Click here to switch to the map view.

The map label for this gene is aer [H]

Identifier: 120612562

GI number: 120612562

Start: 4345722

End: 4347296

Strand: Reverse

Name: aer [H]

Synonym: Aave_3923

Alternate gene names: 120612562

Gene position: 4347296-4345722 (Counterclockwise)

Preceding gene: 120612563

Following gene: 120612561

Centisome position: 81.22

GC content: 73.02

Gene sequence:

>1575_bases
ATGTCGGCCCTGGTACCTGCCGGCGGGGCGGATGCAGCCCTGCGCGAGGACGAATACCTCATCACGCGGACCGACATCGA
GGGCCGCATGGTGTACGTGAACGCGGCCTTCGCCGAGCGCAGCGGCTACGAATCCGGGGAGCTGCTCGGGCAGCCCGCCA
GCATGATGTACGCGCCCGACACGCCGCCCGAGTTGAGCGCCGACCTGTGGCGCACCGTCAAGGCCCACGGTGCCTGGACC
GGCGTGATGCGCCACCGCTGCAAGGACGGCAGCTGCTTCTGGGCGCAGGCCACGATCACGCGCACGATGCAGGACGGCCG
GCACGTGGGCCATACCACCGTGCGCACCCGGGCCGGCGAGCAGGAAGTGGCGCGGATGCGCCGCTTCAACGCCGCCCGGC
AGCGCGGGGCGGTCGCGCTCCACACGCTGCGCGAAGGGCGGCTCGCCCTGCGCGGCATCGGCGGACTGCTGCGCCTCGTG
GCGGCGCCCACCCTCGCGTCGCGATTGGCGCTCGCCCAGGCGGCCAATGCCGTGGTGGTCTGCCTGGCCGCGGCGCAGTG
GCTCGGCGCCCGGGATGCCGTGCCCCCCGCCGCCATCGCGATCTGCGTGGTGTCGCTGGCCCTCGGCGCCGCCCTGGAGA
TGGCCCGGCGGCGCATCCGACGACCCGTGGGCCGCCTGCTGGCACACGCGCGCGGCATCGGCGCGGGCGACCTCACGTGG
CCGGCGGCGCCGGACACGGGCGCGGACGACGAGGTGGCACGCCTCGGCGCCAGCATGGACGTCATGCAGAAAAGCCTGGC
CAGCCTGGTGCGCGACCTGCGCGAGGGCGTGAGGACGGTCGATGGCGCGGCCAGCGAAATCTCCGACGCCAACATGGACC
TGGCGGCGCGCACGGAACAGACCGCTTCCGCCATCGAGCAGGCGGTGGGGCGCATGCACGACCTGAGCGACGCGGTGCAC
CGCAATGCCACCCATGCGGACCGGACGCACCGGCTGGCCGCCTCGTCCCGCGACGCCGCCGAACAGGGGCGCGAGCTGGT
GCGGCAGGTGATCGACGGCATGGGCGACATTGCACGCAGCACCGCGGGCATTTCCGACATCTCCTCGATGATCGAGGGCA
TCGCCTTCCAGACCAACATCCTCGCGCTCAACGCGGCCGTCGAGGCGGCGCGCGCGGGCACCCACGGCCGCGGGTTCGCG
GTGGTGGCCGCCGAAGTGCGCAGCCTCGCCCAGCGCAGCTCGGAAGCGGTCCGGCAGATCAGCCAGTTGCTGGACGTCTC
CCGGGGCCATGTCGCCAGCGGGGAGCGGCTGGCCCAGGCCGCGGGCGGCAGCATCGACGAGATCGTGCGCCTCGCCTCCC
AGGTGCTGGCCACCGTGGGCGAGATGTCCCAGGCCTCCCAAAGCCAGCACGAGGAGATCACGCGCATCAACGGCGTCATC
GGGCGGATCGACGATGCCGTCCGGCAGAACTCCGCCATGGTGGAACAGGCGGCTGCCGCCGCGGCTTCCCTGGCGGACCA
GAGCCGCAGGCTCGACCACTCCGTCTCGCTGTTCAGGACCGGTGCCGCCCATTAA

Upstream 100 bases:

>100_bases
ACTTCACGCTGGCCCTGGCCGTGCTGTCCGCCATGCTCGCGGGGGGCGCGCTGTCGATCTGGGCGGTGGACGTGGAATCG
CGCAACCGCGCGCTCGACTG

Downstream 100 bases:

>100_bases
GGCTTGCAGCGCGCGCTACCTACAATTCGCGCATGCCAGACAAGACCGCGACCGAGGATGAGGAATATGTGTTCTCCGAA
CAGGTGGGGCACCTGCTGCG

Product: Pas/Pac sensor containing methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MSALVPAGGADAALREDEYLITRTDIEGRMVYVNAAFAERSGYESGELLGQPASMMYAPDTPPELSADLWRTVKAHGAWT
GVMRHRCKDGSCFWAQATITRTMQDGRHVGHTTVRTRAGEQEVARMRRFNAARQRGAVALHTLREGRLALRGIGGLLRLV
AAPTLASRLALAQAANAVVVCLAAAQWLGARDAVPPAAIAICVVSLALGAALEMARRRIRRPVGRLLAHARGIGAGDLTW
PAAPDTGADDEVARLGASMDVMQKSLASLVRDLREGVRTVDGAASEISDANMDLAARTEQTASAIEQAVGRMHDLSDAVH
RNATHADRTHRLAASSRDAAEQGRELVRQVIDGMGDIARSTAGISDISSMIEGIAFQTNILALNAAVEAARAGTHGRGFA
VVAAEVRSLAQRSSEAVRQISQLLDVSRGHVASGERLAQAAGGSIDEIVRLASQVLATVGEMSQASQSQHEEITRINGVI
GRIDDAVRQNSAMVEQAAAAAASLADQSRRLDHSVSLFRTGAAH

Sequences:

>Translated_524_residues
MSALVPAGGADAALREDEYLITRTDIEGRMVYVNAAFAERSGYESGELLGQPASMMYAPDTPPELSADLWRTVKAHGAWT
GVMRHRCKDGSCFWAQATITRTMQDGRHVGHTTVRTRAGEQEVARMRRFNAARQRGAVALHTLREGRLALRGIGGLLRLV
AAPTLASRLALAQAANAVVVCLAAAQWLGARDAVPPAAIAICVVSLALGAALEMARRRIRRPVGRLLAHARGIGAGDLTW
PAAPDTGADDEVARLGASMDVMQKSLASLVRDLREGVRTVDGAASEISDANMDLAARTEQTASAIEQAVGRMHDLSDAVH
RNATHADRTHRLAASSRDAAEQGRELVRQVIDGMGDIARSTAGISDISSMIEGIAFQTNILALNAAVEAARAGTHGRGFA
VVAAEVRSLAQRSSEAVRQISQLLDVSRGHVASGERLAQAAGGSIDEIVRLASQVLATVGEMSQASQSQHEEITRINGVI
GRIDDAVRQNSAMVEQAAAAAASLADQSRRLDHSVSLFRTGAAH
>Mature_523_residues
SALVPAGGADAALREDEYLITRTDIEGRMVYVNAAFAERSGYESGELLGQPASMMYAPDTPPELSADLWRTVKAHGAWTG
VMRHRCKDGSCFWAQATITRTMQDGRHVGHTTVRTRAGEQEVARMRRFNAARQRGAVALHTLREGRLALRGIGGLLRLVA
APTLASRLALAQAANAVVVCLAAAQWLGARDAVPPAAIAICVVSLALGAALEMARRRIRRPVGRLLAHARGIGAGDLTWP
AAPDTGADDEVARLGASMDVMQKSLASLVRDLREGVRTVDGAASEISDANMDLAARTEQTASAIEQAVGRMHDLSDAVHR
NATHADRTHRLAASSRDAAEQGRELVRQVIDGMGDIARSTAGISDISSMIEGIAFQTNILALNAAVEAARAGTHGRGFAV
VAAEVRSLAQRSSEAVRQISQLLDVSRGHVASGERLAQAAGGSIDEIVRLASQVLATVGEMSQASQSQHEEITRINGVIG
RIDDAVRQNSAMVEQAAAAAASLADQSRRLDHSVSLFRTGAAH

Specific function: Signal transducer for aerotaxis. The aerotactic response is the accumulation of cells around air bubbles. The nature of the sensory stimulus detected by this protein is the proton motive force or cellular redox state. It uses a FAD prosthetic group as a r

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789453, Length=515, Percent_Identity=30.6796116504854, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI2367378, Length=298, Percent_Identity=43.9597315436242, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1788195, Length=308, Percent_Identity=41.8831168831169, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1787690, Length=305, Percent_Identity=41.6393442622951, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1788194, Length=318, Percent_Identity=38.3647798742138, Blast_Score=196, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal; PF08447 PAS_3 [H]

EC number: NA

Molecular weight: Translated: 55410; Mature: 55279

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALVPAGGADAALREDEYLITRTDIEGRMVYVNAAFAERSGYESGELLGQPASMMYAPD
CCCCCCCCCCCCHHCCCCEEEEEECCCCEEEEEEEHHHHHCCCCCCHHCCCCCCCEECCC
TPPELSADLWRTVKAHGAWTGVMRHRCKDGSCFWAQATITRTMQDGRHVGHTTVRTRAGE
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCHHHHHCCCH
QEVARMRRFNAARQRGAVALHTLREGRLALRGIGGLLRLVAAPTLASRLALAQAANAVVV
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CLAAAQWLGARDAVPPAAIAICVVSLALGAALEMARRRIRRPVGRLLAHARGIGAGDLTW
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PAAPDTGADDEVARLGASMDVMQKSLASLVRDLREGVRTVDGAASEISDANMDLAARTEQ
CCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHH
TASAIEQAVGRMHDLSDAVHRNATHADRTHRLAASSRDAAEQGRELVRQVIDGMGDIARS
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
TAGISDISSMIEGIAFQTNILALNAAVEAARAGTHGRGFAVVAAEVRSLAQRSSEAVRQI
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SQLLDVSRGHVASGERLAQAAGGSIDEIVRLASQVLATVGEMSQASQSQHEEITRINGVI
HHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRIDDAVRQNSAMVEQAAAAAASLADQSRRLDHSVSLFRTGAAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SALVPAGGADAALREDEYLITRTDIEGRMVYVNAAFAERSGYESGELLGQPASMMYAPD
CCCCCCCCCCCHHCCCCEEEEEECCCCEEEEEEEHHHHHCCCCCCHHCCCCCCCEECCC
TPPELSADLWRTVKAHGAWTGVMRHRCKDGSCFWAQATITRTMQDGRHVGHTTVRTRAGE
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCHHHHHCCCH
QEVARMRRFNAARQRGAVALHTLREGRLALRGIGGLLRLVAAPTLASRLALAQAANAVVV
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CLAAAQWLGARDAVPPAAIAICVVSLALGAALEMARRRIRRPVGRLLAHARGIGAGDLTW
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PAAPDTGADDEVARLGASMDVMQKSLASLVRDLREGVRTVDGAASEISDANMDLAARTEQ
CCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHH
TASAIEQAVGRMHDLSDAVHRNATHADRTHRLAASSRDAAEQGRELVRQVIDGMGDIARS
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
TAGISDISSMIEGIAFQTNILALNAAVEAARAGTHGRGFAVVAAEVRSLAQRSSEAVRQI
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SQLLDVSRGHVASGERLAQAAGGSIDEIVRLASQVLATVGEMSQASQSQHEEITRINGVI
HHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRIDDAVRQNSAMVEQAAAAAASLADQSRRLDHSVSLFRTGAAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 9190831; 9380671 [H]