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The map label for this gene is fadA [H]

Identifier: 120612722

GI number: 120612722

Start: 4536993

End: 4538192

Strand: Reverse

Name: fadA [H]

Synonym: Aave_4085

Alternate gene names: 120612722

Gene position: 4538192-4536993 (Counterclockwise)

Preceding gene: 120612723

Following gene: 120612721

Centisome position: 84.78

GC content: 69.75

Gene sequence:

>1200_bases
ATGGCAAAACAAATGCAGGACGCCTACATCGTCGCCGCCACGCGCACGCCCATCGGCAAGTCGCACCGCGGCTACTTCCG
CAACACCCGCCCCGACGACCTGCTGGCCACGACCCTGAAGGCCGCGCTGGCCCAGGTGCCGGGGCTGGACCCGGCCGCCA
TCGAGGACATCATCTGCGGTTGCGCGATTCCCGAGGGCGCACAGGGCCTGAACGTGGCGCGCATCGGCGCCGTGCTGGCG
GGGCTGCCCACCAGCGTGGGCGGCATCACCGTCAACCGCTTCTGCGCCTCGGGCCTCTCGGCCGTGCAGATGGCCGCCGA
CCGCATCCGCGTGGGCGAGGCCGAGGTGATGATCGCCGCGGGTGTCGAGAGCATGAGCATGGTGCCGATGATGGGCAATA
CGCCGTCGCTCTCGCCCAGCATCTTCGCGAAGGACGGCGACGTGGGCATCGCCTACGGCATGGGCCTGACGGCCGAGAAG
GTCGCCCAGCAGTGGAAGGTGTCGCGCGAGGACCAGGATGCCTTCGCGCTGCAGTCGCACCAGCGGGCGCTGGCCGCGCA
GCAGGCGGGCGAATTCACGGACGAGATCACGCCGATCGAAGTGACCGACCGCACCGCGGACCTGGAGTCGGGCGAGAGCG
TCGCGAAGACCCGTACGGTGACGCTGGACGAGGGCGCGCGGCCCGACACCAGTCTGGAGGGGCTCGCCAAGCTCAAGACG
GTGTTCGCCGCGCGCGGCTCGGTCACGGCCGGCAACAGTTCACAGACCAGTGACGGCGCCGGTGCGCTGATCCTCGCGAG
CGAATCGGCCGTGAAGCGCTTCGGCCTGACCCCGCTGGCGCGTTTCGTCAGCTTCGCCAGCAAGGGCGTGCCGCCGAGCA
TCATGGGCATCGGCCCGATCGAGGCCATCCCGGCCGCGCTGCGCTATGCCGGCCTGAATCAGCAGGACATCGACTGGTTC
GAGCTGAACGAGGCCTTCGCCGCGCAGTCGCTCGCCGTGCTGCGCCAGCTGGGCCTGGACCCGGCCAAGGTGAATCCGAT
GGGCGGCGCCATCGCGCTGGGCCATCCGCTGGGCGCCACGGGCGCCATCCGCTCGGCCACGGTCGTGCATGCGCTGCGCA
GAAAGAACCTGAAATACGGCATGGTCACGATGTGCGTGGGCATGGGGCAGGGCGCTGCGGGCATCTTCGAAAGGGTGTGA

Upstream 100 bases:

>100_bases
GGTGCAATGCGAATTCACGTGGGCCTGGGTTCCCTCCAGCCGCCCCGCCAGGTAAACGATTGACTGACCGATCGACGGAT
CGATTGAAGGAGCCTTCTCC

Downstream 100 bases:

>100_bases
GTACATCCCCCTGAGCGGCTTCGCCGCTTCCCCCTTCTCTCGCGCTGGCGCGCGGGAAGGGGGACGACGCCGGTGGCCTG
GCGAAGCCAGATCCACGGCG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MAKQMQDAYIVAATRTPIGKSHRGYFRNTRPDDLLATTLKAALAQVPGLDPAAIEDIICGCAIPEGAQGLNVARIGAVLA
GLPTSVGGITVNRFCASGLSAVQMAADRIRVGEAEVMIAAGVESMSMVPMMGNTPSLSPSIFAKDGDVGIAYGMGLTAEK
VAQQWKVSREDQDAFALQSHQRALAAQQAGEFTDEITPIEVTDRTADLESGESVAKTRTVTLDEGARPDTSLEGLAKLKT
VFAARGSVTAGNSSQTSDGAGALILASESAVKRFGLTPLARFVSFASKGVPPSIMGIGPIEAIPAALRYAGLNQQDIDWF
ELNEAFAAQSLAVLRQLGLDPAKVNPMGGAIALGHPLGATGAIRSATVVHALRRKNLKYGMVTMCVGMGQGAAGIFERV

Sequences:

>Translated_399_residues
MAKQMQDAYIVAATRTPIGKSHRGYFRNTRPDDLLATTLKAALAQVPGLDPAAIEDIICGCAIPEGAQGLNVARIGAVLA
GLPTSVGGITVNRFCASGLSAVQMAADRIRVGEAEVMIAAGVESMSMVPMMGNTPSLSPSIFAKDGDVGIAYGMGLTAEK
VAQQWKVSREDQDAFALQSHQRALAAQQAGEFTDEITPIEVTDRTADLESGESVAKTRTVTLDEGARPDTSLEGLAKLKT
VFAARGSVTAGNSSQTSDGAGALILASESAVKRFGLTPLARFVSFASKGVPPSIMGIGPIEAIPAALRYAGLNQQDIDWF
ELNEAFAAQSLAVLRQLGLDPAKVNPMGGAIALGHPLGATGAIRSATVVHALRRKNLKYGMVTMCVGMGQGAAGIFERV
>Mature_398_residues
AKQMQDAYIVAATRTPIGKSHRGYFRNTRPDDLLATTLKAALAQVPGLDPAAIEDIICGCAIPEGAQGLNVARIGAVLAG
LPTSVGGITVNRFCASGLSAVQMAADRIRVGEAEVMIAAGVESMSMVPMMGNTPSLSPSIFAKDGDVGIAYGMGLTAEKV
AQQWKVSREDQDAFALQSHQRALAAQQAGEFTDEITPIEVTDRTADLESGESVAKTRTVTLDEGARPDTSLEGLAKLKTV
FAARGSVTAGNSSQTSDGAGALILASESAVKRFGLTPLARFVSFASKGVPPSIMGIGPIEAIPAALRYAGLNQQDIDWFE
LNEAFAAQSLAVLRQLGLDPAKVNPMGGAIALGHPLGATGAIRSATVVHALRRKNLKYGMVTMCVGMGQGAAGIFERV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=46.1734693877551, Blast_Score=315, Evalue=5e-86,
Organism=Homo sapiens, GI167614485, Length=403, Percent_Identity=42.1836228287841, Blast_Score=295, Evalue=5e-80,
Organism=Homo sapiens, GI148539872, Length=402, Percent_Identity=41.5422885572139, Blast_Score=261, Evalue=8e-70,
Organism=Homo sapiens, GI4557237, Length=405, Percent_Identity=36.7901234567901, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI4504327, Length=440, Percent_Identity=32.5, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI194353979, Length=395, Percent_Identity=33.4177215189873, Blast_Score=165, Evalue=7e-41,
Organism=Escherichia coli, GI1787663, Length=411, Percent_Identity=45.4987834549878, Blast_Score=322, Evalue=2e-89,
Organism=Escherichia coli, GI48994986, Length=402, Percent_Identity=45.273631840796, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=42.1182266009852, Blast_Score=274, Evalue=6e-75,
Organism=Escherichia coli, GI87082165, Length=404, Percent_Identity=40.8415841584158, Blast_Score=270, Evalue=9e-74,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=30.2600472813239, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI133906874, Length=402, Percent_Identity=42.2885572139304, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI25147385, Length=402, Percent_Identity=32.8358208955224, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17535921, Length=405, Percent_Identity=33.5802469135802, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17551802, Length=441, Percent_Identity=30.8390022675737, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17535917, Length=396, Percent_Identity=29.5454545454545, Blast_Score=147, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6322031, Length=406, Percent_Identity=41.6256157635468, Blast_Score=290, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6325229, Length=412, Percent_Identity=35.6796116504854, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24655093, Length=406, Percent_Identity=40.3940886699507, Blast_Score=275, Evalue=3e-74,
Organism=Drosophila melanogaster, GI17648125, Length=410, Percent_Identity=39.5121951219512, Blast_Score=266, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24640423, Length=407, Percent_Identity=34.6437346437346, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI17137578, Length=444, Percent_Identity=31.981981981982, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41438; Mature: 41307

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQMQDAYIVAATRTPIGKSHRGYFRNTRPDDLLATTLKAALAQVPGLDPAAIEDIICG
CCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAIPEGAQGLNVARIGAVLAGLPTSVGGITVNRFCASGLSAVQMAADRIRVGEAEVMIAA
CCCCCCCCCCCHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
GVESMSMVPMMGNTPSLSPSIFAKDGDVGIAYGMGLTAEKVAQQWKVSREDQDAFALQSH
CCCHHEECCCCCCCCCCCCEEEECCCCEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHHH
QRALAAQQAGEFTDEITPIEVTDRTADLESGESVAKTRTVTLDEGARPDTSLEGLAKLKT
HHHHHHHHHCCHHCCCCCEEECCCCCCCCCCCHHHHEEEEEECCCCCCCCHHHHHHHHHH
VFAARGSVTAGNSSQTSDGAGALILASESAVKRFGLTPLARFVSFASKGVPPSIMGIGPI
HHHHCCCCCCCCCCCCCCCCCEEEEECHHHHHHHCCHHHHHHHHHHHCCCCCCEECCCCH
EAIPAALRYAGLNQQDIDWFELNEAFAAQSLAVLRQLGLDPAKVNPMGGAIALGHPLGAT
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCC
GAIRSATVVHALRRKNLKYGMVTMCVGMGQGAAGIFERV
CHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHCC
>Mature Secondary Structure 
AKQMQDAYIVAATRTPIGKSHRGYFRNTRPDDLLATTLKAALAQVPGLDPAAIEDIICG
CCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAIPEGAQGLNVARIGAVLAGLPTSVGGITVNRFCASGLSAVQMAADRIRVGEAEVMIAA
CCCCCCCCCCCHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
GVESMSMVPMMGNTPSLSPSIFAKDGDVGIAYGMGLTAEKVAQQWKVSREDQDAFALQSH
CCCHHEECCCCCCCCCCCCEEEECCCCEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHHH
QRALAAQQAGEFTDEITPIEVTDRTADLESGESVAKTRTVTLDEGARPDTSLEGLAKLKT
HHHHHHHHHCCHHCCCCCEEECCCCCCCCCCCHHHHEEEEEECCCCCCCCHHHHHHHHHH
VFAARGSVTAGNSSQTSDGAGALILASESAVKRFGLTPLARFVSFASKGVPPSIMGIGPI
HHHHCCCCCCCCCCCCCCCCCEEEEECHHHHHHHCCHHHHHHHHHHHCCCCCCEECCCCH
EAIPAALRYAGLNQQDIDWFELNEAFAAQSLAVLRQLGLDPAKVNPMGGAIALGHPLGAT
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCC
GAIRSATVVHALRRKNLKYGMVTMCVGMGQGAAGIFERV
CHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]