGGCGCGCGAATGCCTGGACCTCGGCGCGCTCTTCGTGGCCGTGGCCATCGACATG
CTGCTGCTGCGCCAGGGCGCCGACGCCGCGGCCGCGAGGTTCCGGGGCGGCGCTGGCGCGGCACCGCGGCAGCCCCCGGC
CTCGCTCCCCTACTGA

Upstream 100 bases:

>100_bases
CGATACCATCGTGGCGGACTACGGCGAGTTCGGCACCGTTGCGTGCCACTTCGGCTGAGCGATTCCCCAGACCCCGCTCT
CCGCGAAACCGCTTCCTTCC

Downstream 100 bases:

>100_bases
ACCCCGCCGGCGGCGGGCTGCCGGCCCCACGCCTGTCATGGTCATCCGCCAATTAAATTGCACGCAATTTAATTGGCCGC
AATAATCCAACCCATGCCTT

Product: 2-dehydro-3-deoxyglucarate aldolase

Products: NA

Alternate protein names: 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; HHED aldolase; 4-hydroxy-2-ketoheptane-1,7-dioate aldolase; HKHD aldolase [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MPQPNRFKRALAAGQPQIGLWSTLASPYASELLAGAGFDWMLLDTEHSPSDVPHMLQQLQAVDAERDGRTAAVVRPAWND
PVLIKRYLDIGAQSLLLPFVQNADEARAAVAAMRYAPRGIRGMGGSVRATRFGRDTGYLAQAENELCLLVQVETAEALER
IEDIAALDGVDGIFIGPADLSASMGHAGRPQHPEVRSAIDGAIRRIRACGKAPGILMADEARARECLDLGALFVAVAIDM
LLLRQGADAAAARFRGGAGAAPRQPPASLPY

Sequences:

>Translated_271_residues
MPQPNRFKRALAAGQPQIGLWSTLASPYASELLAGAGFDWMLLDTEHSPSDVPHMLQQLQAVDAERDGRTAAVVRPAWND
PVLIKRYLDIGAQSLLLPFVQNADEARAAVAAMRYAPRGIRGMGGSVRATRFGRDTGYLAQAENELCLLVQVETAEALER
IEDIAALDGVDGIFIGPADLSASMGHAGRPQHPEVRSAIDGAIRRIRACGKAPGILMADEARARECLDLGALFVAVAIDM
LLLRQGADAAAARFRGGAGAAPRQPPASLPY
>Mature_270_residues
PQPNRFKRALAAGQPQIGLWSTLASPYASELLAGAGFDWMLLDTEHSPSDVPHMLQQLQAVDAERDGRTAAVVRPAWNDP
VLIKRYLDIGAQSLLLPFVQNADEARAAVAAMRYAPRGIRGMGGSVRATRFGRDTGYLAQAENELCLLVQVETAEALERI
EDIAALDGVDGIFIGPADLSASMGHAGRPQHPEVRSAIDGAIRRIRACGKAPGILMADEARARECLDLGALFVAVAIDML
LLRQGADAAAARFRGGAGAAPRQPPASLPY

Specific function: Catalyzes the reversible retro-aldol cleavage of 4- hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde [H]

COG id: COG3836

COG function: function code G; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789514, Length=252, Percent_Identity=46.8253968253968, Blast_Score=235, Evalue=2e-63,
Organism=Escherichia coli, GI1788578, Length=254, Percent_Identity=47.244094488189, Blast_Score=229, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR012689
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: 4.1.2.-

Molecular weight: Translated: 28854; Mature: 28723

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQPNRFKRALAAGQPQIGLWSTLASPYASELLAGAGFDWMLLDTEHSPSDVPHMLQQLQ
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHH
AVDAERDGRTAAVVRPAWNDPVLIKRYLDIGAQSLLLPFVQNADEARAAVAAMRYAPRGI
HHCCCCCCCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
RGMGGSVRATRFGRDTGYLAQAENELCLLVQVETAEALERIEDIAALDGVDGIFIGPADL
CCCCCCCEEEECCCCCCCCEECCCCEEEEEEECHHHHHHHHHHHHHHCCCCEEEECCCCC
SASMGHAGRPQHPEVRSAIDGAIRRIRACGKAPGILMADEARARECLDLGALFVAVAIDM
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHH
LLLRQGADAAAARFRGGAGAAPRQPPASLPY
HHHHCCCCHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PQPNRFKRALAAGQPQIGLWSTLASPYASELLAGAGFDWMLLDTEHSPSDVPHMLQQLQ
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHH
AVDAERDGRTAAVVRPAWNDPVLIKRYLDIGAQSLLLPFVQNADEARAAVAAMRYAPRGI
HHCCCCCCCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
RGMGGSVRATRFGRDTGYLAQAENELCLLVQVETAEALERIEDIAALDGVDGIFIGPADL
CCCCCCCEEEECCCCCCCCEECCCCEEEEEEECHHHHHHHHHHHHHHCCCCEEEECCCCC
SASMGHAGRPQHPEVRSAIDGAIRRIRACGKAPGILMADEARARECLDLGALFVAVAIDM
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHH
LLLRQGADAAAARFRGGAGAAPRQPPASLPY
HHHHCCCCHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA